LIVIVO - Search results -

Search results

Result 1 - 10 of total 62

Search options

Article ; Online: INTERACTION OF ALBUMIN AND IMMUNOGLOBULIN G WITH SYNTHETIC HYDROXYAPATITE

E. Pylypchuk / V. Mishchenko / T. Yu. Gromovoy

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 7, Iss 2, Pp 143-

2012 Volume 146

Abstract: ... that interaction of synthetic hydroxyapatite with a solution of immunoglobulin G leads to its partial dissolution ... complexes with immunoglobulin G. ...

Abstract	It was shown by X-ray phase analysis, IR spectra analysis and MALDI-ToF mass spectrometry methods that interaction of synthetic hydroxyapatite with a solution of immunoglobulin G leads to its partial dissolution due to leaching from the surface of calcium triphosphate which, in our opinion, forms complexes with immunoglobulin G.
Keywords	MALDI-ToF ; X-ray phase analysis ; albumin ; immunoglobulin G ; hydroxyapatite ; interaction ; Chemistry ; QD1-999 ; General. Including alchemy ; QD1-65
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	Academy of Sciences of Moldova, Institute of Chemistry
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Polyelectrolyte complexes based on a novel and sustainable hemicellulose-rich lignosulphonate for drug delivery applications.

Dogaris, Ioannis / Pylypchuk, Ievgen / Henriksson, Gunnar / Abbadessa, Anna

Drug delivery and translational research

2024

Abstract: Polyelectrolyte complexes (PECs) are polymeric structures formed by the self-assembly of oppositely charged polymers. Novel biomaterials based on PECs are currently under investigation as drug delivery systems, among other applications. This strategy ... ...

Abstract	Polyelectrolyte complexes (PECs) are polymeric structures formed by the self-assembly of oppositely charged polymers. Novel biomaterials based on PECs are currently under investigation as drug delivery systems, among other applications. This strategy leverages the ability of PECs to entrap drugs under mild conditions and control their release. In this study, we combined a novel and sustainably produced hemicellulose-rich lignosulphonate polymer (EH, negatively charged) with polyethyleneimine (PEI) or chitosan (CH, positively charged) and agar for the development of drug-releasing PECs. A preliminary screening demonstrated the effect of several parameters (polyelectrolyte ratio, temperature, and type of polycation) on PECs formation. From this, selected formulations were further characterized in terms of thermal properties, surface morphology at the microscale, stability, and ability to load and release methylene blue (MB) as a model drug. EH/PEI complexes had a more pronounced gel-like behaviour compared to the EH/CH complexes. Differential scanning calorimetry (DSC) results supported the establishment of polymeric interactions during complexation. Overall, PECs' stability was positively affected by low pH, ratios close to 1:1, and the addition of agar. PECs with higher EH content showed a higher MB loading, likely promoted by stronger electrostatic interactions. The EH/CH formulation enriched with agar showed the best sustained release profile of MB during the first 30 h in a pH-dependent environment simulating the gastrointestinal tract. Overall, we defined the conditions to formulate novel PECs based on a sustainable hemicellulose-rich lignosulphonate for potential applications in drug delivery, which promotes the valuable synergy between sustainability and the biomedical field.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-024-01573-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Risk of cardiovascular disease in cancer survivors: A cohort study of 446,384 New Zealand primary care patients.

Tawfiq, Essa / Pylypchuk, Romana / Elwood, J Mark / McKeage, Mark / Wells, Sue / Selak, Vanessa

Cancer medicine

2023 Volume 12, Issue 19, Page(s) 20081–20093

Abstract: ... non-Hodgkin lymphoma (1.90, 1.42-2.54), but not for some cancers (e.g., colorectal, 0.87, 0.71-1.06). Risk of CVD death ...

