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  1. Article ; Online: m

    Lobo, João / Costa, Ana Laura / Cantante, Mariana / Guimarães, Rita / Lopes, Paula / Antunes, Luís / Braga, Isaac / Oliveira, Jorge / Pelizzola, Mattia / Henrique, Rui / Jerónimo, Carmen

    Journal of translational medicine

    2019  Volume 17, Issue 1, Page(s) 79

    Abstract: Background: Covalent RNA modifications, such as N-6-methyladenosine (m: Methods: In silico ... as immunohistochemistry for VIRMA, YTHDF3 and m: Results: In our cohort, VIRMA and YTHDF3 mRNA expression levels ... m: Conclusion: Abundance of m ...

    Abstract Background: Covalent RNA modifications, such as N-6-methyladenosine (m
    Methods: In silico analysis of TCGA data disclosed altered expression of VIRMA (52%) and YTHDF3 (48%), prompting subsequent validation. Formalin-fixed paraffin-embedded tissues from 122 TGCTs (2005-2016) were selected. RNA extraction, cDNA synthesis and real-time qPCR (Taqman assays) for VIRMA and YTHDF3 were performed, as well as immunohistochemistry for VIRMA, YTHDF3 and m
    Results: In our cohort, VIRMA and YTHDF3 mRNA expression levels differed among TGCT subtypes, with Seminomas (SEs) depicting higher levels than Non-Seminomatous tumors (NSTs) (p < 0.01 for both). A positive correlation was found between VIRMA and YTHDF3 expression levels. VIRMA discriminated SEs from NSTs with AUC = 0.85 (Sensitivity 77.3%, Specificity 81.1%, PPV 71.6%, NPV 85.3%, Accuracy 79.7%). Immunohistochemistry paralleled transcript findings, as patients with strong m
    Conclusion: Abundance of m
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/metabolism ; Adult ; Animals ; Cohort Studies ; Computer Simulation ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Neoplasm Metastasis ; Neoplasms, Germ Cell and Embryonal/genetics ; Neoplasms, Germ Cell and Embryonal/pathology ; Phenotype ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Reproducibility of Results ; Seminoma/genetics ; Seminoma/pathology ; Testicular Neoplasms/genetics ; Testicular Neoplasms/pathology ; Young Adult
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; VIRMA protein, human ; YTHDF3 protein, human ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2019-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-019-1837-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Remodeling of the m

    Bueno-Costa, Alberto / Piñeyro, David / García-Prieto, Carlos A / Ortiz-Barahona, Vanessa / Martinez-Verbo, Laura / Webster, Natalie A / Andrews, Byron / Kol, Nitzan / Avrahami, Chen / Moshitch-Moshkovitz, Sharon / Rechavi, Gideon / Esteller, Manel

    Leukemia

    2022  Volume 36, Issue 8, Page(s) 2121–2124

    MeSH term(s) Humans ; Macrophages ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-022-01621-1
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  3. Article ; Online: SRSF2 plays an unexpected role as reader of m

    Ma, Hai-Li / Bizet, Martin / Soares Da Costa, Christelle / Murisier, Frédéric / de Bony, Eric James / Wang, Meng-Ke / Yoshimi, Akihide / Lin, Kuan-Ting / Riching, Kristin M / Wang, Xing / Beckman, John I / Arya, Shailee / Droin, Nathalie / Calonne, Emilie / Hassabi, Bouchra / Zhang, Qing-Yang / Li, Ang / Putmans, Pascale / Malbec, Lionel /
    Hubert, Céline / Lan, Jie / Mies, Frédérique / Yang, Ying / Solary, Eric / Daniels, Danette L / Gupta, Yogesh K / Deplus, Rachel / Abdel-Wahab, Omar / Yang, Yun-Gui / Fuks, François

    Molecular cell

    2023  Volume 83, Issue 23, Page(s) 4239–4254.e10

    Abstract: A common mRNA modification is 5-methylcytosine (m ...

