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  1. Article ; Online: Quantitative and qualitative survey feedback of pharmacists regarding current and prospective licensure models.

    Parker, Jessie / Howard, Rebecca / Holick, Andrew / Johanson, Erin

    Journal of the American Pharmacists Association : JAPhA

    2024  , Page(s) 102031

    Abstract: Background: Despite variation in licensure requirements and models for pharmacy practice nationwide, there is little published data within the United States regarding pharmacist perspectives.: Objectives: The purpose of this study was to identify the ...

    Abstract Background: Despite variation in licensure requirements and models for pharmacy practice nationwide, there is little published data within the United States regarding pharmacist perspectives.
    Objectives: The purpose of this study was to identify the demographics, awareness, and perceptions about current pharmacist licensure models.
    Methods: A fifteen-question mixed-methods survey was created and distributed via Qualtrics-XM Survey to all Utah licensed pharmacists (n = 4154). Data collection was August 22-September 22, 2022. Before survey distribution, pilot feedback was sought from the Utah Board of Pharmacy and pharmacists at the 118th National Association of Boards of Pharmacy (NABP) national conference. Exempt status was granted by Roseman University Institutional Review Board. Quantitative and qualitative data analysis allowed for descriptive statistics and thematic content identification.
    Results: The survey collected 972 responses for a response rate of 23% and a completion rate of 94%. Respondents self-identified 36 practice areas. Distribution of years in practice was well dispersed between the predefined ranges. Primary state of licensure was Utah (80%), with additional representation from all 50 states and Guam. The survey showed a variation in awareness regarding other healthcare professional licensing models with 40.83% "aware," 40.62% "unaware," and 18.55% "unsure". A majority showed awareness of the NABP Verify program (55.8%), but unawareness of the Electronic Licensure Transfer Program program (56.14%). Respondents agreed with increased license portability for medically underserved and rural areas (71.79%) and preference for having a law exam (56.72%). Pharmacists (n = 405) noted concerns regarding multistate renewal requirements, fees, and continuing education.
    Conclusion: This study provided baseline data on a topic that is missing in existing literature. Results illustrated a high completion rate, a diversity of demographics including well dispersed age ranges, years in practice, and qualitative responses. The quantitative data shed light on a variety of pharmacist perspectives and varied awareness about NABP licensure programs and compacts.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The laryngopharyngeal nerve: a comprehensive review.

    Shapiro, Stephen / Parker, Andrew L / Cardona, Juan J / Chaiyamoon, Arada / Reina, Francisco / Carrera, Ana / Iwanaga, Joe / Dumont, Aaron S / Tubbs, R Shane

    Anatomy & cell biology

    2023  Volume 56, Issue 3, Page(s) 299–303

    Abstract: The laryngopharyngeal nerve has received much less attention that the other contributions to the pharyngeal ... ...

    Abstract The laryngopharyngeal nerve has received much less attention that the other contributions to the pharyngeal plexus
    Language English
    Publishing date 2023-03-27
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2590173-4
    ISSN 2093-3673 ; 2093-3665
    ISSN (online) 2093-3673
    ISSN 2093-3665
    DOI 10.5115/acb.22.254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chronic graft-versus-host disease exacerbation after SARS-CoV-2 vaccination.

    Trunk, Andrew D / Shewan, Samuel K / Lee, Catherine J / Parker, Charles J / Couriel, Daniel R

    Bone marrow transplantation

    2022  Volume 57, Issue 3, Page(s) 502–503

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Graft vs Host Disease/etiology ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01543-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overview of Preventive Medicine's thematic article collections- A golden jubilee editorial.

    Shinder, Gayle A / Arthur, Andrew / Logel, Margaret / Mullen, Callum J R / Tope, Parker / Franco, Eduardo L

    Preventive medicine

    2022  Volume 162, Page(s) 107178

    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2022.107178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selective Adsorption of Oxygen from Humid Air in a Metal-Organic Framework with Trigonal Pyramidal Copper(I) Sites.

