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Article ; Online: Update on Statin Use in Pregnancy.

Poornima, Indu G / Pulipati, Vishnu Priya / Brinton, Eliot A / Wild, Robert A

2022 Volume 136, Issue 1, Page(s) 12–14

MeSH term(s)	Humans ; Pregnancy ; Female
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Editorial
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.08.029
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Article ; Online: Trastuzumab and pertuzumab in hemodialysis: A case report.

Gaertner, Kelly M / Poornima, Indu G / Hilton, Christie

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2021 Volume 27, Issue 7, Page(s) 1799–1801

Abstract: Introduction: Trastuzumab and pertuzumab are recombinant humanized monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2). Currently, six reported cases on the use of trastuzumab in dialysis, and one on the use of pertuzumab, ... ...

Abstract	Introduction: Trastuzumab and pertuzumab are recombinant humanized monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2). Currently, six reported cases on the use of trastuzumab in dialysis, and one on the use of pertuzumab, have been identified in the literature. This case is one of the first to describe the use of pertuzumab, and adds to currently available reports on the use of trastuzumab, in hemodialysis. Case report: A female receiving hemodialysis three times per week was diagnosed with a clinical T2N1M0, hormone receptor-negative, HER2-positive, invasive ductal carcinoma of the breast. She received six cycles of neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab, with left ventricular ejection fraction (LVEF) remaining stable throughout. Following surgery, she continued dual HER2 blockade with trastuzumab and pertuzumab, after six cycles of which she was found on routine echocardiogram to have an asymptomatic decline in LVEF.Management & outcome: Following the decline in LVEF, trastuzumab and pertuzumab were held, and cardio-oncology was consulted. LVEF recovered within one month, after which she continued on single-agent trastuzumab to complete one year of HER2-directed therapy. Discussion: To our knowledge, this is one of the first published cases describing the use of pertuzumab in a patient receiving hemodialysis. Though our patient did experience a reversible decline in LVEF following twelve cycles of combination trastuzumab and pertuzumab, this case demonstrates the relatively safe and effective use of pertuzumab in a patient with end-stage renal disease undergoing hemodialysis, and lends additional support to the use of trastuzumab in this particular patient population.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols ; Female ; Humans ; Renal Dialysis ; Stroke Volume ; Trastuzumab/therapeutic use ; Ventricular Function, Left
Chemical Substances	Antibodies, Monoclonal, Humanized ; pertuzumab (K16AIQ8CTM) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2021-03-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552211003641
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Article: Hyperlipidemia and risk for preclampsia.

Poornima, Indu G / Indaram, Mahathi / Ross, Joyce D / Agarwala, Anandita / Wild, Robert A

Journal of clinical lipidology

2022 Volume 16, Issue 3, Page(s) 253–260

Abstract: Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality in the US. Preeclampsia (PreE) which includes hypertension and proteinuria during pregnancy, is thought to result from placental ischemia. Risk factors ... ...

Abstract	Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality in the US. Preeclampsia (PreE) which includes hypertension and proteinuria during pregnancy, is thought to result from placental ischemia. Risk factors for PreE parallel those for cardiovascular disease, and recent studies point to hyperlipidemia specifically, hypertriglyceridemia, as a risk factor for PreE. Current practice does not routinely include lipid testing pre-conception or during pregnancy. Professional, societal recommendations should advocate for hyperlipidemia screening, followed by appropriate management, pre-conception and during pregnancy.
MeSH term(s)	Female ; Humans ; Hyperlipidemias/complications ; Hyperlipidemias/epidemiology ; Hypertension/complications ; Placenta ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/etiology ; Pregnancy ; Proteinuria/complications ; Risk Factors
Language	English
Publishing date	2022-02-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2022.02.005
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Article ; Online: Cardiac Sarcoidosis Causing Ventricular Tachycardia After Myocardial Infarction: A Shocking Diagnosis.

Badlani, Jayshiv T / Poornima, Indu G / Thosani, Amit / Biederman, Robert W W

JACC. Case reports

2020 Volume 2, Issue 7, Page(s) 1056–1061

Abstract: Scar-mediated ventricular tachycardia (VT) commonly results from ischemic heart disease. We present a case of recurrent VT, which was initially attributed to ischemic disease; however, the scar location pointed to an alternate pathology. This case ... ...

Abstract	Scar-mediated ventricular tachycardia (VT) commonly results from ischemic heart disease. We present a case of recurrent VT, which was initially attributed to ischemic disease; however, the scar location pointed to an alternate pathology. This case demonstrates the utility of multimodality imaging in diagnosing sarcoidosis as a cause of VT. (
Language	English
Publishing date	2020-06-17
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2020.04.037
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Article ; Online: Triple threat in pregnancy.

Vishwanathan, Swati / Lucke, Michael / Poornima, Indu G

BMJ case reports

2016 Volume 2016

Abstract: A woman aged 22 years with a history of lupus presented in the 18th week of pregnancy with hypertensive emergency and flash pulmonary oedema. Bedside echocardiogram revealed severe left ventricular (LV) dysfunction with an ejection fraction (EF) of 25% ... ...

