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  1. Article: [My Life Work: Challenges to Bone and Soft Tissue Sarcomas].

    Iwamoto, Yukihide

    Fukuoka igaku zasshi = Hukuoka acta medica

    2016  Volume 107, Issue 2, Page(s) 19–26

    MeSH term(s) Bone Neoplasms/history ; History, 20th Century ; History, 21st Century ; Japan ; Sarcoma/history ; Soft Tissue Neoplasms/history
    Language Japanese
    Publishing date 2016-02
    Publishing country Japan
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 41251-x
    ISSN 0016-254X
    ISSN 0016-254X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Successful Management of Radiation-Associated Insufficiency Fracture of the Tibial Plateau with Low-Intensity Pulsed Ultrasound.

    Matsunobu, Tomoya / Maekawa, Akira / Nomoto, Satoshi / Iwamoto, Yukihide

    The American journal of case reports

    2022  Volume 23, Page(s) e934372

    Abstract: BACKGROUND Clinical management of radiation-associated pathological fracture is challenging because of a high nonunion rate and potential for morbidity. We report a case of radiation-associated insufficiency fracture of the tibial plateau after surgery, ... ...

    Abstract BACKGROUND Clinical management of radiation-associated pathological fracture is challenging because of a high nonunion rate and potential for morbidity. We report a case of radiation-associated insufficiency fracture of the tibial plateau after surgery, perioperative chemotherapy, and adjuvant radiation therapy for synovial sarcoma of the proximal calf that was successfully treated with low-intensity pulsed ultrasound (LIPUS). CASE REPORT A healthy 52-year-old Japanese woman presented with a slowly growing, painful soft tissue mass over her proximal calf. Histological examination of core needle biopsy specimens led to a pathological diagnosis of synovial sarcoma. After perioperative ifosfamide and doxorubicin chemotherapy and surgical resection, adjuvant radiation therapy was administered, with a total of 60 Gy in 30 fractions. At 5 months after surgery and 2 months after the completion of radiation therapy, she developed an insufficiency pathological fracture of the proximal tibia without any apparent trauma. The patient was treated with LIPUS for 1 year. There was no collapse or deformity of the knee joint. The patient remained free of symptoms and had no recurrences for 2 years after surgery. CONCLUSIONS This is the first report of radiation-associated pathological fracture that was successfully treated with LIPUS. LIPUS could be a safe and effective treatment option in the management of radiation-associated pathological fractures.
    MeSH term(s) Female ; Fractures, Stress ; Humans ; Middle Aged ; Tibia/diagnostic imaging ; Treatment Outcome ; Ultrasonic Therapy ; Ultrasonic Waves
    Language English
    Publishing date 2022-01-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.934372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Myxoid liposarcoma in an 11-year-old patient.

    Matsunobu, Tomoya / Maekawa, Akira / Inaba, Yuna / Makihara, Kosuke / Hisaoka, Masanori / Iwamoto, Yukihide

    International cancer conference journal

    2023  Volume 12, Issue 4, Page(s) 233–240

    Abstract: Myxoid liposarcoma is a mesenchymal malignancy that most commonly presents in young adults, with peak incidence between the ages of 30-50 years. The clinical behavior of myxoid liposarcoma has been well characterized in adults. However, little is known ... ...

    Abstract Myxoid liposarcoma is a mesenchymal malignancy that most commonly presents in young adults, with peak incidence between the ages of 30-50 years. The clinical behavior of myxoid liposarcoma has been well characterized in adults. However, little is known about the clinical features and treatment outcomes of myxoid liposarcoma in child, owing to its rarity. This case report describes an 11-year-old previously healthy female who presented with a painless mass in her right thigh. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a soft tissue mass with clear margins in the subfascial plane superficial to the gracilis and sartorius muscles. She was diagnosed with myxoid liposarcoma based on histological and molecular cytogenetic examinations of the core-needle biopsy specimen. The patient subsequently underwent wide resection without any adjuvant treatment. The patient has not experienced any symptoms of local recurrence and metastases as of 2.5 years after surgery.
    Language English
    Publishing date 2023-05-09
    Publishing country Singapore
    Document type Journal Article
    ISSN 2192-3183
    ISSN (online) 2192-3183
    DOI 10.1007/s13691-023-00615-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What should we do as orthopedic surgeons in catastrophic disasters?

