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  1. Article ; Online: Biomarker blues: balancing hope and hype in acute kidney injury.

    Waikar, Sushrut S

    Kidney international

    2024  Volume 105, Issue 4, Page(s) 679–682

    MeSH term(s) Humans ; Biomarkers ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Imprecise, Measure it Twice? Dealing With the Biological Variability of Albuminuria in Diabetes.

    Claudel, Sophie E / Waikar, Sushrut S

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Challenges and Opportunities: Studying CKDu in the United States.

    Claudel, Sophie E / Chan, Maya / Scammell, Madeleine K / Waikar, Sushrut S

    Kidney360

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Linking Kidney Vessel Scarring to Cardiovascular Risk-Reply.

    Buckley, Leo / Palsson, Ragnar / Waikar, Sushrut S

    JAMA cardiology

    2023  Volume 8, Issue 10, Page(s) 1000

    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.2755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kidney Disease-Related Mortality Among Asian Americans.

    Claudel, Sophie E / Waikar, Sushrut S / Schmidt, Insa M / Verma, Ashish

    Kidney medicine

    2023  Volume 5, Issue 8, Page(s) 100676

    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Precision nosology versus precision nephrology: defining acute kidney injury, again.

    Waikar, Sushrut S

    Kidney international

    2019  Volume 95, Issue 4, Page(s) 741–743

    Abstract: Consensus definitions for acute kidney injury (AKI) use change in serum creatinine or urine output as the basis for diagnosis and risk stratification. Consensus definitions have been validated largely by prospective associations with in-hospital ... ...

    Abstract Consensus definitions for acute kidney injury (AKI) use change in serum creatinine or urine output as the basis for diagnosis and risk stratification. Consensus definitions have been validated largely by prospective associations with in-hospital mortality. Applying this same approach, Sparrow and colleagues propose a further subclassification of stage 1 AKI into 2 subgroups. Although they are informative for epidemiology, AKI definitions have largely failed to focus on the most interesting and clinically relevant issues: etiology and pathogenesis.
    MeSH term(s) Acute Kidney Injury ; Creatinine ; Humans ; Nephrology ; Prospective Studies ; Risk Factors
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-03-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Separate and Unequal: Race-Based Algorithms and Implications for Nephrology.

    Schmidt, Insa M / Waikar, Sushrut S

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 3, Page(s) 529–533

    MeSH term(s) Black or African American ; Algorithms ; Glomerular Filtration Rate ; Healthcare Disparities/ethics ; Healthcare Disparities/statistics & numerical data ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Kidney Calculi/epidemiology ; Kidney Calculi/etiology ; Kidney Transplantation/ethics ; Nephrology/ethics ; Nephrology/statistics & numerical data ; Racism/ethics ; Racism/prevention & control ; Racism/statistics & numerical data ; Risk Factors ; Social Justice/ethics ; Tissue Donors/ethics ; United States/epidemiology ; White People
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020081175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of Albuminuria With Chronic Kidney Disease Progression in Persons With Chronic Kidney Disease and Normoalbuminuria : A Cohort Study.

    Verma, Ashish / Schmidt, Insa M / Claudel, Sophie / Palsson, Ragnar / Waikar, Sushrut S / Srivastava, Anand

    Annals of internal medicine

    2024  Volume 177, Issue 4, Page(s) 467–475

    Abstract: ... Design: Multicenter prospective cohort study.: Setting: 7 U.S. clinical centers.: Participants ...

