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  1. Article: The prevalence of rodent-borne zoonotic pathogens in the South Gobi desert region of Mongolia.

    Esson, Carol / Samelius, Gustaf / Strand, Tanja M / Lundkvist, Åke / Michaux, Johan R / Råsbäck, Therese / Wahab, Tara / Mijiddorj, Tserennadmid Nadia / Berger, Lee / Skerratt, Lee F / Low, Matthew

    Infection ecology & epidemiology

    2023  Volume 13, Issue 1, Page(s) 2270258

    Abstract: The alpine ecosystems and communities of central Asia are currently undergoing large-scale ecological and socio-ecological changes likely to affect wildlife-livestock-human disease interactions and zoonosis transmission risk. However, relatively little ... ...

    Abstract The alpine ecosystems and communities of central Asia are currently undergoing large-scale ecological and socio-ecological changes likely to affect wildlife-livestock-human disease interactions and zoonosis transmission risk. However, relatively little is known about the prevalence of pathogens in this region. Between 2012 and 2015 we screened 142 rodents in Mongolia's Gobi desert for exposure to important zoonotic and livestock pathogens. Rodent seroprevalence to
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627673-2
    ISSN 2000-8686
    ISSN 2000-8686
    DOI 10.1080/20008686.2023.2270258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnosis and treatment of acute tubular necrosis.

    Esson, Matthew L / Schrier, Robert W

    Annals of internal medicine

    2002  Volume 137, Issue 9, Page(s) 744–752

    Abstract: Background: Acute tubular necrosis (ATN) is common in hospitalized patients, particularly in the intensive care unit. Over the past four decades, the mortality rate from ATN has remained at 50% to 80%.: Purpose: To review recent studies of diagnosis ... ...

    Abstract Background: Acute tubular necrosis (ATN) is common in hospitalized patients, particularly in the intensive care unit. Over the past four decades, the mortality rate from ATN has remained at 50% to 80%.
    Purpose: To review recent studies of diagnosis and treatment strategies for ATN.
    Data sources: MEDLINE search for all clinical studies of therapies for ATN, supplemented by a review of the references of the identified articles.
    Study selection: Prospective studies and major retrospective studies evaluating therapies for ATN.
    Data extraction: Data on the study sample, interventions performed, results, side effects, and duration of follow-up.
    Data synthesis: Early diagnosis of ATN by exclusion of prerenal and postrenal causes of acute renal failure, examination of urinary sediment, and analysis of urine measures (for example, fractional excretion of sodium in the absence of diuretics) can allow the early involvement of nephrologists and improve survival. Enteral rather than parenteral hyperalimentation in severely malnourished patients may improve survival. Sepsis causes 30% to 70% of deaths in patients with ATN; therefore, avoidance of intravenous lines, bladder catheters, and respirators is recommended. Because septic patients are vasodilated, large volumes of administered fluid accumulate in the lung interstitium of these patients. This condition necessitates ventilatory support, which when prolonged leads to acute respiratory distress syndrome, multiorgan failure, and increased mortality. More aggressive dialysis (for example, given daily) with biocompatible membranes may improve survival in some patients with acute renal failure.
    Conclusions: New information about the importance of early diagnosis and supportive care for patients with ATN has emerged. However, randomized trials of these interventions are needed to test their effect on the morbidity and mortality of ATN.
    MeSH term(s) Humans ; Kidney Tubular Necrosis, Acute/complications ; Kidney Tubular Necrosis, Acute/diagnosis ; Kidney Tubular Necrosis, Acute/therapy ; Nutritional Support ; Renal Dialysis
    Language English
    Publishing date 2002-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-137-9-200211050-00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Desensitization of soluble guanylate cyclase in renal cortex during endotoxemia in mice.

    Knotek, Mladen / Esson, Matthew / Gengaro, Patricia / Edelstein, Charles L / Schrier, Robert W

    Journal of the American Society of Nephrology : JASN

    2000  Volume 11, Issue 11, Page(s) 2133–2137

    Abstract: Acute endotoxemic renal failure involves renal vasoconstriction, which presumably occurs despite increased nitric oxide (NO) generation by inducible NO synthase in the kidney. The present study examined the hypothesis that the renal vasoconstriction ... ...

