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  1. Article ; Online: Commentary on The High Cost of Low Quality: Recurring Hypoglycemia in a 63-Year-Old Man.

    Vercollone, Jeffrey

    Clinical chemistry

    2021  Volume 67, Issue 11, Page(s) 1455

    MeSH term(s) Humans ; Hypoglycemia/diagnosis ; Hypoglycemic Agents ; Male ; Middle Aged ; Recurrence
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Commentary on A Rare Cause of Virilization, Short Stature, and Hypertension.

    Vercollone, Jeffrey

    Clinical chemistry

    2020  Volume 66, Issue 12, Page(s) 1494–1495

    MeSH term(s) Female ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Virilism
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvaa244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosed With COVID-19, Nope Just Cabin Fever: The Fundamentals of Staying at Home.

    Vercollone, Jeffrey

    Journal of diabetes science and technology

    2020  Volume 14, Issue 4, Page(s) 805–806

    MeSH term(s) Betacoronavirus ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/instrumentation ; Blood Glucose Self-Monitoring/methods ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Diabetes Complications/prevention & control ; Diabetes Mellitus/therapy ; Endocrinology/trends ; Humans ; Internet ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Quarantine/psychology ; Remote Consultation ; SARS-CoV-2 ; Social Isolation/psychology ; Software ; Telemedicine/methods ; United States
    Chemical Substances Blood Glucose
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/1932296820930027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnosed With COVID-19, Nope Just Cabin Fever

    Vercollone, Jeffrey

    Journal of Diabetes Science and Technology

    The Fundamentals of Staying at Home

    2020  Volume 14, Issue 4, Page(s) 805–806

    Keywords Internal Medicine ; Bioengineering ; Endocrinology, Diabetes and Metabolism ; Biomedical Engineering ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ISSN 1932-2968
    DOI 10.1177/1932296820930027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: MMTV/LTR Promoter-Driven Transgenic Expression of EpCAM Leads to the Development of Large Pancreatic Islets.

    Vercollone, Jeffrey R / Balzar, Maarten / Litvinov, Sergey V / Yang, Wendy / Cirulli, Vincenzo

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2015  Volume 63, Issue 8, Page(s) 613–625

    Abstract: Our previous work demonstrated an important role of EpCAM in the regulation of pancreatic cell adhesion, growth and differentiation. Here we investigated the consequences of human EpCAM (hEpCAM) overexpression under the control of the MMTV-LTR promoter, ... ...

    Abstract Our previous work demonstrated an important role of EpCAM in the regulation of pancreatic cell adhesion, growth and differentiation. Here we investigated the consequences of human EpCAM (hEpCAM) overexpression under the control of the MMTV-LTR promoter, known to drive robust gene expression in a number of ductal epithelia, including the pancreas. In this animal model (MMTV-hEpCAM) we uncovered a striking pancreatic phenotype exhibiting a 12-fold increase in the islet cell mass, with normal expression patterns of insulin and the transcription factor PDX-1. Intriguingly, these large islet clusters revealed an altered architectural organization of α- and δ-cells that appeared interspersed with β-cells in the islet cores. This suggests an effect of the hEpCAM transgene on the function of other cell adhesion molecules that we have previously shown to regulate islet cell type segregation. Consistent with this finding, we show that the pancreatic epithelium in MMTV-hEpCAM transgenic mice exhibits a redistribution of β-catenin, a known regulator of E-cadherin-mediated adhesions. Collectively, these results provide an important in vivo validation of hEpCAM signaling properties in normal epithelia and offer unique opportunities to further explore the function of this glycoprotein in select pancreatic cell lineages to elicit islet cell expansion, and/or regeneration in diabetes.
    MeSH term(s) Animals ; Antigens, Neoplasm/genetics ; Cell Adhesion Molecules/genetics ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule ; Gene Expression ; Humans ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Mammary Tumor Virus, Mouse/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Promoter Regions, Genetic/genetics ; Terminal Repeat Sequences/genetics
    Chemical Substances Antigens, Neoplasm ; Cell Adhesion Molecules ; EPCAM protein, human ; Epithelial Cell Adhesion Molecule
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155415583876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.321: Show issues Location:
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  7. Article ; Online: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.

    Torres, Richard / Croll, Susan D / Vercollone, Jeffrey / Reinhardt, Joel / Griffiths, Jennifer / Zabski, Stephanie / Anderson, Keith D / Adams, Niels C / Gowen, Lori / Sleeman, Mark W / Valenzuela, David M / Wiegand, Stanley J / Yancopoulos, George D / Murphy, Andrew J

    Pain

    2007  Volume 130, Issue 3, Page(s) 267–278

    Abstract: Neuromedin U (NMU) has recently been reported to have a role in nociception and inflammation. To clarify the function of the two known NMU receptors, NMU receptor 1 (NMUR1) and NMU receptor 2 (NMUR2), during nociception and inflammation in vivo, we ... ...

    Abstract Neuromedin U (NMU) has recently been reported to have a role in nociception and inflammation. To clarify the function of the two known NMU receptors, NMU receptor 1 (NMUR1) and NMU receptor 2 (NMUR2), during nociception and inflammation in vivo, we generated mice in which the genes for each receptor were independently deleted. Compared to wild type littermates, mice deficient in NMUR2 showed a reduced thermal nociceptive response in the hot plate, but not in the tail flick, test. In addition, the NMUR2 mutant mice showed a reduced behavioral response and a marked reduction in thermal hyperalgesia following capsaicin injection. NMUR2-deficient mice also showed an impaired pain response during the chronic, but not acute, phase of the formalin test. In contrast, NMUR1-deficient mice did not show any nociceptive differences compared to their wild type littermates in any of the behavioral tests used. We observed the same magnitude of inflammation in both lines of NMU receptor mutant mice compared to their wild type littermates after injection with complete Freund's adjuvant (CFA), suggesting no requirement for either receptor in this response. Thus, the pro-nociceptive effects of NMU in mice appear to be mediated through NMUR2, not NMUR1.
    MeSH term(s) Animals ; Behavior, Animal ; Capsaicin ; Female ; Freund's Adjuvant ; Gene Expression ; Hot Temperature ; Male ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nociceptors/physiology ; Pain Measurement ; Pain Threshold/physiology ; Receptors, Neurotransmitter/genetics ; Receptors, Neurotransmitter/physiology
    Chemical Substances Membrane Proteins ; Receptors, Neurotransmitter ; neuromedin U receptor ; Freund's Adjuvant (9007-81-2) ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2007-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1016/j.pain.2007.01.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1158: Show issues Location:
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