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  1. Book: Pregnancy and endocrine disorders

    Molitch, Mark E.

    (Endocrinology and metabolism clinics of North America ; volume 48, number 3 (September 2019))

    2019  

    Author's details editor Mark E. Molitch
    Series title Endocrinology and metabolism clinics of North America ; volume 48, number 3 (September 2019)
    Collection
    Language English
    Size xvi Seiten, Seite 480-655, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020198847
    ISBN 978-0-323-68224-4 ; 0-323-68224-3
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Hyperglycaemia management in non-critical care settings: guidelines in focus.

    Molitch, Mark E

    The lancet. Diabetes & endocrinology

    2022  Volume 10, Issue 9, Page(s) 614–616

    MeSH term(s) Blood Glucose ; Humans ; Hyperglycemia ; Hypoglycemic Agents
    Chemical Substances Blood Glucose ; Hypoglycemic Agents
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(22)00214-5
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  3. Article ; Online: Central diabetes insipidus from a patient's perspective.

    Molitch, Mark E

    The lancet. Diabetes & endocrinology

    2022  Volume 10, Issue 10, Page(s) 682–683

    MeSH term(s) Diabetes Insipidus, Neurogenic/diagnosis ; Diabetes Insipidus, Neurogenic/etiology ; Diabetes Mellitus ; Humans
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(22)00225-X
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  4. Article ; Online: Glucocorticoid receptor blockers.

    Molitch, Mark E

    Pituitary

    2022  Volume 25, Issue 5, Page(s) 733–736

    Abstract: Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports ... ...

    Abstract Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports documented its efficacy as a glucocorticoid receptor blocker going back to 1985. The SEISMIC trial, published in 2012, provided sufficient data on efficacy and adverse effects for regulatory approval. Mifepristone provides clear benefits on glycemia, blood pressure, muscle weakness, body weight and the other myriad clinical manifestations of Cushing's syndrome. However, because it blocks the glucocorticoid receptor, blood cortisol and ACTH levels actually rise, rather than fall; this complicates patient management. Doses are adjusted based on clinical manifestations rather than hormone levels. Adverse effects include adrenal insufficiency due to overdosage, hypokalemia, and menorrhagia. Treatment of severe adrenal insufficiency requires high doses of dexamethasone. Other glucocorticoid receptor blockers without effects on the progesterone receptor are being developed. Because mifepristone inhibits CYP3A and CYP2C8/2C9, drug-drug interactions can occur. These potential adverse effects can largely be avoided with careful attention to detail. My opinion is that its current place in therapy is in patients with severe disease and in those not responding to other treatments.
    MeSH term(s) Female ; Humans ; Mifepristone/therapeutic use ; Mifepristone/pharmacology ; Receptors, Glucocorticoid/therapeutic use ; Cushing Syndrome/drug therapy ; Hormone Antagonists/therapeutic use ; Receptors, Progesterone/therapeutic use ; Hydrocortisone ; Cytochrome P-450 CYP2C8 ; Cytochrome P-450 CYP3A/therapeutic use ; Adrenal Insufficiency/drug therapy ; Abortifacient Agents/therapeutic use ; Adrenocorticotropic Hormone ; Dexamethasone/therapeutic use
    Chemical Substances Mifepristone (320T6RNW1F) ; Receptors, Glucocorticoid ; Hormone Antagonists ; Receptors, Progesterone ; Hydrocortisone (WI4X0X7BPJ) ; Cytochrome P-450 CYP2C8 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Abortifacient Agents ; Adrenocorticotropic Hormone (9002-60-2) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-022-01227-x
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  5. Article ; Online: Dopamine agonists and antipsychotics.

    Molitch, Mark E

    European journal of endocrinology

    2020  Volume 183, Issue 3, Page(s) C11–C13

    Abstract: There can potentially be a number of clinical interactions that could adversely affect patient outcomes in a patient with a prolactinoma and psychiatric disease that might require antipsychotic and dopamine agonist treatment. Dopamine agonists stimulate ... ...