Abstract	A woman aged 22 years with a history of lupus presented in the 18th week of pregnancy with hypertensive emergency and flash pulmonary oedema. Bedside echocardiogram revealed severe left ventricular (LV) dysfunction with an ejection fraction (EF) of 25% and pericardial effusion. Laboratories revealed hypocomplementemia, proteinuria, elevated C reactive protein and anti-DS-DNA, raising concern for a lupus flare. Cardiac MRI showed an acute intramyocardial oedematous process, consistent with lupus carditis, and further worsening of LVEF to 13%. Shared-decision-making with the patient included discussion of maternal risks of continuation of pregnancy in the setting of worsening heart function and the fetal risks of definitive treatment with cyclophosphamide for a lupus flare and the patient decided to proceed with medical termination of pregnancy. Treatment with immunosuppressants, including cyclophosphamide, and steroids, was then initiated. 2 months after discharge, cardiac MRI showed marked improvement in LVEF to 50% and the patient remains clinically free of heart failure.
MeSH term(s)	Cyclophosphamide/administration & dosage ; Echocardiography ; Female ; Humans ; Hypertension, Pregnancy-Induced/diagnosis ; Hypertension, Pregnancy-Induced/etiology ; Immunosuppressive Agents/administration & dosage ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Magnetic Resonance Angiography ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/etiology ; Proteinuria/diagnosis ; Proteinuria/etiology ; Pulmonary Edema/diagnosis ; Pulmonary Edema/etiology ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology ; Young Adult
Chemical Substances	Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2016-10-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2016-216385
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Article ; Online: Ethnic and Racial Disparities in Resource Utilization and In-hospital Outcomes Among Those Admitted for Atrial Fibrillation: A National Analysis.

Alhuneafat, Laith / Jabri, Ahmad / Poornima, Indu G / Alrifai, Nada / Ali, Mustafa / Elhamdani, Adee / Kyvernitakis, Andreas / Al-Abdouh, Ahmad / Mhanna, Mohammed / Hadaddin, Faris / Butt, Muhammad / Cunningham, Christopher / Karim, Saima / Ziv, Ohad

Current problems in cardiology

2022 Volume 47, Issue 12, Page(s) 101365

Abstract: Disparities in overall outcomes for atrial fibrillation (AF) across racial and ethnic groups have been demonstrated in prior studies. We aim to evaluate in-hospital outcomes and resource utilization across 3 racial/ethnic groups with AF using ... ...

Abstract	Disparities in overall outcomes for atrial fibrillation (AF) across racial and ethnic groups have been demonstrated in prior studies. We aim to evaluate in-hospital outcomes and resource utilization across 3 racial/ethnic groups with AF using contemporary data. We identified patients admitted with AF in the National Inpatient Sample registry from 2015 to 2018. ICD-10-CM codes were used to identify variables of interest. The primary outcomes were in-hospital complications and resource utilization. There were 1,250,075 AF admissions. Our sample was made up of 85.49% White, 8.12% Black, and 6.38% Hispanic patients. Black patients were younger but had a higher burden of cardiovascular comorbidities including obesity, hypertension, and chronic kidney disease. Social determinants were also less favorable in Black patients, with a higher percentage of Medicaid insurance and a high proportion of patients being in the lowest percentile for household income. Total hospital charge was highest in Hispanic patients. Despite higher rates of gastrointestinal bleed, Black patients were least likely to undergo left atrial appendage occlusion device implantation. Black and Hispanic patients were less like to undergo catheter ablation therapy. Black race was an independent predictor of mortality, stroke, mechanical ventilation, acute kidney injury, hemodynamic shock, need for vasopressor, upper gastrointestinal bleed, need for blood transfusion, total hospital charges, and length of stay when compared to other groups. Disparities exist in the risk of AF, and its management among racial and ethnic groups. Health care costs and inpatient outcomes disproportionately impact minorities in the United States.
MeSH term(s)	Humans ; United States/epidemiology ; Ethnicity ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy ; Healthcare Disparities ; Racial Groups ; Hospitals
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2022.101365
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Article ; Online: Cardiac Sarcoidosis Causing Ventricular Tachycardia After Myocardial Infarction

Jayshiv T. Badlani, MD, MS / Indu G. Poornima, MD / Amit Thosani, MD / Robert W.W. Biederman, MD

JACC: Case Reports, Vol 2, Iss 7, Pp 1056-

2020 Volume 1061

Abstract	Scar-mediated ventricular tachycardia (VT) commonly results from ischemic heart disease. We present a case of recurrent VT, which was initially attributed to ischemic disease; however, the scar location pointed to an alternate pathology. This case demonstrates the utility of multimodality imaging in diagnosing sarcoidosis as a cause of VT. (Level of Difficulty: Intermediate.)
Keywords	autoimmune ; cardiac magnetic resonance ; cardiac positron emission tomography ; multimodality imaging ; nuclear medicine ; ventricular tachycardia ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mitral valve repair is an effective treatment for ventricular arrhythmias in mitral valve prolapse syndrome.

