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Article: Central Serous Chorioretinopathy Development following Cessation of Terbinafine Treatment.

Shmueli, Or / Nitzan, Itay / Averbukh, Edward

2022 Volume 13, Issue 3, Page(s) 793

Abstract: This report describes a case of central serous chorioretinopathy (CSCR) occurring following cessation of terbinafine treatment. A 51-year-old man presented for a routine ophthalmic examination. He was treated with oral terbinafine for onychomycosis up to ...

Abstract	This report describes a case of central serous chorioretinopathy (CSCR) occurring following cessation of terbinafine treatment. A 51-year-old man presented for a routine ophthalmic examination. He was treated with oral terbinafine for onychomycosis up to 3 months before the presentation. Spectral-domain optical coherence tomography (OCT) showed extrafoveal subretinal fluid in both eyes with small underlying pigment epithelial detachments. There were no additional relevant findings in the patient history or ocular examination. A diagnosis of CSCR was made. After 10 weeks without treatment, OCT demonstrated almost complete resolution of subretinal fluid in both eyes. The exact key ingredients of the perfect storm leading to CSCR in young, healthy individuals are still unknown. Here, we describe, to our knowledge, the first documented case, where the appearance of CSCR was apparently triggered by cessation of antifungal treatment. This unusual case may provoke further research that will bring us closer to understanding the mechanism behind the appearance of CSCR. It may also widen the scope of the routine anamnesis when dealing with patients newly diagnosed with this enigmatic condition.
Language	English
Publishing date	2022-10-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000527379
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Article ; Online: Cortical Visual Mapping following Ocular Gene Augmentation Therapy for Achromatopsia.

McKyton, Ayelet / Averbukh, Edward / Marks Ohana, Devora / Levin, Netta / Banin, Eyal

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 35, Page(s) 7363–7371

Abstract: The ability of the adult human brain to develop function following correction of congenital deafferentation is controversial. Specifically, cases of recovery from congenital visual deficits are rare. ...

Abstract	The ability of the adult human brain to develop function following correction of congenital deafferentation is controversial. Specifically, cases of recovery from congenital visual deficits are rare.
MeSH term(s)	Adult ; Brain Mapping/methods ; Color Perception ; Color Vision Defects/congenital ; Color Vision Defects/genetics ; Color Vision Defects/physiopathology ; Color Vision Defects/therapy ; Cyclic Nucleotide-Gated Cation Channels/deficiency ; Electroretinography ; Female ; Fixation, Ocular ; Gene Duplication ; Genetic Therapy/methods ; Genetic Vectors/administration & dosage ; Genetic Vectors/therapeutic use ; Humans ; Injections, Intraocular ; Magnetic Resonance Imaging ; Male ; Mutation, Missense ; Photophobia/etiology ; Photophobia/therapy ; Retinal Cone Photoreceptor Cells/physiology ; Treatment Outcome ; Visual Acuity ; Visual Cortex/physiopathology
Chemical Substances	CNGA3 protein, human ; Cyclic Nucleotide-Gated Cation Channels
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.3222-20.2021
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Article ; Online: Correlation of Response between Both Eyes to First- and Second-Line Anti-VEGF Therapy in Diabetic Macular Edema.

Tiosano, Liran / Ayalon, Anfisa / Banin, Eyal / Averbukh, Edward / Jaouni, Tareq / Chowers, Itay

Current eye research

2020 Volume 46, Issue 4, Page(s) 539–545

Abstract: Purpose: To evaluate the anatomical correlation between fellow eyes for bilateral second-line anti-VEGF treatment in eyes with bilateral diabetic macular edema (DME) with incomplete response to first-line bevacizumab therapy.: Methods: Seventy-four ... ...