    Abstract There can potentially be a number of clinical interactions that could adversely affect patient outcomes in a patient with a prolactinoma and psychiatric disease that might require antipsychotic and dopamine agonist treatment. Dopamine agonists stimulate the dopamine D2 receptor, resulting in a decrease in prolactin (PRL) levels and in prolactinoma size but action on dopamine receptors in the meso-limbic system may rarely cause psychosis and more commonly cause impulse control disorders. The psychiatric benefits of antipsychotic agents involve blocking the D2 and other dopamine receptors but this blockade often also causes hyperprolactinemia. In patients with macroprolactinomas and psychosis, observation, estrogen/progestin replacement, and surgery can be considered in addition to dopamine agonists. In those who require dopamine agonists for PRL and tumor size control, the introduction of antipsychotics may blunt this effect, so that higher doses of the dopamine agonists may be needed. Alternatively, antipsychotics that have less of a blocking effect at the D2 receptor, such as aripiprazole, can be tried, if appropriate. For patients already on antipsychotic drugs who are found to have a macroprolactinoma for which dopamine agonists are required, dopamine agonists can be initiated at low dose and the dose escalated slowly. However, such patients require careful monitoring of psychiatric status to avoid the rare complication of exacerbation of the underlying psychosis. Again, if appropriate, use of antipsychotics that have less of a blocking effect at the D2 receptor may allow lower doses of dopamine agonists to be used in this situation.
    MeSH term(s) Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/adverse effects ; Drug Interactions ; Humans ; Hyperprolactinemia/chemically induced ; Mental Disorders/chemically induced ; Mental Disorders/drug therapy ; Prolactin/metabolism ; Prolactinoma/drug therapy ; Prolactinoma/pathology ; Receptors, Dopamine D2/drug effects
    Chemical Substances Antipsychotic Agents ; DRD2 protein, human ; Dopamine Agonists ; Receptors, Dopamine D2 ; Prolactin (9002-62-4)
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-20-0607
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  6. Article ; Online: Pregnancy and Endocrine Disorders.

    Molitch, Mark E

    Endocrinology and metabolism clinics of North America

    2019  Volume 48, Issue 3, Page(s) xv–xvi

    MeSH term(s) Endocrine System Diseases/diagnosis ; Endocrine System Diseases/therapy ; Endocrinology/methods ; Endocrinology/standards ; Endocrinology/trends ; Female ; Humans ; Placenta/physiology ; Practice Patterns, Physicians' ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/therapy ; Pregnancy Outcome
    Language English
    Publishing date 2019-06-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2019.06.001
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  7. Article ; Online: Management of Diabetes Mellitus in Patients With CKD: Core Curriculum 2022.

    Hahr, Allison J / Molitch, Mark E

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 79, Issue 5, Page(s) 728–736

    Abstract: The most common cause of kidney failure in the United States and across the world is diabetes mellitus (DM). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in persons with diabetes, and chronic kidney disease (CKD) further ... ...

    Abstract The most common cause of kidney failure in the United States and across the world is diabetes mellitus (DM). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in persons with diabetes, and chronic kidney disease (CKD) further increases overall CVD risk. It is important to individualize glycemic targets for patients to maintain glucose levels that will reduce the development and progression of complications while avoiding hypoglycemia. CKD alters the relationship of glucose levels to measures of long-term control, such as hemoglobin A
    MeSH term(s) Blood Glucose ; Cardiovascular Diseases/complications ; Curriculum ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Female ; Humans ; Hypoglycemia ; Hypoglycemic Agents/therapeutic use ; Male ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/epidemiology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Blood Glucose ; Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.05.023
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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  8. Article ; Online: Prolactin and Other Pituitary Disorders in Kidney Disease.