Abbadi, Deepika R / Purbey, Rahul / Poornima, Indu G

International journal of cardiology

2014 Volume 177, Issue 1, Page(s) e16–8

MeSH term(s)	Adult ; Female ; Heart Valve Prosthesis Implantation/methods ; Humans ; Mitral Valve/pathology ; Mitral Valve/surgery ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/diagnosis ; Mitral Valve Prolapse/surgery ; Tachycardia, Ventricular/complications ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/surgery ; Treatment Outcome
Language	English
Publishing date	2014-11-15
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2014.07.174
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Zs.A 1673: Show issues

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Article: Are we Justified Doing Routine Intracytoplasmic Sperm Injection in Nonmale Factor Infertility? A Retrospective Study Comparing Reproductive Outcomes between

Biliangady, Reeta / Kinila, Poornima / Pandit, Rubina / Tudu, Nutan Kumari / Sundhararaj, Uma Maheswari / Gopal, Indu S T / Swamy, Ambika G

Journal of human reproductive sciences

2019 Volume 12, Issue 3, Page(s) 210–215

Abstract: Introduction: Intracytoplasmic sperm insemination (ICSI) came into use in 1992 to improve fertilization in couples with male factor infertility undergoing : Methods: This is a retrospective single centre study undertaken at a private IVF center. A ... ...

Abstract	Introduction: Intracytoplasmic sperm insemination (ICSI) came into use in 1992 to improve fertilization in couples with male factor infertility undergoing Methods: This is a retrospective single centre study undertaken at a private IVF center. A total of 350 patients with normal male factor were included in the study of which 186 underwent conventional IVF and 134 were subjected to ICSI. They were then compared for various reproductive parameters with Live Birth Rate (LBR) being the primary outcome. Results: Fertilization rates (89.99% vs 85.1%), Blastocyst formation rates (62.86% vs 50.61%) and clinical pregnancy rates (37.85% vs 32.35%) were found to be higher in the IVF group compared to the ICSI group though not statistically significant. The live birth rates in the IVF group was also higher than the ICSI group (32.71% vs 24.26%). Conclusion: IVF edged over ICSI in all aspects resulting in better clinical outcome with higher take home babies in non-male factor infertility. Our results show that routine ICSI should not be used as a blanket therapy for all cases in ART.
Language	English
Publishing date	2019-09-23
Publishing country	India
Document type	Journal Article
ZDB-ID	2418984-4
ISSN	1998-4766 ; 0974-1208
ISSN (online)	1998-4766
ISSN	0974-1208
DOI	10.4103/jhrs.JHRS_8_19
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Article: Is It Time to Move Toward Freeze-All Strategy? - A Retrospective Study Comparing Live Birth Rates between Fresh and First Frozen Blastocyst Transfer.

Biliangady, Reeta / Pandit, Rubina / Tudu, Nutan Kumari / Kinila, Poornima / Maheswari, Uma / Gopal, Indu S T / Swamy, Ambika G

Journal of human reproductive sciences

2019 Volume 12, Issue 4, Page(s) 321–326

Abstract: Background: Cryopreservation of all embryos followed by transfer in subsequent cycles has emerged as an effective alternative to fresh embryo transfer (ET) in order to overcome the negative effect of superovulation on endometrial receptivity.: Aims: ... ...

Abstract	Background: Cryopreservation of all embryos followed by transfer in subsequent cycles has emerged as an effective alternative to fresh embryo transfer (ET) in order to overcome the negative effect of superovulation on endometrial receptivity. Aims: The aim of this study was to compare the reproductive outcomes between fresh ET and first frozen ET (FET) from "freeze-all" group of embryos. Setting: This study was conducted at a private Design: This was a retrospective study. Patients and methods: A total of 503 patients fulfilling the inclusion criteria between 2012 and 2017 were included. Of 503, 386 patients underwent fresh ET and 117 patients underwent FET following cryopreservation of all embryos. The results of only first FET were considered to eliminate the confounding factor of poor-quality embryos in subsequent transfer. Results: FET resulted in statistically significant higher live birth rate (44.44% vs. 33.41%), implantation rate (45.08% vs. 30.22%), and clinical pregnancy rate (57.26% vs. 38.6%) compared to fresh ETs. No difference was observed in the abortion rate between the two groups. Conclusion: Reproductive outcomes were significantly better in the freeze-all group compared to fresh ET suggesting that the altered hormone levels during controlled ovarian stimulation could mediate an asynchrony between the endometrium and the transferred embryos, leading to implantation failure.
Language	English
Publishing date	2019-12-17
Publishing country	India
Document type	Journal Article
ZDB-ID	2418984-4
ISSN	1998-4766 ; 0974-1208
ISSN (online)	1998-4766
ISSN	0974-1208
DOI	10.4103/jhrs.JHRS_146_18
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