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  1. Article: Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy.

    Anyanwu, Chinekwu / Motamedi, Gholam K

    Brain sciences

    2018  Volume 8, Issue 4

    Abstract: Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory). Epilepsy surgery offers a potential cure or significant improvement to those with focal onset drug- ... ...

    Abstract Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory). Epilepsy surgery offers a potential cure or significant improvement to those with focal onset drug-resistant seizures. Unfortunately, epilepsy surgery is still underutilized which might be in part because of the complexity of presurgical evaluation. This process includes classifying the seizure type, lateralizing and localizing the seizure onset focus (epileptogenic zone), confirming the safety of the prospective brain surgery in terms of potential neurocognitive deficits (language and memory functions), before devising a surgical plan. Each one of the above steps requires special tests. In this paper, we have reviewed the process of presurgical evaluation in patients with drug-resistant focal onset epilepsy.
    Language English
    Publishing date 2018-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci8040049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Case report: An EEG captured case of migralepsy/migraine aura-triggered seizures.

    Hareem, Anam / Pahlavanzadeh, Mahsa / Calvo, Nicholas E / Monjazeb, Sanaz / Anyanwu, Chinekwu

    Frontiers in neurology

    2022  Volume 13, Page(s) 953224

    Abstract: Introduction: Migraine and epilepsy are common chronic neurological disorders presenting with paroxysmal attacks of transient cerebral dysfunction, followed by subsequent return to baseline between episodes. The term "migralepsy" has been proposed to ... ...

    Abstract Introduction: Migraine and epilepsy are common chronic neurological disorders presenting with paroxysmal attacks of transient cerebral dysfunction, followed by subsequent return to baseline between episodes. The term "migralepsy" has been proposed to define migraine-triggered epileptic seizures classified by the ICHD-III as a complication of migraine with an aura.
    Case: A 55-year-old man with a 30-year history of migraine without aura presented with a new onset left parietal pain accompanied by visual disturbances occurring up to 20 times per day. His visual distortions included kaleidoscopic vision, flashes of shadows, and a right superior quadrantanopia lasting 20 min. He described discrete 2-min episodes of scintillating scotomas in his right visual field. Ictal EEG demonstrated a left occipital onset focal aware seizure with his clinical symptoms. The patient was started on valproic Acid and has remained asymptomatic.
    Discussion: The diagnostic criteria as set out by the ICHD-III for migralepsy and other syndromes with migrainous and ictal features remain confusing for practitioners as there is much overlap in clinical manifestations of these entities. EEG should be obtained when ictal features are noted among patients presenting with headache.
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.953224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Management of pediatric refractory epilepsy

    Anyanwu, Chinekwu / Motamedi, Gholam K.

    Journal of Pediatric Epilepsy

    2012  Volume 01, Issue 04, Page(s) 203–209

    Abstract: About half of patients with epilepsy will become seizure free upon treatment with the first antiepileptic drug (AED). After trying further medications, overall, two thirds of patients will become seizure free on AED(s), while the remaining one third will ...

    Abstract About half of patients with epilepsy will become seizure free upon treatment with the first antiepileptic drug (AED). After trying further medications, overall, two thirds of patients will become seizure free on AED(s), while the remaining one third will continue having seizures. Patients who have failed treatment with adequate trials of two appropriate and tolerated AEDs, whether as monotherapy or in combination, are considered refractory (drug resistant). Appropriate diagnosis and optimal control of seizures are essential for a successful treatment and improved quality of life of patients with epilepsy. Since the introduction of a number of newer AEDs in the last decade, there have been improvements in tolerability and side effect profile of AED therapy. Failure to respond to the initial pharmacologic treatment should prompt trials of alternative options including reevaluation for accurate diagnosis and optimizing AED therapy, epilepsy (resective) surgery, vagus nerve stimulation, ketogenic diet, and a series of potentially effective pharmacological and surgical treatments currently under investigation.
    Keywords Pediatric refractory epilepsy ; drug resistant epilepsy ; pharmacotherapy
    Language English
    Publishing date 2012-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-4588 ; 2146-457X
    ISSN (online) 2146-4588
    ISSN 2146-457X
    DOI 10.3233/PEP-12032
    Database Thieme publisher's database

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  4. Article ; Online: Ethosuximide-induced conversion of typical childhood absence to Rolandic spikes.

