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  1. Article ; Online: Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks [Corrigendum: Sept. 2019, 5(9), p. e02461]

    Spizzirri, U. G. / Carullo, G. / De Cicco, L. / Crispini, A. / Scarpelli, F. / Restuccia, D. / Aiello, F.

    Heliyon. 2019 Aug., v. 5, no. 8, p. e02291

    2019  

    Abstract: ... ol. In this context, the synthesis of a cocrystal between (+)-catechin and L-(+)-ascorbic acid, was ...

    Abstract Tea (Camellia Sinensis) is one of the most popular drink, consumed as infusion or bottled ready to drink beverages. Although tea leaves contain many antioxidants compounds, after processing they can drastically decrease, sometimes up to a full degradation, as in the case of catechin, a very healthy flavan-3-ol. In this context, the synthesis of a cocrystal between (+)-catechin and L-(+)-ascorbic acid, was proved to be a useful strategy to make a new ingredient able to ameliorate the antioxidant profile of both infusions and bottled teas. The obtained cocrystal showed a three-fold higher solubility than (+)catechin and its formation was elucidated unambiguously by FT-IR, thermal (DSC) and diffraction (PXRD) analyses. Antioxidant characteristics of the samples were evaluated by colorimetric assays. As expected, infusions showed much better antioxidant features than ready-to-use lemon and peach teas. The same trend was confirmed after the addition of the cocrystal at two concentration levels. In particular, supplementation at concentration of 2 mg mL⁻¹ improved the bottled tea antioxidant values to the level showed by the not-added infusion tea.
    Keywords Camellia sinensis ; antioxidants ; catechin ; colorimetry ; ingredients ; lemons ; peaches ; solubility ; tea ; Coordination chemistry ; Pharmaceutical chemistry ; Food science ; Food quality ; Food processing ; Chemical characterization of food ; (+)-catechin ; L-(+)-ascorbic acid ; Cocrystal ; Fruit juice
    Language English
    Dates of publication 2019-08
    Size p. e02291
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note NAL-AP-2-clean ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e02291
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Facial Feminization Surgery: Anatomical Differences, Preoperative Planning, Techniques, and Ethical Considerations.

    Barnett, Sarah L / Choe, Joshua / Aiello, Christopher / Bradley, James P

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Facial Feminization Surgery (FFS) is a transformative surgical approach aimed at aligning the facial features of transgender women with their gender identity. Through a systematic analysis, this paper explores the clinical differences between male and ... ...

    Abstract Facial Feminization Surgery (FFS) is a transformative surgical approach aimed at aligning the facial features of transgender women with their gender identity. Through a systematic analysis, this paper explores the clinical differences between male and female facial skeletons along with the craniofacial techniques employed in FFS for each region. The preoperative planning stage is highlighted, emphasizing the importance of virtual planning and AI morphing as valuable tools to be used to achieve surgical precision. Consideration is given to special circumstances, such as procedure sequencing for older patients and silicone removal. Clinical outcomes, through patient-reported outcome measures and AI-based gender-typing assessments, showcase the efficacy of FFS in achieving proper gender recognition and alleviating gender dysphoria. This comprehensive review not only offers valuable insights into the current state of knowledge regarding FFS but also emphasizes the potential of artificial intelligence in outcome evaluation and surgical planning to further advance patient care and satisfaction with FFS.
    MeSH term(s) Humans ; Female ; Male ; Feminization/surgery ; Artificial Intelligence ; Gender Identity ; Face/surgery ; Transsexualism/surgery
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bastos, J.C.S.; Kohn, L.K.; Fantinatti-Garboggini, F.; Padilla, M.A.; Flores, E.F.; da Silva, B.P.; de Menezes, C.B.A.; Arns, C.W. Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus. Viruses 2013, 5, 1219-1230.

    Juliana Cristina Santiago Bastos / Luciana Konecny Kohn / Fabiana Fantinatti-Garboggini / Marina Aiello Padilla / Eduardo Furtado Flores / Bárbara Pereira da Silva / Cláudia Beatriz Afonso de Menezes / Clarice Weis Arns

    Viruses, Vol 5, Iss 7, Pp 1682-

    2013  Volume 1683

    Abstract: The authors wish to add the following Acknowledgments and completed Table 1 to their paper published in Viruses [1], doi:10.3390/v5051219, website: http://www.mdpi.com/1999-4915/5/5/1219. ...

