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  1. Article ; Online: Better diagnostic tools needed to distinguish typhoid from other causes of acute febrile illness.

    Shakoor, Sadia / Dittrich, Sabine

    Bulletin of the World Health Organization

    2023  Volume 101, Issue 11, Page(s) 683–683A

    MeSH term(s) Humans ; Typhoid Fever/complications ; Typhoid Fever/diagnosis ; Causality ; Fever/etiology
    Language English
    Publishing date 2023-11-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.23.290678
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 215: Show issues Location:
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  2. Article ; Online: Perspective on the Integration of Diagnostic Algorithms for Fever Management.

    Nkeramahame, Juvenal / Olliaro, Piero / Horgan, Philip / Dittrich, Sabine

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue Suppl 2, Page(s) S211–S213

    MeSH term(s) Humans ; Fever/diagnosis ; Fever/etiology ; Algorithms
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad325
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    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 480: Show issues

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  3. Article: Diagnostics for Typhoid Fever: Current Perspectives and Future Outlooks for Product Development and Access.

    Sapkota, Jyotshna / Roberts, Tamalee / Basnyat, Buddha / Baker, Stephen / Hampton, Lee M / Dittrich, Sabine

    Open forum infectious diseases

    2023  Volume 10, Issue Suppl 1, Page(s) S17–S20

    Abstract: Typhoid is an enteric disease caused ... ...

    Abstract Typhoid is an enteric disease caused by
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad120
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  4. Article ; Online: Influence of Natural Convection and Volume Change on Numerical Simulation of Phase Change Materials for Latent Heat Storage

    Mönch, Sabine Hanna / Dittrich, Robert

    2022  

    Abstract: For the numerical simulation of a heat storage based on phase change materials (PCMs) an enhanced model is presented, considering the physical effects of convection flow in the liquid phase as well as the volume change during phase change. A modified ... ...

    Abstract For the numerical simulation of a heat storage based on phase change materials (PCMs) an enhanced model is presented, considering the physical effects of convection flow in the liquid phase as well as the volume change during phase change. A modified heat capacity is used to realize the phase change. The phase change material is initially defined as a liquid with temperature-dependent material properties. A volume force is added to the Navier-Stokes equations to allow a circulating flow field in the liquid phase and prevent flow motion in the solid phase. The volume change is implemented with the Arbitrary Lagrangian-Eulerian method. A laboratory phase change experiment was performed using the PCM RT42 with a melting temperature of 42 °C. The laboratory experiment was calculated numerically using the enhanced model to evaluate the numerical model and to investigate the influence of the simulation parameters on the thermal behavior of the PCM. The thermal conductivity is determined as the main influencing parameter. A good agreement of the simulated melting front throughout a major part of the laboratory experiment has been shown. COMSOL Multiphysics provides a default model for phase change, which neglects convection flow and volume change. Compared to the default model, the enhanced model achieves more accurate results but requires more computational cost for complex latent heat storage systems. Using the default model without convection can be reasonable, considering that the heat storage design is either over-dimensioned or a suitable correction factor must be applied.

    15

    8
    Keywords phase change materials ; solid-liquid phase change ; natural convection ; numerical simulation ; latent heat storage ; heat transfer and fluid flow coupling
    Subject code 621
    Language English
    Publishing date 2022-04-08
    Publishing country de
    Document type Article ; Online
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  5. Article: Missed opportunities for integrated testing of HIV and tuberculosis on the GeneXpert platform in Lesotho.

    Gwaza, Gamuchirai P / Leqheka, Monkoe / Mots'oane, Tsietso / Dittrich, Sabine / Kao, Kekeletso

    African journal of laboratory medicine

    2023  Volume 12, Issue 1, Page(s) 2132

    Abstract: Background: Integrated testing, treatment and care are key strategies for addressing the dual burdens of tuberculosis and HIV. The GeneXpert instrument allows simultaneous HIV and tuberculosis testing, but its utilisation for integrated testing remains ... ...

    Abstract Background: Integrated testing, treatment and care are key strategies for addressing the dual burdens of tuberculosis and HIV. The GeneXpert instrument allows simultaneous HIV and tuberculosis testing, but its utilisation for integrated testing remains suboptimal.
    Objective: The study determined the extent to which tuberculosis testing and HIV early infant detection (EID) were integrated on the GeneXpert platform, or the potential for integration at selected health facilities.
    Methods: A mixed methods evaluation was conducted using retrospective secondary data analysis of laboratory records from 2017 to 2019, and semi-structured interviews. Data were collected between January 2020 and March 2020 in Lesotho.
    Results: Forty-four health staff were interviewed across 13 health facilities: one regional, nine district, and three clinic level. Six were government facilities, six were mission hospitals, and one was a non-profit clinic. All facilities selected had at least one GeneXpert instrument used for tuberculosis or HIV testing; none included simultaneous testing for tuberculosis and HIV. In 2017, the average utilisation rate for the GeneXpert instrument for tuberculosis and EID testing was 63% and 24%, while in 2019, the average utilisation rate was 61% for tuberculosis testing and 27% for EID.
    Conclusion: Except for three sites where the testing rates were high, utilisation rates were sufficiently low that all the HIV EID and tuberculosis tests undertaken in 2017 and 2019 could have been performed using only the instruments currently dedicated to tuberculosis testing. There is a missed opportunity for the integration of testing for tuberculosis and HIV on the GeneXpert instrument.
    What this study adds: This study adds to the body of evidence on the need for integration of testing and highlights some practical and technical considerations for successful implementation of integrated tuberculosis and HIV testing.
    Language English
    Publishing date 2023-08-28
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2708535-1
    ISSN 2225-2010 ; 2225-2002
    ISSN (online) 2225-2010
    ISSN 2225-2002
    DOI 10.4102/ajlm.v12i1.2132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mapping the global landscape of chikungunya rapid diagnostic tests: A scoping review.

