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Article: [Bronchoscopic autologous blood injection for lung volume reduction].

Kobayashi, Hideo / Kanoh, Soichiro

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2009 Volume 47, Issue 9, Page(s) 765–771

Abstract: Bronchoscopic lung volume reduction (BLVR) for emphysematous lung diseases has attracted clinical attention. We evaluated the newly developed procedure of BLVR performed by transbronchial infusion of autologous blood. The subjects were 4 patients with a ... ...

Abstract	Bronchoscopic lung volume reduction (BLVR) for emphysematous lung diseases has attracted clinical attention. We evaluated the newly developed procedure of BLVR performed by transbronchial infusion of autologous blood. The subjects were 4 patients with a mean age of 57 years with emphysematous lung diseases, consisting of 1 with emphysematous bulla, 1 with lymphangioleiomyomatosis and 2 with advanced emphysema. Informed consent was obtained from all patients, and the Institutional Review Board of Ethics approved the treatment protocol. Intervention was performed as follows: A catheter was inserted into the target area through a flexible bronchoscope under fluoroscopic guidance, and autologous blood followed by thrombin solution was infused via the catheter. This simple procedure was repeated to several different areas as necessary. This BLVR therapy was well tolerated in all 4 patients. There were no severe complications. Symptomatic improvement was noted in all patients. Spirometry showed a mean increase in FVC from 2.68 to 2.75L and FEV1 from 1.10 to 1.25 L, whereas body plethysmography showed a mean reduction in FRC from 5.09 to 4.75L and TLC from 7.18 to 6.80 L. No consistent change in D(Lco)/VA was observed. Arterial blood gas value and the 6-minute walk distance improved in 3 and 2 patients, respectively. This bronchoscopic approach is minimally invasive, easy and inexpensive. BLVR by injection of autologous blood appears to represent a good therapeutic option, and warrants further investigation.
MeSH term(s)	Adult ; Aged ; Blood Transfusion, Autologous/methods ; Bronchoscopy/methods ; Female ; Fluoroscopy ; Humans ; Male ; Middle Aged ; Pneumonectomy/methods ; Pulmonary Disease, Chronic Obstructive/surgery ; Pulmonary Emphysema/surgery ; Treatment Outcome
Language	Japanese
Publishing date	2009-09
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bronchoscopic blood injection reducing lung volume in lymphangioleiomyomatosis.

Kanoh, Soichiro / Kobayashi, Hideo / Motoyoshi, Kazuo

The Annals of thoracic surgery

2009 Volume 87, Issue 4, Page(s) 1266–1268

Abstract: Bronchoscopic lung-volume reduction for hyperinflated air-trapping disease is currently being investigated. A 41-year-old woman with pulmonary lymphangioleiomyomatosis presented with exertional dyspnea. A chest computed tomographic scan showed ... ...

Abstract	Bronchoscopic lung-volume reduction for hyperinflated air-trapping disease is currently being investigated. A 41-year-old woman with pulmonary lymphangioleiomyomatosis presented with exertional dyspnea. A chest computed tomographic scan showed hyperinflation with diffuse cystic lesions throughout both lung fields. To reduce lung volume, transbronchial autologous blood was followed by thrombin solution, which was infused into cystic areas under fluoroscopic guidance. A post-treatment computed tomographic scan showed volume reduction corresponding to decreased total lung capacity by 240 mL on body plethysmography. Dyspnea was significantly improved. Bronchoscopic treatment by blood infusion is less invasive and appears clinically valuable, potentially providing therapeutic benefit in hyperinflated lung diseases such as lymphangioleiomyomatosis.
MeSH term(s)	Adult ; Blood Transfusion/methods ; Bronchoscopy ; Female ; Humans ; Lung Neoplasms/therapy ; Lymphangioleiomyomatosis/therapy
Language	English
Publishing date	2009-04
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2008.08.037
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Article ; Online: Tracheo-broncho-bronchiolar lesions in Sjögren's syndrome.

Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo / Aida, Shinsuke

Respirology (Carlton, Vic.)

2008 Volume 13, Issue 1, Page(s) 159–161

Abstract: A 53-year-old woman reported having a persistent cough and bloody sputum. She did not smoke but had received a diagnosis of Sjögren's syndrome. Chest CT revealed middle lobe syndrome, bronchiectasis and diffuse centrilobular nodular lesions. Bronchoscopy ...

