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Article ; Online: Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis.

Wang, Shanshan / Nie, Yao / Yan, Xu / Ko, Tzu-Ping / Huang, Chun-Hsiang / Chan, Hsiu-Chien / Guo, Rey-Ting / Xiao, Rong

Acta crystallographica. Section F, Structural biology communications

2014 Volume 70, Issue Pt 6, Page(s) 800–802

Abstract: The NADH-dependent (R)-carbonyl reductase from Candida parapsilosis (RCR) catalyzes the asymmetric ... reduction of 2-hydroxyacetophenone (HAP) to produce (R)-1-phenyl-1,2-ethanediol [(R)-PED], which is used ...

Abstract	The NADH-dependent (R)-carbonyl reductase from Candida parapsilosis (RCR) catalyzes the asymmetric reduction of 2-hydroxyacetophenone (HAP) to produce (R)-1-phenyl-1,2-ethanediol [(R)-PED], which is used as a versatile building block for the synthesis of pharmaceuticals and fine chemicals. To gain insight into the catalytic mechanism, the structures of complexes of RCR with ligands, including the coenzyme, are important. Here, the recombinant RCR protein was expressed and purified in Escherichia coli and was crystallized in the presence of NAD+. The crystals, which belonged to the orthorhombic space group P2₁2₁2₁, with unit-cell parameters a=85.64, b=106.11, c=145.55 Å, were obtained by the sitting-drop vapour-diffusion method and diffracted to 2.15 Å resolution. Initial model building indicates that RCR forms a homotetramer, consistent with previous reports of medium-chain-type alcohol dehydrogenases.
MeSH term(s)	Amino Acid Sequence ; Candida/enzymology ; Crystallization ; Crystallography, X-Ray ; Molecular Sequence Data ; Oxidoreductases/chemistry ; Oxidoreductases/metabolism
Chemical Substances	Oxidoreductases (EC 1.-)
Language	English
Publishing date	2014-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2053-230X
ISSN (online)	2053-230X
DOI	10.1107/S2053230X1400908X
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Article: The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis.

Kolluri, Siva Kumar / Corr, Maripat / James, Sharon Y / Bernasconi, Michele / Lu, Desheng / Liu, Wen / Cottam, Howard B / Leoni, Lorenzo M / Carson, Dennis A / Zhang, Xiao-kun

Proceedings of the National Academy of Sciences of the United States of America

2005 Volume 102, Issue 7, Page(s) 2525–2530

Abstract: ... but the mechanism of chemoprevention is unknown. Here, we show that the R-enantiomer of the nonsteroidal ... was associated with loss of the retinoid X receptor (RXRalpha) protein in the adenocarcinoma cells ... but not in normal prostatic epithelium. R-etodolac specifically bound recombinant RXRalpha, inhibited ...

Abstract	Prostate cancer is often slowly progressive, and it can be difficult to treat with conventional cytotoxic drugs. Nonsteroidal antiinflammatory drugs inhibit the development of prostate cancer, but the mechanism of chemoprevention is unknown. Here, we show that the R-enantiomer of the nonsteroidal antiinflammatory drug etodolac inhibited tumor development and metastasis in the transgenic mouse adenocarcinoma of the prostate (TRAMP) model, by selective induction of apoptosis in the tumor cells. This proapoptotic effect was associated with loss of the retinoid X receptor (RXRalpha) protein in the adenocarcinoma cells, but not in normal prostatic epithelium. R-etodolac specifically bound recombinant RXRalpha, inhibited RXRalpha transcriptional activity, and induced its degradation by a ubiquitin and proteasome-dependent pathway. The apoptotic effect of R-etodolac could be controlled by manipulating cellular RXRalpha levels. These results document that pharmacologic antagonism of RXRalpha transactivation is achievable and can have profound inhibitory effects in cancer development.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Etodolac/chemistry ; Etodolac/metabolism ; Etodolac/pharmacology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Conformation/drug effects ; RNA, Small Interfering/genetics ; Retinoid X Receptor alpha/chemistry ; Retinoid X Receptor alpha/genetics ; Retinoid X Receptor alpha/metabolism ; Stereoisomerism ; Transcriptional Activation/drug effects ; Transfection
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; RNA, Small Interfering ; Retinoid X Receptor alpha ; Etodolac (2M36281008)
Language	English
Publishing date	2005-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0409721102
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Article: [Multi-phase CT synthesis-assisted segmentation of abdominal organs].

