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  1. Book ; Online: Bratton's family medicine board review

    Bratton, Robert L.

    2011  

    Abstract: Zsfg.: "Bratton's Family Medicine Board Review, Fourth Edition, is a directed review of important topics that typically appear on American Board of Family Medicine (ABFM) in-training examinations, board certification examinations, and recertification ... ...

    Title variant Family medicine board review
    Author's details Robert L. Bratton
    Abstract Zsfg.: "Bratton's Family Medicine Board Review, Fourth Edition, is a directed review of important topics that typically appear on American Board of Family Medicine (ABFM) in-training examinations, board certification examinations, and recertification examinations. This material is not intended for a comprehensive review but, instead, should direct the examinee to areas of weakness that may need further review. Family medicine is a broad field, and to provide a complete, comprehensive review of all topics that may be covered is extremely time consuming if not impossible. Several other courses attempt to provide this type of review; however, this book is more abbreviated and focuses on topics that are commonly found on board examinations. Adequate preparation for any test is the key to success and rewarding results. Given this, we all know the importance of practice tests and the benefits of testing our knowledge base before the actual examination. This review book is structured for the examinee with limited time and resources for review and should be used only by those individuals with an established foundation of knowledge within the field of family medicine. Its primary purpose is to identify areas of weakness that can be improved on"
    Keywords Family practice ; Examination questions
    Language English
    Size 1 Online-Ressource
    Edition 4th ed.
    Publisher Wolters Kluwer/Lippincott Williams & Wilkins Health
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-1-608-31719-6 ; 1-608-31719-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: How to be the best doctor.

    Bratton, Robert L

    Physician executive

    2014  Volume 40, Issue 1, Page(s) 14–8, 20

    MeSH term(s) Clinical Competence ; Humans ; Physician's Role ; Physician-Patient Relations ; United States
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1404480-8
    ISSN 0898-2759
    ISSN 0898-2759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: How to prepare for your CMO/VPMA interview.

    Bratton, Robert L

    Physician executive

    2013  Volume 39, Issue 3, Page(s) 54–57

    MeSH term(s) Humans ; Personnel Selection/organization & administration ; Physician Executives ; Planning Techniques ; Risk Management ; United States
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1404480-8
    ISSN 0898-2759
    ISSN 0898-2759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Keys to success for department chairs and section heads.

    Bratton, Robert L

    Physician executive

    2012  Volume 38, Issue 2, Page(s) 44–6, 48, 50–1

    MeSH term(s) Hospital Departments ; Humans ; Leadership ; Personality ; Physician Executives/psychology
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1404480-8
    ISSN 0898-2759
    ISSN 0898-2759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: One year as chief medical officer: challenges encountered and lessons learned.

    Bratton, Robert L

    Physician executive

    2011  Volume 37, Issue 1, Page(s) 50–57

    MeSH term(s) Ambulatory Care Facilities ; Anecdotes as Topic ; Arizona ; Humans ; Physician Executives
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1404480-8
    ISSN 0898-2759
    ISSN 0898-2759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Vesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection.

    Uhlorn, Brittany L / Jackson, Robert / Li, Shuaizhi / Bratton, Shauna M / Van Doorslaer, Koenraad / Campos, Samuel K

    PLoS pathogens

    2020  Volume 16, Issue 11, Page(s) e1009028

    Abstract: Oncogenic human papillomaviruses (HPVs) replicate in differentiating epithelium, causing 5% of cancers worldwide. Like most other DNA viruses, HPV infection initiates after trafficking viral genome (vDNA) to host cell nuclei. Cells possess innate ... ...