    Huang, Wenyu / Molitch, Mark E

    Seminars in nephrology

    2021  Volume 41, Issue 2, Page(s) 156–167

    Abstract: Prolactin levels are increased in chronic kidney disease (CKD) as a result of reduced clearance and increased secretion. Hyperprolactinemia manifests as galactorrhea and hypogonadism. Treatment of hyperprolactinemia should focus on improving bothersome ... ...

    Abstract Prolactin levels are increased in chronic kidney disease (CKD) as a result of reduced clearance and increased secretion. Hyperprolactinemia manifests as galactorrhea and hypogonadism. Treatment of hyperprolactinemia should focus on improving bothersome galactorrhea or hypogonadism by using dopamine agonists and/or replacement of sex hormone(s). Changes in the hypothalamic-pituitary-adrenal axis in CKD are characterized by increases in adrenocorticotropic hormone (ACTH) and cortisol levels, largely preserved circadian rhythms of ACTH and cortisol, and a normal response of cortisol to ACTH, metyrapone, and insulin-induced hypoglycemia. However, the hypothalamic-pituitary-adrenal axis is less inhibited by 1 mg dexamethasone but retains normal suppression by higher-dose dexamethasone. Diagnosis of adrenal insufficiency in CKD patients, as in normal subjects, usually is made by finding a subnormal cortisol response to ACTH. The mainstay of treatment of adrenal insufficiency is to replace glucocorticoid hormone. Cushing's disease in CKD is difficult to diagnose and relies on the dexamethasone suppression test and the midnight salivary cortisol test because the 24-hour urine free cortisol test is not useful because it is increased already in CKD. Treatment of Cushing's disease involves surgery, complemented by radiation and/or medical therapy if necessary. Growth hormone levels are increased and insulin-like growth factor 1 levels are normal in patients with CKD. In a normal patient with CKD, as in one with acromegaly, there can be a paradoxic increase in growth hormone after an oral glucose load. Therefore, diagnosis of acromegaly in renal insufficiency is challenging. The treatment of choice for acromegaly is surgery, although data for medical treatment for acromegaly in CKD are rare. In patients with renal impairment, arginine vasopressin levels are increased as a result of decreased clearance, and there also is impairment of arginine vasopressin signaling in renal tubules. Diabetes insipidus can be masked in advanced kidney disease until kidney transplantation. Diagnosis of the syndrome of inappropriate antidiuretic hormone is similar in mild or moderate kidney disease as in normal subjects, but is challenging in patients with advanced kidney disease owing to the impairment in urine dilution.
    MeSH term(s) Cushing Syndrome ; Humans ; Hydrocortisone ; Hypothalamo-Hypophyseal System ; Pituitary Diseases ; Pituitary-Adrenal System ; Prolactin ; Renal Insufficiency, Chronic/complications
    Chemical Substances Prolactin (9002-62-4) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2021.03.010
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  9. Article ; Online: Glycemic Control Assessment in the Dialysis Patient: Is Glycated Albumin the Answer?

    Molitch, Mark E

    American journal of nephrology

    2017  Volume 47, Issue 1, Page(s) 18–20

    MeSH term(s) Blood Glucose ; Blood Glucose Self-Monitoring ; Glycated Hemoglobin A/analysis ; Renal Dialysis ; Serum Albumin
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Serum Albumin ; glycated serum albumin
    Language English
    Publishing date 2017-12-22
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000485844
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  10. Book: Challenging cases in endocrinology

    Molitch, Mark E.

    (Contemporary endocrinology)

    2002  

    Author's details ed. by Mark E. Molitch
    Series title Contemporary endocrinology
    Keywords Endocrine Diseases / diagnosis ; Endocrine Diseases / therapy
    Language English
    Size XI, 421 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013311192
    ISBN 0-89603-914-5 ; 978-0-89603-914-8
    Database Catalogue ZB MED Medicine, Health

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    2002 A 1413 order for loan Magazin

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