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  1. Article: Preeclampsia Management and Maternal Ophthalmic Artery Doppler Measurements between 19 and 23 Weeks of Gestation.

    Gyokova, Elitsa / Hristova-Atanasova, Eleonora / Iskrov, Georgi

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13040950
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  2. Article: Diabetic Retinopathy Screening and Registration in Europe-Narrative Review.

    Hristova, Elitsa / Koseva, Darina / Zlatarova, Zornitsa / Dokova, Klara

    Healthcare (Basel, Switzerland)

    2021  Volume 9, Issue 6

    Abstract: Diabetic retinopathy (DR) is a leading cause of preventable vision impairment and blindness in the European Region. Despite the fact that almost all European countries have some kind of prophylactic eye examination for people with diabetes, the ... ...

    Abstract Diabetic retinopathy (DR) is a leading cause of preventable vision impairment and blindness in the European Region. Despite the fact that almost all European countries have some kind of prophylactic eye examination for people with diabetes, the examinations are not properly arranged and are not organized according to the principles of screening in medicine. In 2021, the current COVID-19 pandemic moved telemedicine to the forefront healthcare services. Due to that, a lot more patients could benefit from comfortable and faster access to ophthalmology specialist care. This study aimed to conduct a narrative literature review on current DR screening programs and registries in the European Union for the last 20 years. With the implementation of telemedicine in daily medical practice, performing screening programs became much more attainable. Remote assessment of retinal pictures simultaneously saves countries time, money, and other resources.
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9060745
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  3. Article ; Online: Diabetic Retinopathy Screening and Registration in Europe—Narrative Review

    Elitsa Hristova / Darina Koseva / Zornitsa Zlatarova / Klara Dokova

    Healthcare, Vol 9, Iss 745, p

    2021  Volume 745

    Abstract: Diabetic retinopathy (DR) is a leading cause of preventable vision impairment and blindness in the European Region. Despite the fact that almost all European countries have some kind of prophylactic eye examination for people with diabetes, the ... ...

    Abstract Diabetic retinopathy (DR) is a leading cause of preventable vision impairment and blindness in the European Region. Despite the fact that almost all European countries have some kind of prophylactic eye examination for people with diabetes, the examinations are not properly arranged and are not organized according to the principles of screening in medicine. In 2021, the current COVID-19 pandemic moved telemedicine to the forefront healthcare services. Due to that, a lot more patients could benefit from comfortable and faster access to ophthalmology specialist care. This study aimed to conduct a narrative literature review on current DR screening programs and registries in the European Union for the last 20 years. With the implementation of telemedicine in daily medical practice, performing screening programs became much more attainable. Remote assessment of retinal pictures simultaneously saves countries time, money, and other resources.
    Keywords diabetic retinopathy ; population screening ; registry ; Medicine ; R
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: UV damage of the anterior ocular surface - microstructural evidence by in vivo confocal microscopy.

    Grupcheva, Christina N / Grupchev, Dimitar I / Radeva, Mladena N / Hristova, Elitsa G

    Contact lens & anterior eye : the journal of the British Contact Lens Association

    2018  Volume 41, Issue 6, Page(s) 482–488

    Abstract: Purpose: To evaluate and describe the microstructural changes at the ocular surface in response to habitual ocular sun exposure, correlate them with the UV protection habits and follow their dynamics using in vivo confocal microscopy(ICM).: Methods: ... ...

