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  1. Article ; Online: A silver(I) coordinated phenanthroline-based polymer with high ethylene/ethane adsorption selectivity.

    Yu, Chao / Cowan, Matthew G / Noble, Richard D / Zhang, Wei

    Chemical communications (Cambridge, England)

    2014  Volume 50, Issue 43, Page(s) 5745–5747

    Abstract: ... ideal ethylene/ethane adsorption selectivity (15/1) and high ethylene uptake (5.0 mmol g(-1)) at ambient ...

    Abstract We report a non-porous silver(i) coordinated phenanthroline-based polymer, which exhibits a high ideal ethylene/ethane adsorption selectivity (15/1) and high ethylene uptake (5.0 mmol g(-1)) at ambient temperature and pressure. Both silver(i) coordination and polymer structures are important for the high uptake of ethylene.
    Language English
    Publishing date 2014-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c4cc02143f
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  2. Article ; Online: High ethene/ethane selectivity in 2,2'-bipyridine-based silver(i) complexes by removal of coordinated solvent.

    Cowan, Matthew G / McDanel, William M / Funke, Hans H / Kohno, Yuki / Gin, Douglas L / Noble, Richard D

    Angewandte Chemie (International ed. in English)

    2015  Volume 54, Issue 19, Page(s) 5740–5743

    Abstract: ... and [Ag(I) (6,6'-dimethyl-2,2'-bipyridine)][OTf] (2) show ethene/ethane sorption selectivities of 390 ... when tested at an applied gas pressure of 90 kPa and a temperature of (20±1) °C. These ethene/ethane ... selectivities are 13 times higher than those reported for known solid sorbents for ethene/ethane separation ...

    Abstract Following removal of coordinated CH3 CN, the resulting complexes [Ag(I) (2,2'-bipyridine)][BF4 ] (1) and [Ag(I) (6,6'-dimethyl-2,2'-bipyridine)][OTf] (2) show ethene/ethane sorption selectivities of 390 and 340, respectively, and corresponding ethene sorption capacities of 2.38 and 2.18 mmol g(-1) when tested at an applied gas pressure of 90 kPa and a temperature of (20±1) °C. These ethene/ethane selectivities are 13 times higher than those reported for known solid sorbents for ethene/ethane separation. For 2, ethene sorption reached 90 % of equilibrium capacity within 15 minutes, and this equilibrium capacity was maintained over the three sorption/desorption cycles tested. The rates of ethene sorption were also measured. To our knowledge, these are the first complexes, designed for olefin/paraffin separations, which have open silver(I) sites. The high selectivities arise from these open silver(I) sites and the relatively low molecular surface areas of the complexes.
    Language English
    Publishing date 2015-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201500251
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  3. Article: A silver(i) coordinated phenanthroline-based polymer with high ethylene/ethane adsorption selectivity

    Yu, Chao / Cowan, Matthew G / Noble, Richard D / Zhang, Wei

    Chemical communications. 2014 May 1, v. 50, no. 43

    2014  

    Abstract: ... ideal ethylene/ethane adsorption selectivity (15/1) and high ethylene uptake (5.0 mmol g⁻¹) at ambient ...

    Abstract We report a non-porous silver(i) coordinated phenanthroline-based polymer, which exhibits a high ideal ethylene/ethane adsorption selectivity (15/1) and high ethylene uptake (5.0 mmol g⁻¹) at ambient temperature and pressure. Both silver(i) coordination and polymer structures are important for the high uptake of ethylene.
    Keywords adsorption ; ambient temperature ; chemical reactions ; ethane ; ethylene ; polymers ; silver
    Language English
    Dates of publication 2014-0501
    Size p. 5745-5747.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c4cc02143f
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  4. Article: Time-resolved infrared (TRIR) study on the formation and reactivity of organometallic methane and ethane complexes in room temperature solution.

    Cowan, Alexander J / Portius, Peter / Kawanami, Hajime K / Jina, Omar S / Grills, David C / Sun, Xue-Zhong / McMaster, Jonathan / George, Michael W

    Proceedings of the National Academy of Sciences of the United States of America

    2007  Volume 104, Issue 17, Page(s) 6933–6938

    Abstract: ... methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L ... and ethane complexes with CO have been measured, and the DeltaH++ values represent lower limits ...