    Abstract Background: Albuminuria is a major risk factor for chronic kidney disease (CKD) progression, especially when categorized as moderate (30 to 300 mg/g) or severe (>300 mg/g). However, there are limited data on the prognostic value of albuminuria within the normoalbuminuric range (<30 mg/g) in persons with CKD.
    Objective: To estimate the increase in the cumulative incidence of CKD progression with greater baseline levels of albuminuria among persons with CKD who had normoalbuminuria (<30 mg/g).
    Design: Multicenter prospective cohort study.
    Setting: 7 U.S. clinical centers.
    Participants: 1629 participants meeting criteria from the CRIC (Chronic Renal Insufficiency Cohort) study with CKD (estimated glomerular filtration rate [eGFR], 20 to 70 mL/min/1.73 m
    Measurements: Baseline spot urine albumin divided by spot urine creatinine to calculate UACR as the exposure variable. The 10-year adjusted cumulative incidences of CKD progression (composite of 50% eGFR decline or kidney failure [dialysis or kidney transplantation]) from confounder adjusted survival curves using the G-formula.
    Results: Over a median follow-up of 9.8 years, 182 of 1629 participants experienced CKD progression. The 10-year adjusted cumulative incidences of CKD progression were 8.7% (95% CI, 5.9% to 11.6%), 11.5% (CI, 8.8% to 14.3%), and 19.5% (CI, 15.4% to 23.5%) for UACR levels of 0 to less than 5 mg/g, 5 to less than 15 mg/g, and 15 mg/g or more, respectively. Comparing persons with UACR 15 mg/g or more to those with UACR 5 to less than 15 mg/g and 0 to less than 5 mg/g, the absolute risk differences were 7.9% (CI, 3.0% to 12.7%) and 10.7% (CI, 5.8% to 15.6%), respectively. The 10-year adjusted cumulative incidence increased linearly based on baseline UACR levels.
    Limitation: UACR was measured once.
    Conclusion: Persons with CKD and normoalbuminuria (<30 mg/g) had excess risk for CKD progression, which increased in a linear fashion with higher levels of albuminuria.
    Primary funding source: None.
    MeSH term(s) Humans ; Cohort Studies ; Albuminuria ; Creatinine/urine ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/urine ; Glomerular Filtration Rate ; Albumins ; Disease Progression
    Chemical Substances Creatinine (AYI8EX34EU) ; Albumins
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-2814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

    Claudel, Sophie E / Waikar, Sushrut S / Gopal, Deepa M / Verma, Ashish

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background and aims: The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood.: Methods: We included adults ... ...

    Abstract Background and aims: The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood.
    Methods: We included adults with CKD (eGFR<60 ml/min/1.73m
    Results: Across 1,068 adults with CKD, the mean [SD] age was 71.9[12.7] years and 61.2% were female; 78.8% had elevated NT-proBNP and 42.6% had elevated hs-cTnT based on traditional clinical reference limits. The 99
    Conclusions and relevance: Community dwelling adults with CKD have elevated concentrations of cardiac biomarkers, above established reference ranges. Of the troponin assays, hs-cTnI concentration appears to be most stable across eGFR categories and is associated with CVD mortality.
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.12.23299886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Severe hyponatremia due to surreptitious water intoxication in a hospitalized patient.

    Claudel, Sophie E / Waikar, Sushrut S / Verma, Ashish

    CEN case reports

    2022  Volume 12, Issue 2, Page(s) 135–138

    Abstract: Hyponatremia is a common electrolyte abnormality among hospitalized patients and often present as first sign of other underlying medical conditions. Severe hyponatremia can be life threatening and requires prompt diagnosis and treatment. We present a ... ...

    Abstract Hyponatremia is a common electrolyte abnormality among hospitalized patients and often present as first sign of other underlying medical conditions. Severe hyponatremia can be life threatening and requires prompt diagnosis and treatment. We present a case of refractory hyponatremia that was a diagnostic challenge requiring a prolonged hospitalization. Diagnosis of primary polydipsia was ultimately suspected due to improbable 24-h urine studies and confirmed through complete removal of free water access in the form of disconnecting the bathroom faucet in the patient's hospital room. Diagnosis and management of primary polydipsia is further discussed.
    MeSH term(s) Humans ; Hyponatremia ; Water Intoxication ; Polydipsia, Psychogenic
    Language English
    Publishing date 2022-09-15
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-022-00733-y
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