Abstract	Purpose: To evaluate the anatomical correlation between fellow eyes for bilateral second-line anti-VEGF treatment in eyes with bilateral diabetic macular edema (DME) with incomplete response to first-line bevacizumab therapy. Methods: Seventy-four eyes ( Results: The mean±SD age was 76 ± 8 years. The mean±SD number of bevacizumab injections prior the switch was 11.03 ± 5.1 in the first eye (FE) and 10.9 ± 5.2 in the second eye (SE). The central subfield thickness (CST) reduced from 472 ± 171 microns at baseline to 418 ± 161 after the last bevacizumab injection and 365 ± 74 after 3 ranibizumab injections in the FE ( Conclusions: This study demonstrated a strong anatomical correlation responses between the eyes in patients with bilateral DME for both first-line bevacizumab therapy and second-line ranibizumab therapy. Response to second-line therapy was favorable and correlated among eyes regardless they were from the same or different individuals.
MeSH term(s)	Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/physiopathology ; Drug Substitution ; Female ; Humans ; Intravitreal Injections ; Macular Edema/drug therapy ; Male ; Ranibizumab/therapeutic use ; Retina/diagnostic imaging ; Retina/pathology ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology
Chemical Substances	Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2020-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2020.1812085
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Article: Glial-derived mitochondrial signals impact neuronal proteostasis and aging.

Bar-Ziv, Raz / Dutta, Naibedya / Hruby, Adam / Sukarto, Edward / Averbukh, Maxim / Alcala, Athena / Henderson, Hope R / Durieux, Jenni / Tronnes, Sarah U / Ahmad, Qazi / Bolas, Theodore / Perez, Joel / Dishart, Julian G / Vega, Matthew / Garcia, Gilberto / Higuchi-Sanabria, Ryo / Dillin, Andrew

bioRxiv : the preprint server for biology

2023

Abstract: The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response ( ... ...

Abstract	The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPR
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.20.549924
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Article: The evidence supporting the early treatment for type 1 retinopathy of prematurity needs further evaluation.

Averbukh, Edward

Archives of ophthalmology (Chicago, Ill. : 1960)

2005 Volume 123, Issue 3, Page(s) 406; discussion 409–10

MeSH term(s)	Humans ; Infant, Newborn ; Laser Coagulation ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Retinopathy of Prematurity/classification ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/surgery ; Visual Acuity
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	211580-3
ISSN	1538-3601 ; 0003-9950 ; 0093-0326
ISSN (online)	1538-3601
ISSN	0003-9950 ; 0093-0326
DOI	10.1001/archopht.123.3.406-a
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Article ; Online: Glial-derived mitochondrial signals affect neuronal proteostasis and aging.

Science advances

2023 Volume 9, Issue 41, Page(s) eadi1411

Abstract	The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPR
MeSH term(s)	Animals ; Proteostasis ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Neurons/metabolism ; Caenorhabditis elegans/metabolism ; Aging ; Neuroglia/metabolism
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adi1411
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Article ; Online: Socioeconomic status and visual outcome in patients with neovascular age-related macular degeneration.

Levinger, Nadav / Beykin, Gala / Grunin, Michelle / Almeida, Diego / Levy, Jaime / Levine, Hagai / Averbukh, Edward / Chowers, Itay

European journal of ophthalmology

2020 Volume 31, Issue 3, Page(s) 1094–1100

Abstract: Purpose: Visual outcome in patients with neovascular age-related macular degeneration is variable. We aimed to evaluate for association between socioeconomic status visual acuity in neovascular age-related macular degeneration.: Methods: A ... ...

Abstract	Purpose: Visual outcome in patients with neovascular age-related macular degeneration is variable. We aimed to evaluate for association between socioeconomic status visual acuity in neovascular age-related macular degeneration. Methods: A retrospective single-center study of a consecutive group of neovascular age-related macular degeneration patients was performed. Socioeconomic status was determined for each patient based on the 2008 Israeli census. Medical information was extracted from medical records and included visual acuity and optical coherence tomography parameters. Associations between socioeconomic status and clinical outcomes were analyzed. Results: A total of 233 patients were included in the analysis. A correlation was found between low baseline visual acuity of the first eye diagnosed with neovascular age-related macular degeneration and low socioeconomic status (r = -0.13, p = 0.049; n = 233). The difference between the visual acuity of the lowest and the highest socioeconomic status categories at baseline was approximately 3 ETDRS lines (p = 0.048). Socioeconomic status and baseline visual acuity of the second eye of the same individual with neovascular age-related macular degeneration were not correlated (r = -0.05, p = 0.95). Socioeconomic status was not associated with the number of anti-vascular endothelial growth factor injections of the first or second eye, or the visual acuity outcome of the first or second eye after 1 year of therapy (p = 0.421, p = 0.9, respectively). Central subfield thickness of the first eye at presentation as measured by spectral-domain optical coherence tomography was associated with socioeconomic status (r = -0.31 p = 0.001). Conclusion: Individuals of lower socioeconomic status presented at more advanced stage of the disease when developing neovascular age-related macular degeneration in the first eye but not in the second eye. The research underscores the importance of improving referral patterns and awareness for the lowest socioeconomic status classes.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Retrospective Studies ; Social Class ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120920783
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Zs.A 3342: Show issues