    Anyanwu, Chinekwu / Ghavami, Forough / Schuelein, Marianne / Motamedi, Gholam K

    Journal of child neurology

    2013  Volume 28, Issue 1, Page(s) 111–114

    Abstract: Coexistence of 2 idiopathic epilepsy syndromes (ie, childhood absence and Rolandic epilepsy), as evidenced by electroencephalographic (EEG) findings with or without clinical features of the 2 conditions, is uncommon and remains controversial. Few case ... ...

    Abstract Coexistence of 2 idiopathic epilepsy syndromes (ie, childhood absence and Rolandic epilepsy), as evidenced by electroencephalographic (EEG) findings with or without clinical features of the 2 conditions, is uncommon and remains controversial. Few case reports support this coexistence either as a continuum or drug-induced conversion, whereas a large sample case review did not find such co-occurrence. The authors report a case of conversion of typical absence to Rolandic spikes after treatment with ethosuximide. An 11-year-old girl was diagnosed with typical childhood absence epilepsy at the age of 6 years with classic clinical and EEG features. She became seizure-free on ethosuximide but her follow-up EEGs consistently recorded right centrotemporal and centroparietal spikes without associated clinical seizures. This case may suggest simultaneous presence of these 2 common childhood idiopathic epilepsies either as a continuum or a drug-induced conversion.
    MeSH term(s) Anticonvulsants/adverse effects ; Child ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Epilepsy, Rolandic/chemically induced ; Epilepsy, Rolandic/diagnosis ; Ethosuximide/adverse effects ; Female ; Frontal Lobe/pathology ; Humans ; Magnetic Resonance Imaging
    Chemical Substances Anticonvulsants ; Ethosuximide (5SEH9X1D1D)
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/0883073812439250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2301: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: New onset left frontal lobe seizure presenting with ictal asystole.

    Enkiri, Sean A / Ghavami, Forough / Anyanwu, Chinekwu / Eldadah, Zayd / Morrissey, Richard L / Motamedi, Gholam K

    Seizure

    2011  Volume 20, Issue 10, Page(s) 817–819

    Abstract: Ictal asystole is a presumably rare but potentially fatal complication of seizures, most often of temporal lobe origin. It is believed that at least some cases of sudden unexplained death in epilepsy (SUDEP) might be triggered by ictal bradycardia or ... ...

    Abstract Ictal asystole is a presumably rare but potentially fatal complication of seizures, most often of temporal lobe origin. It is believed that at least some cases of sudden unexplained death in epilepsy (SUDEP) might be triggered by ictal bradycardia or asystole. Current standard practice is to implant a permanent pacemaker in these patients to prevent syncope and/or death. However, emerging data suggests that effective medical or surgical treatment of epilepsy might be enough to prevent cardiac asystole, eliminating the need for permanent pacemaker placement. We describe a case of new onset left frontal lobe epilepsy in a young athletic patient who presented with near-syncopal episodes but whose comprehensive work-up revealed frequent events of ictal bradycardia and asystole. He responded well to monotherapy using oxcarbazepine, avoiding a permanent pacemaker.
    MeSH term(s) Adult ; Anticonvulsants/therapeutic use ; Bradycardia/etiology ; Carbamazepine/analogs & derivatives ; Carbamazepine/therapeutic use ; Electrocardiography ; Electroencephalography ; Frontal Lobe/physiopathology ; Heart Arrest/etiology ; Humans ; Male ; Seizures/complications ; Seizures/drug therapy ; Seizures/physiopathology
    Chemical Substances Anticonvulsants ; Carbamazepine (33CM23913M) ; oxcarbazepine (VZI5B1W380)
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2011.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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