Abstract	Background: Given advances in the management of cancer, it is increasingly important for clinicians to appropriately manage the risk of cardiovascular disease (CVD) among cancer survivors. It is unclear whether CVD risk is increased among cancer survivors overall, and there is inconsistency in evidence to date about CVD incidence and mortality by cancer type. Methods: Patients aged 30-74 years entered an open cohort study at the time of first CVD risk assessment, between 2004 and 2018, in primary care in New Zealand. Patients with established CVD or cancer within 2 years prior to study entry were excluded. Cancer diagnosis (1995-2016) was determined from a national cancer registry. Cause-specific hazard models were used to examine the association between history of cancer and two outcomes: (1) CVD-related hospitalization and/or death and (2) CVD death. Results: The study included 446,384 patients, of whom 14,263 (3.2%) were cancer survivors. Risk of CVD hospitalization and/or death was increased among cancer survivors compared with patients without cancer at cohort entry (multivariable-adjusted hazard ratio, mHR, 1.11, 95% CI 1.05-1.18), more so for CVD death (1.31, 1.14-1.52). Risk of CVD hospitalization and/or death was increased in patients with myeloma (2.66, 1.60-4.42), lung cancer (2.19, 1.48-3.24) and non-Hodgkin lymphoma (1.90, 1.42-2.54), but not for some cancers (e.g., colorectal, 0.87, 0.71-1.06). Risk of CVD death was increased in several cancer types including melanoma (1.73, 1.25-2.38) and breast cancer (1.56, 1.16-2.11). Conclusion: CVD risk management needs to be prioritized among cancer survivors overall, and particularly in those with myeloma, lung cancer and non-Hodgkin lymphoma given consistent evidence of increased risk.
MeSH term(s)	Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cohort Studies ; Cancer Survivors ; Multiple Myeloma/complications ; New Zealand/epidemiology ; Lymphoma, Non-Hodgkin/complications ; Lung Neoplasms/complications ; Primary Health Care ; Risk Factors
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6580
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Removal of Diclofenac, Paracetamol, and Carbamazepine from Model Aqueous Solutions by Magnetic Sol-Gel Encapsulated Horseradish Peroxidase and Lignin Peroxidase Composites.

Pylypchuk, Ievgen V / Daniel, Geoffrey / Kessler, Vadim G / Seisenbaeva, Gulaim A

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 2

Abstract: Sustainable and green synthesis of nanocomposites for degradation of pharmaceuticals was developed via immobilization and stabilization of the biological strong oxidizing agents, peroxidase enzymes, on a solid support. Sol-gel encapsulated enzyme ... ...

Abstract	Sustainable and green synthesis of nanocomposites for degradation of pharmaceuticals was developed via immobilization and stabilization of the biological strong oxidizing agents, peroxidase enzymes, on a solid support. Sol-gel encapsulated enzyme composites were characterized using electron microscopy (TEM, SEM), atomic force microscopy, FTIR spectroscopy, and thermogravimetric analysis. Horseradish peroxidase (HRP) and lignin peroxidase (LiP) were adsorbed onto magnetite nanoparticles and sol-gel encapsulated in a surface silica layer. Encapsulation enhanced the stability of the biocatalysts over time and thermal stability. The biocatalysts showed appreciable selectivity in oxidation of the organic drinking water pollutants diclofenac, carbamazepine, and paracetamol with improved activity being pharmaceutical specific for each enzyme. In particular, sol-gel encapsulated LiP- and HRP-based nanocomposites were active over 20 consecutive cycles for 20 days at 55 °C (24 h/cycle). The stability of the sol-gel encapsulated catalysts in acidic medium was also improved compared to native enzymes. Carbamazepine and diclofenac were degraded to 68% and 64% by sol-gel LiP composites respectively at pH 5 under elevated temperature. Total destruction of carbamazepine and diclofenac was achieved at pH 3 (55 °C) within 3 days, in the case of both immobilized HRP and LiP. Using NMR spectroscopy, characterization of the drug decomposition products, and decomposition pathways by the peroxidase enzymes suggested.
Language	English
Publishing date	2020-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10020282
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Self-assembly of plant protein fibrils interacting with superparamagnetic iron oxide nanoparticles.

Li, Jing / Pylypchuk, Ievgen / Johansson, Daniel P / Kessler, Vadim G / Seisenbaeva, Gulaim A / Langton, Maud

Scientific reports

2019 Volume 9, Issue 1, Page(s) 8939

Abstract: In situ fibrillation of plant proteins in presence of the superparamagnetic iron oxide nanoparticles (NP) promoted formation of a hybrid nanocomposite. The morphology of NP-fibril composite was revealed using ex-situ atomic force microscopy (AFM) in air. ...

Abstract	In situ fibrillation of plant proteins in presence of the superparamagnetic iron oxide nanoparticles (NP) promoted formation of a hybrid nanocomposite. The morphology of NP-fibril composite was revealed using ex-situ atomic force microscopy (AFM) in air. The NP-fibrils were associated into extended multi-fibril structures, indicating that the addition of NPs promoted protein association via β-sheet assembly. Real-time movement of NPs attached to fibrils under an external magnetic field was visualized using in-situ AFM in liquid, revealing that composite structures were stable at low pH, and displaying dipolar property of the NPs in the composite at high pH. Changes in magnetic properties of NPs when interacting with protein fibrils were quantitatively mapped using magnetic force microscopy (MFM). The magnetic moment of the NPs in composite was increased by co-existing with protein at low pH, while their dipolar nature was maintained at high pH. Self-assembly of the protein into fibrils is accelerated with increasing NP concentration within an optimal range, which is attributed to a fibrillation-competent conformation of the peptides. The latter was explained by the formation of favorable hydrogen bonds, electrostatic interactions, and efficient surface energy transfer between NPs and proteins.
MeSH term(s)	Electrophoresis, Polyacrylamide Gel ; Magnetics ; Magnetite Nanoparticles/chemistry ; Microscopy, Atomic Force ; Plant Proteins/chemistry ; Protein Binding ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Magnetite Nanoparticles ; Plant Proteins
Language	English
Publishing date	2019-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-45437-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Barriers to Evidence-Based Colorectal Cancer Care in Ukraine.

