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  1. Article ; Online: Commentary on: Research priorities for a multicenter child abuse pediatrics network - CAPNET by Lindberg D et al., 2017: Need for internationally agreed definitions of Child Maltreatment for research purposes.

    Maguire, Sabine

    Child abuse & neglect

    2017  Volume 70, Page(s) 411–413

    MeSH term(s) Advisory Committees ; Child ; Child Abuse ; Child Welfare ; Consensus ; Female ; Humans ; Internationality ; Pediatrics ; Research
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Review
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2017.03.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1437: Show issues Location:
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  2. Article ; Online: Care coordination for children with a disability or developmental difficulty: Empowers families and reduces the burden on staff supporting them.

    Myers, Sarah / Collins, Bethan / Maguire, Sabine

    Child: care, health and development

    2023  Volume 50, Issue 1, Page(s) e13158

    Abstract: Background: Almost half of all children and young people with a disability or developmental difficulty (DDD) have complex disability and are likely to require multidisciplinary care. Care coordination (CC) aims to provide a single point of contact and a ...

    Abstract Background: Almost half of all children and young people with a disability or developmental difficulty (DDD) have complex disability and are likely to require multidisciplinary care. Care coordination (CC) aims to provide a single point of contact and a coordinated service, thereby improving care experiences, meeting unmet needs and empowering families. The impact of CC for children with DDD was evaluated.
    Method: Between May and August 2020, an in-depth evaluation of CC in Gwent, South Wales was conducted. Of 284 families who accessed CC, 38 were approached, as well as 177 health and social care professionals based at Serennu, Nevill Hall and Caerphilly Children's Centres. Nine families and 14 professionals completed semi-structured interviews. Interview transcripts were analysed using thematic analysis.
    Results: This evaluation found perceived improvements in families' abilities to navigate, organize and understand care and increased parental engagement. Professionals observed fewer missed appointments, and both professionals and families described CC as a source of holistic support, including practical advice regarding housing, finances and emotional support. Professionals commented on CC easing pressure on their service. Potential limitations included restricted staff capacity and the role not being defined clearly for families and professionals.
    Conclusions: At a time of increased stress for families of children with DDD, and scarce resources to support them, care coordinators play a vital role in assisting families to engage with health services, while feeling supported and empowered. CC reduces the burden on professionals, while enhancing relationships with families.
    MeSH term(s) Child ; Humans ; Adolescent ; Disabled Persons ; Parents/psychology ; Social Support ; Health Services
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 223039-2
    ISSN 1365-2214 ; 0305-1862
    ISSN (online) 1365-2214
    ISSN 0305-1862
    DOI 10.1111/cch.13158
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  3. Article ; Online: High incidence of occult, serious injury in possibly-abused infants presenting with isolated bruising.

    Maguire, Sabine

    The Journal of pediatrics

    2015  Volume 166, Issue 1, Page(s) 206–207

    MeSH term(s) Child Abuse/diagnosis ; Contusions/diagnosis ; Female ; Humans ; Male ; Soft Tissue Injuries/diagnosis
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2014.10.044
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  4. Article: Evaluation of Fecal Egg Count Tests for Effective Control of Equine Intestinal Strongyles.

    Lejeune, Manigandan / Mann, Sabine / White, Holly / Maguire, Danielle / Hazard, Jaime / Young, Rebecca / Stone, Charles / Antczak, Doug / Bowman, Dwight

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: The American Association of Equine Practitioners strongly advocates evidence-based intestinal strongyle control in horses. It recommends targeted treatment of all heavy egg shedders (>500 eggs per gram (EPG) of feces), while the low shedders (0-200 EPG) ... ...

