LIVIVO - Search results -

Search results

Result 1 - 10 of total 237

Search options

Article: Revealing the association between vitamin D metabolic pathway gene variants and lung cancer risk: a systematic review and meta-analysis.

Elsalahaty, Mohamed I / Alkafaas, Samar Sami / Bashir, Aya O / El-Tarabily, Khaled A / El-Saadony, Mohamed T / Yousef, Eman H

Frontiers in genetics

2024 Volume 15, Page(s) 1302527

Abstract: Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been ... ...

Abstract	Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been studied in regards to lung cancer, but the findings have been inconclusive. We here present a systematic review and meta-analysis of seven genes in this pathway:
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1302527
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Ameliorative effect of vitamin E and selenium against bisphenol A-induced toxicity in spinal cord and submandibular salivary glands of adult male albino rats.

Bashir, Dina W / Ahmed, Yasmine H / El-Sakhawy, Mohamed A

International journal of environmental health research

2022 Volume 33, Issue 10, Page(s) 993–1009

Abstract: Bisphenol A (BPA) used in plastic industry. This study evaluate ameliorative effect of vitamin E and selenium in combating BPA toxicity in spinal cord (SC) and submandibular glands (SMGs). Thirty rats divided into three groups [Group I, controls; Group ... ...

Abstract	Bisphenol A (BPA) used in plastic industry. This study evaluate ameliorative effect of vitamin E and selenium in combating BPA toxicity in spinal cord (SC) and submandibular glands (SMGs). Thirty rats divided into three groups [Group I, controls; Group II, BPA orally (25 mg/kg) three times a week, 60 days; Group III, BPA (25 mg/kg) plus vitamin E and selenium in water (1 ml/L/day)]. By histopathological, immunohistochemical, and biochemical investigations. Bisphenol A group showed degenerative alterations. SC gray matter showed pyknotic nuclei and white matter revealed neuropil degeneration. Myelinated fibers showed dispersed myelin. SMGs, exhibited vacuolated cytoplasm in acinar cells. Intense glial fibrillary acidic protein in SC and strong proliferating cell nuclear antigen in acinar and ductal cell nuclei of SMGs. Malondialdehyde elevated in SC and catalase decreased in SMG. Group III, SC and SMG revealed partial recovery. Vitamin E and selenium displayed protective effects against BPA toxicity in SC and SMGs.
MeSH term(s)	Rats ; Male ; Animals ; Vitamin E/pharmacology ; Selenium/pharmacology ; Submandibular Gland ; Benzhydryl Compounds/toxicity ; Spinal Cord ; Oxidative Stress
Chemical Substances	Vitamin E (1406-18-4) ; Selenium (H6241UJ22B) ; bisphenol A (MLT3645I99) ; Benzhydryl Compounds
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1104887-6
ISSN	1369-1619 ; 0960-3123
ISSN (online)	1369-1619
ISSN	0960-3123
DOI	10.1080/09603123.2022.2067327
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3517: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Selective Serotonin Reuptake Inhibitors and Other Treatment Modalities for Deep Space Missions.

El-Khoury, Bashir B / Ray, Kristi L / Altchuler, Steven I / Reichard, John F / Dukes, Charles H

Aerospace medicine and human performance

2023 Volume 94, Issue 11, Page(s) 843–851

Abstract: INTRODUCTION: ...

Abstract	INTRODUCTION:
MeSH term(s)	Humans ; Selective Serotonin Reuptake Inhibitors/adverse effects ; Mental Disorders ; Anxiety ; Space Flight
Chemical Substances	Selective Serotonin Reuptake Inhibitors
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809085-8
ISSN	2375-6322 ; 2375-6314
ISSN (online)	2375-6322
ISSN	2375-6314
DOI	10.3357/AMHP.6272.2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 57: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: DiaNet v2 deep learning based method for diabetes diagnosis using retinal images.