    Abstract Purpose: To evaluate and describe the microstructural changes at the ocular surface in response to habitual ocular sun exposure, correlate them with the UV protection habits and follow their dynamics using in vivo confocal microscopy(ICM).
    Methods: For a period of minimum 4 months 200 subjects (400 eyes), aged 28 ± 7.3 years, were recruited with the agreement that they will spend their summer exclusively in the region of the Black Sea coast at 43 °N latitude and will be examined before and after the summer. All subjects filled in a questionnaire about habitual UV protection and were examined clinically and by ICM.
    Results: Questionnaire results demonstrated that 83.5% (167 participants) of the subjects considered the sun dangerous for their eyes, but 78% (156 subjects) believed that there is danger exclusively during the summer period. Although no clinical changes were detected, microstructural analysis of the cornea demonstrated statistically significant (p = 0.021) decrease of the basal epithelial density - from 6167 ± 151 cells/mm
    Conclusion: Summer sun exposure for one season leads to clinically undetectable, microstructural changes affecting the cornea, bulbar and palpebral conjunctiva with transient, but possibly cumulative nature.
    MeSH term(s) Adult ; Conjunctiva/pathology ; Conjunctiva/radiation effects ; Environmental Exposure/adverse effects ; Epithelium, Corneal/pathology ; Epithelium, Corneal/radiation effects ; Eye Burns/diagnosis ; Eye Burns/prevention & control ; Eye Protective Devices ; Female ; Follow-Up Studies ; Humans ; Male ; Microscopy, Confocal/methods ; Prognosis ; Prospective Studies ; Sunburn/diagnosis ; Sunburn/prevention & control ; Ultraviolet Rays/adverse effects
    Language English
    Publishing date 2018-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2004847-6
    ISSN 1476-5411 ; 1367-0484
    ISSN (online) 1476-5411
    ISSN 1367-0484
    DOI 10.1016/j.clae.2018.06.004
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  5. Article ; Online: Effects of anthropogenic and environmental stressors on the current status of red mullet (Mullus barbatus L., 1758) populations inhabiting the Bulgarian Black Sea waters

    Ivelina Zlateva / Violin Raykov / Albena Alexandrova / Petya Ivanova / Nesho Chipev / Kremena Stefanova / Nina Dzhembekova / Valentina Doncheva / Violeta Slabakova / Elitsa Stefanova / Svetlana Mihova / Nadezhda Valcheva / Ognyana Hristova / Boryana Dzhurova / Dimitar Dimitrov / Almira Georgieva / Elina Tsvetanova / Madlena Andreeva / Ivan Popov /
    Mariya Yankova / Yordan Raev / Konstantin Petrov

    Nature Conservation, Vol 54, Iss , Pp 55-

    2023  Volume 79

    Abstract: The red mullet (Mullus barbatus Linnaeus, 1758) is a keynote species for the Bulgarian Black Sea ecosystem and fisheries; nevertheless, existing knowledge on population status is very scarce. The present study was intended to assess the health status and ...

    Abstract The red mullet (Mullus barbatus Linnaeus, 1758) is a keynote species for the Bulgarian Black Sea ecosystem and fisheries; nevertheless, existing knowledge on population status is very scarce. The present study was intended to assess the health status and adaptive potential of M. barbatus populations inhabiting the Bulgarian waters of the Black Sea. Our findings revealed that populations of M. barbatus are exposed to a variety of anthropogenic and environmental stressors. The species’ status was assessed using representative genetic, morphological, biochemical and chemical biomarkers from specimens obtained in the research area’s northern and southern regions. Based on mtDNA markers, genetic analysis revealed low haplotype and nucleotide diversity, typically observed in overexploited or “threatened” populations. Examining the morphology of the specimens revealed no discernible pattern of differentiation. Except for aluminium and chrome, metal and PAH concentrations in fish were below the regulatory thresholds. The specimens from the southern region ingested more microplastics than those from the northern region. The majority of specimens collected from the southern region also exhibited elevated levels of oxidative stress and decreased antioxidant defence, which can be interpreted as an early indication that they had reached the limits of their adaptive potential. Further research on the composite effects of the stressogenic environment on the Black Sea biota are critically needed, as well as the introduction of new indicators and thresholds at molecular and cellular levels for adequate monitoring of both the ecological state of the marine environment and its biota.
    Keywords Ecology ; QH540-549.5 ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 333
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Country-wide seroprevalence studies on Crimean-Congo hemorrhagic fever and hantavirus infections in general population of Bulgaria.