    Abstract We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L) [where M = Mn or Re, R = H or CH3 (Re only); and L = CH4 or C2H6]. In all cases, the methane complexes are found to be short-lived and significantly more reactive than the analogous n-heptane complexes. Re(Cp)(CO)2(CH4) and Re(Cp*)(CO)2(L) [Cp* = eta5-C5(CH3)(5) and L = CH4, C2H6] were found to be in rapid equilibrium with the alkyl hydride complexes. In the presence of CO, both alkane and alkyl hydride complexes decay at the same rate. We have used picosecond time-resolved infrared spectroscopy to directly monitor the photolysis of Re(Cp*)(CO)3 in scCH4 and demonstrated that the initially generated Re(Cp*)(CO)2(CH4) forms an equilibrium mixture of Re(Cp*)(CO)2(CH4)/Re(Cp*)(CO)2(CH3)H within the first few nanoseconds (tau = 2 ns). The ratio of alkane to alkyl hydride complexes varies in the order Re(Cp)(CO)2(C2H6):Re(Cp)(CO)2(C2H5)H > Re(Cp*)(CO)2(C2H6):Re(Cp*)(CO)2(C2H5)H approximately equal to Re(Cp)(CO)2(CH4):Re(Cp)(CO)2(CH3)H > Re(Cp*)(CO)2(CH4):Re(Cp*)(CO)2(CH3)H. Activation parameters for the reactions of the organometallic methane and ethane complexes with CO have been measured, and the DeltaH++ values represent lower limits for the CH4 binding enthalpies to the metal center of W-CH4 (30 kJ.mol(-1)), Mn-CH4 (39 kJ.mol(-1)), and Re-CH4 (51 kJ.mol(-1)) bonds in W(CO)5(CH4), Mn(Cp)(CO)2(CH4), and Re(Cp)(CO)2(CH4), respectively.
    Language English
    Publishing date 2007-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0610567104
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    Zs.A 1148: Show issues Location:
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  5. Article: Time-resolved infrared (TRIR) study on the formation and reactivity of organometallic methane and ethane complexes in room temperature solution

    Cowan, Alexander J / Portius, Peter / Kawanami, Hajime K / Jina, Omar S / Grills, David C / Sun, Xue-Zhong / McMaster, Jonathan / George, Michael W

    Proceedings of the National Academy of Sciences of the United States of America. 2007 Apr. 24, v. 104, no. 17

    2007  

    Abstract: ... methane and ethane complexes in solution at room temperature: W(CO)₅(CH₄) and M(η⁵Formula C₅R₅)(CO)₂(L ... ethane complexes with CO have been measured, and the ΔH[double dagger] values represent lower limits ...

    Abstract We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)₅(CH₄) and M(η⁵Formula C₅R₅)(CO)₂(L) [where M = Mn or Re, R = H or CH₃ (Re only); and L = CH₄ or C₂H₆]. In all cases, the methane complexes are found to be short-lived and significantly more reactive than the analogous n-heptane complexes. Re(Cp)(CO)₂(CH₄) and Re(Cp*)(CO)₂(L) [Cp* = η⁵Formula C₅(CH₃)₅ and L = CH₄, C₂H₆] were found to be in rapid equilibrium with the alkyl hydride complexes. In the presence of CO, both alkane and alkyl hydride complexes decay at the same rate. We have used picosecond time-resolved infrared spectroscopy to directly monitor the photolysis of Re(Cp*)(CO)₃ in scCH₄ and demonstrated that the initially generated Re(Cp*)(CO)₂(CH₄) forms an equilibrium mixture of Re(Cp*)(CO)₂(CH₄)/Re(Cp*)(CO)₂(CH₃)H within the first few nanoseconds (τ = 2 ns). The ratio of alkane to alkyl hydride complexes varies in the order Re(Cp)(CO)₂(C₂H₆):Re(Cp)(CO)₂(C₂H₅)H > Re(Cp*)(CO)₂(C₂H₆):Re(Cp*)(CO)₂(C₂H₅)H [almost equal to] Re(Cp)(CO)₂(CH₄):Re(Cp)(CO)₂(CH₃)H > Re(Cp*)(CO)₂(CH₄):Re(Cp*)(CO)₂(CH₃)H. Activation parameters for the reactions of the organometallic methane and ethane complexes with CO have been measured, and the ΔH[double dagger] values represent lower limits for the CH₄ binding enthalpies to the metal center of WFormula CH₄ (30 kJ·mol⁻¹), MnFormula CH₄ (39 kJ·mol⁻¹), and ReFormula CH₄ (51 kJ·mol⁻¹) bonds in W(CO)₅(CH₄), Mn(Cp)(CO)₂(CH₄), and Re(Cp)(CO)₂(CH₄), respectively.
    Language English
    Dates of publication 2007-0424
    Size p. 6933-6938.
    Publishing place National Academy of Sciences
    Document type Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
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  6. Article ; Online: National Institute on Drug Abuse Clinical Trials Network Meeting Report: Advancing Emergency Department Initiation of Buprenorphine for Opioid Use Disorder.