Lu, Pamela W / Semeniv, Solomiia / Shabat, Galyna / Welten, Vanessa / Pylypchuk, Volodymyr I / Galyuk, Volodymyr / Fields, Adam C / Melnitchouk, Nelya

World journal of surgery

2021 Volume 45, Issue 11, Page(s) 3288–3294

Abstract: Background: The incidence of colorectal cancer (CRC) is increasing in many low- to middle-income countries, including Ukraine. Ukraine reports high mortality rates in CRC patients. To identify potential areas for targeted interventions to improve CRC ... ...

Abstract	Background: The incidence of colorectal cancer (CRC) is increasing in many low- to middle-income countries, including Ukraine. Ukraine reports high mortality rates in CRC patients. To identify potential areas for targeted interventions to improve CRC care in Ukraine, we investigated Ukrainian clinician perspectives on evidence-based CRC treatment guidelines. Methods: An explanatory sequential mixed-methods study design was used. A survey was administered to attendees of a regional surgical conference. Semi-structured interviews were subsequently performed with practicing clinicians in Ukraine. Interviews were coded to identify prominent themes. Results: Quantitative: 105 clinicians completed the survey. 76% of respondents reported using guidelines in daily practice. Lack of English proficiency was cited by 28.6% of respondents as a barrier to guideline use. Improved knowledge and additional financial resources were reported as factors that would be helpful in providing evidence-based care. Quantitative: 15 clinicians were interviewed. Two major themes were identified: limitations in access to the medical literature resources (language barriers and financial barriers), and sense of clinician initiative and willingness to learn despite hardships. Conclusions: Clinicians in Ukraine have positive perspectives on utilization of evidence-based CRC treatment guidelines. However, they face major barriers in accessing resources needed to keep up-to-date on the current literature. Fortunately, there exists both willingness and initiative on the clinician level to pursue continuing education. Efforts should be made on the international society level to improve open-access and foreign language translation availability to support physicians in Ukraine and other low- to middle-income countries.
MeSH term(s)	Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; Humans ; Ukraine
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06267-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1336: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Electric Transport Properties in the 2D-MoS2

Vainberg, V. V. / Pylypchuk, O. S. / Poroshin, V. N. / Olenchuk, M. V. / Dovbeshko, G. I.

2021

Abstract: The features of electric transport in the powder samples consisting of the nanosize 2D-MoS2 flakes with different number of layers have been studied under the conditions of uniaxial pressure. There have been measured current-voltage characteristics at ... ...

Abstract	The features of electric transport in the powder samples consisting of the nanosize 2D-MoS2 flakes with different number of layers have been studied under the conditions of uniaxial pressure. There have been measured current-voltage characteristics at the room temperature in the voltage range of 0 through 1.5 V at 3 magnitudes of the uniaxial pressure from 5 through 25 bars. The current-voltage characteristics are shown to be non-linear and to form a loop during successive increasing and decreasing voltage. The long-term decays of the current on applying voltage to the sample and of the voltage on the sample in the no-load mode on switching off have been observed. The observed results are explained by the model of the surface charge accumulation causing polarization. Comment: 9 pages, 4 figures
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
Publishing date	2021-10-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: [ROBOTIC PANCREATECTOMY. TECHNICAL ASPECTS].

Marino, M / Pylypchuk, V I / Gulotta, G / Yavorskyi, A M / Shabat, G I

Klinichna khirurhiia

2018 , Issue 11, Page(s) 8–11

MeSH term(s)	Blood Loss, Surgical/prevention & control ; Clinical Competence ; Duodenum/pathology ; Duodenum/surgery ; Humans ; Italy ; Laparoscopy/methods ; Learning Curve ; Length of Stay ; Operative Time ; Pancreas/pathology ; Pancreas/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/instrumentation ; Pancreaticoduodenectomy/methods ; Robotic Surgical Procedures/instrumentation ; Robotic Surgical Procedures/methods ; Surgeons/education ; Ukraine
Language	Ukrainian
Publishing date	2018-09-28
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	411775-x
ISSN	0023-2130
ISSN	0023-2130
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 734: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: THE INVESTIGATION OF THE ENDOGENOUS INTOXICATION INDICES IN RATS IN THE DYNAMICS OF THE CRUSHSYNDROME DEVELOPMENT

Pylypchuk T. P. / Krynytska I. I. Ya.