    Abstract The American Association of Equine Practitioners strongly advocates evidence-based intestinal strongyle control in horses. It recommends targeted treatment of all heavy egg shedders (>500 eggs per gram (EPG) of feces), while the low shedders (0-200 EPG) are left untreated. As 50-75% of adult horses in a herd are low shedders, preventing them from unnecessary anthelmintic exposure is critical for tackling resistance. There are various fecal egg count (FEC) techniques with many modifications and variations in use, but none is identified as a gold standard. The hypothesis of the study was that the diagnostic performance of 12 commonly used quantitation methodologies (three techniques with four variants) differs. In this regard, method comparison studies were performed using polystyrene beads as proxy for intestinal strongyle eggs. Mini-FLOTAC-based variants had the lowest coefficient of variation (CV%) in bead recovery, whereas McMaster variants had the highest. All four variants of Mini-FLOTAC and the NaNO
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12111283
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  5. Article ; Online: Generation of CHOPi012-A iPSC line from a patient with visceral myopathy-related chronic intestinal pseudo-obstruction.

    Hashmi, Sohaib K / Schneider, Sabine / Gagne, Alyssa L / Maguire, Jean Ann / Gadue, Paul / Heuckeroth, Robert O / French, Deborah L

    Stem cell research

    2023  Volume 71, Page(s) 103176

    Abstract: Visceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening ... ...

    Abstract Visceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening abdominal distension, and may depend on intravenous nutrition for survival. Unfortunately, our limited understanding of the pathophysiology of visceral myopathies means that current therapies remain supportive, with no mechanism-based treatments. We developed a patient-derived iPSC line with a c.769C > T p.R257C/+ mutation, the most common genetic cause of visceral myopathy. This cell line will facilitate studies of how the ACTG2 R257C heterozygous variant affects smooth muscle development and function.
    MeSH term(s) Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Actins/metabolism ; Intestinal Pseudo-Obstruction/genetics ; Intestinal Pseudo-Obstruction/metabolism ; Intestines ; Mutation
    Chemical Substances Actins
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Generation of CHOPe003-A ESC line to study an ACTG2 variant affecting smooth muscle development and function.

    Hashmi, Sohaib K / Schneider, Sabine / Gagne, Alyssa L / Maguire, Jean Ann / Anderson, Sierra / Gadue, Paul / Heuckeroth, Robert O / French, Deborah L

    Stem cell research

    2023  Volume 71, Page(s) 103186

    Abstract: Dysfunction of visceral smooth muscle ("visceral myopathy") impairs bowel, bladder, and uterine function. Symptoms of this life-threatening condition include massive intestinal distension with slow transit, vomiting, feeding intolerance, growth failure, ... ...

    Abstract Dysfunction of visceral smooth muscle ("visceral myopathy") impairs bowel, bladder, and uterine function. Symptoms of this life-threatening condition include massive intestinal distension with slow transit, vomiting, feeding intolerance, growth failure, poor bladder emptying, and difficult vaginal delivery. The most common genetic cause of visceral myopathy is a heterozygous point mutation (R257C) in gamma smooth muscle actin (ACTG2). We genetically modified the WAe0009-A human embryonic stem cell line to carry the c.769C>T p.R257C/+ mutation. This cell line will facilitate studies of how the ACTG2 R257C heterozygous variant affects smooth muscle development and function.
    MeSH term(s) Humans ; Female ; Cell Line ; Embryonic Stem Cells ; Heterozygote ; Muscle Development ; Muscular Diseases ; Actins/genetics
    Chemical Substances ACTG2 protein, human ; Actins
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103186
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  7. Article ; Online: "They just get it" an exploration of father's experiences and perceptions of a support group for men caring for children with disabilities and/or developmental delay.

    Batchelor, Molly / Maguire, Sabine / Shearn, Julia

    Journal of applied research in intellectual disabilities : JARID

    2020  Volume 34, Issue 1, Page(s) 263–273

    Abstract: Background: Support groups available to parents/carers of children with a disability or developmental delay (DDD) are predominately attended by women. Limited data exists reporting experiences of the few male-only support groups. This paper examines ... ...

