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Article ; Online: Advances in Respiratory Medicine

Kuziemski, Krzysztof / Franczuk, Monika / Majewski, Sebastian / Zielonka, Tadeusz M / Barczyk, Adam

2024 Volume 92, Issue 2, Page(s) 156–157

Abstract: Advances in Respiratory ... ...

Abstract	Advances in Respiratory Medicine
MeSH term(s)	Humans ; Bronchodilator Agents/therapeutic use ; Asthma/drug therapy ; Pulmonary Medicine ; Dry Powder Inhalers ; Administration, Inhalation ; Respiratory Function Tests
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.3390/arm92020017
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Article ; Online: Evaluation of Conventional Cardiovascular Risk Factors and Ordinal Coronary Artery Calcium Scoring in a Lung Cancer Screening Cohort.

Kasprzyk, Piotr / Undrunas, Aleksandra / Dziadziuszko, Katarzyna / Dziedzic, Robert / Kuziemski, Krzysztof / Szurowska, Edyta / Rzyman, Witold / Zdrojewski, Tomasz

Journal of cardiovascular development and disease

2024 Volume 11, Issue 1

Abstract: 1) Background: Lung cancer screening (LCS) consists of low-dose computed tomography (LDCT) results to reduce lung cancer-related mortality. The LCS program has a unique opportunity to impact CVD mortality by providing tools for CVD risk assessment and ... ...

Abstract	(1) Background: Lung cancer screening (LCS) consists of low-dose computed tomography (LDCT) results to reduce lung cancer-related mortality. The LCS program has a unique opportunity to impact CVD mortality by providing tools for CVD risk assessment and implementing preventative strategies. In this study, we estimated standardized CVD risk (SCORE) and assessed the prevalence of coronary artery calcium (CAC) in a Polish LCS cohort. (2) Methods: In this observational study, 494 LCS participants aged 50-79 years with a cigarette smoking history of at least 30 pack-years were included. Medical history, anthropometric measurements, blood pressure measurements, serum glucose, and cholesterol levels were assessed in one visit. CVD risk assessment using SCORE tables was performed. The results were compared to the general population (NATPOL 2011 study). On LDCT scans, CAC was classified using an Ordinal Score ranging from 0 to 12. (3) Results: The prevalence of classic cardiovascular risk factors was very high. Among study participants, 83.7% of men and 40.7% of women were classified with a very high CVD SCORE risk (>10%). CAC was reported in 190 (47%) participants. Calcification was categorized as severe (CAC ≥ 4) in 84 (21%) participants. (4) Conclusions: Due to the high cardiovascular risk, intensive preventive strategies are recommended for LCS participants.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd11010016
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Article: The impact of intravenous dobutamine on spirometry with bronchodilator test.

Romantowski, Jan / Janowiak, Piotr / Wabich, Elzbieta / Kuziemski, Krzysztof

Respiratory medicine case reports

2020 Volume 31, Page(s) 101264

Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2020.101264
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Article ; Online: Analysing COVID-19 treatment outcomes in dedicated wards at a large university hospital in northern Poland: a result-based observational study.

Palus, Damian Krystian / Gołębiewska, Martyna Ewa / Piątek, Olga / Grudziński, Krzysztof / Majeranowski, Alan / Owczuk, Radosław / Kuziemski, Krzysztof / Stefaniak, Tomasz

BMJ open

2023 Volume 13, Issue 6, Page(s) e066734

Abstract: Objectives: Presenting outcomes of patients hospitalised for COVID-19 should be put in context and comparison with other facilities. However, varied methodology applied in published studies can impede or even hinder a reliable comparison. The aim of ... ...