    Abstract The authors wish to add the following Acknowledgments and completed Table 1 to their paper published in Viruses [1], doi:10.3390/v5051219, website: http://www.mdpi.com/1999-4915/5/5/1219.
    Keywords n/a ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2013-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Facial Feminization Surgery

    Sarah L. Barnett / Joshua Choe / Christopher Aiello / James P. Bradley

    Medicina, Vol 59, Iss 12, p

    Anatomical Differences, Preoperative Planning, Techniques, and Ethical Considerations

    2023  Volume 2070

    Abstract: Facial Feminization Surgery (FFS) is a transformative surgical approach aimed at aligning the facial features of transgender women with their gender identity. Through a systematic analysis, this paper explores the clinical differences between male and ... ...

    Abstract Facial Feminization Surgery (FFS) is a transformative surgical approach aimed at aligning the facial features of transgender women with their gender identity. Through a systematic analysis, this paper explores the clinical differences between male and female facial skeletons along with the craniofacial techniques employed in FFS for each region. The preoperative planning stage is highlighted, emphasizing the importance of virtual planning and AI morphing as valuable tools to be used to achieve surgical precision. Consideration is given to special circumstances, such as procedure sequencing for older patients and silicone removal. Clinical outcomes, through patient-reported outcome measures and AI-based gender-typing assessments, showcase the efficacy of FFS in achieving proper gender recognition and alleviating gender dysphoria. This comprehensive review not only offers valuable insights into the current state of knowledge regarding FFS but also emphasizes the potential of artificial intelligence in outcome evaluation and surgical planning to further advance patient care and satisfaction with FFS.
    Keywords facial feminization surgery ; virtual surgical planning ; artificial intelligence ; gender dysphoria ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mechanisms of Endothelial Dysfunction and Cardiovascular System Adaptation.

    Sobrevia, Luis / Aiello, Ernesto Alejandro / Contreras, Paola

    Current vascular pharmacology

    2022  Volume 20, Issue 3, Page(s) 201–204

    MeSH term(s) Cardiovascular Diseases/diagnosis ; Endothelium, Vascular ; Humans ; Vascular Diseases
    Language English
    Publishing date 2022-09-27
    Publishing country United Arab Emirates
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/157016112003220825112123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Impact of Corticosteroids on Human Airway Smooth Muscle Contractility and Airway Hyperresponsiveness: A Systematic Review.

    Calzetta, Luigino / Chetta, Alfredo / Aiello, Marina / Pistocchini, Elena / Rogliani, Paola

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Classically, the effects elicited by corticosteroids (CS) are mediated by the binding and activation of cytosolic glucocorticoid receptors (GR). However, several of the non-genomic effects of CS seem to be mediated by putative non-classic membrane ... ...

    Abstract Classically, the effects elicited by corticosteroids (CS) are mediated by the binding and activation of cytosolic glucocorticoid receptors (GR). However, several of the non-genomic effects of CS seem to be mediated by putative non-classic membrane receptors characterized by pharmacological properties that are different from those of classic cytosolic GR. Since pre-clinical findings suggest that inhaled CS (ICS) may also regulate the bronchial contractile tone via putative CS membrane-associate receptors, the aim of this review was to systematically report and discuss the impact of CS on human airway smooth muscle (ASM) contractility and airway hyperresponsiveness (AHR). Current evidence indicates that CS have significant genomic/non-genomic beneficial effects on human ASM contractility and AHR, regardless of their anti-inflammatory effects. CS are effective in reducing either the expression, synthesis or activity of α-actin, CD38, inositol phosphate, myosin light chain kinase, and ras homolog family member A in response to several pro-contractile stimuli; overall these effects are mediated by the genomic action of CS. Moreover, CS elicited a strong bronchorelaxant effect via the rapid activation of the Gsα-cyclic-adenosine-monophosphate-protein-kinase-A pathway in hyperresponsive airways. The possibility of modulating the dose of the ICS in a triple ICS/long-acting β
    Language English
    Publishing date 2022-12-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Potential Role of Naringin and Naringenin as Nutraceuticals Against Metabolic Syndrome.

    Massaro, Luca / Raguzzini, Anna / Aiello, Paola / Valencia, Débora Villaño

    Endocrine, metabolic & immune disorders drug targets

    2022  Volume 23, Issue 4, Page(s) 428–445

    Abstract: Metabolic syndrome, an increasing problem in western society, is a cluster of conditions that affect cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great ... ...

