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Article ; Online: Nifedipine-Induced Shock in Pregnancy With Aortic Stenosis.

Soares, Cullen / Gilson, Michael

2019 Volume 172, Issue 3, Page(s) 221–222

MeSH term(s)	Aortic Valve Stenosis/complications ; Calcium Gluconate/therapeutic use ; Chest Pain/etiology ; Electrocardiography ; Female ; Fetofetal Transfusion/therapy ; Fluid Therapy ; Humans ; Hypotension/etiology ; Nifedipine/administration & dosage ; Nifedipine/adverse effects ; Norepinephrine/therapeutic use ; Pregnancy ; Pregnancy Complications, Cardiovascular ; Ringer's Lactate ; Shock/etiology ; Shock/therapy ; Tocolytic Agents/administration & dosage ; Tocolytic Agents/adverse effects ; Troponin/blood ; Vasoconstrictor Agents/therapeutic use
Chemical Substances	Ringer's Lactate ; Tocolytic Agents ; Troponin ; Vasoconstrictor Agents ; Nifedipine (I9ZF7L6G2L) ; Calcium Gluconate (SQE6VB453K) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2019-10-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L19-0481
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Article ; Online: Infective Endocarditis with Pseudoaneurysm of the Mitral-Aortic Intervalvular Fibrosa Presenting as Complete Heart Block.

Soares, Cullen / Arikan, Pinar / Gilson, Michael

Rhode Island medical journal (2013)

2021 Volume 104, Issue 6, Page(s) 13–15

Abstract: A 79-year-old male with a history of ESRD and treated MRSA endocarditis was found to have a recurrence of MRSA bacteremia. He was treated with antibiotics. During his hospitalization, he suddenly developed complete heart block requiring transcutaneous ... ...

Abstract	A 79-year-old male with a history of ESRD and treated MRSA endocarditis was found to have a recurrence of MRSA bacteremia. He was treated with antibiotics. During his hospitalization, he suddenly developed complete heart block requiring transcutaneous pacing, and subsequently transvenous pacing wires were placed. Transesophageal echocardiography demonstrated pseudo- aneurysm of the mitral-aortic intervalvular fibrosa as well as aortic valve thickening, and a mitral vegetation. Cardiothoracic surgery was consulted to obtain source control, but the patient was deemed to be a poor surgical candidate. While continuing medical therapy and transvenous pacing, the patient developed refractory hypotension, acidosis, and ultimately expired.
MeSH term(s)	Aged ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/therapy ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Echocardiography, Transesophageal ; Endocarditis/diagnostic imaging ; Endocarditis/therapy ; Heart Block/diagnosis ; Heart Block/therapy ; Humans ; Male ; Mitral Valve/diagnostic imaging
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: Stress Testing and Risk Prediction in People With Known Symptomatic Multivessel Coronary Artery Disease.

Erqou, Sebhat / Soares, Cullen / Wu, Wen-Chih

JAMA internal medicine

2019 Volume 180, Issue 1, Page(s) 165–166

MeSH term(s)	Coronary Artery Disease ; Exercise Test ; Humans ; Myocardial Ischemia
Language	English
Publishing date	2019-12-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2019.5854
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Article ; Online: Longitudinal Echocardiogram Imaging in the First Genetically Modified Porcine to Human Cardiac Xenotransplant.

Hong, Susie N / Mohiuddin, Muhammad M / Ananthram, Manjula / Soares, Cullen / Goerlich, Corbin E / Dickfeld, Timm L / Hanna, Peter / Hong, Charles C / Benitez, Michael / Joseph, Susan M / Gupta, Anuj / Grazioli, Alison / Griffith, Bartley P

JACC. Cardiovascular imaging

2023 Volume 16, Issue 4, Page(s) 553–557

MeSH term(s)	Humans ; Animals ; Swine ; Predictive Value of Tests ; Echocardiography/methods ; Heart
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2023.01.012
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Article ; Online: Diagnosing Lemierre's Syndrome as the Cause of Multifocal Pneumonia During the COVID-19 Pandemic.

Soares, Cullen / Blackwood, Kristy / Vecchio, Marc / Francis, Elizabeth R / Zhu, Shenjun / Johnson, Jennie

Rhode Island medical journal (2013)

2021 Volume 104, Issue 7, Page(s) 46–49

Abstract: A 21-year-old male with no past medical history presented with a sore throat, cough, and shortness of breath after attending a party days earlier. He was initially treated for community-acquired pneumonia, but subsequently developed a new oxygen ... ...