    Iwamoto, Yukihide

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2012  Volume 17, Issue 1, Page(s) 1–2

    MeSH term(s) Clinical Competence ; Disasters ; Emergencies ; Emergency Medical Services/organization & administration ; Humans ; Japan ; Orthopedic Procedures ; Practice Guidelines as Topic ; Relief Work ; Wounds and Injuries/surgery
    Language English
    Publishing date 2012-01-12
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1007/s00776-011-0195-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of the JOA in the globalization of orthopedics.

    Iwamoto, Yukihide

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2009  Volume 14, Issue 2, Page(s) 131

    MeSH term(s) Humans ; Japan ; Orthopedics/organization & administration ; Societies, Medical/organization & administration
    Language English
    Publishing date 2009-04-01
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1007/s00776-009-1319-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Seikei geka shujutsu no yōten to mōten

    Iwamoto, Yukihide

    (Seikei geka knack & pitfalls)

    2011  

    Author's details henshū Iwamoto Yukihide
    Series title Seikei geka knack & pitfalls
    MeSH term(s) Orthopedic Procedures ; Reconstructive Surgical Procedures ; Wounds and Injuries/surgery
    Language Japanese
    Size xii, 381 pages :, illustrations.
    Edition Dai 1-han.
    Document type Book
    ISBN 9784830627699 ; 4830627697
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: Malignant Transformation of Giant Cell Tumor of Bone 7 years After Initial Surgery: A Case Report and Literature Review.

    Matsunobu, Tomoya / Maekawa, Akira / Jotatsu, Mao / Makihara, Kosuke / Hisaoka, Masanori / Iwamoto, Yukihide

    JBJS case connector

    2021  Volume 11, Issue 2

    Abstract: Case: A 64-year-old man with a history of giant cell tumor of bone (GCTB) in the fibula 7 years earlier developed a recurrence with histologic features of osteosarcoma. Both the primary GCTB and the secondary osteosarcoma were found to have the H3F3A ... ...

    Abstract Case: A 64-year-old man with a history of giant cell tumor of bone (GCTB) in the fibula 7 years earlier developed a recurrence with histologic features of osteosarcoma. Both the primary GCTB and the secondary osteosarcoma were found to have the H3F3A gene mutation. Despite immediate above-the-knee amputation, the patient died of respiratory failure because of lung metastases 3 months later.
    Conclusion: This is the first report of proven H3F3A mutation in both the primary GCTB and the secondary osteosarcoma in the same case. Clinicians should consider secondary malignancy in patients presenting with a lesion at the site of a previously treated GCTB after a long interval.
    MeSH term(s) Bone Neoplasms/complications ; Bone Neoplasms/surgery ; Cell Transformation, Neoplastic ; Giant Cell Tumor of Bone/surgery ; Humans ; Male ; Middle Aged ; Neoplasms, Second Primary ; Osteosarcoma/complications ; Osteosarcoma/surgery
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e20.00417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach.

    Matsunobu, Tomoya / Maekawa, Akira / Nabeshima, Akira / Sakamoto, Akio / Tamura, Kazuki / Odate, Seiichi / Iwamoto, Yukihide

    The American journal of case reports

    2021  Volume 22, Page(s) e931796

    Abstract: BACKGROUND Giant cell tumor of bone (GCTB) is a locally aggressive, intermediate tumor that rarely metastasizes. GCTB typically affects the ends of long bones and rarely involves the ribs. Curettage is typically the treatment of choice for GCTB in long ... ...