Huang, P / Zhong, L / Zheng, K / Chen, Z / Xiao, R / Quan, X / Yang, W

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2024 Volume 44, Issue 1, Page(s) 83–92

Abstract: Objective: To propose a method for abdominal multi-organ segmentation assisted by multi-phase CT synthesis.: Methods: Multi-phase CT synthesis for synthesizing high-quality CT images was used to increase the information details for image segmentation. ...

Abstract	Objective: To propose a method for abdominal multi-organ segmentation assisted by multi-phase CT synthesis. Methods: Multi-phase CT synthesis for synthesizing high-quality CT images was used to increase the information details for image segmentation. A transformer block was introduced to help to capture long-range semantic information in cooperation with perceptual loss to minimize the differences between the real image and synthesized image. Results: The model was trained using multi-phase CT dataset of 526 total cases from Nanfang Hospital. The mean maximum absolute error (MAE) of the synthesized non-contrast CT, venous phase contrast- enhanced CT (CECT), and delay phase CECT images from arterial phase CECT was 19.192±3.381, 20.140±2.676 and 22.538±2.874, respectively, which were better than those of images synthesized using other methods. Validation of the multi-phase CT synthesis-assisted abdominal multi-organ segmentation method showed an average dice coefficient of 0.847 for the internal validation set and 0.823 for the external validation set. Conclusion: The propose method is capable of synthesizing high-quality multi-phase CT images to effectively reduce the errors in registration between different phase CT images and improve the performance for segmentation of 13 abdominal organs.
MeSH term(s)	Tomography, X-Ray Computed/methods ; Image Processing, Computer-Assisted/methods
Language	Chinese
Publishing date	2024-01-31
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2024.01.10
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Article: [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade].

Liu, Z / Xuan, C / Han, X / Zheng, Z / Xiao, R / Bao, L / Xu, X

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2023 Volume 43, Issue 2, Page(s) 166–174

Abstract: Objective: To investigate the effects of LASS2/TMSG1 gene overexpression on proliferation and apoptosis of human lung cancer A549 cells and explore the possible mechanism.: Methods: We examined LASS2/TMSG1 expression level in a previously constructed ...

Abstract	Objective: To investigate the effects of LASS2/TMSG1 gene overexpression on proliferation and apoptosis of human lung cancer A549 cells and explore the possible mechanism. Methods: We examined LASS2/TMSG1 expression level in a previously constructed A549 cell line overexpressing LASS2/TMSG1 using Western blotting. The proliferation and apoptosis of the cells were detected using colony-forming assay, CCK-8 assay, Hoechst/PI double staining and flow cytometry. Fourteen nude mice were randomized into 2 groups ( Results: Compared with the negative control cells, A549 cells with LASS2/TMSG1 overexpression had significantly lowered proliferation ability Conclusion: Overexpression of LASS2/TMSG1 gene can significantly inhibit the proliferation and promote early apoptosis of human lung cancer A549 cells both
MeSH term(s)	Animals ; Humans ; Mice ; A549 Cells ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Lung Neoplasms ; Membrane Proteins/metabolism ; Mice, Nude ; p38 Mitogen-Activated Protein Kinases/metabolism ; Signal Transduction ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Membrane Proteins ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Tumor Suppressor Proteins ; CERS2 protein, human (EC 2.3.1.24) ; Cers2 protein, mouse (EC 2.3.1.24)
Language	Chinese
Publishing date	2023-03-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2023.02.02
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Article: Body mass index's effect on CRSwNP extends to pathological endotype and recurrence.