    Carsch, Kurtis M / Huang, Adrian J / Dods, Matthew N / Parker, Surya T / Rohde, Rachel C / Jiang, Henry Z H / Yabuuchi, Yuto / Karstens, Sarah L / Kwon, Hyunchul / Chakraborty, Romit / Bustillo, Karen C / Meihaus, Katie R / Furukawa, Hiroyasu / Minor, Andrew M / Head-Gordon, Martin / Long, Jeffrey R

    Journal of the American Chemical Society

    2024  Volume 146, Issue 5, Page(s) 3160–3170

    Abstract: High or enriched-purity ... ...

    Abstract High or enriched-purity O
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c10753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Quorum-sensing

    Podkowik, Magdalena / Perault, Andrew I / Putzel, Gregory / Pountain, Andrew / Kim, Jisun / Dumont, Ashley / Zwack, Erin / Ulrich, Robert J / Karagounis, Theodora K / Zhou, Chunyi / Haag, Andreas F / Shenderovich, Julia / Wasserman, Gregory A / Kwon, Junbeom / Chen, John / Richardson, Anthony R / Weiser, Jeffrey N / Nowosad, Carla R / Lun, Desmond S /
    Parker, Dane / Pironti, Alejandro / Zhao, Xilin / Drlica, Karl / Yanai, Itai / Torres, Victor J / Shopsin, Bo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.08.544038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Golden Jubilee Editorial - Preventive Medicine's contributions to the science of cervical cancer elimination.

    Logel, Margaret / Tope, Parker / Arthur, Andrew / Mullen, Callum J R / Shinder, Gayle A / Franco, Eduardo L

    Preventive medicine

    2022  Volume 164, Page(s) 107317

    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/prevention & control
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2022.107317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Systematic Review and Meta-analysis of Non-pharmacological Methods to Manipulate Experimentally Induced Secondary Hypersensitivity.

    Bedwell, Gillian J / Chikezie, Prince C / Siboza, Felicia T / Mqadi, Luyanduthando / Rice, Andrew S C / Kamerman, Peter R / Parker, Romy / Madden, Victoria J

    The journal of pain

    2023  Volume 24, Issue 10, Page(s) 1759–1797

    Abstract: This systematic review and meta-analysis investigated the effects of non-pharmacological manipulations on experimentally induced secondary hypersensitivity in pain-free humans. We investigated the magnitude (change/difference in follow-up ratings from ... ...

    Abstract This systematic review and meta-analysis investigated the effects of non-pharmacological manipulations on experimentally induced secondary hypersensitivity in pain-free humans. We investigated the magnitude (change/difference in follow-up ratings from pre-manipulation ratings) of secondary hypersensitivity (primary outcome), and surface area of secondary hypersensitivity (secondary outcome), in 27 studies representing 847 participants. Risk of bias assessment concluded most studies (23 of 27) had an unclear or high risk of performance and detection bias. Further, 2 (of 27) studies had a high risk of measurement bias. Datasets were pooled by the method of manipulation and outcome. The magnitude of secondary hypersensitivity was decreased by diverting attention, anodal transcranial direct current stimulation, or emotional disclosure; increased by directing attention toward the induction site, nicotine deprivation, or negative suggestion; and unaffected by cathodal transcranial direct current stimulation or thermal change. Area of secondary hypersensitivity was decreased by anodal transcranial direct current stimulation, emotional disclosure, cognitive behavioral therapy, hyperbaric oxygen therapy, placebo analgesia, or spinal manipulation; increased by directing attention to the induction site, nicotine deprivation, or sleep disruption (in males only); and unaffected by cathodal transcranial direct current stimulation, thermal change, acupuncture, or electroacupuncture. Meta-analytical pooling was only appropriate for studies that used transcranial direct current stimulation or hyperbaric oxygen therapy, given the high clinical heterogeneity among the studies and unavailability of data. The evidence base for this question remains small. We discuss opportunities to improve methodological rigor including manipulation checks, structured blinding strategies, control conditions or time points, and public sharing of raw data. PERSPECTIVE: We described the effects of several non-pharmacological manipulations on experimentally induced secondary hypersensitivity in humans. By shedding light on the potential for non-pharmacological therapies to influence secondary hypersensitivity, it provides a foundation for the development and testing of targeted therapies for secondary hypersensitivity.
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2018789-0
    ISSN 1528-8447 ; 1526-5900
    ISSN (online) 1528-8447
    ISSN 1526-5900
    DOI 10.1016/j.jpain.2023.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line.