Abstract	A 21-year-old male with no past medical history presented with a sore throat, cough, and shortness of breath after attending a party days earlier. He was initially treated for community-acquired pneumonia, but subsequently developed a new oxygen requirement. CT imaging of the chest showed multifocal airspace disease, concerning for COVID-19. Testing for SARS-CoV-2 was negative by RT-PCR and antibody testing. Blood cultures subsequently grew Streptococcus anginosus. A CT scan of his neck demonstrated a right peritonsillar abscess and right internal-jugular thrombus, consistent with Lemierre's syndrome. He underwent incision and drainage of the peritonsillar abscess and completed 4 weeks of IV antibiotics, which improved his symptoms. It is important to recognize that the differential diagnosis of multifocal pneumonia is broad and includes Lemierre's syndrome. The COVID-19 pandemic presents challenges with regards to anchoring bias for multifocal pneumonia.
MeSH term(s)	Adult ; COVID-19 ; Humans ; Lemierre Syndrome/diagnosis ; Male ; Pandemics ; Pneumonia ; SARS-CoV-2 ; Young Adult
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: Preadmission Oral Anticoagulation for Atrial Fibrillation/Flutter and Death or Thrombotic Events During COVID-19 Admission.

Louis, David W / Kennedy, Kevin F / Saad, Marwan / Salber, Greg / Imran, Hafiz / Wark, Tyler / Soares, Cullen / Ghosalkar, Dhairyasheel / Cherala, Rasan / Poppas, Athena / Abbott, J Dawn / Aronow, Herbert D

The American journal of cardiology

2022 Volume 181, Page(s) 38–44

Abstract: Atrial fibrillation/flutter (AF) and COVID-19 are associated with an elevated risk of arterial and venous thrombosis. Whether preadmission oral anticoagulation (OAC) for AF reduces the incidence of in-hospital death or thrombotic events among patients ... ...

Abstract	Atrial fibrillation/flutter (AF) and COVID-19 are associated with an elevated risk of arterial and venous thrombosis. Whether preadmission oral anticoagulation (OAC) for AF reduces the incidence of in-hospital death or thrombotic events among patients with COVID-19 is unknown. We identified 630 patients with pre-existing AF and a hospitalization diagnosis of COVID-19 and stratified them according to preadmission OAC use. Multivariable logistic regression was employed to relate preadmission OAC to composite in-hospital mortality or thrombotic events. Unadjusted composite in-hospital mortality or thrombotic complications occurred less often in those on than not on preadmission OAC (27.1% vs 46.8%, p <0.001). After adjustment, the incidence of composite in-hospital all-cause mortality or thrombotic complications remained lower with preadmission OAC (odds ratio 0.37, confidence interval 0.25 to 0.53, p <0.0001). Secondary outcomes including all-cause mortality (16.3% vs 24.9%, p = 0.007), intensive care unit admission (14.7% vs 29.0%, p <0.001), intubation (6.4% vs 18.6%, p <0.001), and noninvasive ventilation (18.6% vs 27.5%, p = 0.007) occurred less frequently, and length of stay was shorter (6 vs 7 days, p <0.001) in patients on than those not on preadmission OAC. A higher CHA<sub>2</sub>DS<sub>2</sub>-VASc score was associated with an increased risk of thrombotic events. In conclusion, among patients with baseline AF who were hospitalized with COVID-19, those on preadmission OAC had lower rates of death, arterial and venous thrombotic events, and less severe COVID-19.
MeSH term(s)	Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Atrial Flutter/drug therapy ; COVID-19/complications ; COVID-19/epidemiology ; Hospital Mortality ; Hospitalization ; Humans ; Risk Assessment ; Risk Factors ; Stroke/epidemiology ; Thrombosis/epidemiology ; Thrombosis/etiology ; Thrombosis/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.07.006
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Article ; Online: Performance of Cardiovascular Risk Prediction Models Among People Living With HIV: A Systematic Review and Meta-analysis.

Soares, Cullen / Kwok, Michael / Boucher, Kent-Andrew / Haji, Mohammed / Echouffo-Tcheugui, Justin B / Longenecker, Christopher T / Bloomfield, Gerald S / Ross, David / Jutkowtiz, Eric / Sullivan, Jennifer L / Rudolph, James L / Wu, Wen-Chih / Erqou, Sebhat

JAMA cardiology

2022 Volume 8, Issue 2, Page(s) 139–149

Abstract: Importance: Extant data on the performance of cardiovascular disease (CVD) risk score models in people living with HIV have not been synthesized.: Objective: To synthesize available data on the performance of the various CVD risk scores in people ... ...