    Cowan, Ethan / Perrone, Jeanmarie / Bernstein, Steven L / Coupet, Edouard / Fiellin, David A / Hawk, Kathryn / Herring, Andrew / Huntley, Kristen / McCormack, Ryan / Venkatesh, Arjun / D'Onofrio, Gail

    Annals of emergency medicine

    2023  Volume 82, Issue 3, Page(s) 326–335

    Abstract: Opioid use disorder and opioid overdose deaths are a major public health crisis, yet highly effective evidence-based treatments are available that reduce morbidity and mortality. One such treatment, buprenorphine, can be initiated in the emergency ... ...

    Abstract Opioid use disorder and opioid overdose deaths are a major public health crisis, yet highly effective evidence-based treatments are available that reduce morbidity and mortality. One such treatment, buprenorphine, can be initiated in the emergency department (ED). Despite evidence of efficacy and effectiveness for ED-initiated buprenorphine, universal uptake remains elusive. On November 15 and 16, 2021, the National Institute on Drug Abuse Clinical Trials Network convened a meeting of partners, experts, and federal officers to identify research priorities and knowledge gaps for ED-initiated buprenorphine. Meeting participants identified research and knowledge gaps in 8 categories, including ED staff and peer-based interventions; out-of-hospital buprenorphine initiation; buprenorphine dosing and formulations; linkage to care; strategies for scaling ED-initiated buprenorphine; the effect of ancillary technology-based interventions; quality measures; and economic considerations. Additional research and implementation strategies are needed to enhance adoption into standard emergency care and improve patient outcomes.
    MeSH term(s) United States ; Humans ; Buprenorphine/therapeutic use ; Narcotic Antagonists/therapeutic use ; National Institute on Drug Abuse (U.S.) ; Opioid-Related Disorders/drug therapy ; Emergency Service, Hospital
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Narcotic Antagonists
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.03.025
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  7. Article ; Online: Is preexposure prophylaxis ready for prime time use in HIV prevention research?

    Cowan, Ethan A / Macklin, Ruth

    AIDS (London, England)

    2014  Volume 28, Issue 3, Page(s) 293–295

    MeSH term(s) Biomedical Research/methods ; Chemoprevention ; Clinical Trials as Topic ; HIV Infections/prevention & control ; Humans
    Language English
    Publishing date 2014-01-28
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000000055
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  8. Article ; Online: Early emergency department experience with 7-day extended-release injectable buprenorphine for opioid use disorder.

    D'Onofrio, Gail / Perrone, Jeanmarie / Hawk, Kathryn F / Cowan, Ethan / McCormack, Ryan / Coupet, Edouard / Owens, Patricia H / Martel, Shara H / Huntley, Kristen / Walsh, Sharon L / Lofwall, Michelle R / Herring, Andrew

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2023  Volume 30, Issue 12, Page(s) 1264–1271

    Abstract: As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical ... ...

    Abstract As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical challenges such as the ability to fill a prescription and transportation, concerns regarding diversion, and availability of urgent referral sites. Extended-release buprenorphine (XR-BUP) preparations such as a new 7-day injectable could potentially solve some of these issues. We describe the pharmacokinetics of a new 7-day XR-BUP formulation and the feasibility of its use in the ED setting. We report our early experiences with this medication (investigational drug CAM2038), in the context of an ongoing clinical trial entitled Emergency Department-Initiated BUP VAlidaTION (ED INNOVATION), to inform emergency clinicians as they consider incorporating this medication into their practice. The medication was approved by the European Medicines Agency in 2018 and the U.S. Food and Drug Administration in 2023 for those 18 years or older for the treatment of moderate to severe opioid use disorder (OUD). We report our experience with approximately 800 ED patients with OUD who received the 7-day XR-BUP preparation in the ED between June 2020 and July 2023.
    MeSH term(s) Humans ; Buprenorphine/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Emergency Service, Hospital ; Analgesics, Opioid/therapeutic use
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Narcotic Antagonists ; Analgesics, Opioid
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14782
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  9. Article: URINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW.

    Cowan, Ethan / Perrone, Jeanmarie / Dziura, James / Edelman, E Jennifer / Hawk, Kathryn / Herring, Andrew / McCormack, Ryan / Murphy, Alexandra / Phadke, Manali / Fiellin, David A / D'Onofrio, Gail

    The Journal of emergency medicine

    2023  Volume 65, Issue 4, Page(s) e357–e365

    Abstract: Background: Opioid overdose deaths in 2021 were the highest ever, driven by fentanyl and polysubstance use.: Objective: The aim of the study was to characterize drug use, assessed by urine drug screens (UDSs), in patients with untreated opioid use ... ...