    Abstract Oncogenic human papillomaviruses (HPVs) replicate in differentiating epithelium, causing 5% of cancers worldwide. Like most other DNA viruses, HPV infection initiates after trafficking viral genome (vDNA) to host cell nuclei. Cells possess innate surveillance pathways to detect microbial components or physiological stresses often associated with microbial infections. One of these pathways, cGAS/STING, induces IRF3-dependent antiviral interferon (IFN) responses upon detection of cytosolic DNA. Virion-associated vDNA can activate cGAS/STING during initial viral entry and uncoating/trafficking, and thus cGAS/STING is an obstacle to many DNA viruses. HPV has a unique vesicular trafficking pathway compared to many other DNA viruses. As the capsid uncoats within acidic endosomal compartments, minor capsid protein L2 protrudes across vesicular membranes to facilitate transport of vDNA to the Golgi. L2/vDNA resides within the Golgi lumen until G2/M, whereupon vesicular L2/vDNA traffics along spindle microtubules, tethering to chromosomes to access daughter cell nuclei. L2/vDNA-containing vesicles likely remain intact until G1, following nuclear envelope reformation. We hypothesize that this unique vesicular trafficking protects HPV from cGAS/STING surveillance. Here, we investigate cGAS/STING responses to HPV infection. DNA transfection resulted in acute cGAS/STING activation and downstream IFN responses. In contrast, HPV infection elicited minimal cGAS/STING and IFN responses. To determine the role of vesicular trafficking in cGAS/STING evasion, we forced premature viral penetration of vesicular membranes with membrane-perturbing cationic lipids. Such treatment renders a non-infectious trafficking-defective mutant HPV infectious, yet susceptible to cGAS/STING detection. Overall, HPV evades cGAS/STING by its unique subcellular trafficking, a property that may contribute to establishment of infection.
    MeSH term(s) Alphapapillomavirus/genetics ; Alphapapillomavirus/immunology ; Alphapapillomavirus/physiology ; Biological Transport ; Capsid/metabolism ; Endosomes/virology ; Genome, Viral/genetics ; Humans ; Interferon Regulatory Factor-3/metabolism ; Membrane Proteins/metabolism ; Mutation ; Nucleotidyltransferases/metabolism ; Papillomavirus Infections/virology ; Virion ; Virus Internalization
    Chemical Substances IRF3 protein, human ; Interferon Regulatory Factor-3 ; Membrane Proteins ; STING1 protein, human ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-)
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Millennium Primary Care Reimbursement Plan: a proposal for debate.

    Bratton, Robert L

    Family medicine

    2003  Volume 35, Issue 10, Page(s) 745–747

    MeSH term(s) Family Practice/economics ; Humans ; Reimbursement Mechanisms
    Language English
    Publishing date 2003-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639374-3
    ISSN 0742-3225
    ISSN 0742-3225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2327: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Book: Bratton's 1000 facts to help you pass the family medicine boards

    Bratton, Robert L

    2009  

    Title variant Bratton's one thousand facts to help you pass the family medicine boards ; 1000 facts to help you pass the family medicine boards
    Author's details Robert L. Bratton
    MeSH term(s) Family Practice
    Language English
    Size xvii, 166 p.
    Publisher Wolters Kluwer/Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book
    Note Includes index.
    ISBN 9780781795364 ; 0781795362
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Patient-Reported Outcome Measures for Severe Recurrent Bilateral Nasal Polyps: Psychometric Evaluation and Content Validity.

    Gater, Adam / Tolley, Chloe / Williams-Hall, Rebecca / Trennery, Claire / Bradley, Helena / Sikirica, Mirko V / Nelsen, Linda / Sousa, Ana R / Bratton, Daniel J / Chan, Robert / von Maltzahn, Robyn

    OTO open

    2023  Volume 7, Issue 4, Page(s) e84

    Abstract: Objective: To date, no patient-reported outcome measures have been specifically developed to assess pharmacological treatment effect in participants with severe chronic rhinosinusitis (CRS) with recurrent bilateral nasal polyps (NP). These studies aimed ...

