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  1. Article ; Online: Reply to "Causes and manifestation of chylothorax in children".

    Shen, Kunling

    Pediatric investigation

    2018  Volume 2, Issue 3, Page(s) 204

    Language English
    Publishing date 2018-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The relationship between changes in peak expiratory flow and asthma exacerbations in asthmatic children.

    Chen, Xiongbin / Han, Peng / Kong, Yan / Shen, Kunling

    BMC pediatrics

    2024  Volume 24, Issue 1, Page(s) 284

    Abstract: Background: Asthma is one of the most common chronic airway diseases in children. Preventing asthma exacerbation is one of the objectives of all asthma action plans. In patients with poor perception, it is difficult to identify acute asthma ... ...

    Abstract Background: Asthma is one of the most common chronic airway diseases in children. Preventing asthma exacerbation is one of the objectives of all asthma action plans. In patients with poor perception, it is difficult to identify acute asthma exacerbations by clinical asthma score, asthma control test or asthma control questionnaire. The aim of this study is to analyze whether children with asthma have changes in peak expiratory flow(PEF)before an acute asthma exacerbation and to evaluate the relationship between PEF and asthma exacerbation.
    Methods: Basic information (including sex, age, atopy, etc.) and clinical information of asthmatic children who registered in the Electronic China Children's Asthma Action Plan (e-CCAAP) from 1 September 2017 to 31 August 2021 were collected. Subjects with 14 consecutive days of PEF measurements were eligible. Subjects in this study were divided into an exacerbation group and a control group. We analyzed the relationship between changes in PEF% pred and the presence of asthma symptoms.
    Result: A total of 194 children with asthma who met the inclusion criteria were included, including 144 males (74.2%) and 50 females (25.8%), with a male-to-female ratio of 2.88:1. The mean age of the subjects was 9.51 ± 2.5 years. There were no significant differences in sex, age, allergy history or baseline PEF between the two groups. In children with and without a history of allergy, there was no significant difference between the variation in PEF at 14 days. Patients who only had a reduced in PEF but no symptoms of asthma exacerbation had the greatest reduction in PEF compared to the other groups. The most common cause of acute exacerbations of asthma is upper respiratory tract infection. Among the causes of acute exacerbations of asthma, the variation in PEF caused by air pollution was significantly higher than that of other causes (P < 0.05). In acute exacerbations, the decrease in PEF was significantly greater in the exacerbation group than in the control group. In children with asthma symptoms, there was a decrease in PEF approximately 1.34 days before the onset of symptoms.
    Conclusion: Children with asthma show a decrease in PEF 1.34 days before the onset of asthma symptoms. We recommend that asthmatic children who show a decrease in PEF should step-up asthma therapy. The most common cause of acute exacerbations of asthma was upper respiratory tract infections, and the variation in PEF caused by air pollution was significantly higher than that caused by other factors.
    MeSH term(s) Humans ; Asthma/physiopathology ; Asthma/complications ; Female ; Male ; Child ; Peak Expiratory Flow Rate ; Disease Progression ; China/epidemiology ; Adolescent
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-024-04754-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Age, Sex, and Geographical Distribution of Self-Reported Asthma Triggers on Children With Asthma in China.

    Zhang, Changhao / Kong, Yan / Shen, Kunling

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 689024

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.689024
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  4. Article ; Online: The Relationship of Satisfaction and Worry about Physical Activity with Physical-Activity Level in Children with Asthma.

    Zhang, Changhao / Xu, Wei / Xu, Baoping / Shen, Kunling

    Indian journal of pediatrics

    2021  Volume 88, Issue 5, Page(s) 492–493

    MeSH term(s) Anxiety ; Asthma ; Child ; Exercise ; Humans ; Personal Satisfaction
    Language English
    Publishing date 2021-02-03
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-020-03615-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 2020 Global Pediatric Pulmonology Alliance (GPPA) Forum on COVID-19.