Abstract	Objectives: Presenting outcomes of patients hospitalised for COVID-19 should be put in context and comparison with other facilities. However, varied methodology applied in published studies can impede or even hinder a reliable comparison. The aim of this study is to share our experience in pandemic management and highlight previously under-reported factors affecting mortality. We present outcomes of COVID-19 treatment in our facility that will allow for an intercentre comparison. We use simple statistical parameters-case fatality ratio (CFR) and length of stay (LOS). Setting: Large clinical hospital in northern Poland serving over 120 000 patients annually. Participants: Data were collected from patients hospitalised in COVID-19 general and intensive care unit (ICU) isolation wards from November 2020 to June 2021. The sample consisted of 640 patients-250 (39.1 %) were women and 390 (60.9 %) were men, with a median age of 69 (IQR 59-78) years. Results: Values of LOS and CFR were calculated and analysed. Overall CFR for the analysed period was 24.8%, varying from 15.9 % during second quarter 2021 to 34.1% during fourth quarter 2020. The CFR was 23.2% in the general ward and 70.7% in the ICU. All ICU patients required intubation and mechanical ventilation, and 44 (75.9 %) of them developed acute respiratory distress syndrome. The average LOS was 12.6 (±7.5) days. Conclusions: We highlighted the importance of some of the under-reported factors affecting CFR, LOS and thus, mortality. For further multicentre analysis, we recommend broad analysis of factors affecting mortality in COVID-19 using simple and transparent statistical and clinical parameters.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; COVID-19 Drug Treatment ; Poland ; COVID-19 ; Hospitals, University ; Treatment Outcome
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-066734
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Article ; Online: Analysing COVID-19 treatment outcomes in dedicated wards at a large university hospital in northern Poland

Radosław Owczuk / Krzysztof Kuziemski / Damian Krystian Palus / Martyna Ewa Gołębiewska / Olga Piątek / Krzysztof Grudziński / Alan Majeranowski / Tomasz Stefaniak

BMJ Open, Vol 13, Iss

a result-based observational study

2023 Volume 6

Abstract: Objectives Presenting outcomes of patients hospitalised for COVID-19 should be put in context and comparison with other facilities. However, varied methodology applied in published studies can impede or even hinder a reliable comparison. The aim of this ... ...

Abstract	Objectives Presenting outcomes of patients hospitalised for COVID-19 should be put in context and comparison with other facilities. However, varied methodology applied in published studies can impede or even hinder a reliable comparison. The aim of this study is to share our experience in pandemic management and highlight previously under-reported factors affecting mortality. We present outcomes of COVID-19 treatment in our facility that will allow for an intercentre comparison. We use simple statistical parameters—case fatality ratio (CFR) and length of stay (LOS).Setting Large clinical hospital in northern Poland serving over 120 000 patients annually.Participants Data were collected from patients hospitalised in COVID-19 general and intensive care unit (ICU) isolation wards from November 2020 to June 2021. The sample consisted of 640 patients—250 (39.1 %) were women and 390 (60.9 %) were men, with a median age of 69 (IQR 59–78) years.Results Values of LOS and CFR were calculated and analysed. Overall CFR for the analysed period was 24.8%, varying from 15.9 % during second quarter 2021 to 34.1% during fourth quarter 2020. The CFR was 23.2% in the general ward and 70.7% in the ICU. All ICU patients required intubation and mechanical ventilation, and 44 (75.9 %) of them developed acute respiratory distress syndrome. The average LOS was 12.6 (±7.5) days.Conclusions We highlighted the importance of some of the under-reported factors affecting CFR, LOS and thus, mortality. For further multicentre analysis, we recommend broad analysis of factors affecting mortality in COVID-19 using simple and transparent statistical and clinical parameters.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
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Article ; Online: The prevalence of dyspnea in the adult Polish population.

Undrunas, Aleksandra / Bandosz, Piotr / Rutkowski, Marcin / Puch-Walczak, Aleksandra / Kuziemski, Krzysztof / Zdrojewski, Tomasz

International journal of occupational medicine and environmental health

2022 Volume 35, Issue 6, Page(s) 747–752

Abstract: Objectives: Dyspnea is one of the most predominant symptom in clinical practice. There is a lack of data about incidents of dyspnea among Polish adults therefore it would be important to establish prevalence of this symptom before COVID-19 pandemic to ... ...