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Article: Endogenous fungal endophthalmitis: risk factors, clinical course, and visual outcome in 13 patients.

Corredores, Jamel / Hemo, Itzhak / Jaouni, Tareq / Habot-Wilner, Zohar / Kramer, Michal / Shulman, Shiri / Jabaly-Habib, Haneen / Al-Talbishi, Ala'a / Halpert, Michael / Averbukh, Edward / Levy, Jaime / Deitch-Harel, Iris / Amer, Radgonde

International journal of ophthalmology

2021 Volume 14, Issue 1, Page(s) 97–105

Abstract: Aim: To analyze the risk factors, ophthalmological features, treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis (EFE).: Methods: Data retrieved from the medical files included age at ... ...

Abstract	Aim: To analyze the risk factors, ophthalmological features, treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis (EFE). Methods: Data retrieved from the medical files included age at presentation to the uveitis clinic, gender, ocular symptoms and their duration before presentation, history of fever, eye affected, anatomical diagnosis and laboratory evidence of fungal infection. Medical therapy recorded included systemic antifungal therapy and its duration, use of intravitreal antifungal agents and use of oral/intravitreal steroids. Surgical procedures and the data of ophthalmologic examination at presentation and at last follow-up were also collected. Results: Included were 13 patients (20 eyes, mean age 58y). Ten patients presented after gastrointestinal or urological interventions and two presented after organ transplantation. In one patient, there was no history of previous intervention. Diagnostic vitrectomy was performed in 16 eyes (80%) and vitreous cultures were positive in 10 of the vitrectomized eyes (62.5%). In only 4 patients (31%), blood cultures were positive. All patients received systemic antifungal therapy. Sixteen eyes (80%) received intravitreal antifungal agent with voriconazole being the most commonly used. Visual acuity (VA) improved from 0.9±0.9 at initial exam to 0.5±0.8 logMAR at last follow-up ( Conclusion: High index of suspicion in patients with inciting risk factors is essential because of the low yield of blood cultures and the good general condition of patients at presentation. Visual prognosis is improved with the prompt institution of systemic and intravitreal pharmacotherapy and the immediate surgical intervention. Oral±local steroids could be considered in cases of prolonged or marked inflammatory responses in order to hasten control of inflammation and limit ocular complications.
Language	English
Publishing date	2021-01-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2021.01.14
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Article ; Online: Evaluation of the association of single nucleotide polymorphisms in the PRPH2 gene with adult-onset foveomacular vitelliform dystrophy.

Grunin, Michelle / Tiosano, Liran / Jaouni, Tareq / Averbukh, Edward / Sharon, Dror / Chowers, Itay

Ophthalmic genetics

2016 Volume 37, Issue 3, Page(s) 285–289

Abstract: Objective: A minority of patients with adult-onset foveomacular vitelliform dystrophy (AFVD) carry mutations in the PRPH2 gene. This gene is highly polymorphic and it was suggested that single-nucleotide polymorphisms (SNPs) in PRPH2 may also be ... ...

