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  1. Article: A brief history of the treatment of viral hepatitis C.

    Strader, Doris B / Seeff, Leonard B

    Clinical liver disease

    2012  Volume 1, Issue 1, Page(s) 6–11

    Language English
    Publishing date 2012-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1
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  2. Article ; Online: Utility of laboratory monitoring during hepatitis C treatment with ribavirin-free direct-acting antiviral regimens.

    VanOpdorp, Jocelyn R / Ferrentino, Nicholas / Strader, Doris B / Lidofsky, Steven D

    Journal of viral hepatitis

    2019  Volume 26, Issue 6, Page(s) 778–781

    MeSH term(s) Aged ; Antiviral Agents/therapeutic use ; Drug Monitoring ; Drug Therapy, Combination ; Female ; Hepacivirus/drug effects ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/drug therapy ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic/standards ; RNA, Viral/blood ; Retrospective Studies ; Ribavirin/therapeutic use ; Sustained Virologic Response
    Chemical Substances Antiviral Agents ; RNA, Viral ; Ribavirin (49717AWG6K)
    Language English
    Publishing date 2019-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13083
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  3. Article ; Online: Coinfection with HIV and hepatitis C virus in injection drug users and minority populations.

    Strader, Doris B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2005  Volume 41 Suppl 1, Page(s) S7–13

    Abstract: Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common. In the United States, it has been estimated that 25% of persons infected with HIV are also infected with HCV. The prevalence of coinfection with HIV and HCV is ... ...

    Abstract Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common. In the United States, it has been estimated that 25% of persons infected with HIV are also infected with HCV. The prevalence of coinfection with HIV and HCV is highest among those infected via percutaneous routes. In fact, in urban areas in the United States, 50%-90% of persons infected with HIV via injection drug use are coinfected with HCV. In addition, limited data from drug treatment centers in these urban areas suggest that the prevalence of coinfection with HIV and HCV may be highest among African Americans and Hispanics. Little information is available with regard to the epidemiology of coinfection with HIV and HCV among injection drug users (IDUs) or minority populations. Likewise, although there is a growing body of data on the potential complexities of treating HCV among IDUs and the poor response to current anti-HCV treatment among African Americans, few data address the therapy of coinfection with HIV and HCV among IDUs and minority populations.
    MeSH term(s) Antiretroviral Therapy, Highly Active/adverse effects ; Chemical and Drug Induced Liver Injury ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Humans ; Liver Diseases/virology ; Minority Groups ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/therapy
    Language English
    Publishing date 2005-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/429489
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  4. Article: Understudied populations with hepatitis C.

    Strader, Doris B

    Hepatology (Baltimore, Md.)

    2002  Volume 36, Issue 5 Suppl 1, Page(s) S226–36

    Abstract: Managing patients with hepatitis C virus (HCV) infection consists primarily of antiviral treatment, currently with peginterferon and ribavirin. Unfortunately, treatment recommendations derive largely from trials that have focused on highly selected ... ...

    Abstract Managing patients with hepatitis C virus (HCV) infection consists primarily of antiviral treatment, currently with peginterferon and ribavirin. Unfortunately, treatment recommendations derive largely from trials that have focused on highly selected patient populations. As a consequence of the strict inclusion and exclusion criteria in these studies, more than half of all HCV-infected patients would be ineligible for enrollment. Even among the selected patients enrolled into studies, only 50% achieve a sustained virological response (SVR). Patients not eligible for current therapies include those with mild disease and normal alanine aminotransferase (ALT) levels, patients with advanced and decompensated liver disease, children, the elderly, patients with ongoing or recent alcohol and substance abuse, renal disease, human immunodeficiency virus (HIV) infection, severe psychiatric or neurologic illness, autoimmune disorders, solid organ transplant, and other significant comorbid conditions. Because these patients have been excluded from most clinical trials, little is known about the safety or efficacy of therapy in these populations. The expense and side effects of therapy are also an impediment to treatment of patients who are on public assistance, in prisons, and in institutions. Clearly, new efforts and new approaches are needed to expand the eligibility for antiviral therapy of hepatitis C and make treatment more available for understudied populations with this disease.
    MeSH term(s) Antiviral Agents/therapeutic use ; Clinical Trials as Topic ; Hepatitis C/drug therapy ; Humans ; Patient Selection ; Treatment Outcome
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2002-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1053/jhep.2002.36991
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  5. Article ; Online: Diagnosis, management, and treatment of hepatitis C: an update.

    Ghany, Marc G / Strader, Doris B / Thomas, David L / Seeff, Leonard B

    Hepatology (Baltimore, Md.)

    2009  Volume 49, Issue 4, Page(s) 1335–1374

    MeSH term(s) Biopsy ; Counseling ; Drug Users ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Hepatitis C/therapy ; Humans ; Interferon alpha-2 ; Interferon-alpha/therapeutic use ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Mental Disorders/complications ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins ; Retreatment ; Ribavirin/therapeutic use ; Treatment Failure
    Chemical Substances Interferon alpha-2 ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (3WJQ0SDW1A) ; Ribavirin (49717AWG6K) ; peginterferon alfa-2b (G8RGG88B68) ; peginterferon alfa-2a (Q46947FE7K)
    Language English
    Publishing date 2009-04-10
    Publishing country United States
    Document type Journal Article ; Practice Guideline
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.22759
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  6. Article ; Online: An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases.

    Ghany, Marc G / Nelson, David R / Strader, Doris B / Thomas, David L / Seeff, Leonard B

    Hepatology (Baltimore, Md.)