Al-Absi, Hamada R H / Pai, Anant / Naeem, Usman / Mohamed, Fatma Kassem / Arya, Saket / Sbeit, Rami Abu / Bashir, Mohammed / El Shafei, Maha Mohammed / El Hajj, Nady / Alam, Tanvir

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1595

Abstract: Diabetes mellitus (DM) is a prevalent chronic metabolic disorder linked to increased morbidity and mortality. With a significant portion of cases remaining undiagnosed, particularly in the Middle East North Africa (MENA) region, more accurate and ... ...

Abstract	Diabetes mellitus (DM) is a prevalent chronic metabolic disorder linked to increased morbidity and mortality. With a significant portion of cases remaining undiagnosed, particularly in the Middle East North Africa (MENA) region, more accurate and accessible diagnostic methods are essential. Current diagnostic tests like fasting plasma glucose (FPG), oral glucose tolerance tests (OGTT), random plasma glucose (RPG), and hemoglobin A1c (HbA1c) have limitations, leading to misclassifications and discomfort for patients. The aim of this study is to enhance diabetes diagnosis accuracy by developing an improved predictive model using retinal images from the Qatari population, addressing the limitations of current diagnostic methods. This study explores an alternative approach involving retinal images, building upon the DiaNet model, the first deep learning model for diabetes detection based solely on retinal images. The newly proposed DiaNet v2 model is developed using a large dataset from Qatar Biobank (QBB) and Hamad Medical Corporation (HMC) covering wide range of pathologies in the the retinal images. Utilizing the most extensive collection of retinal images from the 5545 participants (2540 diabetic patients and 3005 control), DiaNet v2 is developed for diabetes diagnosis. DiaNet v2 achieves an impressive accuracy of over 92%, 93% sensitivity, and 91% specificity in distinguishing diabetic patients from the control group. Given the high prevalence of diabetes and the limitations of existing diagnostic methods in clinical setup, this study proposes an innovative solution. By leveraging a comprehensive retinal image dataset and applying advanced deep learning techniques, DiaNet v2 demonstrates a remarkable accuracy in diabetes diagnosis. This approach has the potential to revolutionize diabetes detection, providing a more accessible, non-invasive and accurate method for early intervention and treatment planning, particularly in regions with high diabetes rates like MENA.
MeSH term(s)	Humans ; Blood Glucose/metabolism ; Deep Learning ; Diabetes Mellitus/diagnostic imaging ; Glucose Tolerance Test ; Glycated Hemoglobin ; Fasting
Chemical Substances	Blood Glucose ; Glycated Hemoglobin
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49677-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Innovative biosynthesis, artificial intelligence-based optimization, and characterization of chitosan nanoparticles by Streptomyces microflavus and their inhibitory potential against Pectobacterium carotovorum.

El-Naggar, Noura El-Ahmady / Bashir, Shimaa I / Rabei, Nashwa H / Saber, WesamEldin I A

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21851

Abstract: ... an initial pH of 5.5, 1% chitosan, 40 °C, and a 12 h incubation period. Innovatively, the artificial ...