    Abstract Objective: To date, no patient-reported outcome measures have been specifically developed to assess pharmacological treatment effect in participants with severe chronic rhinosinusitis (CRS) with recurrent bilateral nasal polyps (NP). These studies aimed to assess (1) the psychometric properties and (2) content validity of Visual Analogue Scales (VAS) assessing NP symptom severity.
    Study design: (1) Retrospective psychometric validation study using clinical trial data and (2) cross-sectional qualitative patient interview study.
    Setting: (1) Multicentre trial; (2) real-world.
    Methods: (1) Psychometric validation was performed using data from a randomized, double-blind, placebo-controlled, Phase II study (NCT01362244) investigating the effect of mepolizumab in 105 participants with severe, recurrent bilateral NP currently needing polypectomy surgery. (2) Content validity was explored through cognitive debriefing interviews in 27 adults with severe CRS with recurrent bilateral NP who had received NP surgery in the past 10 years (NCT03221192).
    Results: (1) Acceptable reliability, validity, and responsiveness were shown for individual VAS items, although the loss of smell VAS item performed poorly in several analyses, suggesting further evaluation of this item is needed. (2) All individual VAS items were well understood, considered relevant and were consistently interpreted by most participants, providing evidence for their content validity.
    Conclusion: These findings support the use of symptom VAS measures to evaluate disease experience and treatment effect in clinical trials of participants with severe CRS with recurrent bilateral NP.
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 2473-974X
    ISSN (online) 2473-974X
    DOI 10.1002/oto2.84
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Operative Outcomes of Women Undergoing Coronary Artery Bypass Surgery in the US, 2011 to 2020.

    Gaudino, Mario / Chadow, David / Rahouma, Mohamed / Soletti, Giovanni Jr / Sandner, Sigrid / Perezgrovas-Olaria, Roberto / Audisio, Katia / Cancelli, Gianmarco / Bratton, Brenden A / Fremes, Stephen / Kurlansky, Paul / Girardi, Leonard / Habib, Robert H

    JAMA surgery

    2023  Volume 158, Issue 5, Page(s) 494–502

    Abstract: Importance: It has been reported that women undergoing coronary artery bypass have higher mortality and morbidity compared with men but it is unclear if the difference has decreased over the last decade.: Objective: To evaluate trends in outcomes of ... ...

    Abstract Importance: It has been reported that women undergoing coronary artery bypass have higher mortality and morbidity compared with men but it is unclear if the difference has decreased over the last decade.
    Objective: To evaluate trends in outcomes of women undergoing coronary artery bypass in the US from 2011 to 2020.
    Design, setting, and participants: This retrospective cohort study at hospitals contributing to the Adult Cardiac Surgery Database of the Society of Thoracic Surgeons included 1 297 204 patients who underwent primary isolated coronary artery bypass from 2011 to 2020.
    Exposure: Coronary artery bypass.
    Main outcomes and measures: The primary outcome was operative mortality. The secondary outcome was the composite of operative mortality and morbidity (including operative mortality, stroke, kidney failure, reoperation, deep sternal wound infection, prolonged mechanical ventilation, and prolonged hospital stay). The attributable risk (the association of female sex with coronary artery bypass grafting outcomes) for the primary and secondary outcomes was calculated.
    Results: Between 2011 and 2020, 1 297 204 patients underwent primary isolated coronary artery bypass grafting with a mean age of 66.0 years, 317 716 of which were women (24.5%). Women had a higher unadjusted operative mortality (2.8%; 95% CI, 2.8-2.9 vs 1.7%; 95% CI, 1.7-1.7; P < .001) and overall unadjusted incidence of the composite of operative mortality and morbidity compared with men (22.9%; 95% CI, 22.7-23.0 vs 16.7%; 95% CI, 16.6-16.8; P < .001). The attributable risk of female sex for operative mortality varied from 1.28 in 2011 to 1.41 in 2020, with no significant change over the study period (P for trend = 0.38). The attributable risk for the composite of operative mortality and morbidity was 1.08 in both 2011 and 2020 with no significant change over the study period (P for trend = 0.71).
    Conclusions and relevance: Women remain at significantly higher risk for adverse outcomes following coronary artery bypass grafting and no significant improvement has been seen over the course of the last decade. Further investigation into the determinants of operative outcomes in women is urgently needed.
    MeSH term(s) Male ; Adult ; Humans ; Female ; Aged ; Retrospective Studies ; Coronary Artery Bypass/adverse effects ; Risk Factors ; Morbidity ; Incidence
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.8156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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