    Abstract Acute endotoxemic renal failure involves renal vasoconstriction, which presumably occurs despite increased nitric oxide (NO) generation by inducible NO synthase in the kidney. The present study examined the hypothesis that the renal vasoconstriction during endotoxemia occurs in part because of desensitization of soluble guanylate cyclase (sGC). Endotoxic shock was induced in male B6/129F2/J mice by an intraperitoneal injection of Escherichia coli lipopolysaccharide. The endotoxemia resulted in shock and renal failure as evidenced by a decrease in mean arterial pressure and an increase in serum creatinine and urea nitrogen. Serum NO increased in a time-dependent manner, reaching the highest levels at 24 h, in parallel with induction of inducible NO synthase protein in the renal cortex. In renal cortical slices obtained from endotoxemic mice, cyclic guanosine monophosphate (cGMP) increased significantly at 6 h and 15 h as compared with control but normalized at 24 h after injection of lipopolysaccharide. Incubation of renal cortical slices in the presence of a phosphodiesterase inhibitor isobutylmethylxantine did not alter the pattern of changes in cGMP. Incubation of renal cortical slices with 2 mM sodium nitroprusside resulted in a similar accumulation of cGMP in slices taken from control and endotoxemic mice at 6 h and 15 h. However, in slices from 24-h endotoxemic mice, accumulation of cGMP in response to sodium nitroprusside was significantly lower. This lower stimulability of sGC was not paralleled by a decrease in its abundance in renal cortex on immunoblot. Taken together, these results demonstrate a desensitization of sGC in renal cortex during endotoxemia, which may contribute to the associated renal vasoconstriction.
    MeSH term(s) Acute Kidney Injury/enzymology ; Acute Kidney Injury/metabolism ; Animals ; Cyclic GMP/metabolism ; Endotoxemia/embryology ; Endotoxemia/metabolism ; Enzyme Induction ; Guanylate Cyclase/antagonists & inhibitors ; Guanylate Cyclase/metabolism ; Kidney Cortex/enzymology ; Kidney Cortex/metabolism ; Male ; Mice ; Mice, Inbred Strains ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type II ; Nitroprusside/pharmacology ; Shock, Septic/enzymology ; Shock, Septic/metabolism ; Solubility
    Chemical Substances Nitroprusside (169D1260KM) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2000-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.V11112133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Protein-templated gold nanoparticle synthesis: protein organization, controlled gold sequestration, and unexpected reaction products.

    Hart, Cassidy / Abuladel, Nouf / Bee, Madeleine / Kreider, Megan C / CVitan, Alexander C / Esson, Moira M / Farag, Andrew / Ibeh, Trisha / Kalivas, Eleni N / Larco, Daniel-Mario / Walker Long, Andrew / Lymperopoulos, Loukas / Mendel, Zachary / Miles, Nancy / Zareba, Carly M / Schwabacher, James C / Slucher, Helen / Vinals, Javier / Heddleston, John M /
    Li, Wenyue / Fox, Douglas M / Hartings, Matthew R

    Dalton transactions (Cambridge, England : 2003)

    2017  Volume 46, Issue 47, Page(s) 16465–16473

    Abstract: Emerging applications that exploit the properties of nanoparticles for biotechnology require that the nanoparticles be biocompatible or support biological recognition. These types of particles can be produced through syntheses that involve biologically ... ...

    Abstract Emerging applications that exploit the properties of nanoparticles for biotechnology require that the nanoparticles be biocompatible or support biological recognition. These types of particles can be produced through syntheses that involve biologically relevant molecules (proteins or natural extracts, for example). Many of the protocols that rely on these molecules are performed without a clear understanding of the mechanism by which the materials are produced. We have investigated a previously described reaction in which gold nanoparticles are produced from the reaction of chloroauric acid and proteins in solution. We find that modifications to the starting conditions can alter the product from the expected solution-suspended colloids to a product where colloids are formed within a solid, fibrous protein structure. We have interrogated this synthesis, exploiting the change in products to better understand this reaction. We have evaluated the kinetics and products for 7 different proteins over a range of concentrations and temperatures. The key factor that controls the synthetic outcome (colloid or fiber) is the concentration of the protein relative to the gold concentration. We find that the observed fibrous structures are more likely to form at low protein concentrations and when hydrophilic proteins are used. An analysis of the reaction kinetics shows that AuNP formation occurs faster at lower protein (fiber-forming) concentrations than at higher protein (colloid-forming) concentrations. These results contradict traditional expectations for reaction kinetics and protein-fiber formation and are instructive of the manner in which proteins template gold nanoparticle production.
    MeSH term(s) Animals ; Chemistry Techniques, Synthetic ; Gold/chemistry ; Kinetics ; Metal Nanoparticles/chemistry ; Nanotechnology/methods ; Proteins/chemistry
    Chemical Substances Proteins ; Gold (7440-57-5)
    Language English
    Publishing date 2017-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c7dt03275g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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