    Abstract Metabolic syndrome, an increasing problem in western society, is a cluster of conditions that affect cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proven antiinflammatory activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal mechanisms by which these flavonoids exert their action involve AMPK and PPARα up-regulation and the down-regulation of genes involved in lipid metabolism. Although different studies have been carried out to define the pharmacological effects of these flavonoids, their therapeutic use is still limited.
    MeSH term(s) Animals ; Metabolic Syndrome/drug therapy ; Flavanones/pharmacology ; Flavanones/therapeutic use ; Flavonoids/therapeutic use ; Dietary Supplements
    Chemical Substances naringin (N7TD9J649B) ; naringenin (HN5425SBF2) ; Flavanones ; Flavonoids
    Language English
    Publishing date 2022-08-28
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530322666220827141203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Standardizing digital biobanks: integrating imaging, genomic, and clinical data for precision medicine.

    Brancato, Valentina / Esposito, Giuseppina / Coppola, Luigi / Cavaliere, Carlo / Mirabelli, Peppino / Scapicchio, Camilla / Borgheresi, Rita / Neri, Emanuele / Salvatore, Marco / Aiello, Marco

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 136

    Abstract: Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequencing (NGS), which help characterize ... ...

    Abstract Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequencing (NGS), which help characterize individual differences in patients. However, this information needs to be available and suitable to promote and support scientific research and technological development, supporting the effective adoption of the precision medicine approach in clinical practice. Digital biobanks can catalyze this process, facilitating the sharing of curated and standardized imaging data, clinical, pathological and molecular data, crucial to enable the development of a comprehensive and personalized data-driven diagnostic approach in disease management and fostering the development of computational predictive models. This work aims to frame this perspective, first by evaluating the state of standardization of individual diagnostic domains and then by identifying challenges and proposing a possible solution towards an integrative approach that can guarantee the suitability of information that can be shared through a digital biobank. Our analysis of the state of the art shows the presence and use of reference standards in biobanks and, generally, digital repositories for each specific domain. Despite this, standardization to guarantee the integration and reproducibility of the numerical descriptors generated by each domain, e.g. radiomic, pathomic and -omic features, is still an open challenge. Based on specific use cases and scenarios, an integration model, based on the JSON format, is proposed that can help address this problem. Ultimately, this work shows how, with specific standardization and promotion efforts, the digital biobank model can become an enabling technology for the comprehensive study of diseases and the effective development of data-driven technologies at the service of precision medicine.
    MeSH term(s) Humans ; Biological Specimen Banks ; Precision Medicine ; Reproducibility of Results ; Genomics
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04891-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes.

    Patel, Heta P / Coppola, Stefano / Pomp, Wim / Aiello, Umberto / Brouwer, Ineke / Libri, Domenico / Lenstra, Tineke L

    Molecular cell

    2023  Volume 83, Issue 10, Page(s) 1573–1587.e8

    Abstract: DNA supercoiling has emerged as a major contributor to gene regulation in bacteria, but how DNA supercoiling impacts transcription dynamics in eukaryotes is unclear. Here, using single-molecule dual-color nascent transcription imaging in budding yeast, ... ...

    Abstract DNA supercoiling has emerged as a major contributor to gene regulation in bacteria, but how DNA supercoiling impacts transcription dynamics in eukaryotes is unclear. Here, using single-molecule dual-color nascent transcription imaging in budding yeast, we show that transcriptional bursting of divergent and tandem GAL genes is coupled. Temporal coupling of neighboring genes requires rapid release of DNA supercoils by topoisomerases. When DNA supercoils accumulate, transcription of one gene inhibits transcription at its adjacent genes. Transcription inhibition of the GAL genes results from destabilized binding of the transcription factor Gal4. Moreover, wild-type yeast minimizes supercoiling-mediated inhibition by maintaining sufficient levels of topoisomerases. Overall, we discover fundamental differences in transcriptional control by DNA supercoiling between bacteria and yeast and show that rapid supercoiling release in eukaryotes ensures proper gene expression of neighboring genes.
    MeSH term(s) Transcription, Genetic ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA Topoisomerases, Type II/genetics ; DNA ; DNA, Bacterial/genetics ; DNA, Superhelical/genetics ; DNA Topoisomerases, Type I/metabolism
    Chemical Substances Transcription Factors ; DNA Topoisomerases, Type II (EC 5.99.1.3) ; DNA (9007-49-2) ; DNA, Bacterial ; DNA, Superhelical ; DNA Topoisomerases, Type I (EC 5.99.1.2)
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Retinol binding protein 3 as biomarker for diabetic retinopathy.

    Fickweiler, Ward / Aiello, Lloyd P / Sun, Jennifer K / King, George L

    Annals of translational medicine

    2020  Volume 7, Issue 22, Page(s) 706

    Language English
    Publishing date 2020-01-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.10.95
    Database MEDical Literature Analysis and Retrieval System OnLINE

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