    Abstract Background: Opioid overdose deaths in 2021 were the highest ever, driven by fentanyl and polysubstance use.
    Objective: The aim of the study was to characterize drug use, assessed by urine drug screens (UDSs), in patients with untreated opioid use disorder (OUD) presenting to 28 emergency departments (EDs) nationally and by region.
    Methods: We analyzed UDSs from patients enrolled in the CTN-0099 ED-INNOVATION (Emergency Department-Initiated Buprenorphine Validation) trial between July 12, 2020 and March 9, 2022. Participants were adult ED patients with OUD not engaged in addiction treatment with a UDS positive for an opioid, but negative for methadone. Sites were divided into "East" and "West" regions.
    Results: A UDS was available for all 925 enrolled participants, 543 from East and 382 from West. Fentanyl was in 702 specimens (76%) (n = 485 [89%] East vs. n = 217 [57%] West; p < 0.01) and was the only opioid in 269 (29%). After fentanyl, the most common opioids were morphine (presumably heroin; n = 411 [44%]; n = 192 [35%] East vs. n = 219 [57%] West; p < 0.01) and buprenorphine (n = 329 [36%]; n = 186 [35%] East vs. n = 143 [37%] West; p = 0.32). The most common drugs found with opioids were stimulants (n = 545 [59%]), tetrahydrocannabinol (n = 417 [45%]), and benzodiazepines (n = 151 [16%]). Amphetamine-type stimulants were more common in West (n = 209 [55%] vs. East (n = 125 [23%]). Cocaine was more common in East (n = 223 [41%]) vs. West (n = 82 [21%]). The presence of multiple drugs was common (n = 759 [82%]).
    Conclusions: Most participants had UDS specimens containing multiple substances; a high proportion had fentanyl, stimulants, and buprenorphine. Regional differences were noted. Given the increased risk of death with fentanyl and polysubstance use, ED providers should be providing risk reduction counseling, treatment, and referral.
    MeSH term(s) Adult ; Humans ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/drug therapy ; Buprenorphine/therapeutic use ; Fentanyl/therapeutic use ; Emergency Service, Hospital ; Drug Overdose/drug therapy
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.06.007
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  10. Article ; Online: Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner.

    Anderson, Ethan M / Tsvetkov, Evgeny / Galante, Allison / DeVries, Derek / McCue, Lauren M / Wood, Daniel / Barry, Sarah / Berto, Stefano / Lavin, Antonieta / Taniguchi, Makoto / Cowan, Christopher W

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 7, Page(s) e2210953120

    Abstract: Opioid use produces enduring associations between drug reinforcement/euphoria and discreet or diffuse cues in the drug-taking environment. These powerful associations can trigger relapse in individuals recovering from opioid use disorder (OUD). Here, we ... ...

    Abstract Opioid use produces enduring associations between drug reinforcement/euphoria and discreet or diffuse cues in the drug-taking environment. These powerful associations can trigger relapse in individuals recovering from opioid use disorder (OUD). Here, we sought to determine whether the epigenetic enzyme, histone deacetylase 5 (HDAC5), regulates relapse-associated behavior in an animal model of OUD. We examined the effects of nucleus accumbens (NAc) HDAC5 on both heroin- and sucrose-seeking behaviors using operant self-administration paradigms. We utilized cre-dependent viral-mediated approaches to investigate the cell-type-specific effects of HDAC5 on heroin-seeking behavior, gene expression, and medium spiny neuron (MSN) cell and synaptic physiology. We found that NAc HDAC5 functions during the acquisition phase of heroin self-administration to limit future relapse-associated behavior. Moreover, overexpressing HDAC5 in the NAc suppressed context-associated and reinstated heroin-seeking behaviors, but it did not alter sucrose seeking. We also found that HDAC5 functions within dopamine D1 receptor-expressing MSNs to suppress cue-induced heroin seeking, and within dopamine D2 receptor-expressing MSNs to suppress drug-primed heroin seeking. Assessing cell-type-specific transcriptomics, we found that HDAC5 reduced expression of multiple ion transport genes in both D1- and D2-MSNs. Consistent with this observation, HDAC5 also produced firing rate depression in both MSN classes. These findings revealed roles for HDAC5 during active heroin use in both D1- and D2-MSNs to limit distinct triggers of drug-seeking behavior. Together, our results suggest that HDAC5 might limit relapse vulnerability through regulation of ion channel gene expression and suppression of MSN firing rates during active heroin use.
    MeSH term(s) Mice ; Animals ; Mice, Transgenic ; Heroin/metabolism ; Heroin/pharmacology ; Cocaine/pharmacology ; Reinforcement, Psychology ; Drug-Seeking Behavior/physiology ; Epigenesis, Genetic ; Nucleus Accumbens/physiology ; Self Administration
    Chemical Substances Heroin (70D95007SX) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2210953120
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