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Article ; Online: Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet.

Pati, Paramita / Pollock, Jennifer S / Gamble, Karen L

2023 Volume 35, Issue 1, Page(s) 7–9

Abstract: The timing of food intake is vital for metabolic health in obesity. A recent study in mice from Hepler et al. in Science shows the importance of the adipocyte circadian clock in metabolic health, highlighting the creatine pathway and thermogenesis with ... ...

Abstract	The timing of food intake is vital for metabolic health in obesity. A recent study in mice from Hepler et al. in Science shows the importance of the adipocyte circadian clock in metabolic health, highlighting the creatine pathway and thermogenesis with the alignment of the timing of high-fat feeding.
MeSH term(s)	Mice ; Animals ; Eating ; Diet, High-Fat ; Circadian Rhythm ; Adipocytes/metabolism ; Thermogenesis ; Feeding Behavior
Language	English
Publishing date	2023-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2022.12.008
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Zs.A 6169: Show issues

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Article ; Online: Looking Forward to a Bright Future at APS.

Silverthorn, Dee / Pollock, Jennifer S / Samson, Willis Rick

Physiology (Bethesda, Md.)

2022 Volume 37, Issue 6, Page(s) 286–288

Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Editorial
ZDB-ID	2158667-6
ISSN	1548-9221 ; 1548-9213
ISSN (online)	1548-9221
ISSN	1548-9213
DOI	10.1152/physiol.00026.2022
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Zs.A 2164: Show issues

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Article ; Online: SONAR propels endothelin A receptor antagonists to success.

Pollock, Jennifer S / Pollock, David M

Nature reviews. Nephrology

2019 Volume 15, Issue 8, Page(s) 461–462

MeSH term(s)	Atrasentan ; Diabetes Mellitus, Type 2 ; Double-Blind Method ; Endothelin A Receptor Antagonists ; Humans ; Renal Insufficiency, Chronic
Chemical Substances	Endothelin A Receptor Antagonists ; Atrasentan (V6D7VK2215)
Language	English
Publishing date	2019-06-19
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-019-0169-9
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Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 107: Show issues

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Article ; Online: HDAC1: an environmental sensor regulating endothelial function.

Dunaway, Luke S / Pollock, Jennifer S

Cardiovascular research

2021 Volume 118, Issue 8, Page(s) 1885–1903

Abstract: The histone deacetylases (HDACs) are a family of enzymes that catalyse lysine deacetylation of both histone and non-histone proteins. Here, we review, summarize, and provide perspectives on the literature regarding one such HDAC, HDAC1, in endothelial ... ...

Abstract	The histone deacetylases (HDACs) are a family of enzymes that catalyse lysine deacetylation of both histone and non-histone proteins. Here, we review, summarize, and provide perspectives on the literature regarding one such HDAC, HDAC1, in endothelial biology. In the endothelium, HDAC1 mediates the effects of external and environmental stimuli by regulating major endothelial functions such as angiogenesis, inflammatory signalling, redox homeostasis, and nitric oxide signalling. Angiogenesis is most often, but not exclusively, repressed by endothelial HDAC1. The regulation of inflammatory signalling is more complex as HDAC1 promotes or suppresses inflammatory signalling depending upon the environmental stimuli. HDAC1 is protective in models of atherosclerosis where loss of HDAC1 results in increased cytokine and cell adhesion molecule (CAM) abundance. In other models, HDAC1 promotes inflammation by increasing CAMs and repressing claudin-5 expression. Consistently, from many investigations, HDAC1 decreases antioxidant enzyme expression and nitric oxide production in the endothelium. HDAC1 decreases antioxidant enzyme expression through the deacetylation of histones and transcription factors, and also regulates nitric oxide production through regulating both the expression and activity of nitric oxide synthase 3. The HDAC1-dependent regulation of endothelial function through the deacetylation of both histone and non-histone proteins ultimately impacts whole animal physiology and health.
MeSH term(s)	Animals ; Antioxidants ; Endothelium ; Histone Deacetylase 1/metabolism ; Histone Deacetylases/metabolism ; Histones/metabolism ; Nitric Oxide/metabolism
Chemical Substances	Antioxidants ; Histones ; Nitric Oxide (31C4KY9ESH) ; Histone Deacetylase 1 (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2021-07-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvab198
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Zs.A 565: Show issues

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Article ; Online: Innovating and Building Momentum for Physiology's Future.

S Pollock, Jennifer / Samuelson, Linda / Silverthorn, Dee

Physiology (Bethesda, Md.)