    Shen, Kunling / Li, Spencer / Guan, Yu / Yang, Yonghong

    Pediatric investigation

    2020  Volume 4, Issue 4, Page(s) 225–229

    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12229
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  6. Article ; Online: Pulmonary Infection with Lophomonas blattarum.

    Ding, Qin / Shen, Kunling

    Indian journal of pediatrics

    2020  Volume 88, Issue 1, Page(s) 23–27

    Abstract: Objective: To describe the characteristics of Lophomonas blattarum infection in children based on a retrospective review of medical records data from Beijing Children's Hospital, Capital Medical University, China.: Methods: This study included 53 ... ...

    Abstract Objective: To describe the characteristics of Lophomonas blattarum infection in children based on a retrospective review of medical records data from Beijing Children's Hospital, Capital Medical University, China.
    Methods: This study included 53 cases from July 2014 through December 2016. The data were tabulated and statistically analysed in a Microsoft Excel spreadsheet and SPSS 17.0.
    Results: The average age of the 53 patients was 7.10 ± 0.56 years, and the male/female ratio was 3:2.3. The most common clinical manifestation was cough, and almost half of the patients had fever. Furthermore, all patients were treated with metronidazole and recovered.
    Conclusions: For children who have had long-term respiratory symptoms, the possibility of Lophomonas blattarum infection should be ruled out. Metronidazole is effective in treating L. blattarum infection in children.
    MeSH term(s) Child ; China/epidemiology ; Cough ; Female ; Humans ; Lung Diseases, Parasitic ; Male ; Pneumonia ; Retrospective Studies
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-020-03311-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Type I interferon: From innate response to treatment for COVID-19.

    Lin, Fuyu / Shen, Kunling

    Pediatric investigation

    2020  Volume 4, Issue 4, Page(s) 275–280

    Abstract: Effective prophylactic and therapeutic interventions are urgently needed to address the coronavirus disease 2019 (COVID-19) pandemic. Various antiviral drugs have recently been tested. Type I interferon (IFN) is a regulatory protein involved in the ... ...

    Abstract Effective prophylactic and therapeutic interventions are urgently needed to address the coronavirus disease 2019 (COVID-19) pandemic. Various antiviral drugs have recently been tested. Type I interferon (IFN) is a regulatory protein involved in the innate immune response, with broad-spectrum antiviral activities and the ability to directly block viral replication and support the immune response to eliminate virus infection. Insufficient virus-induced type I IFN production is characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, because SARS-CoV-2 suppresses the IFN response by interacting with essential IFN signaling pathways. Exogenous type I IFN is recommended for treating COVID-19. Unexpectedly however, angiotensin converting enzyme-2 (ACE2) receptor, which acts as a SARS-CoV-2 receptor, was shown to be stimulated by IFN, raising doubts about the suitability of IFN use. However, further studies have excluded concerns regarding IFN administration. Type I IFNs, including IFN-α1b, have been used clinically as antiviral drugs for many years and have shown strong antiviral activity against SARS-CoV-2
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antibiotic prescriptions for children younger than 5 years with acute upper respiratory infections in China: a retrospective nationwide claims database study.

    Xue, Fengxia / Xu, Baoping / Shen, Adong / Shen, Kunling

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 339

    Abstract: Background: In China, there were few studies to estimate antibiotic use for children with upper respiratory infections at the national level. The aim of this study was to describe the antibiotic prescribing practice for children aged < 5 years old with ... ...