    Abstract A common mRNA modification is 5-methylcytosine (m
    MeSH term(s) Humans ; Leukemia/genetics ; Myelodysplastic Syndromes/genetics ; Neoplasms/genetics ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; Serine-Arginine Splicing Factors/genetics ; RNA Methylation/genetics
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; Serine-Arginine Splicing Factors (170974-22-8) ; SRSF2 protein, human (147153-65-9)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.11.003
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  4. Article ; Online: Carfilzomib 56 mg/m

    Weisel, Katja / Nooka, Ajay K / Terpos, Evangelos / Spencer, Andrew / Goldschmidt, Hartmut / Dirnberger, Franziska / DeCosta, Lucy / Yusuf, Akeem / Kumar, Shaji

    Leukemia & lymphoma

    2022  Volume 63, Issue 8, Page(s) 1887–1896

    Abstract: Given the increasing use of frontline lenalidomide-based therapies in multiple myeloma (MM), there is an emerging need for lenalidomide-sparing regimens at relapse. Carfilzomib plus dexamethasone and daratumumab (KdD) and daratumumab plus bortezomib and ... ...

    Abstract Given the increasing use of frontline lenalidomide-based therapies in multiple myeloma (MM), there is an emerging need for lenalidomide-sparing regimens at relapse. Carfilzomib plus dexamethasone and daratumumab (KdD) and daratumumab plus bortezomib and dexamethasone (DVd) are lenalidomide-sparing triplet regimens that are approved for relapsed and/or refractory MM (R/RMM). In the absence of a head-to-head trial comparing these treatments, a matching-adjusted indirect treatment comparison (MAIC) was conducted to assess the efficacy and safety of KdD versus DVd. Results showed that treatment with KdD decreases the risk of progression or death versus DVd (HR 0.64; 95% confidence interval (CI): 0.46-0.90). Time-dependent analysis demonstrated a larger benefit for KdD after the first eight cycles. Unmatched subgroup analysis indicated that KdD may be particularly effective in lenalidomide-exposed and -refractory patients. The present analysis suggests that KdD improves outcomes compared with DVd in patients with R/RMM and may provide a rationale for a preferential treatment.
    MeSH term(s) Antibodies, Monoclonal ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bortezomib/therapeutic use ; Dexamethasone/therapeutic use ; Humans ; Lenalidomide/therapeutic use ; Multiple Myeloma/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Oligopeptides
    Chemical Substances Antibodies, Monoclonal ; Oligopeptides ; daratumumab (4Z63YK6E0E) ; Bortezomib (69G8BD63PP) ; carfilzomib (72X6E3J5AR) ; Dexamethasone (7S5I7G3JQL) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2047962
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    Zs.A 2997: Show issues Location:
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  5. Article: Impact of NG-Test CTX-M MULTI Immunochromatographic Assay on Antimicrobial Management of

    Boattini, Matteo / Bianco, Gabriele / Ghibaudo, Davide / Comini, Sara / Corcione, Silvia / Cavallo, Rossana / De Rosa, Francesco Giuseppe / Costa, Cristina

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: ... This study was aimed at assessing the impact of direct detection of CTX-M ESBL-producers on antimicrobial ...

    Abstract Rapid detection of extended-spectrum-β-lactamase (ESBL) is of paramount importance to accelerate clinical decision-making, optimize antibiotic treatment, and implement adequate infection control measures. This study was aimed at assessing the impact of direct detection of CTX-M ESBL-producers on antimicrobial management of
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030473
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  6. Article ; Online: M. genitalium Detection Through Multiplex Real-Time PCR Assay: Three-Year Study From a Portuguese Tertiary Referral Center.

    Palmeiro, A G / Duarte, S / Barreto, M R / Borges-Costa, J

    Actas dermo-sifiliograficas

    2024  

    Language Spanish
    Publishing date 2024-02-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2023.03.018
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  7. Article ; Online: M. genitalium Detection Through Multiplex Real-Time PCR Assay: Three-Year Study From a Portuguese Tertiary Referral Center.

    G Palmeiro, A / Duarte, S / Barreto, M R / Borges-Costa, J

    Actas dermo-sifiliograficas

    2024  

    Title translation [Artículo traducido] Detección de Mycoplasma genitalium por PCR multiplex en tiempo real: un estudio de 3 años de un hospital portugués de tercer nivel.
    Language Spanish
    Publishing date 2024-04-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2024.03.028
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  8. Article ; Online: The Xpert® MTB/RIF cycle threshold value predicts M. tuberculosis transmission to close contacts in a Brazilian prospective multicenter cohort.