    Abstract BACKGROUND Giant cell tumor of bone (GCTB) is a locally aggressive, intermediate tumor that rarely metastasizes. GCTB typically affects the ends of long bones and rarely involves the ribs. Curettage is typically the treatment of choice for GCTB in long bones. However, the optimal treatment of GCTB in ribs remains unclear. We report the case of a patient with asymptomatic GCTB of the first rib that was successfully treated with combined preoperative denosumab therapy and surgery via a transmanubrial approach without resection of the clavicle. CASE REPORT A healthy 27-year-old woman presented with a bone tumor involving the left first rib that was incidentally discovered on routine chest X-ray. Histological examination of core-needle biopsy specimens of the lesion led to a pathological diagnosis of GCTB. After preoperative denosumab treatment for 6 months, en bloc resection via a transmanubrial approach was performed. There were no serious postoperative complications. The patient remained free of symptoms and had no recurrence 4.5 years after surgery. CONCLUSIONS Compared with other ribs, masses located in the first rib can be challenging to treat surgically because of the clavicle and neighboring neurovascular structures. This report is the first to describe GCTB located on the anterior aspect of the first rib that was successfully treated with combined preoperative denosumab therapy and surgery via a transmanubrial approach, with no recurrence or functional impairment of the shoulder girdle.
    MeSH term(s) Adult ; Bone Density Conservation Agents ; Denosumab/therapeutic use ; Female ; Giant Cell Tumor of Bone/diagnostic imaging ; Giant Cell Tumor of Bone/drug therapy ; Giant Cell Tumor of Bone/surgery ; Humans ; Neoplasm Recurrence, Local ; Ribs/surgery
    Chemical Substances Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.931796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cardiac Tamponade as an Unusual Initial Clinical Manifestation of CIC-DUX4 Sarcoma.

    Maekawa, Akira / Matsunobu, Tomoya / Nabeshima, Akira / Fukushima, Suguru / Makihara, Kosuke / Hisaoka, Masanori / Iwamoto, Yukihide

    The American journal of case reports

    2021  Volume 22, Page(s) e929349

    Abstract: BACKGROUND CIC-rearranged sarcoma (CRS) is a recently described subset of undifferentiated small-round-cell sarcomas of bone and soft tissue. DUX4 is the most common gene involved in CRS. CRS usually presents in the soft tissue of the trunk and ... ...

    Abstract BACKGROUND CIC-rearranged sarcoma (CRS) is a recently described subset of undifferentiated small-round-cell sarcomas of bone and soft tissue. DUX4 is the most common gene involved in CRS. CRS usually presents in the soft tissue of the trunk and extremities, and is recognized as being clinically aggressive, with poor prognosis. Our case highlights an unusual presentation of CRS with cardiac tamponade. CASE REPORT A 48-year-old man presented with hypotension caused by hemorrhagic cardiac tamponade. ¹⁸F-fluorodeoxyglucose-positron emission tomography showed increased uptake in multiple lesions, including lesions in the left proximal humerus and several lymph nodes. Biopsy specimens of the humerus revealed proliferation of round-shaped cells. In addition, CIC-DUX4 gene rearrangement was detected by polymerase chain reaction and direct sequencing, leading to a diagnosis of cardiac tamponade caused by CRS. Although the patient received systemic chemotherapy as well as radiotherapy to the mediastinal lesion and left humerus, he died of progressive disease 12 months after diagnosis. CONCLUSIONS Because CRS is a recently proposed entity that is distinct from Ewing sarcoma, the clinical presentation and outcome of CRS has not been well documented in the literature. This is the first case report of CRS presenting as cardiac tamponade. Although cardiac tamponade due to metastatic sarcoma is extremely rare, CRS can be included in the differential diagnosis.
    MeSH term(s) Biomarkers, Tumor ; Cardiac Tamponade/diagnosis ; Cardiac Tamponade/etiology ; Humans ; Male ; Middle Aged ; Oncogene Proteins, Fusion ; Sarcoma ; Sarcoma, Ewing ; Sarcoma, Small Cell ; Soft Tissue Neoplasms
    Chemical Substances Biomarkers, Tumor ; CIC-DUX4 fusion protein, human ; Oncogene Proteins, Fusion
    Language English
    Publishing date 2021-02-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.929349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Corticosteroids treatments and osteonecrosis of the femoral head].

    Yamamoto, Takuaki / Iwamoto, Yukihide

    Fukuoka igaku zasshi = Hukuoka acta medica

    2015  Volume 106, Issue 3, Page(s) 47–53

    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Animals ; Disease Models, Animal ; Femur Head/drug effects ; Femur Head/pathology ; Humans ; Osteonecrosis/chemically induced ; Osteonecrosis/epidemiology ; Osteonecrosis/prevention & control ; Risk Factors
    Chemical Substances Adrenal Cortex Hormones
    Language Japanese
    Publishing date 2015-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 41251-x
    ISSN 0016-254X
    ISSN 0016-254X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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