Abstract	Microbial-based strategy in nanotechnology offers economic, eco-friendly, and biosafety advantages over traditional chemical and physical protocols. The current study describes a novel biosynthesis protocol for chitosan nanoparticles (CNPs), employing a pioneer Streptomyces sp. strain NEAE-83, which exhibited a significant potential for CNPs biosynthesis. It was identified as Streptomyces microflavus strain NEAE-83 based on morphological, and physiological properties as well as the 16S rRNA sequence (GenBank accession number: MG384964). CNPs were characterized by SEM, TEM, EDXS, zeta potential, FTIR, XRD, TGA, and DSC. CNPs biosynthesis was maximized using a mathematical model, face-centered central composite design (CCFCD). The highest yield of CNPs (9.41 mg/mL) was obtained in run no. 27, using an initial pH of 5.5, 1% chitosan, 40 °C, and a 12 h incubation period. Innovatively, the artificial neural network (ANN), was used for validating and predicting CNPs biosynthesis based on the trials data of CCFCD. Despite the high precision degree of both models, ANN was supreme in the prediction of CNPs biosynthesis compared to CCFCD. ANN had a higher prediction efficacy and, lower error values (RMSE, MDA, and SSE). CNPs biosynthesized by Streptomyces microflavus strain NEAE-83 showed in-vitro antibacterial activity against Pectobacterium carotovorum, which causes the potato soft rot. These results suggested its potential application for controlling the destructive potato soft rot diseases. This is the first report on the biosynthesis of CNPs using a newly isolated; Streptomyces microflavus strain NEAE-83 as an eco-friendly approach and optimization of the biosynthesis process by artificial intelligence.
MeSH term(s)	Pectobacterium carotovorum/genetics ; RNA, Ribosomal, 16S/genetics ; Chitosan ; Artificial Intelligence ; Streptomyces/genetics ; Solanum tuberosum/genetics ; Nanoparticles
Chemical Substances	RNA, Ribosomal, 16S ; Chitosan (9012-76-4)
Language	English
Publishing date	2022-12-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25726-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anatomical, histological, and histochemical alterations in portio vaginalis uteri with an evaluation of the vaginal artery vascularity during the luteal and early pregnant stages in domestic buffaloes (Bubalus bubalis).

Abouelela, Yara S / Shaker, Nora A / El-Shahat, Khaled H / Bashir, Dina W / El-Sherbiny, Hossam R / Abdelnaby, Elshymaa A

BMC veterinary research

2023 Volume 19, Issue 1, Page(s) 260

Abstract: The portio-vaginalis uteri (PVU) and its mucus secretion have shown an essential role in conception. A significant endeavour to improve buffaloes' reproductive efficiency is the investigation of their basic reproductive pattern, which provides a ... ...

Abstract	The portio-vaginalis uteri (PVU) and its mucus secretion have shown an essential role in conception. A significant endeavour to improve buffaloes' reproductive efficiency is the investigation of their basic reproductive pattern, which provides a reference for applications in breeding and pregnancy. The present study aimed to evaluate the anatomical and histological alterations in PVU regarding to the vaginal artery (VA) hemodynamic at luteal and early pregnant stages in buffalos. Egyptian live buffaloes (n = 16) and fresh genitals (n = 25) of mature buffalo were used. Different luteal and early pregnant stages were macroscopically identified with the shape and mucosal colouration with discharges of the PVU. Histological examination showed a significant difference in area % of alcian blue and periodic acid Schiff positive granules which considered an indication for presence of acidic and neutral mucins respectively in the epithelial cells of PVU mucosa which increased in pregnant stage than in other luteal stages. VA assessment demonstrated an increase in luminal diameter and thickness of tunica muscularis in pregnant stage than other stages (P < 0.05). Middle uterine (MUA) and VA arteries peak velocity point (PSV mm/sec) were elevated (P < 0.05) in pregnant stage, with a marked reduction in both resistance and pulsatility indices (RI and PI), and ratio of systolic /diastolic (S/D). Positive correlation was detected between VA. PSV and, MUA. PSV (r = 0.87), but a negative relation was detected with VA. S/D (r = -0.77), VA.PI (r = -0.89), VA. RI (r = -0.97), MUA. S/D (r = -0.94), MUA. PI (r = -0.85), and MUA. RI (r = -0.88). Doppler indices were negatively corrected with the VA. PSV (r = -0.68). It was concluded that there was a significant alterations in histological features of the cervical PVU at different physiological stages (luteal and early pregnant) in buffalos in relation to the MUA and VA hemodynamic pattern and that hypotheses can be established regarding the female cyclicity that affected by both arteries hemodynamics change.
MeSH term(s)	Pregnancy ; Female ; Animals ; Buffaloes/physiology ; Lutein ; Uterus ; Reproduction ; Arteries ; Bison ; Blood Flow Velocity
Chemical Substances	Lutein (X72A60C9MT)
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2191675-5
ISSN	1746-6148 ; 1746-6148
ISSN (online)	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-023-03816-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Pharmacological Screening of

Saleem, Uzma / Hira, Sundas / Anwar, Fareeha / Shah, Muhammad Ajmal / Bashir, Samia / Baty, Roua S / Badr, Reem H / Blundell, Renald / Batiha, Gaber El-Saber / Ahmad, Bashir

Frontiers in pharmacology

2021 Volume 12, Page(s) 664832

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.664832
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Optimal Parathyroid Hormone Cut-Off Threshold for Early and Safe Management of Hypocalcemia After Total Thyroidectomy.