    Abstract Background: In China, there were few studies to estimate antibiotic use for children with upper respiratory infections at the national level. The aim of this study was to describe the antibiotic prescribing practice for children aged < 5 years old with upper respiratory infections (URIs) using a nationwide claims database.
    Methods: This was a retrospective cross-sectional study using a sampled database from the China Health Insurance Research Association (CHIRA). Study subjects included children younger than 5 years with outpatient visits in 2015 that resulted in a diagnosis of a upper respiratory infection. We calculated the percentage of visits who received antibiotics, the proportion of injection formulations, the percentage of combined antibiotics and the proportion of each antibiotic class. The patterns of antibiotic prescription were also described by medical institution type, city level and geographical region.
    Results: Among the 92,821 visits, 27.1% were prescribed antibiotics, of which 27.0% received injection formulations. The rate of antibiotic prescribing varied by age group (P < 0.001), with the lowest (16.0%) in infants and the highest in patients at age 3 to < 4 years (29.9%) and age 4 to < 5 years (32.5%). The Midwestern region, underdeveloped cities and low-level hospitals represented relatively higher rates of prescribing antibiotics (P < 0.001) and higher proportions of injection dosage forms (P < 0.001). The most 3 common antibiotic classes prescribed of all visits with antibiotic prescriptions were the third-generation cephalosporins (34.9%), macrolides (24.3%), and the second-generation cephalosporins (23.3%).
    Conclusions: In mainland China, the overall rate of antibacterial prescribing and the proportion of injection formulations prescribed in children under 5 years with URIs were at a low level, but still higher in underdeveloped regions and cities. Moreover, the overuse of the second and third generation cephalosporins, macrolides, remains a serious issue. Further efforts should be focused on reducing those non-first-line antibiotic prescribing and narrowing the gaps among regions and cities.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child, Preschool ; China ; Cross-Sectional Studies ; Databases, Factual ; Drug Prescriptions/statistics & numerical data ; Female ; Humans ; Infant ; Male ; Respiratory Tract Infections/drug therapy ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05997-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Analysis of risk factors for acute attacks complicated by respiratory failure in children with asthma.

    Han, Peng / Jiao, Anxia / Yin, Ju / Zou, Huimin / Liu, Yuliang / Li, Zheng / Wang, Quan / Wu, Jie / Shen, Kunling

    Frontiers in pediatrics

    2024  Volume 11, Page(s) 1335540

    Abstract: Objective: To describe the proportion and clinical characteristics of hospitalized children with acute asthma attacks complicated by respiratory failure and to analyze the risk factors.: Methods: This retrospective study analyzed hospital admissions ... ...

    Abstract Objective: To describe the proportion and clinical characteristics of hospitalized children with acute asthma attacks complicated by respiratory failure and to analyze the risk factors.
    Methods: This retrospective study analyzed hospital admissions of children and adolescents with acute asthma attacks between January 2016 and December 2021. Inclusion criteria were used to identify eligible cases, and demographic information and disease characteristics were collected. Patients were categorized into respiratory failure group and the other group based on the result of artery blood gas analysis. Multivariate logistic regression was utilized to investigate the risk factors associated with respiratory failure resulting from acute asthma attacks. The data were analyzed using SPSS 22.0, and significance was considered at
    Results: Our research involved 225 participants, with 18.7% diagnosed with respiratory failure. The respiratory failure group was found to be younger and have higher percentage of male, while birth weight, nationality, and type of residence did not differ between the two groups. In the respiratory failure group, a significant difference was observed in emergency hospitalization, ICU treatment, severe to critical attack, dyspnea and allergy history. The two groups did not differ in admission season, first asthma diagnosis, respiratory infection and comorbidity. The respiratory failure group exhibited a higher proportion of atopy-only asthma and a lower proportion of T2-high asthma. The eosinophil count, and eosinophil percentage were lower in the respiratory failure group, while neutrophil count was higher. Having a history of allergies (OR = 2.46, 95% CI: 1.08-5.59) and neutrophil count (OR = 1.10, 95% CI: 1.00-1.21) were the risk factors for respiratory failure in children with asthma. There also existed that the risk of respiratory failure increases with decreasing age of the children (OR = 0.85, 95% CI: 0.73-0.99).
    Conclusion: Notably, risk factors for respiratory failure in hospitalized asthma children include age, having a history of allergies, and neutrophil count. The identification of the above factors and the implementation of timely intervention can optimize the treatment of asthma in children.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1335540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Congenital chylothorax: Rare disease, wide concern.

    Shen, Kunling / Zhaori, Getu

    Pediatric investigation

    2017  Volume 1, Issue 1, Page(s) 26

    Language English
    Publishing date 2017-12-27
    Publishing country United States
    Document type Editorial
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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