Abstract	Objectives: Dyspnea is one of the most predominant symptom in clinical practice. There is a lack of data about incidents of dyspnea among Polish adults therefore it would be important to establish prevalence of this symptom before COVID-19 pandemic to assess the impact of this infection on the functioning of the adult Polish population in the future. The aim of the study was to establish prevalence of dyspnea in adult Polish population. Material and methods: It was an observational-cross-sectional study, with representative sample of adult Poles aged 18-79 years. The 2413 participants were surveyed. Responders were asked if and when dyspnea occurs and what is its severity in relation to 1 of 4 categories (A, B, C, and D) describing the impact of dyspnea on reduced exercise tolerance and daily activities. Results: The 67.1% of the respondents answered negatively to all question about experiencing dyspnea (females (F) 61% vs. males (M) 74%, p < 0.05). Dyspnea only during intense physical exertion (A), was reported by 22.8% (F 26.2% vs. M 19.2%, p = 0.07). Dyspnea limiting daily activities (B, C and D) was reported by 10.1% (F 13.1% vs. M 7%, p < 0.05). Significant differences in the severity of dyspnea were found between the age groups. People diagnosed with chronic heart failure or lung diseases significantly more often reported dyspnea than people without these conditions. Conclusions: Every tenth Pole reported dyspnea limiting performing activities of daily living. Additionally, about 20% of Poles experienced dyspnea considered as "gray area," only during intense physical exertion, that requires deepening and clarifying the medical history. Int J Occup Med Environ Health. 2022;35(6):747-52.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Activities of Daily Living ; COVID-19 ; Cross-Sectional Studies ; Dyspnea ; Pandemics ; Poland ; Prevalence
Language	English
Publishing date	2022-09-28
Publishing country	Poland
Document type	Journal Article ; Observational Study
ZDB-ID	1199049-1
ISSN	1896-494X ; 0867-8383 ; 1232-1087
ISSN (online)	1896-494X
ISSN	0867-8383 ; 1232-1087
DOI	10.13075/ijomeh.1896.01959
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Article ; Online: Prevalence, symptom burden and under-diagnosis of chronic obstructive pulmonary disease in Polish lung cancer screening population: a cohort observational study.

Undrunas, Aleksandra / Kasprzyk, Piotr / Rajca, Aleksandra / Kuziemski, Krzysztof / Rzyman, Witold / Zdrojewski, Tomasz

BMJ open

2022 Volume 12, Issue 4, Page(s) e055007

Abstract: Objectives: Lung cancer screening using low-dose CT may be not effective without considering the presence of comorbidities related to chronic smoking. The aim of the study was to establish the prevalence of chronic obstructive pulmonary disease (COPD) ... ...

Abstract	Objectives: Lung cancer screening using low-dose CT may be not effective without considering the presence of comorbidities related to chronic smoking. The aim of the study was to establish the prevalence of chronic obstructive pulmonary disease (COPD) in group of phighlight the potential benefits atients participating in the largest Polish lung cancer screening programme MOLTEST-BIS and attempt to confirm the necessity of combined lung cancer and COPD screening. Design: Cohort, prospective study. Setting: Medical University of Gdańsk, Poland PARTICIPANTS: The study included 754 participants in lung cancer screening trial from the Pomeranian region, aged 50-70 years old, current and former smokers with a smoking history ≥30 pack-years. Primary and secondary outcome measures: Questionnaire, physical examination, anthropometric measurements, spirometry test before and after inhaled bronchodilator (400 µg of salbutamol) RESULTS: Obstructive disorders were diagnosed in 186 cases (103 male and 83 female). In the case of 144 participants (19.73%), COPD was diagnosed. Only 13.3% of participants with COPD were known about the disease earlier. According to classification of airflow limitation 55.6% of diagnosed COPD were in Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (mild), 38.9% in GOLD 2 (moderate), 4.9% in GOLD 3 (severe) and 0.7% in GOLD 4 (very severe) stage. Women with recognition of COPD were younger than men (63.7 vs 66.3 age) and they smoked less cigarettes (41.1 vs 51.9 pack-years). Conclusions: Prevalence of COPD in Polish lung cancer screening cohort is significant. The COPD in this group is remarkably under-diagnosed. Most diagnosed COPD cases were in the initial stage of advancement. This early detection of airflow limitation highlights the potential benefits arising from combined oncological-pulmonary screening.NKBBN.
MeSH term(s)	Aged ; Early Detection of Cancer ; Female ; Forced Expiratory Volume ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Male ; Middle Aged ; Poland/epidemiology ; Prevalence ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Risk Factors ; Spirometry
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-055007
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Article ; Online: Coinfection of COVID-19 and pneumocystosis in a patient after kidney transplantation.