Chen, W / Bai, Y / Fang, P / Chen, J / Wang, X / Li, Y / Luo, X / Xiao, Z / Iyer, R / Shan, F / Yuan, T / Wu, M / Huang, X / Fang, D / Yang, Q / Zhang, Y

Rhinology

2024

Abstract: Background: Elevated body mass index (BMI) has been recognized as an important contributor to corticosteroid insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to delineate the effects of elevated BMI on immunological endotype ... ...

Abstract	Background: Elevated body mass index (BMI) has been recognized as an important contributor to corticosteroid insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to delineate the effects of elevated BMI on immunological endotype and recurrence in CRSwNP individuals. Methodology: A total of 325 patients with CRSwNP undergoing FESS were recruited and stratified by BMI. H&E staining was employed for histological evaluation. Characteristics of inflammatory patterns were identified by immunohistochemical staining. The predictive factors for recurrence were determined and evaluated by multivariable logistic regression analysis and the receiver operating characteristic (ROC) curves across all subjects and by weight group. Results: In all patients with CRSwNP, 26.15% subjects were classified as overweight/obese group across BMI categories and exhibited a higher symptom burden. The upregulated eosinophil/neutrophil-dominant cellular endotype and amplified type 2/ type 3 coexisting inflammation was present in overweight/obese compared to underweight/normal weight controls. Additionally, a higher recurrent proportion was shown in overweight/obese patients than that in underweight/normal weight cohorts. Multivariable logistic regression analysis identified BMI as an independent predictor for recurrence. The predictive capacity of each conventional parameter (tissue eosinophil and CLCs count, and blood eosinophil percentage) alone or in combination was poor in overweight/obese subjects. Conclusions: Overweight/obese CRSwNP stands for a unique phenotype and endotype. Conventional parameters predicting recurrence are compromised in overweight/obese CRSwNP, and there is an urgent need for novel biomarkers that predict recurrence for these patients.
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin23.402
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Article ; Online: Dose adjustment strategy of levetiracetam in pregnant patients with epilepsy: Case report and literature review.

Liu, Renzhu / Xiao, Lu / Liu, Xiang / Xiao, Can

Medicine

2024 Volume 103, Issue 17, Page(s) e37977

Abstract: Rationale: Pregnant patients with epilepsy are prone to preterm delivery, stillbirth, or cesarean section, and their mortality rate is almost 10 times higher than that of normal pregnant women. The potential negative influences of antiepileptic drugs ( ... ...

Abstract	Rationale: Pregnant patients with epilepsy are prone to preterm delivery, stillbirth, or cesarean section, and their mortality rate is almost 10 times higher than that of normal pregnant women. The potential negative influences of antiepileptic drugs (AEDs) on the fetus are weighed against the necessity for achieving optimal control of seizures. Treatment with AEDs during pregnancy is a major challenge for pregnant women and healthcare teams. Patient concerns: This paper reports two cases of young women diagnosed with pregnancy and epilepsy. Intervention: The dose of levetiracetam was adjusted under the guidance of therapeutic drug monitoring to reduce the effects of seizures on the fetus and the incidence of reproductive toxicity caused by adverse drug reactions. Outcomes: Epilepsy was well controlled in the two pregnant patients, and the newborns had no genetic disorders. Lessons: It is recommended to regularly monitor the serum LEV level in pregnant patients with epilepsy. This practice serves as a foundation for adjusting the drug treatment plan and offering more precise guidance for medication management during pregnancy.
MeSH term(s)	Humans ; Levetiracetam/administration & dosage ; Levetiracetam/therapeutic use ; Female ; Pregnancy ; Anticonvulsants/administration & dosage ; Anticonvulsants/therapeutic use ; Anticonvulsants/adverse effects ; Epilepsy/drug therapy ; Pregnancy Complications/drug therapy ; Adult ; Drug Monitoring/methods
Chemical Substances	Levetiracetam (44YRR34555) ; Anticonvulsants
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Case Reports ; Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037977
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Article: [Limitations and cautions of a family history of HBV-related cirrhosis/hepatocellular carcinoma as a condition for initiating antiviral therapy in patients with HBV infection].