Abstract	Importance: Extant data on the performance of cardiovascular disease (CVD) risk score models in people living with HIV have not been synthesized. Objective: To synthesize available data on the performance of the various CVD risk scores in people living with HIV. Data sources: PubMed and Embase were searched from inception through January 31, 2021. Study selection: Selected studies (1) were chosen based on cohort design, (2) included adults with a diagnosis of HIV, (3) assessed CVD outcomes, and (4) had available data on a minimum of 1 CVD risk score. Data extraction and synthesis: Relevant data related to study characteristics, CVD outcome, and risk prediction models were extracted in duplicate. Measures of calibration and discrimination are presented in tables and qualitatively summarized. Additionally, where possible, estimates of discrimination and calibration measures were combined and stratified by type of risk model. Main outcomes and measures: Measures of calibration and discrimination. Results: Nine unique observational studies involving 75 304 people (weighted average age, 42 years; 59 490 male individuals [79%]) living with HIV were included. In the studies reporting these data, 86% were receiving antiretroviral therapy and had a weighted average CD4+ count of 449 cells/μL. Included in the study were current smokers (50%), patients with diabetes (5%), and patients with hypertension (25%). Ten risk prediction scores (6 in the general population and 4 in the HIV-specific population) were analyzed. Most risk scores had a moderate performance in discrimination (C statistic: 0.7-0.8), without a significant difference in performance between the risk scores of the general and HIV-specific populations. One of the HIV-specific risk models (Data Collection on Adverse Effects of Anti-HIV Drugs Cohort 2016) and 2 of the general population risk models (Framingham Risk Score [FRS] and Pooled Cohort Equation [PCE] 10 year) had the highest performance in discrimination. In general, models tended to underpredict CVD risk, except for FRS and PCE 10-year scores, which were better calibrated. There was substantial heterogeneity across the studies, with only a few studies contributing data for each risk score. Conclusions and relevance: Results of this systematic review and meta-analysis suggest that general population and HIV-specific CVD risk models had comparable, moderate discrimination ability in people living with HIV, with a general tendency to underpredict risk. These results reinforce the current recommendations provided by the American College of Cardiology/American Heart Association guidelines to consider HIV as a risk-enhancing factor when estimating CVD risk.
MeSH term(s)	Adult ; United States ; Humans ; Male ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/diagnosis ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Heart Disease Risk Factors ; Risk Assessment
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Meta-Analysis ; Systematic Review
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2022.4873
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Article ; Online: Aortic Valve Calcification Is Associated with Future Cognitive Impairment.

Chung, Hojune E / Chen, Jessica / Ghosalkar, Dhairyasheel / Christensen, Jared L / Chu, Alice J / Mantsounga, Chris S / Neverson, Jade / Soares, Cullen / Shah, Nishant R / Wu, Wen-Chih / Choudhary, Gaurav / Morrison, Alan R

Journal of Alzheimer's disease reports

2021 Volume 5, Issue 1, Page(s) 337–343

Abstract: Background: While an association between atherosclerosis and dementia has been identified, few studies have assessed the longitudinal relationship between aortic valve calcification (AVC) and cognitive impairment (CI).: Objective: We sought to ... ...

Abstract	Background: While an association between atherosclerosis and dementia has been identified, few studies have assessed the longitudinal relationship between aortic valve calcification (AVC) and cognitive impairment (CI). Objective: We sought to determine whether AVC derived from lung cancer screening CT (LCSCT) was associated with CI in a moderate-to-high atherosclerotic risk cohort. Methods: This was a single site, retrospective analysis of 1401 U.S. veterans (65 years [IQI: 61, 68] years; 97%male) who underwent quantification of AVC from LCSCT indicated for smoking history. The primary outcome was new diagnosis of CI identified by objective testing (Mini-Mental Status Exam or Montreal Cognitive Assessment) or by ICD coding. Time-to-event analysis was carried out using AVC as a continuous variable. Results: Over 5 years, 110 patients (8%) were diagnosed with CI. AVC was associated with new diagnosis of CI using 3 Models for adjustment: 1) age (HR: 1.104; CI: 1.023-1.191; Conclusion: This is the first study demonstrating that among mostly male individuals who underwent LCSCT, quantified aortic valve calcification is associated with new diagnosis of CI.
Language	English
Publishing date	2021-04-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4823
ISSN (online)	2542-4823
DOI	10.3233/ADR-200253
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Article ; Online: Coronary Artery Calcification and Plaque Characteristics in People Living With HIV: A Systematic Review and Meta-Analysis.