Abstract	A 53-year-old woman reported having a persistent cough and bloody sputum. She did not smoke but had received a diagnosis of Sjögren's syndrome. Chest CT revealed middle lobe syndrome, bronchiectasis and diffuse centrilobular nodular lesions. Bronchoscopy displayed multiple whitish polypoid lesions protruding from the cartilage rings and tracheobronchopathia osteochondroplastica was histologically confirmed by the presence of bony tissue in the tracheo-bronchial wall. Video-assisted thoracoscopic biopsy demonstrated lymphocyte aggregation causing follicular broncho-bronchiolitis. Erythromycin therapy resulted in improvement of the follicular bronchiolitis but not the tracheobronchopathia osteochondroplastica.
MeSH term(s)	Bronchial Diseases/diagnosis ; Bronchial Diseases/etiology ; Bronchial Diseases/therapy ; Female ; Humans ; Middle Aged ; Sjogren's Syndrome/complications ; Tracheal Diseases/diagnosis ; Tracheal Diseases/etiology ; Tracheal Diseases/therapy
Language	English
Publishing date	2008-01
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/j.1440-1843.2007.01155.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Solitary nodular sarcoidosis demonstrating reversed tuberculin skin reaction].

Osoreda, Hisayuki / Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2008 Volume 46, Issue 8, Page(s) 679–683

Abstract: A 29-year-old woman was admitted because of chest radiograph abnormality. She had no respiratory complaints. Chest CT demonstrated an ill-defined nodule of 20mm with the "sarcoid galaxy sign" in the right upper lobe. Transbronchial biopsy (TBB) specimens ...

Abstract	A 29-year-old woman was admitted because of chest radiograph abnormality. She had no respiratory complaints. Chest CT demonstrated an ill-defined nodule of 20mm with the "sarcoid galaxy sign" in the right upper lobe. Transbronchial biopsy (TBB) specimens from right S2 revealed non-caseating epithelioid cell granuloma. Initial clinical findings suggested mycobacterial infection. However, while waiting for the results of mycobacterial cultures in bronchial washing fluid, the tuberculin skin reaction was found to be negative, and enlargement of nodule, mediastinal lymphadenopathy and elevated soluble IL-2R were observed. Cultures for mycobacterium were negative and repeat TBB specimens revealed granulomatous inflammation. We diagnosed with sarcoidosis based on these findings. Solitary nodular sarcoidosis is rare with only 17 cases having been reported. These cases were diagnosed with difficulty because of non-specific clinical findings and of the 17, 16 cases (94%) were diagnosed by surgical procedures. We observed the clinico-radiological course of solitary nodules and the change in tuberculin reaction. Although a negative tuberculin skin reaction was commonly recognized in sarcoidosis patients, we confirmed that initial positive tuberculin reaction changed to negative according to disease progress. To the best of our knowledge, this is the first case report in adults.
MeSH term(s)	Adult ; Female ; Humans ; Sarcoidosis, Pulmonary/diagnosis ; Sarcoidosis, Pulmonary/immunology ; Tuberculin Test
Language	Japanese
Publishing date	2008-08
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
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Article: [Bronchoscopic follow-up of secondary racemose hemangioma of the bronchial artery].

Shinoda, Masahiro / Kobayashi, Hideo / Kawano, Syuichi / Kanoh, Soichiro / Ozeki, Yuichi

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2010 Volume 48, Issue 1, Page(s) 23–27

Abstract: A 63-year-old woman with cystic bronchiectasis who had been treated in our institute was admitted for recurrent prolonged hemoptysis. Bronchoscopic examination showed bloody discharges in the left basal bronchus and a bulging polypoid lesion covered with ...

Abstract	A 63-year-old woman with cystic bronchiectasis who had been treated in our institute was admitted for recurrent prolonged hemoptysis. Bronchoscopic examination showed bloody discharges in the left basal bronchus and a bulging polypoid lesion covered with intact bronchial mucosa in the left B8. In comparison with the bronchoscopic examination 6 years ago, the lesion was larger and the mucosal color changed more injected. A bronchial arteriogram revealed a convoluted and dilated left bronchial artery. Because bronchial artery embolization failed, a left lower lobectomy was performed. The diagnosis of secondary racemose hemangioma of the bronchial artery was pathologically established. A racemose hemangioma of the bronchial artery is characterized by an enlarged and convoluted bronchial artery. The bronchoscopic findings of this disorder have been rarely reported. This case may provide valuable information about serial bronchoscopic findings and the progression of secondary racemose hemangioma in the bronchial artery.
MeSH term(s)	Bronchial Arteries/pathology ; Bronchoscopy ; Female ; Follow-Up Studies ; Hemangioma/pathology ; Humans ; Middle Aged ; Vascular Neoplasms/pathology
Language	Japanese
Publishing date	2010-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
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Article: Serum surfactant protein-A, but not surfactant protein-D or KL-6, can predict preclinical lung damage induced by smoking.

Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2008 Volume 13, Issue 4, Page(s) 385–392

Abstract: Serum surfactant protein (SP)-A offers a useful clinical marker for interstitial lung disease (ILD). However, SP-A is occasionally elevated in non-ILD pulmonary patients. The present study was conducted to investigate factors that affect serum SP- A ... ...

Abstract	Serum surfactant protein (SP)-A offers a useful clinical marker for interstitial lung disease (ILD). However, SP-A is occasionally elevated in non-ILD pulmonary patients. The present study was conducted to investigate factors that affect serum SP- A levels in respiratory medicine. Serum SP-A, serum SP-D, serum Klebs von den Lungen (KL)-6 and pulmonary function tests were evaluated in 929 patients (current smokers, n=255; ex-smokers, n=242; never-smokers, n=432) without ILD or pulmonary alveolar proteinosis. Serum SP-A was significantly higher in current smokers than in never- or ex-smokers (p<0.01 and p<0.05, respectively). Serum SP- A was significantly higher in chronic obstructive pulmonary disease (COPD) and pulmonary thromboembolism than in other diseases (p<0.01). Serum SP-A correlated positively with amount of smoking (p<0.01) and negatively with forced expiratory volume in 1 s/forced vital capacity (p<0.05). Serum SP-D and KL-6 were unaffected by smoking. Smoking should be taken into account when evaluating serum SP-A levels, and different baseline levels of serum SP-A should be established for smokers and non-smokers. Serum SP-A may also represent a useful marker for predicting COPD in the preclinical stage.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Female ; Forced Expiratory Volume/physiology ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/physiopathology ; Lung Diseases/blood ; Male ; Middle Aged ; Mucin-1/blood ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Surfactant-Associated Protein A/blood ; Pulmonary Surfactant-Associated Protein D/blood ; Respiratory Function Tests ; Smoking/blood ; Smoking/pathology ; Smoking Cessation
Chemical Substances	Biomarkers ; MUC1 protein, human ; Mucin-1 ; Pulmonary Surfactant-Associated Protein A ; Pulmonary Surfactant-Associated Protein D
Language	English
Publishing date	2008-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1324372-x
ISSN	1354-750X
ISSN	1354-750X
DOI	10.1080/13547500801903651
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Article: [Resected pulmonary sarcoidosis after corticosteroid treatment still showing pathological granulomatous inflammation].

Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo / Ozeki, Yuichi

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2007 Volume 45, Issue 8, Page(s) 598–603

Abstract: It is not well understood what kind of histologic resolution is obtained with corticosteroid medication in sarcoidosis, or how we are able to judge cure in that disease. We examined the cases of sarcoidosis who were under steroid medication and received ... ...

Abstract	It is not well understood what kind of histologic resolution is obtained with corticosteroid medication in sarcoidosis, or how we are able to judge cure in that disease. We examined the cases of sarcoidosis who were under steroid medication and received lobectomy and lymphadenectomy for combined lung cancer. Steroid treatment had been introduced for the relief of visual disturbance, not for the pulmonary lesion. Administration of corticosteroid improves clinical, laboratory, bronchoalveolar lavage and radiological findings, but it is difficult to make histological granulomatous inflammation completely disappear. Improvement of radiological and clinical problems in sarcoidosis is not the same as complete cure in patients with steroid-treated sarcoidosis.
MeSH term(s)	Adrenal Cortex Hormones/pharmacology ; Adrenal Cortex Hormones/therapeutic use ; Female ; Granuloma/pathology ; Humans ; Inflammation ; Lung/diagnostic imaging ; Lung/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/surgery ; Lymph Node Excision ; Middle Aged ; Pneumonectomy ; Radiography ; Sarcoidosis, Pulmonary/complications ; Sarcoidosis, Pulmonary/drug therapy ; Sarcoidosis, Pulmonary/pathology
Chemical Substances	Adrenal Cortex Hormones
Language	Japanese
Publishing date	2007-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
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Article ; Online: Tracheobronchial pulmonary disease associated with pyoderma gangrenosum.

Kanoh, Soichiro / Kobayashi, Hideo / Sato, Ken / Motoyoshi, Kazuo / Aida, Shinsuke

Mayo Clinic proceedings

2009 Volume 84, Issue 6, Page(s) 555–557

Abstract: We report a tracheobronchial pulmonary manifestation caused by pyoderma gangrenosum, a neutrophilic dermatosis of unknown etiology. A 54-year-old man presented with pulmonary infiltrates followed by multiple painful cutaneous pustules on the scrotum. ... ...