2021 Volume 37, Issue 1, Page(s) 2–3

Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Editorial
ZDB-ID	2158667-6
ISSN	1548-9221 ; 1548-9213
ISSN (online)	1548-9221
ISSN	1548-9213
DOI	10.1152/physiol.00042.2021
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Article ; Online: Adverse childhood events and cardiovascular diseases: the potential role of Sirt1.

Rodriguez-Miguelez, Paula / Pollock, Jennifer S

American journal of physiology. Heart and circulatory physiology

2021 Volume 321, Issue 3, Page(s) H577–H579

MeSH term(s)	Cardiovascular Diseases/epidemiology ; Child ; Humans ; Nitric Oxide Synthase Type III ; Sirtuin 1 ; Vasodilation
Chemical Substances	Nitric Oxide Synthase Type III (EC 1.14.13.39) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00452.2021
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Article ; Online: US Generic Antiseizure Medication Supply Chain: Observations from Analysis of US Government Databases.

Javarayee, Pradeep / Meylor, Jennifer / Shahrukh, Shamshad / Pollock, Shannon / Andrade-Machado, Rene / Sah, Jeetendra / Patel, Hema

Seizure

2024 Volume 117, Page(s) 83–89

Abstract: Background: Generic drug manufacturing has shifted away from the U.S. in the last few decades ... identifier. Repackaged ASM FDFs constituted 48 % of NDC-9 s. Gabapentin and pregabalin were the most common ...

Abstract	Background: Generic drug manufacturing has shifted away from the U.S. in the last few decades. The medication supply chain, from manufacturers to resellers, has become increasingly globalized and complex. This has led to bottlenecks in their manufacture resulting in medication shortages. Review of this process as it pertains to antiseizure medications (ASM) shows gaps in our comprehension of its complexities. Understanding these processes will be essential for preventing medication shortages. Objectives: The aim of this research is to examine the generic ASM supply with an emphasis on production, labeling, and repackaging. Methods: Data from the United States Food and Drug Administration (FDA) and the National Library of Medicine (NLM) website DailyMed was used to evaluate supply chain details to gather information on antiseizure medication formulations, manufacturing locations, and labeling. Results: Out of 3142 ASM-related active National Drug Code (NDC-9) codes, 2663 NDC-9 codes with Abbreviated New Drug Application (ANDA) status were included in the analysis. Most (94.8 %) were enteral, with only 5.2 % being parenteral (intravenous and intramuscular route). We identified the manufacturing country for 82 % of these codes, corresponding to 306 unique ANDA numbers. 119 manufacturing sites in 12 countries produce generic ASM Finished Dosage Forms (FDF): 103 for enteral and 21 for parenteral. India is the main producer of enteral ASM FDFs with 49 sites, followed by the US with 36. Regarding parenteral formulation, five countries had 21 unique manufacturing locations. 42 % of the 103 enteral ASM FDFs manufacturing sites produced multiple ASM FDFs, with one facility making eight distinct ASMs. 34.4 % of facilities were associated with over 3 ANDAs, and 15.1 % with more than 5. 22.7 % of ANDAs lacked a manufacturing facility identifier. Repackaged ASM FDFs constituted 48 % of NDC-9 s. Gabapentin and pregabalin were the most common oral ASMs. Conclusions: India is the major source for generic ASM FDFs manufacturing, leading to concerns about overall supply dependency on that country. There is a paucity of facilities for the global supply of parenteral ASM FDFs. There is missing data for many NDC-9 codes emphasizing urgency for transparency in the supply chain.
MeSH term(s)	Humans ; United States ; Drugs, Generic/supply & distribution ; Anticonvulsants/supply & distribution ; Anticonvulsants/therapeutic use ; United States Food and Drug Administration ; Databases, Factual ; National Library of Medicine (U.S.) ; Drug Industry
Chemical Substances	Drugs, Generic ; Anticonvulsants
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2024.02.003
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Zs.A 3573: Show issues

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Article ; Online: Racial and ethnic differences in diagnosis age and blood biomarkers in a pediatric inflammatory bowel disease cohort.

Kemp, Keri M / Nagaraj, Pooja K / Orihuela, Catheryn A / Lorenz, Robin G / Maynard, Craig L / Pollock, Jennifer S / Jester, Traci

Journal of pediatric gastroenterology and nutrition

2024 Volume 78, Issue 3, Page(s) 634–643

Abstract: Objective: Prompt diagnosis of pediatric-onset inflammatory bowel disease (IBD) is crucial for preventing a complicated disease course; however, it is not well understood how social determinants of health might affect pediatric IBD diagnosis. This study ...