    Ariyasinghe, Nethika R / de Souza Santos, Roberta / Gross, Andrew / Aghamaleky-Sarvestany, Arwin / Kreimer, Simion / Escopete, Sean / Parker, Sarah J / Sareen, Dhruv

    Physiological genomics

    2023  Volume 55, Issue 8, Page(s) 324–337

    Abstract: The vascular endothelium constitutes the inner lining of the blood vessel, and malfunction and injuries of the endothelium can cause cardiovascular diseases as well as other diseases including stroke, tumor growth, and chronic kidney failure. Generation ... ...

    Abstract The vascular endothelium constitutes the inner lining of the blood vessel, and malfunction and injuries of the endothelium can cause cardiovascular diseases as well as other diseases including stroke, tumor growth, and chronic kidney failure. Generation of effective sources to replace injured endothelial cells (ECs) could have significant clinical impact, and somatic cell sources like peripheral or cord blood cannot credibly supply enough endothelial cell progenitors for multitude of treatments. Pluripotent stem cells are a promising source for a reliable EC supply, which have the potential to restore tissue function and treat vascular diseases. We have developed methods to differentiate induced pluripotent stem cells (iPSCs) efficiently and robustly across multiple iPSC lines into nontissue-specific pan vascular ECs (iECs) with high purity. These iECs present with canonical endothelial cell markers and exhibit measures of endothelial cell functionality with the uptake of Dil fluorescent dye-labeled acetylated low-density lipoprotein (Dil-Ac-LDL) and tube formation. Using proteomic analysis, we revealed that the iECs are more proteomically similar to established human umbilical vein ECs (HUVECs) than to iPSCs. Posttranslational modifications (PTMs) were most shared between HUVECs and iECs, and potential targets for increasing the proteomic similarity of iECs to HUVECs were identified. Here we demonstrate an efficient robust method to differentiate iPSCs into functional ECs, and for the first time provide a comprehensive protein expression profile of iECs, which indicates their similarities with a widely used immortalized HUVECs, allowing for further mechanistic studies of EC development, signaling, and metabolism for future regenerative applications.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells/metabolism ; Cells, Cultured ; Cell Differentiation ; Proteomics ; Human Umbilical Vein Endothelial Cells ; Endothelium, Vascular
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00166.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication.

    Miotto, Paula M / Yang, Chieh-Hsin / Keenan, Stacey N / De Nardo, William / Beddows, Cait A / Fidelito, Gio / Dodd, Garron T / Parker, Benjamin L / Hill, Andrew F / Burton, Paul R / Loh, Kim / Watt, Matthew J

    Nature metabolism

    2024  Volume 6, Issue 2, Page(s) 254–272

    Abstract: Small extracellular vesicles (EVs) are signalling messengers that regulate inter-tissue communication through delivery of their molecular cargo. Here, we show that liver-derived EVs are acute regulators of whole-body glycaemic control in mice. Liver EV ... ...

    Abstract Small extracellular vesicles (EVs) are signalling messengers that regulate inter-tissue communication through delivery of their molecular cargo. Here, we show that liver-derived EVs are acute regulators of whole-body glycaemic control in mice. Liver EV secretion into the circulation is increased in response to hyperglycaemia, resulting in increased glucose effectiveness and insulin secretion through direct inter-organ EV signalling to skeletal muscle and the pancreas, respectively. This acute blood glucose lowering effect occurs in healthy and obese mice with non-alcoholic fatty liver disease, despite marked remodelling of the liver-derived EV proteome in obese mice. The EV-mediated blood glucose lowering effects were recapitulated by administration of liver EVs derived from humans with or without progressive non-alcoholic fatty liver disease, suggesting broad functional conservation of liver EV signalling and potential therapeutic utility. Taken together, this work reveals a mechanism whereby liver EVs act on peripheral tissues via endocrine signalling to restore euglycaemia in the postprandial state.
    MeSH term(s) Humans ; Animals ; Mice ; Non-alcoholic Fatty Liver Disease ; Glycemic Control ; Blood Glucose ; Mice, Obese ; Extracellular Vesicles
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00971-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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