Abstract	We report a tracheobronchial pulmonary manifestation caused by pyoderma gangrenosum, a neutrophilic dermatosis of unknown etiology. A 54-year-old man presented with pulmonary infiltrates followed by multiple painful cutaneous pustules on the scrotum. Skin biopsy showed pronounced neutrophilic infiltration without microorganism or granuloma, consistent with pyoderma gangrenosum. Bronchoscopy revealed multiple scattered polypoid nodules with a yellowish irregular surface from the trachea to bilateral bronchi; the appearance closely mimicked that of a skin lesion. Endobronchial biopsy demonstrated inflamed granulation and necrosis with infiltration by numerous neutrophils without vasculitis or granulomas, interpreted as pyoderma gangrenosum of the bronchi. Although the etiology of pyoderma gangrenosum is poorly understood, this case suggests that a common pathogenesis may account for the simultaneous cutaneous and airway inflammation.
MeSH term(s)	Bronchoscopy ; Humans ; Lung Diseases/complications ; Lung Diseases/diagnosis ; Lung Diseases/pathology ; Male ; Middle Aged ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/pathology ; Scrotum/pathology
Language	English
Publishing date	2009-05-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.4065/84.6.555
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Article: [Analysis of endobronchial aspergillosis in patients without obvious systemic predisposing factors].

Osoreda, Hisayuki / Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo / Ozeki, Yuichi

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2009 Volume 47, Issue 8, Page(s) 669–674

Abstract: Background: Endobronchial aspergillosis is still an insufficiently recognized concept.: Patients and methods: Ten patients who did not have obvious predisposing factors and parenchymal fungal infection were analyzed. They were confirmed to have ... ...

Abstract	Background: Endobronchial aspergillosis is still an insufficiently recognized concept. Patients and methods: Ten patients who did not have obvious predisposing factors and parenchymal fungal infection were analyzed. They were confirmed to have endobronchial Aspergillus by histology and culture, and were classified according to the presence of bronchiectasis, allergic reaction, and asthmatic symptom. Results: Bronchiectasis was detected in all 10 patients, IgE elevation (>370 IU/ml) in 7, Aspergillus specific IgE-RAST in 8, eosinophilia in 7, and asthmatic symptom in 5. Cases were classified into allergic bronchopulmonary aspergillosis (ABPA) (5 cases), ABPA not fulfilling Rosenberg's criteria (2 cases), and endobronchial aspergilloma (3 cases). Conclusion: We proposed classifying endobronchial aspergillosis without obvious systemic predisposing factors into "ABPA", "ABPA without asthma", "ABPA-S (seropositive)", and "Endobronchial aspergilloma". A fifth subtype of endobronchial aspergillosis containing "saprophyte" is warranted.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Aspergillosis/classification ; Pulmonary Aspergillosis/diagnosis
Language	Japanese
Publishing date	2009-08
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Disseminated Mycobacterium avium infection in an immunocompetent aged patient].

Shimokawaji, Tadasuke / Kobayashi, Hideo / Kanoh, Soichiro / Motoyoshi, Kazuo

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

2006 Volume 44, Issue 6, Page(s) 464–467

Abstract: We reported an immunocompetent elderly patient with disseminated Mycobacterium avium infection exhibiting bronchial, pulmonary, nodal, otitic and osteitic lesions. An 82-year-old man was initially hospitalized with cervical and mediastinal ... ...

Abstract	We reported an immunocompetent elderly patient with disseminated Mycobacterium avium infection exhibiting bronchial, pulmonary, nodal, otitic and osteitic lesions. An 82-year-old man was initially hospitalized with cervical and mediastinal lymphadenopathy. M. avium was demonstrated in gastric juice and a lymph node. An endobronchial polypoid lesion was formed by perforation of mediastinal mycobacterial lymphadenitis into the right main bronchus. Combined treatment by CAM, RFP, EB, and SM caused the lesions to diminish and the treatment was continued for 18 months. One year after completion of treatment the patient was re-admitted with complaints of left ear pain, and a subcutaneous abscess on his back. M. avium was again demonstrated from external ear exudate and aspirated subcutaneous pus. Re-treatment with combined chemotherapy induced prompt resolution of the ear and bone lesions. It is unusual that immunocompetent patients suffer disseminated non-tuberculous mycobacterial infection, but chest physicians should pay attention to M. avium infection because of its worldwide dissemination.
MeSH term(s)	Aged, 80 and over ; Bronchitis/etiology ; Humans ; Immunocompromised Host ; Lymphadenitis/etiology ; Male ; Mycobacterium avium Complex/isolation & purification ; Mycobacterium avium-intracellulare Infection/etiology ; Otitis Media/etiology
Language	Japanese
Publishing date	2006-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1456536-5
ISSN	1345-9538 ; 1343-3490
ISSN (online)	1345-9538
ISSN	1343-3490
Database	MEDical Literature Analysis and Retrieval System OnLINE

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