Abstract	Objective: A minority of patients with adult-onset foveomacular vitelliform dystrophy (AFVD) carry mutations in the PRPH2 gene. This gene is highly polymorphic and it was suggested that single-nucleotide polymorphisms (SNPs) in PRPH2 may also be associated with AFVD. We aimed to evaluate for such an association. Methods: A single center cohort from a tertiary referral center including 52 consecutive patients with a clinical diagnosis of AFVD and 91 unaffected individuals was assessed. Sanger sequencing was performed for the PRPH2, BEST1, and IMPG1/2 genes. Investigation as to the frequency of minor alleles for SNPs in PRPH2 was performed and compared to HapMap and Exome Variant Server (EVS) data. Results: None of the patients carry a mutation in PRPH2, BEST1, or IMPG1/2. Five of 14 known SNPs (rs835, rs361524, rs434102, rs425876, rs390659) in exon 3 of PRPH2 were identified in AFVD patients. A high frequency and percentage of minor alleles of these five SNPs was found in the Israeli AFVD patients and controls compared with European, Chinese, Japanese and African populations identified via HapMap and EVS (p < 0.05). Power calculation suggested that the sample size was sufficient (80%) to rule out an association with an odds ratio above 2.5. Conclusions: These results suggest that genetic variants in PRPH2 do not compose a major genetic risk factor for AFVD. The Israeli population shows a higher percentage of minor allele frequencies in SNPs in the PRPH2 gene, as compared with other populations. This emphasizes the need for appropriate genetic background when performing SNP association testing.
MeSH term(s)	Adult ; Exons/genetics ; Female ; Gene Frequency ; Humans ; Male ; Middle Aged ; Mutation ; Peripherins/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Vitelliform Macular Dystrophy/genetics
Chemical Substances	PRPH2 protein, human ; Peripherins
Language	English
Publishing date	2016-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1199279-7
ISSN	1744-5094 ; 0167-6784 ; 1381-6810
ISSN (online)	1744-5094
ISSN	0167-6784 ; 1381-6810
DOI	10.3109/13816810.2015.1059456
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Zs.A 1708: Show issues

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Article ; Online: Characterising the phenotype and progression of sporadic adult-onset foveomacular vitelliform dystrophy.

Tiosano, Liran / Grunin, Michelle / Hagbi-Levi, Shira / Banin, Eyal / Averbukh, Edward / Chowers, Itay

The British journal of ophthalmology

2016 Volume 100, Issue 11, Page(s) 1476–1481

Abstract: Background/aims: Adult-onset foveomacular vitelliform dystrophy (AFVD) is a relatively common macular degeneration which might lead to substantial visual loss. Our purpose was to describe the natural course of genetically evaluated patients with ... ...

Abstract	Background/aims: Adult-onset foveomacular vitelliform dystrophy (AFVD) is a relatively common macular degeneration which might lead to substantial visual loss. Our purpose was to describe the natural course of genetically evaluated patients with sporadic AFVD. Methods: A retrospective, consecutive, cohort study included 95 eyes of 51 patients. Mutations in genes previously associated with AFVD (PRPH2, BEST1, IMPG-1 and IMPG-2) were evaluated. Demographics, clinical characteristics, and spectral domain optical coherence tomography features were analysed. Main outcome measures were changes in the best corrected visual acuity (BCVA) and lesion morphology during the follow-up. Results: The mean age (±SD) at diagnosis was 73.8±10.7 years. Mean (±SD) follow-up period was 30.4±16.3 months (range 0-44 months; median 25 months). All patients were genotyped negative for the evaluated mutations. Fifty-three of the eyes were followed for at least 36 months. At baseline these eyes had a mean BCVA (±SD) of 0.27±0.35 LogMAR, and at 36-months BCVA decreased to 0.38±0.35 (p=0.02). At baseline, 23 of these 53 eyes (43.4%) had the vitelliform stage, while only 10 eyes (18.9%) remained at this stage at 36 months (p=0.01). Ellipsoid zone alterations progressed during the follow-up (n=53 eyes) and showed correlation with BCVA reduction (Pearson's correlation coefficient=0.7, p=0.03). Conclusions: Sporadic AFVD is a slowly progressing macular degeneration of older people. It is associated with visual decline at the rate of approximately one ETDRS line during 3 years. Patients with sporadic AFVD are usually negative for the known mutations previously associated with this phenotype, and present at an age that is higher than described for monogenic AFVD.
MeSH term(s)	Aged ; Aged, 80 and over ; Disease Progression ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Macula Lutea/blood supply ; Macula Lutea/diagnostic imaging ; Male ; Middle Aged ; Phenotype ; Retinal Vessels/diagnostic imaging ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Visual Acuity ; Vitelliform Macular Dystrophy/diagnosis ; Vitelliform Macular Dystrophy/physiopathology
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2015-307658
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