    Moreira, José / Brasil, Patrícia / Dittrich, Sabine / Siqueira, André M

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 7, Page(s) e0010067

    Abstract: Background: Chikungunya (CHIKV) is a reemerging arboviral disease and represents a global health threat because of the unprecedented magnitude of its spread. Diagnostics strategies rely heavily on reverse transcriptase-polymerase chain reaction (RT-PCR) ...

    Abstract Background: Chikungunya (CHIKV) is a reemerging arboviral disease and represents a global health threat because of the unprecedented magnitude of its spread. Diagnostics strategies rely heavily on reverse transcriptase-polymerase chain reaction (RT-PCR) and antibody detection by enzyme-linked Immunosorbent assay (ELISA). Rapid diagnostic tests (RDTs) are available and promise to decentralize testing and increase availability at lower healthcare system levels.
    Objectives: We aim to identify the extent of research on CHIKV RDTs, map the global availability of CHIKV RDTs, and evaluate the accuracy of CHIKV RDTs for the diagnosis of CHIKV.
    Eligibility criteria: We included studies reporting symptomatic individuals suspected of CHIKV, tested with CHIKV RDTs, against the comparator being a validated laboratory-based RT-PCR or ELISA assay. The primary outcome was the accuracy of the CHIKV RDT when compared with reference assays.
    Sources of evidence: Medline, EMBASE, and Scopus were searched from inception to 13 October 2021. National regulatory agencies (European Medicines Agency, US Food and Drug Administration, and the Brazilian National Health Surveillance Agency) were also searched for registered CHIKV RDTs.
    Results: Seventeen studies were included and corresponded to 3,222 samples tested with RDTs between 2005 and 2018. The most development stage of CHIKV RDTs studies was Phase I (7/17 studies) and II (7/17 studies). No studies were in Phase IV. The countries that manufacturer the most CHIKV RDTs were Brazil (n = 17), followed by the United States of America (n = 7), and India (n = 6). Neither at EMA nor FDA-registered products were found. Conversely, the ANVISA has approved 23 CHIKV RDTs. Antibody RDTs (n = 43) predominated and demonstrated sensitivity between 20% and 100%. The sensitivity of the antigen RDTs ranged from 33.3% to 100%.
    Conclusions: The landscape of CHIKV RDTs is fragmented and needs coordinated efforts to ensure that patients in CHIKV-endemic areas have access to appropriate RDTs. Further research is crucial to determine the impact of such tests on integrated fever case management and prescription practices for acute febrile patients.
    MeSH term(s) Brazil ; Chikungunya Fever/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Humans ; India ; Sensitivity and Specificity
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010067
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  7. Article ; Online: Orientia tsutsugamushi.

    Wongsantichon, Jantana / Jaiyen, Yanin / Dittrich, Sabine / Salje, Jeanne

    Trends in microbiology

    2020  Volume 28, Issue 9, Page(s) 780–781

    MeSH term(s) Animals ; Host Microbial Interactions ; Humans ; Mites/microbiology ; Orientia tsutsugamushi ; Scrub Typhus/immunology ; Scrub Typhus/microbiology ; Scrub Typhus/transmission
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2020.02.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Barriers to integrating diagnostic services for febrile illness to support surveillance and patient management in Asia‐Pacific

    Gamuchirai Pamela Gwaza / Marie Lamy / Rittika Datta / Sabine Dittrich

    Asia & the Pacific Policy Studies, Vol 9, Iss 2, Pp 196-

    2022  Volume 212

    Abstract: Abstract As malaria cases continue to decline in Asia, an integrated service delivery approach is ever more urgent to ensure that no malaria and fever cases are missed, and that malaria health workers continue contributing to broader infectious disease ... ...