Wang, X R / Xiao, L / Zhang, C M / Wang, B / Xu, H T / Xian, J C

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2024 Volume 31, Issue 11, Page(s) 1217–1219

MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Hepatitis B virus/genetics ; Liver Neoplasms ; Liver Cirrhosis ; Antiviral Agents/therapeutic use
Chemical Substances	Antiviral Agents
Language	Chinese
Publishing date	2024-01-18
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20220607-00307
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Article: [The role of DNA methylation in the screening of endometrial cancer in postmenopausal women].

Kong, L H / Xiao, X P / Wan, R / Chao, X P / Chen, X J / Wang, J / Wu, H W / Li, L

Zhonghua yi xue za zhi

2023 Volume 103, Issue 12, Page(s) 907–912

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Pregnancy ; Humans ; Female ; Postmenopause ; DNA Methylation ; Ultrasonography ; Early Detection of Cancer/adverse effects ; Endometrial Neoplasms/genetics ; Endometrium/diagnostic imaging ; Endometrium/pathology ; Uterine Hemorrhage ; Sensitivity and Specificity ; Hysteroscopy/adverse effects
Language	Chinese
Publishing date	2023-03-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20220929-02058
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Article: [Continuous positive airway pressure therapy affects the recurrence of atrial fibrillation in patients with obstructive sleep apnea: a systematic review and meta-analysis].

Wang, Y X / Luo, J M / Huang, R / Xiao, Y

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2023 Volume 46, Issue 8, Page(s) 751–759

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Atrial Fibrillation/therapy ; Atrial Fibrillation/complications ; Continuous Positive Airway Pressure/adverse effects ; Recurrence ; Sleep Apnea, Obstructive ; Hypertension
Language	Chinese
Publishing date	2023-08-03
Publishing country	China
Document type	Meta-Analysis ; Systematic Review ; English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20230213-00064
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Article ; Online: Analysis of immune cell infiltration characteristics in severe acute pancreatitis through integrated bioinformatics.

Xiao, Shuai / Han, Xiao / Bai, Shuhui / Chen, Rui

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8711

Abstract: The etiopathogenesis of severe acute pancreatitis (SAP) remains poorly understood. We aim to investigate the role of immune cells Infiltration Characteristics during SAP progression. Gene expression profiles of the GSE194331 dataset were retrieved from ... ...

Abstract	The etiopathogenesis of severe acute pancreatitis (SAP) remains poorly understood. We aim to investigate the role of immune cells Infiltration Characteristics during SAP progression. Gene expression profiles of the GSE194331 dataset were retrieved from the GEO. Lasso regression and random forest algorithms were employed to select feature genes from genes related to SAP progression and immune responses. CIBERSORT was utilized to estimate differences in immune cell types and proportions and the relationship between immune cells and gene expression. We performed pathway enrichment analysis using GSEA to examine disparities in KEGG signaling pathways when comparing the two groups. Additionally, CMap analysis was executed to identify prospective small molecular compounds. The three hub genes (CBLB, JADE2, RNF144A) were identified that can predict SAP progression. Analysis of CIBERSORT and TISIDB databases has shown that there are significant differences in immune cell expression levels between the normal and SAP groups, and three hub genes (CBLB, JADE2, RNF144A) were highly correlated with multiple immune cells, regulating the characteristics of immune cell infiltration in the microenvironment. Finally, drug prediction through the Connectivity Map database suggested that compounds such as Entecavir, KU-0063794, Y-27632, and Antipyrine have certain effects as potential targeted drugs for the treatment of SAP. CBLB, JADE2, and RNF144A are hub genes in SAP, potentially playing important roles in SAP progression. This finding further broadens the understanding of the etiopathogenesis of SAP and provides a feasible basis for future research on diagnostic and immunotherapeutic targets for SAP.
MeSH term(s)	Humans ; Acute Disease ; Prospective Studies ; Pancreatitis/genetics ; Drug Delivery Systems ; Computational Biology
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59205-1
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