    2011  Volume 54, Issue 4, Page(s) 1433–1444

    MeSH term(s) Antiviral Agents/therapeutic use ; Drug Resistance, Viral ; Female ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/physiopathology ; Humans ; Male ; Oligopeptides/therapeutic use ; Prognosis ; Proline/analogs & derivatives ; Proline/therapeutic use ; Protease Inhibitors/therapeutic use ; Randomized Controlled Trials as Topic/standards ; Recurrence ; Risk Assessment ; Societies, Medical ; Treatment Outcome ; United States
    Chemical Substances Antiviral Agents ; Oligopeptides ; Protease Inhibitors ; telaprevir (655M5O3W0U) ; N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide (89BT58KELH) ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2011-09-26
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Practice Guideline
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.24641
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  7. Article: Diagnosis, management, and treatment of hepatitis C.

    Strader, Doris B / Wright, Teresa / Thomas, David L / Seeff, Leonard B

    Hepatology (Baltimore, Md.)

    2004  Volume 39, Issue 4, Page(s) 1147–1171

    MeSH term(s) Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/surgery ; Humans ; Liver Transplantation
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2004-04
    Publishing country United States
    Document type Guideline ; Journal Article ; Practice Guideline
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.20119
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  8. Article ; Online: National Institutes of Health consensus development conference statement: management of hepatitis B.

    Sorrell, Michael F / Belongia, Edward A / Costa, Jose / Gareen, Ilana F / Grem, Jean L / Inadomi, John M / Kern, Earl R / McHugh, James A / Petersen, Gloria M / Rein, Michael F / Strader, Doris B / Trotter, Hartwell T

    Hepatology (Baltimore, Md.)

    2009  Volume 49, Issue 5 Suppl, Page(s) S4–S12

    MeSH term(s) Hepatitis B, Chronic/epidemiology ; Hepatitis B, Chronic/prevention & control ; Hepatitis B, Chronic/therapy ; Humans ; Practice Guidelines as Topic ; Research
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Consensus Development Conference, NIH ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.22946
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  9. Article ; Online: National Institutes of Health Consensus Development Conference Statement: management of hepatitis B.

    Sorrell, Michael F / Belongia, Edward A / Costa, Jose / Gareen, Ilana F / Grem, Jean L / Inadomi, John M / Kern, Earl R / McHugh, James A / Petersen, Gloria M / Rein, Michael F / Strader, Doris B / Trotter, Hartwell T

    Annals of internal medicine

    2009  Volume 150, Issue 2, Page(s) 104–110

    MeSH term(s) Adult ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Biomedical Research ; Carcinoma, Hepatocellular/virology ; Global Health ; Hepatitis B/epidemiology ; Hepatitis B/physiopathology ; Hepatitis B/therapy ; Humans ; Liver Cirrhosis/virology ; Liver Neoplasms/virology ; Prevalence ; Risk Assessment ; Treatment Outcome
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2009-01-05
    Publishing country United States
    Document type Consensus Development Conference, NIH ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-150-2-200901200-00100
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  10. Article: More severe parenchymal injury in chronic hepatitis C acquired by recent injection drug use.

    Yeh, Matthew M / Buskell, Zelma J / Seeff, Leonard B / Strader, Doris / Wright, Elizabeth C / Goodman, Zachary D

    Journal of clinical gastroenterology

    2005  Volume 39, Issue 8, Page(s) 722–727

    Abstract: Objective: Histologic liver injury is reported to be less severe in persons who acquire hepatitis C through injection drug use (IDU) than by blood transfusion. Because age correlates with histologic severity, it may be that differences between routes of ...

    Abstract Objective: Histologic liver injury is reported to be less severe in persons who acquire hepatitis C through injection drug use (IDU) than by blood transfusion. Because age correlates with histologic severity, it may be that differences between routes of acquisition reflect the younger age of most drug abusers. The early histopathologic changes of hepatitis C acquired through IDU are less defined, probably because of the lack of liver biopsy material from a cohort of patients not long after initial exposure. The availability of material from a cohort of patients who had liver biopsy for IDU-related hepatitis C in the 1970s enabled us to compare the histology with that of current patients.
    Methods: Liver biopsies of a group of injection drug users (n=70, all males; mean age, 27.6 years, designated as Group 1) in the 1970s cohort were compared with biopsies of patients (n=63, all males; mean age, 48 years, designated as Group 2, 23 who admitted past IDU) entering a treatment trial in 1999. All patients were positive for anti-HCV at the time of biopsy.
    Results: The histologic features of the 23 patients in Group 2 with a history of IDU did not differ significantly from the other 40 patients who denied past IDU. Using a modified Histologic Activity Index (HAI), there was no difference between Group 1 and Group 2 in portal inflammation or periportal injury. However, parenchymal (lobular) injury and inflammation was significantly (P<0.0001) greater in Group 1 than Group 2. Fibrosis was significantly (P=0.014) greater in Group 2.
    Conclusions: The degree of parenchymal injury was greater in Group 1 than Group 2, perhaps because they were closer to the time of exposure or possibly because of a stronger immunologic response in younger patients. The degree of hepatic fibrosis was greater in Group 2, suggesting that progression with age may be the natural history of chronic hepatitis C.
    MeSH term(s) Adult ; Aged ; Biopsy ; Disease Progression ; Follow-Up Studies ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/transmission ; Humans ; Liver/pathology ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Substance Abuse, Intravenous/pathology ; Time Factors
    Language English
    Publishing date 2005-07-16
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/01.mcg.0000173852.70419.21
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