    Abstract Abstract As malaria cases continue to decline in Asia, an integrated service delivery approach is ever more urgent to ensure that no malaria and fever cases are missed, and that malaria health workers continue contributing to broader infectious disease control efforts. However, despite its perceived merit, translating integrated surveillance into practice poses several systemic challenges. This article aims to identify what is hindering improved processes for integrating diagnostic and surveillance services for febrile illnesses. Data from peer‐reviewed and grey literature were reviewed using a systems approach based on the World Health Organisation health systems building blocks to fully understand the connections between different elements and system implications of integration. We include snippets from Sri Lanka, Myanmar, Malaysia and Nepal, highlighting expanded diagnostic integration best practices. This review provides a foundation for ‘integration roadmaps’ that can be adapted to different contexts and guide national stakeholders on the operational and political steps for a successful integration model. Such a model can support malaria elimination efforts and serve as a public health tool in the context of disease surveillance and regional health security.
    Keywords Asia‐Pacific ; febrile illness ; health security ; health system integration ; malaria ; Political science ; J ; Political science (General) ; JA1-92
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Mapping the global landscape of chikungunya rapid diagnostic tests

    José Moreira / Patrícia Brasil / Sabine Dittrich / André M Siqueira

    PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e

    A scoping review.

    2022  Volume 0010067

    Abstract: Background Chikungunya (CHIKV) is a reemerging arboviral disease and represents a global health threat because of the unprecedented magnitude of its spread. Diagnostics strategies rely heavily on reverse transcriptase-polymerase chain reaction (RT-PCR) ... ...

    Abstract Background Chikungunya (CHIKV) is a reemerging arboviral disease and represents a global health threat because of the unprecedented magnitude of its spread. Diagnostics strategies rely heavily on reverse transcriptase-polymerase chain reaction (RT-PCR) and antibody detection by enzyme-linked Immunosorbent assay (ELISA). Rapid diagnostic tests (RDTs) are available and promise to decentralize testing and increase availability at lower healthcare system levels. Objectives We aim to identify the extent of research on CHIKV RDTs, map the global availability of CHIKV RDTs, and evaluate the accuracy of CHIKV RDTs for the diagnosis of CHIKV. Eligibility criteria We included studies reporting symptomatic individuals suspected of CHIKV, tested with CHIKV RDTs, against the comparator being a validated laboratory-based RT-PCR or ELISA assay. The primary outcome was the accuracy of the CHIKV RDT when compared with reference assays. Sources of evidence Medline, EMBASE, and Scopus were searched from inception to 13 October 2021. National regulatory agencies (European Medicines Agency, US Food and Drug Administration, and the Brazilian National Health Surveillance Agency) were also searched for registered CHIKV RDTs. Results Seventeen studies were included and corresponded to 3,222 samples tested with RDTs between 2005 and 2018. The most development stage of CHIKV RDTs studies was Phase I (7/17 studies) and II (7/17 studies). No studies were in Phase IV. The countries that manufacturer the most CHIKV RDTs were Brazil (n = 17), followed by the United States of America (n = 7), and India (n = 6). Neither at EMA nor FDA-registered products were found. Conversely, the ANVISA has approved 23 CHIKV RDTs. Antibody RDTs (n = 43) predominated and demonstrated sensitivity between 20% and 100%. The sensitivity of the antigen RDTs ranged from 33.3% to 100%. Conclusions The landscape of CHIKV RDTs is fragmented and needs coordinated efforts to ensure that patients in CHIKV-endemic areas have access to appropriate RDTs. Further research is ...
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The impact of C-reactive protein testing on treatment-seeking behavior and patients' attitudes toward their care in Myanmar and Thailand.

    Greer, Rachel C / Althaus, Thomas / Dittrich, Sabine / Butler, Christopher C / Cheah, Phaik Yeong / Wangrangsimakul, Tri / Smithuis, Frank M / Day, Nicolas P J / Lubell, Yoel

    Healthcare in low-resource settings

    2024  Volume 11, Issue 1, Page(s) 11278

    Abstract: C-reactive protein (CRP) point-of-care testing can reduce antibiotic prescribing in primary care patients with febrile and respiratory illness, yet little is known about its effects on treatment-seeking behavior. If patients go on to source antibiotics ... ...

    Abstract C-reactive protein (CRP) point-of-care testing can reduce antibiotic prescribing in primary care patients with febrile and respiratory illness, yet little is known about its effects on treatment-seeking behavior. If patients go on to source antibiotics elsewhere, the impact of CRP testing will be limited. A randomized controlled trial assessed the impact of CRP testing on antibiotic prescriptions in Myanmar and Thai primary care patients with a febrile illness. Here we report patients' treatment-seeking behavior before and during the two-week study period. Self-reported antibiotic use is compared against urine antibacterial activity. Patients' opinions towards CRP testing were evaluated. Antibiotic use before study enrolment was reported by 5.4% while antimicrobial activity was detected in 20.8% of samples tested. During the study period, 14.8% of the patients sought additional healthcare, and 4.3% sourced their own antibiotics. Neither were affected by CRP testing. Overall, patients' satisfaction with their care and CRP testing was high. CRP testing did not affect patients' treatment-seeking behavior during the study period whilst modestly reducing antibiotic prescriptions. CRP testing appears to be acceptable to patients and their caregivers.
    Language English
    Publishing date 2024-02-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2710774-7
    ISSN 2281-7824
    ISSN 2281-7824
    DOI 10.4081/hls.2023.11278
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