Skonieczny, Piotr / Heleniak, Zbigniew / Szostakiewicz, Maria / Kuziemski, Krzysztof / Dębska-Ślizień, Alicja

Polish archives of internal medicine

2021 Volume 131, Issue 6, Page(s) 566–567

MeSH term(s)	COVID-19 ; Coinfection ; Humans ; Kidney Transplantation ; Pneumonia, Pneumocystis ; SARS-CoV-2
Language	English
Publishing date	2021-05-11
Publishing country	Poland
Document type	Journal Article ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15996
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Article ; Online: Prevalence, symptom burden and under-diagnosis of chronic obstructive pulmonary disease in Polish lung cancer screening population

Tomasz Zdrojewski / Piotr Kasprzyk / Aleksandra Undrunas / Aleksandra Rajca / Krzysztof Kuziemski / Witold Rzyman

BMJ Open, Vol 12, Iss

a cohort observational study

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
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Article ; Online: Is the 2016 ESC diagnostic algorithm useful for assessing the prevalence of chronic heart failure in population-based studies?

Puch-Walczak, Aleksandra / Kunicka, Katarzyna / Jagiełło, Kacper / Puzio, Ewa / Jankowska, Hanna / Hoffman, Piotr / Dudziak, Maria / Kuziemski, Krzysztof / Drygas, Wojciech / Zdrojewski, Tomasz

Kardiologia polska

2024 Volume 82, Issue 2, Page(s) 175–182

Abstract: Background: Chronic heart failure (CHF) is a major healthcare problem. However, there are no epidemiological studies assessing the prevalence of CHF in the general population with diagnosis based on algorithms recommended for clinical practice.: Aim: ...

Abstract	Background: Chronic heart failure (CHF) is a major healthcare problem. However, there are no epidemiological studies assessing the prevalence of CHF in the general population with diagnosis based on algorithms recommended for clinical practice. Aim: The aim of the HF-Pomorskie survey was to assess the prevalence of three basic components of the 2016 ESC diagnostic algorithm for CHF (symptoms, N-terminal pro B-type natriuretic peptide [NT-proBNP], and abnormalities on echocardiography) and to determine whether this algorithm may be applicable to studies in general population samples. Methods: The study was performed in a representative sample of 313 adults (170 women and 143 men) aged between 20 and 90 years (mean 55.2 years [15.3]) in Northern Poland. A questionnaire to determine New York Heart Association [NYHA] class, laboratory tests including NT-proBNP, as well as transthoracic echocardiography and spirometry examinations were performed in all subjects. Results: Dyspnea (NYHA class II-IV) was reported by 13.7% of recruited participants. Dyspnea and elevated levels of NT-proBNP (>125 pg/ml) were found in 7.7% of all examined subjects, while dyspnea, elevated NT-proBNP levels accompanied by systolic or diastolic abnormalities on echocardiography occurred in 4.8%. In the group without dyspnea (86.3% of all examined subjects), every sixth subject had an elevated level of NT-proBNP. On the other hand, 5.8% of studied subjects reported a previous diagnosis of CHF, which was confirmed using the current ESC algorithm in 78% of them. Conclusions: The prevalence of CHF assessed by the 2016 ESC diagnostic algorithm in the representative sample of adults was equal to 4.8%. The clinical algorithm for the diagnosis of CHF is fully applicable to the representative surveys in the general population. However, due to logistic and economic factors, echocardiography examination and NT-proBNP determination can be limited to patients reporting dyspnea or previous diagnosis of CHF.
MeSH term(s)	Male ; Adult ; Humans ; Female ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Prevalence ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Chronic Disease ; Algorithms ; Dyspnea/diagnosis ; Dyspnea/epidemiology
Language	English
Publishing date	2024-02-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/v.phj.98958
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