    Christova, Iva / Panayotova, Elitsa / Trifonova, Iva / Taseva, Evgenia / Hristova, Teodora / Ivanova, Vladislava

    Journal of medical virology

    2017  Volume 89, Issue 10, Page(s) 1720–1725

    Abstract: Crimean-Congo hemorrhagic fever (CCHF) and hantavirus infections are the two viral hemorrhagic fevers spread in Europe. To test actual circulation of CCHF virus (CCHFV) and hantaviruses in Bulgaria, we conducted country-wide seroepidemiological studies. ... ...

    Abstract Crimean-Congo hemorrhagic fever (CCHF) and hantavirus infections are the two viral hemorrhagic fevers spread in Europe. To test actual circulation of CCHF virus (CCHFV) and hantaviruses in Bulgaria, we conducted country-wide seroepidemiological studies. Serum samples were collected prospectively from 1500 residents of all 28 districts in Bulgaria. CCHFV seroprevalence of 3.7% was revealed. Anamnesis for tick bites, contact with livestock, age over 40 years and residency in Haskovo district were found as risk factors. The highest CCHFV seroprevalence was observed in the known endemic districts in southeastern Bulgaria: Haskovo (28%) and Yambol (12%). Reactive samples were found in residents of 20 of the 28 districts in Bulgaria. In comparison with the previous studies, the data presented indicate that CCHFV increased substantially its circulation in the endemic regions and was introduced in many new areas. Hantavirus seroprevalence was based on results of the immunoblot and estimated as 3.1%. Surprisingly, contrary to all available data, Puumala virus seroprevalence rate was 2.3% versus 0.8% of Dobrava-Belgrade virus. Evidence for hantavirus IgG seropositivity was found in residents of 23 of the 28 districts in the country. The first hantavirus seroprevalence study in Bulgaria showed that Puumala virus is probably more wide-spread in the country than Dobrava-Belgrade virus.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Bulgaria/epidemiology ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Hantavirus/immunology ; Hantavirus/isolation & purification ; Hantavirus Infections/epidemiology ; Hantavirus Infections/immunology ; Hantavirus Infections/virology ; Hemorrhagic Fever Virus, Crimean-Congo/immunology ; Hemorrhagic Fever Virus, Crimean-Congo/isolation & purification ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/immunology ; Hemorrhagic Fever, Crimean/virology ; Humans ; Immunoglobulin G/blood ; Infant ; Male ; Middle Aged ; Seroepidemiologic Studies ; Tick Bites ; Young Adult
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2017-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.24868
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  7. Article: Investigating micronucleus assay applicability for prediction of normal tissue intrinsic radiosensitivity in gynecological cancer patients.

    Encheva, Elitsa / Deleva, Sofia / Hristova, Rositsa / Hadjidekova, Valeria / Hadjieva, Tatiana

    Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

    2011  Volume 17, Issue 1, Page(s) 24–31

    Abstract: Background: Pelvic organs morbidity after irradiation of cancer patients remains a major problem although new technologies have been developed and implemented. A relatively simple and suitable method for routine clinical practice is needed for ... ...

    Abstract Background: Pelvic organs morbidity after irradiation of cancer patients remains a major problem although new technologies have been developed and implemented. A relatively simple and suitable method for routine clinical practice is needed for preliminary assessment of normal tissue intrinsic radiosensitivity. The micronucleus test (MNT) determines the frequency of the radiation induced micronuclei (MN) in peripheral blood lymphocytes, which could serve as an indicator of intrinsic cell radiosensitivity.
    Aim: To investigate a possible use of the micronucleus test (MNT) for acute radiation morbidity prediction in gynecological cancer patients.
    Materials and methods: Forty gynecological cancer patients received 50 Gy conventional external pelvic irradiation after radical surgery. A four-field "box" technique was applied with 2D planning. The control group included 10 healthy females. Acute normal tissue reactions were graded according to NCI CTCAE v.3.0. From all reaction scores, the highest score named "summarized clinical radiosensitivity" was selected for a statistical analysis. MNT was performed before and after in vitro irradiation with 1.5 Gy. The mean radiation induced frequency of micronuclei per 1000 binucleated cells (MN/1000) and lymphocytes containing micronuclei per 1000 binucleated cells (cells with MN/1000) were evaluated for both patients and controls. AN ARBITRARY CUT OFF VALUE WAS CREATED TO PICK UP A RADIOSENSITIVE INDIVIDUAL: the mean value of spontaneous frequency of cells with MN/1000 ± 2SD, found in the control group.
    Results: Both mean spontaneous frequency of cells with MN/1000 and MN/1000 were registered to be significantly higher in cancer patients compared to the control group (t = 2.46, p = 0.02 and t = 2.51, p = 0.02). No statistical difference was registered when comparing radiation induced MN frequencies between those groups. Eighty percent (32) of patients developed grade 2 summarized clinical radiosensitivity, with great variations in MNT parameters. Only three patients with grade 2 "summarized clinical radiosensitivity" had values of cells with MN/1000 above the chosen radiosensitivity threshold.
    Conclusion: The present study was not able to confirm in vitro MNT applicability for radiosensitivity prediction in pelvic irradiation.
    Language English
    Publishing date 2011-10-29
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2188087-6
    ISSN 1507-1367
    ISSN 1507-1367
    DOI 10.1016/j.rpor.2011.10.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6108: Show issues Location:
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  8. Article: Catalytic activity of NiW electrodeposits