    Garcia, Leandro S / Costa, Allyson G / Araújo-Pereira, Mariana / Spener-Gomes, Renata / Aguiar, Amanda França / Souza, Alexandra B / Lima, Lucas O A / Benjamin, Aline / Rocha, Michael S / Moreira, Adriana S R / Silva, Jaquelane / Santos, Saulo R N / Lourenço, Maria Cristina / Figueiredo, Marina C / Turner, Megan M / Kritski, Afranio L / Rolla, Valeria C / Sterling, Timothy R / Andrade, Bruno B /
    Cordeiro-Santos, Marcelo

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: The Xpert® MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form of cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as a potential ... ...

    Abstract Background: The Xpert® MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form of cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as a potential risk measure of bacterial spread for tuberculosis cases, which can impact infection control. However, the role of Ct values in assessing Mtb transmission to close contacts has not yet been demonstrated.
    Methods: A prospective study was performed to investigate the association between Xpert® MTB/RIF Ct values and Mtb transmission to close contacts of patients with culture-confirmed pulmonary TB in a multi-center Brazilian cohort. We evaluated clinical and laboratory data, such as age, sex, race, smoking habits, drug use, alcohol use, chest radiograph, Xpert® MTB/RIF results among pulmonary tuberculosis cases, and QuantiFERON(QFT)-Plus results at baseline and after six months for close contacts who had a negative result at baseline.
    Results: A total of 1,055 close contacts of 382 pulmonary tuberculosis cases were included in the study. The median Ct values from pulmonary tuberculosis cases of QFT-Plus positive (at baseline or six months) close contacts were lower compared with those who were QFT-Plus negative. An adjusted logistic regression demonstrated that reduced Ct values from the index cases were independently associated with QFT-Plus conversion from negative to positive (OR: 1.61, 95% CI: 1.12-2.32) after adjusting for clinical characteristics.
    Conclusion: Close contacts of pulmonary TB index cases exhibiting low Xpert MTB/RIF Ct values displayed higher rates of TB infection, reflecting Mtb transmission.
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad794
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  9. Article: Association between Ustekinumab Trough Levels, Serum IL-22, and Oncostatin M Levels and Clinical and Biochemical Outcomes in Patients with Crohn's Disease.

    Bertin, Luisa / Barberio, Brigida / Gubbiotti, Alessandro / Bertani, Lorenzo / Costa, Francesco / Ceccarelli, Linda / Visaggi, Pierfrancesco / Bodini, Giorgia / Pasta, Andrea / Sablich, Renato / Urbano, Maria Teresa / Ferronato, Antonio / Buda, Andrea / De Bona, Manuela / Del Corso, Giulio / Massano, Alessandro / Angriman, Imerio / Scarpa, Marco / Zingone, Fabiana /
    Savarino, Edoardo Vincenzo

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061539
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  10. Article ; Online: Electrochemical immunosensor for point-of-care detection of soybean Gly m TI allergen in foods.

    Dias, Catarina / Costa, Joana / Mafra, Isabel / Fernandes, Daniela / Brandão, Ana T S C / Silva, A Fernando / Pereira, Carlos M / Costa, Renata

    Talanta

    2023  Volume 268, Issue Pt 1, Page(s) 125284

    Abstract: ... immunosensor, targeting the soybean trypsin inhibitor (Gly m TI) allergen using commercial anti-Gly m TI IgG ...

    Abstract Soybean is a legume with high technological functionality, commonly used by the food industry as an ingredient in different products. However, soybean is an allergenic food whose undeclared presence in processed foods may represent a public health risk. In this work, it was developed an efficient electrochemical immunosensor, targeting the soybean trypsin inhibitor (Gly m TI) allergen using commercial anti-Gly m TI IgG, aiming at detecting/quantifying minute amounts of soybean in different food formulations. For this purpose, model mixtures of different foods (sausages, cooked-hams, biscuits) were prepared to contain known amounts of soybean protein isolate (100,000-0.1 mg kg
    MeSH term(s) Humans ; Glycine max ; Allergens ; Biosensing Techniques ; Point-of-Care Systems ; Immunoassay
    Chemical Substances Allergens
    Language English
    Publishing date 2023-10-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125284
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