Вісник проблем біології і медицини, Vol 2, Iss 1, Pp 171-

2019 Volume 175

Abstract: ... mature white male rats weighing 180-200 g, which were modeled with crush-syndrome of medium degree ...

Abstract	Long-term compression syndrome (crush-syndrome) occupies 15-24 % in the structure of traumatic lesions and is characterized by severe course, development of a syndrome of systemic inflammatory response and disseminated intravascular coagulation syndrome, leading to multiple organ failure and high mortality of the victims, even in specialized hospitals. The aim of our study was to investigate the dynamics of endogenous intoxication indices changes in rats blood and liver on the model of endotoxicosis, which is formed under conditions of crush-syndrome. Experiments were carried out on 40 inbred, sexually mature white male rats weighing 180-200 g, which were modeled with crush-syndrome of medium degree. The rats were divided into five groups: intact animals, experimental group 1 1 day of observation, experimental group 2 3rd day of observation, experimental group 3 7 days of observation, experimental group 4 14 days of observation. Blood serum and liver homogenate were used for the investigations. Determination of the content of middle-mass molecules was carried out in accordance with the Lifshits R.I. method. In the dynamics of the post-traumatic period of the crush-syndrome, an increase in the level of endogenous intoxication has been established, as indicated by an increase in the content of medium mass molecules, with a peak at the third day of observation. Thus, on the 3rd day of observation, the content of MSM1 in serum was significantly increased by 23.6 % compared with the 1st day and 2.1 times exceeded the control group data. Regarding the changes in the content of MSM2 in blood serum in the crush-syndrome dynamics, the 3rd day of observation revealed a probable prevalence of this index by 2.4 times vs intact rats, which was significantly higher by 38.1% vs the data for 1st day of observation. When comparing the dynamics of changes in endogenous intoxication indices, their synchronous development in blood and liver, with predominance in the liver has been established. It is associated with destructive ...
Keywords	crush-syndrome ; endogenous intoxication ; rats ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Ukrainian Medical Stomatological Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Simultaneous Removal of Acetaminophen, Diclofenac, and Cd(II) by Trametes versicolor Laccase Immobilized on Fe3O4/SiO2-DTPA Hybrid Nanocomposites

Pylypchuk, Ievgen V / Gulaim A. Seisenbaeva / Vadim G. Kessler

ACS sustainable chemistry & engineering. 2018 June 21, v. 6, no. 8

2018

Abstract: For simultaneous water purification from both inorganic and organic pollutants, a novel multifunctional hybrid nanoadsorbent has been produced. Core–shell magnetic submicro-particles with iron oxide core and silica shell were used as substrate for ... ...

Abstract	For simultaneous water purification from both inorganic and organic pollutants, a novel multifunctional hybrid nanoadsorbent has been produced. Core–shell magnetic submicro-particles with iron oxide core and silica shell were used as substrate for immobilization of different functions. The activity toward heavy metals was provided via attachment of 3-aminopropyl-triethoxysilane (APTES) through the silanol group to the silica surface with subsequent chemical grafting of diethylenetriamine pentaacetic acid (DTPA) onto the APTES via an amide bonding. The residual APTES amino functions were partially converted into aldehyde ones via treatment with glutaraldehyde. Both aldehyde and carboxylic functions turned to be involved in laccase immobilization. The obtained hybrid multifunctional adsorbent exhibited relatively high capacity for Cd(II) removal. On average, the composite removed 76% of Cd(II) ions from the 0.1 μM model solution. At the same time, due to the immobilized laccase, high performance for drug removal was revealed. Immobilized laccase retained up to 100% activity in 50 ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) oxidation cycles, even in the presence of Cd(II). The adsorbent was able to remove up to 99% of acetaminophen in 1 mg/mL solution during 18 h, and a total of 95% of acetaminophen and 85% diclofenac removal reached in acetaminophen/diclofenac mixtures (0.5 mg/mL + 25 μg/mL, respectively). Comparable results were achieved with acetaminophen/diclofenac mixtures also in the presence of Cd(II) ions (99% of acetaminophen and 95% of diclofenac removal). Obtained composites as well as the products of the drug oligomerization were characterized by SEM, AFM, NMR, FTIR, and UV–vis spectroscopy. Chemical mechanisms of drug removal via oxidation/polymerization have been elucidated.
Keywords	acetaminophen ; adsorbents ; atomic force microscopy ; cadmium ; Coriolus versicolor ; diclofenac ; Fourier transform infrared spectroscopy ; glutaraldehyde ; heavy metals ; ions ; iron oxides ; laccase ; magnetism ; models ; nanocomposites ; nuclear magnetic resonance spectroscopy ; oligomerization ; oxidation ; pollutants ; polymerization ; scanning electron microscopy ; silica ; ultraviolet-visible spectroscopy ; water purification
Language	English
Dates of publication	2018-0621
Size	p. 9979-9989.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.8b01207
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED