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  1. Article ; Online: Preoperative Evaluations Before Transplantation-Essential Tools, Not Obstacles.

    Weinrauch, Larry A / D'Elia, John A

    JAMA internal medicine

    2023  Volume 183, Issue 7, Page(s) 745

    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.1239
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  2. Article ; Online: More on Semaglutide in Early Type 1 Diabetes.

    Weinrauch, Larry A / D'Elia, John A

    The New England journal of medicine

    2023  Volume 390, Issue 3, Page(s) 291

    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/drug therapy ; Glucagon-Like Peptides/therapeutic use ; Hypoglycemic Agents/therapeutic use
    Chemical Substances semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2311608
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  3. Article ; Online: Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis.

    D'Elia, John A / Weinrauch, Larry A

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, ... ...

    Abstract A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, Europe, and the Middle East. However, the migration of populations in times of drought, famine, and hostilities may increase the global reach of this ancient pathogen. Given an increased spread from China and India to African countries, drug-resistant
    MeSH term(s) Humans ; Calcium Channels/genetics ; Calcium ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/genetics ; Anti-Bacterial Agents/therapeutic use ; Gram-Negative Bacteria ; Calcium, Dietary ; Mutation ; Mycobacterium tuberculosis/genetics ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use
    Chemical Substances Calcium Channels ; Calcium (SY7Q814VUP) ; Anti-Bacterial Agents ; Calcium, Dietary ; Antitubercular Agents
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119670
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  4. Article: Hyperglycemia and Hyperlipidemia with Kidney or Liver Transplantation: A Review.

    D'Elia, John A / Weinrauch, Larry A

    Biology

    2023  Volume 12, Issue 9

    Abstract: Although solid organ transplantation in persons with diabetes mellitus is often associated with hyperglycemia, the risk of hyperlipidemia in all organ transplant recipients is often underestimated. The diagnosis of diabetes often predates transplantation; ...

    Abstract Although solid organ transplantation in persons with diabetes mellitus is often associated with hyperglycemia, the risk of hyperlipidemia in all organ transplant recipients is often underestimated. The diagnosis of diabetes often predates transplantation; however, in a moderate percentage of allograft recipients, perioperative hyperglycemia occurs triggered by antirejection regimens. Post-transplant prescription of glucocorticoids, calcineurin inhibitors and mTOR inhibitors are associated with increased lipid concentrations. The existence of diabetes mellitus prior to or following a liver transplant is associated with shorter times of useful allograft function. A cycle involving Smad, TGF beta, m-TOR and toll-like receptors has been identified in the contribution of rejection and aging of allografts. Glucocorticoids (prednisone) and calcineurin inhibitors (cyclosporine and tacrolimus) induce hyperglycemia associated with insulin resistance. Azathioprine, mycophenolate and prednisone are associated with lipogenesis. mTOR inhibitors (rapamycin) are used to decrease doses of atherogenic agents used for immunosuppression. Post-transplant medication management must balance immune suppression and glucose and lipid control. Concerns regarding rejection often override those relative to systemic and organ vascular aging and survival. This review focuses attention on the underlying mechanism of relationships between glycemia/lipidemia control, transplant rejection and graft aging.
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12091185
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  5. Article ; Online: The Importance of Bubbles at High Altitude.

    D'Elia, John A / Weinrauch, Larry A

    The American journal of medicine

    2022  Volume 135, Issue 7, Page(s) e218

    MeSH term(s) Altitude ; Humans ; Models, Biological ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.03.007
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  6. Article ; Online: Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis

    John A. D’Elia / Larry A. Weinrauch

    International Journal of Molecular Sciences, Vol 24, Iss 9670, p

    2023  Volume 9670

    Abstract: A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, ... ...

    Abstract A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, Europe, and the Middle East. However, the migration of populations in times of drought, famine, and hostilities may increase the global reach of this ancient pathogen. Given an increased spread from China and India to African countries, drug-resistant Mycobacterium tuberculosis has become an emerging topic of concern for Europe and North America. Due to the dangers associated with the spread of pathogens among different populations, the World Health Organization continues to expand healthcare advisories for therapeutic approaches for both stationary and migrating populations. As much of the literature focuses on endemic to pandemic viruses, we remain concerned that other treatable communicable diseases may be ignored. One such disease is multidrug-resistant tuberculosis. We focus on molecular mechanisms that this pathogen relies upon for the development of multidrug resistance via gene mutation and the evolutionary development of new enzyme and calcium channels.
    Keywords antibiotic resistance ; calcium ion channels ; extrusion of antibiotics ; innate immunity ; adaptive immunity ; Mycobacterium tuberculosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Hyperglycemia and Hyperlipidemia with Kidney or Liver Transplantation

    John A. D’Elia / Larry A. Weinrauch

    Biology, Vol 12, Iss 1185, p

    A Review

    2023  Volume 1185

    Abstract: Although solid organ transplantation in persons with diabetes mellitus is often associated with hyperglycemia, the risk of hyperlipidemia in all organ transplant recipients is often underestimated. The diagnosis of diabetes often predates transplantation; ...

    Abstract Although solid organ transplantation in persons with diabetes mellitus is often associated with hyperglycemia, the risk of hyperlipidemia in all organ transplant recipients is often underestimated. The diagnosis of diabetes often predates transplantation; however, in a moderate percentage of allograft recipients, perioperative hyperglycemia occurs triggered by antirejection regimens. Post-transplant prescription of glucocorticoids, calcineurin inhibitors and mTOR inhibitors are associated with increased lipid concentrations. The existence of diabetes mellitus prior to or following a liver transplant is associated with shorter times of useful allograft function. A cycle involving Smad, TGF beta, m-TOR and toll-like receptors has been identified in the contribution of rejection and aging of allografts. Glucocorticoids (prednisone) and calcineurin inhibitors (cyclosporine and tacrolimus) induce hyperglycemia associated with insulin resistance. Azathioprine, mycophenolate and prednisone are associated with lipogenesis. mTOR inhibitors (rapamycin) are used to decrease doses of atherogenic agents used for immunosuppression. Post-transplant medication management must balance immune suppression and glucose and lipid control. Concerns regarding rejection often override those relative to systemic and organ vascular aging and survival. This review focuses attention on the underlying mechanism of relationships between glycemia/lipidemia control, transplant rejection and graft aging.
    Keywords solid organ allografts: liver ; kidney ; hyperglycemia ; diabetes ; hyperlipidemia ; allograft survival ; transplantation ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Renal transplant outcomes and diabetes.

    Weinrauch, Larry A / D'Elia, John A

    BMJ open diabetes research & care

    2021  Volume 9, Issue 1

    MeSH term(s) Cohort Studies ; Diabetes Mellitus, Type 1 ; Humans ; Kidney Failure, Chronic ; Kidney Transplantation/adverse effects ; United States
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2021-002294
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  9. Article ; Online: The Diabetic Cardiorenal Nexus.

    D'Elia, John A / Bayliss, George P / Weinrauch, Larry A

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: The end-stage of the clinical combination of heart failure and kidney disease has become known as cardiorenal syndrome. Adverse consequences related to diabetes, hyperlipidemia, obesity, hypertension and renal impairment on cardiovascular function, ... ...

    Abstract The end-stage of the clinical combination of heart failure and kidney disease has become known as cardiorenal syndrome. Adverse consequences related to diabetes, hyperlipidemia, obesity, hypertension and renal impairment on cardiovascular function, morbidity and mortality are well known. Guidelines for the treatment of these risk factors have led to the improved prognosis of patients with coronary artery disease and reduced ejection fraction. Heart failure hospital admissions and readmission often occur, however, in the presence of metabolic, renal dysfunction and relatively preserved systolic function. In this domain, few advances have been described. Diabetes, kidney and cardiac dysfunction act synergistically to magnify healthcare costs. Current therapy relies on improving hemodynamic factors destructive to both the heart and kidney. We consider that additional hemodynamic solutions may be limited without the use of animal models focusing on the cardiomyocyte, nephron and extracellular matrices. We review herein potential common pathophysiologic targets for treatment to prevent and ameliorate this syndrome.
    MeSH term(s) Animals ; Cardio-Renal Syndrome/therapy ; Diabetes Mellitus ; Heart ; Heart Failure ; Kidney
    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137351
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  10. Article ; Online: Pollution and Organ Transplantation.

    Weinrauch, Larry A / D'Elia, John A

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 22, Page(s) 2875–2876

    MeSH term(s) Air Pollution ; Heart Transplantation ; Organ Transplantation
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.01.065
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