Abstract	Objective: Prompt diagnosis of pediatric-onset inflammatory bowel disease (IBD) is crucial for preventing a complicated disease course; however, it is not well understood how social determinants of health might affect pediatric IBD diagnosis. This study examined differences in diagnosis age, biomarkers of disease severity, and anthropometrics with sociodemographic factors in a pediatric IBD cohort. Methods: Pediatric IBD patients (n = 114) and their parents/caregivers were enrolled from the Children's of Alabama Pediatric IBD Clinic in Birmingham, Alabama. Primary analyses examined associations of child race and ethnicity, parental income, parental education, single-parent household status, insurance type, and distance to a tertiary pediatric gastroenterology referral center with diagnosis age. Secondary analyses examined differences in biomarker levels, height, and body mass index at the time of diagnosis. Results: Racial and ethnic minority children were diagnosed at an older age compared to Non-Hispanic White children (14.4 ± 0.40 vs. 11.7 ± 0.38 years; p < 0.001), and this trend was robust to adjustment with other sociodemographic variables. Parental attainment of a college education attenuated the link between minority race and ethnicity and the likelihood of older age at diagnosis, while other sociodemographic variables had no moderating effect. Racial and ethnic minority children were 5.7 times more likely to have clinically elevated erythrocyte sedimentation rate at diagnosis compared to Non-Hispanic White children (p = .024). Conclusions: These results suggest that child race and ethnicity may exert a primary effect on the age at diagnosis with pediatric-onset IBD. This study highlights the need for further research on racial and ethnic disparities to promote health equity in pediatric-onset IBD.
MeSH term(s)	Child ; Humans ; Ethnicity ; Health Promotion ; Inflammatory Bowel Diseases/diagnosis ; Minority Groups ; Racial Groups ; Alabama ; Adolescent
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1002/jpn3.12131
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Article: Mentoring for Collaborations and Team Science.

Pollock, David M / Pollock, Jennifer S

The Physiologist

2015 Volume 58, Issue 6, Page(s) 279, 282–4

MeSH term(s)	Biomedical Research/organization & administration ; Cooperative Behavior ; Humans ; Mentors
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	208883-6
ISSN	1522-1202 ; 0031-9376
ISSN (online)	1522-1202
ISSN	0031-9376
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Article ; Online: Early Life Stress, Coping, and Cardiovascular Reactivity to Acute Social Stress.

Mrug, Sylvie / Pollock, Jennifer S / Pollock, David M / Seifert, Michael E / Johnson, Kim A / Knight, David C

Psychosomatic medicine

2022 Volume 85, Issue 2, Page(s) 118–129

Abstract: Objective: Early life stress (ELS) occurring during childhood and adolescence is an established risk factor for later cardiovascular disease and dysregulated reactivity to acute social stress. This study examined whether ELS associations with baseline ... ...

Abstract	Objective: Early life stress (ELS) occurring during childhood and adolescence is an established risk factor for later cardiovascular disease and dysregulated reactivity to acute social stress. This study examined whether ELS associations with baseline cardiovascular functioning, cardiovascular stress reactivity and recovery, and emotional stress reactivity vary across levels of emotion-oriented, task-oriented, and avoidant coping styles. Methods: The sample included 1027 adolescents and young adults (mean age = 19.29 years; 50% female; 64% Black, 34% non-Hispanic White) who reported on their ELS exposure and coping styles. Participants completed a standardized acute social stress test (the Trier Social Stress Test [TSST]), with heart rate (HR) and blood pressure (BP) measured before, during, and after the TSST. Self-reports of negative emotions during the TSST indexed emotional stress reactivity. Results: Multiple regression models adjusting for demographic factors and body mass index showed that ELS was associated with lower HR stress reactivity, avoidant coping was related to lower systolic BP and diastolic BP during stress and lower systolic BP during recovery, and higher emotion-oriented coping and lower task-oriented coping predicted greater emotional stress reactivity. A consistent pattern emerged where emotion-oriented coping amplified the associations between ELS and maladaptive stress responses (blunted cardiovascular stress reactivity and recovery; enhanced emotional stress reactivity), whereas lower levels of emotion-oriented coping were associated with resilient profiles among those who experienced ELS (lower resting HR, lower emotional stress reactivity, average HR and BP stress reactivity and recovery). However, low levels of emotion-oriented coping also conferred a risk of higher BP during recovery for those with high levels of ELS. Conclusions: These results suggest that low to moderate levels of emotion-oriented coping promote optimal cardiovascular and emotional reactivity to acute stress among individuals exposed to ELS.
MeSH term(s)	Adolescent ; Young Adult ; Humans ; Female ; Adult ; Male ; Adverse Childhood Experiences ; Stress, Psychological ; Adaptation, Psychological ; Emotions/physiology ; Self Report
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000001165
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