    Abstract Background: Support groups available to parents/carers of children with a disability or developmental delay (DDD) are predominately attended by women. Limited data exists reporting experiences of the few male-only support groups. This paper examines experiences of fathers of children with DDD attending a male-only support group from South Wales.
    Method: All fifteen members from a support group for fathers/male carers of children with DDD were invited to take part in qualitative interviews and seven participated. The data were analysed following Braun and Clarke's (Qualitative research in psychology, 2006, 3:77) thematic framework.
    Results: Within the group, fathers felt understood by similarly situated men, and a sense of connectivity and belonging. Fathers perceived exclusion elsewhere, including mixed-gender groups. Fathers felt permission to talk in a way consistent with their male identities, and valued receiving, and giving, support.
    Conclusions: Mixed-gender support groups may not meet the needs of fathers, and there are potential benefits in providing male-only groups.
    MeSH term(s) Child ; Disabled Children ; Fathers ; Female ; Humans ; Intellectual Disability ; Male ; Perception ; Qualitative Research ; Self-Help Groups
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1326222-1
    ISSN 1468-3148 ; 0952-9608 ; 1360-2322
    ISSN (online) 1468-3148
    ISSN 0952-9608 ; 1360-2322
    DOI 10.1111/jar.12804
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4157: Show issues Location:
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  8. Article ; Online: Generation of CHOPi012-A iPSC line from a patient with visceral myopathy-related chronic intestinal pseudo-obstruction

    Sohaib K. Hashmi / Sabine Schneider / Alyssa L. Gagne / Jean Ann Maguire / Paul Gadue / Robert O. Heuckeroth / Deborah L. French

    Stem Cell Research, Vol 71, Iss , Pp 103176- (2023)

    2023  

    Abstract: Visceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening ... ...

    Abstract Visceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening abdominal distension, and may depend on intravenous nutrition for survival. Unfortunately, our limited understanding of the pathophysiology of visceral myopathies means that current therapies remain supportive, with no mechanism-based treatments. We developed a patient-derived iPSC line with a c.769C > T p.R257C/+ mutation, the most common genetic cause of visceral myopathy. This cell line will facilitate studies of how the ACTG2 R257C heterozygous variant affects smooth muscle development and function.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Response to comments from Professor Niels Lynøe

    Kemp, Alison Mary / Maguire, Sabine Ann / Debelle, Geoff D

    Archives of disease in childhood

    2018  Volume 103, Issue 7, Page(s) 715

    MeSH term(s) Craniocerebral Trauma/diagnosis ; Humans ; Infant ; Shaken Baby Syndrome/diagnosis
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2018-315382
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  10. Article: What Do Confessions Reveal About Abusive Head Trauma? A Systematic Review.

    Edwards, George A / Maguire, Sabine A / Gaither, Julie R / Leventhal, John M

    Child abuse review (Chichester, England : 1992)

    2020  Volume 29, Issue 3, Page(s) 253–268

    Abstract: Although confessions related to abusive head trauma (AHT) are reported, no detailed analysis exists. Therefore, we systematically reviewed studies of AHT confessions and examined the details, including country of origin, mechanisms and perpetrators' ... ...

    Abstract Although confessions related to abusive head trauma (AHT) are reported, no detailed analysis exists. Therefore, we systematically reviewed studies of AHT confessions and examined the details, including country of origin, mechanisms and perpetrators' characteristics [PUBLISHER - THE PRECEDING UNDERLINED TEXT IS FOR THE MARGIN]. Employing 36 search terms across three search engines, we searched Medline and CINAHL from 1963 to 2018. All relevant studies underwent two independent reviews and data extraction. Descriptive statistics were used to characterise the sample; chi square and Fisher's exact tests were used to assess differences in demographic and clinical characteristics. Of 6759 identified studies, 157 full texts were reviewed and 55 articles from 15 countries spanning four continents were included. Included articles contained 434 confessions. The mechanisms of abuse included shaking alone (64.1%), impact alone (17.1%), shaking plus impact (18.0%) and other (0.9%). There was no statistically significant difference in the percentage of confessions reporting shaking alone when comparing continents: North America (64.0%), Europe (64.2%) and Oceania (60.0%;
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141428-5
    ISSN 1099-0852 ; 1099-0852 ; 0952-9136
    ISSN (online) 1099-0852
    ISSN 1099-0852 ; 0952-9136
    DOI 10.1002/car.2627
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