Soares, Cullen / Samara, Amjad / Yuyun, Matthew F / Echouffo-Tcheugui, Justin B / Masri, Ahmad / Samara, Ahmad / Morrison, Alan R / Lin, Nina / Wu, Wen-Chih / Erqou, Sebhat

Journal of the American Heart Association

2021 Volume 10, Issue 19, Page(s) e019291

Abstract: Background Studies have reported that people living with HIV have higher burden of subclinical cardiovascular disease, but the data are not adequately synthesized. We performed meta-analyses of studies of coronary artery calcium and coronary plaque in ... ...

Abstract	Background Studies have reported that people living with HIV have higher burden of subclinical cardiovascular disease, but the data are not adequately synthesized. We performed meta-analyses of studies of coronary artery calcium and coronary plaque in people living with HIV. Methods and Results We performed systematic search in electronic databases, and data were abstracted in standardized forms. Study-specific estimates were pooled using meta-analysis. 43 reports representing 27 unique studies and involving 10 867 participants (6699 HIV positive, 4168 HIV negative, mean age 52 years, 86% men, 32% Black) were included. The HIV-positive participants were younger (mean age 49 versus 57 years) and had lower Framingham Risk Score (mean score 6 versus 18) compared with the HIV-negative participants. The pooled estimate of percentage with coronary artery calcium >0 was 45% (95% CI, 43%-47%) for HIV-positive participants, and 52% (50%-53%) for HIV-negative participants. This difference was no longer significant after adjusting for difference in Framingham Risk Score between the 2 groups. The odds ratio of coronary artery calcium progression for HIV-positive versus -negative participants was 1.64 (95% CI, 0.91-2.37). The pooled estimate for prevalence of noncalcified plaque was 49% (95% CI, 47%-52%) versus 20% (95% CI, 17%-23%) for HIV-positive versus HIV-negative participants, respectively. Odds ratio for noncalcified plaque for HIV-positive versus -negative participants was 1.23 (95% CI, 1.08-1.38). There was significant heterogeneity that was only partially explained by available study-level characteristics. Conclusions People living with HIV have higher prevalence of noncalcified coronary plaques and similar prevalence of coronary artery calcium, compared with HIV-negative individuals. Future studies on coronary artery calcium and plaque progression can further elucidate subclinical atherosclerosis in people living with HIV.
MeSH term(s)	Calcium ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic/epidemiology
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Systematic Review
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.120.019291
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Article ; Online: Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures.

Belov, Vladimir / Erwin-Grabner, Tracy / Aghajani, Moji / Aleman, Andre / Amod, Alyssa R / Basgoze, Zeynep / Benedetti, Francesco / Besteher, Bianca / Bülow, Robin / Ching, Christopher R K / Connolly, Colm G / Cullen, Kathryn / Davey, Christopher G / Dima, Danai / Dols, Annemiek / Evans, Jennifer W / Fu, Cynthia H Y / Gonul, Ali Saffet / Gotlib, Ian H /

Grabe, Hans J / Groenewold, Nynke / Hamilton, J Paul / Harrison, Ben J / Ho, Tiffany C / Mwangi, Benson / Jaworska, Natalia / Jahanshad, Neda / Klimes-Dougan, Bonnie / Koopowitz, Sheri-Michelle / Lancaster, Thomas / Li, Meng / Linden, David E J / MacMaster, Frank P / Mehler, David M A / Melloni, Elisa / Mueller, Bryon A / Ojha, Amar / Oudega, Mardien L / Penninx, Brenda W J H / Poletti, Sara / Pomarol-Clotet, Edith / Portella, Maria J / Pozzi, Elena / Reneman, Liesbeth / Sacchet, Matthew D / Sämann, Philipp G / Schrantee, Anouk / Sim, Kang / Soares, Jair C / Stein, Dan J / Thomopoulos, Sophia I / Uyar-Demir, Aslihan / van der Wee, Nic J A / van der Werff, Steven J A / Völzke, Henry / Whittle, Sarah / Wittfeld, Katharina / Wright, Margaret J / Wu, Mon-Ju / Yang, Tony T / Zarate, Carlos / Veltman, Dick J / Schmaal, Lianne / Thompson, Paul M / Goya-Maldonado, Roberto

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1084

Abstract: Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample ... ...

Abstract	Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (N = 5365) to provide a generalizable ML classification benchmark of major depressive disorder (MDD) using shallow linear and non-linear models. Leveraging brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD versus healthy controls (HC) with a balanced accuracy of around 62%. But after harmonizing the data, e.g., using ComBat, the balanced accuracy dropped to approximately 52%. Accuracy results close to random chance levels were also observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may yield more encouraging prospects.
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/psychology ; Benchmarking ; Brain/diagnostic imaging ; Neuroimaging/methods ; Machine Learning ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47934-8
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