    Mitov, Mario / Elitsa Hristova / Georgi Hristov / Rashko Rashkov / Marina Arnaudova / Alexander Popov

    Environmental chemistry letters. 2009 Sept., v. 7, no. 3

    2009  

    Abstract: NiW systems are known as one of the best catalysts for various desulfurization processes. In this study, we examined catalytic properties of NiW electrodeposits, produced from two different electrolytes, towards sulfide ion oxidation in alkaline solution. ...

    Abstract NiW systems are known as one of the best catalysts for various desulfurization processes. In this study, we examined catalytic properties of NiW electrodeposits, produced from two different electrolytes, towards sulfide ion oxidation in alkaline solution. Despite the big difference in morphology and structure of both materials, they exhibit almost the same catalytic activity for the examined reaction. A possible explanation of this experimental fact is that the overall reaction is controlled by the transport of oxygen through the catalyst samples.
    Keywords catalysts ; catalytic activity ; desulfurization ; electrolytes ; oxidation ; oxygen ; sulfides
    Language English
    Dates of publication 2009-09
    Size p. 249-253.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 2107984-5
    ISSN 1610-3661 ; 1610-3653
    ISSN (online) 1610-3661
    ISSN 1610-3653
    DOI 10.1007/s10311-008-0156-z
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  9. Article: Complex performance of novel CoNiMnB electrodeposits in alkaline borohydride solutions

    Mitov, Mario / Georgi Hristov / Elitsa Hristova / Rashko Rashkov / Marina Arnaudova / Andreas Zielonka

    Environmental chemistry letters. 2009 June, v. 7, no. 2

    2009  

    Abstract: The complex performance of newly synthesized CoNiMnB electrodeposits in base-stabilized sodium borohydride solutions was examined. The rate of hydrogen generation due to borohydride hydrolysis was determined at different temperatures. Activation energy ... ...

    Abstract The complex performance of newly synthesized CoNiMnB electrodeposits in base-stabilized sodium borohydride solutions was examined. The rate of hydrogen generation due to borohydride hydrolysis was determined at different temperatures. Activation energy of approximately 33 kJ/mol was estimated, which is lower than the values reported for other catalysts. At electrochemical conditions, there is a competition between borohydride hydrolysis and electrooxidation reactions. The electrooxidation of borohydride takes place with low overpotentials at relatively high current densities. The long-term discharge at galvanostatic conditions as well as possibilities for partial storage of generated hydrogen indicates potentials for application of studied electrodeposits as anode material in direct borohydride fuel cells (DBFC).
    Keywords activation energy ; anodes ; catalysts ; electrochemistry ; fuel cells ; hydrogen ; hydrogen production ; hydrolysis ; temperature
    Language English
    Dates of publication 2009-06
    Size p. 167-173.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 2107984-5
    ISSN 1610-3661 ; 1610-3653
    ISSN (online) 1610-3661
    ISSN 1610-3653
    DOI 10.1007/s10311-008-0153-2
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