Bashir, Abdalla Y / Alzubaidi, Ahmad N / Bashir, Mohammad A / Obed, Aiman H / Zakarneh, Rami K / Ennab, Hassan Z / Abu-Hijleh, Omar M / El-Zaheri, Mohamed M / Bashir, Ahmad A

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2021 Volume 27, Issue 9, Page(s) 925–933

Abstract: Objective: To define optimal intact parathyroid hormone (iPTH) cut-off threshold predictive of hypocalcemia after total thyroidectomy for safe and effective postoperative management.: Methods: This prospective single center study was done in 2 phases. ...

Abstract	Objective: To define optimal intact parathyroid hormone (iPTH) cut-off threshold predictive of hypocalcemia after total thyroidectomy for safe and effective postoperative management. Methods: This prospective single center study was done in 2 phases. In phase I, predictors of symptomatic hypocalcemia were analyzed and the receiver operating characteristic curve was used to define the optimal iPTH cut-off threshold predictive of hypocalcemia. Phase II studied giving prompt prophylactic supplemental calcium and vitamin D to all patients who had iPTH levels below the calculated threshold, while phase I patients were given prompt selective supplementation if they had postoperative hypocalcemia or symptoms. Results: Univariate analysis of patients in phase I showed that postoperative iPTH was the only significant variable that can predict symptomatic hypocalcemia. Using receiver operating characteristic curve and Youden index, the confirmed optimal cut-off threshold predictive of hypocalcemia was iPTH 19.95 pg/mL, with area under the curve of 0.903, 100% sensitivity, negative predictive value, and highest Youden index, while iPTH 15 pg/mL and iPTH 10 pg/mL were less optimal. Symptomatic hypocalcemia occurred in 30% of the phase I cohort who received selective supplementation versus 3% of those in the phase II cohort who received prophylactic supplementation. Return to emergency department and need for intravenous calcium were also significantly better in phase II. Conclusion: iPTH cut-off for post-thyroidectomy hypocalcemia was 19.95 pg/mL. Low-risk patients were discharged with no supplementation while all high-risk patients received prompt calcium and vitamin D supplementation, which led to effective hypocalcemia management and safe 24-hour discharge.
MeSH term(s)	Calcium ; Humans ; Hypocalcemia/drug therapy ; Hypocalcemia/epidemiology ; Hypocalcemia/etiology ; Parathyroid Hormone ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Prospective Studies ; Thyroidectomy/adverse effects
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.1016/j.eprac.2021.02.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5034: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 508: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Health Impact of Household Waste Burning in Khartoum State, Sudan [Response to Letter]

Waleed Makki H / Mohamed TSA / Abd El‑Raheem GOH / Bashir Abdel Mahmoud AZ / Mustafa Elfadul M / Homeida M / Noma M

Risk Management and Healthcare Policy, Vol Volume 16, Pp 2953-

2023 Volume 2954

Abstract: ... El‑Raheem,3 Al-Zamzami Bashir Abdel Mahmoud,4 Maisa Mustafa Elfadul,5 Mamoun Homeida,6 ...

Abstract	Hiba Waleed Makki,1 Hana Waleed Makki,1 Tala Siefuddin Awadelkarem Mohamed,2 Ghada Omer Hamad Abd El‑Raheem,3 Al-Zamzami Bashir Abdel Mahmoud,4 Maisa Mustafa Elfadul,5 Mamoun Homeida,6 Mounkaila Noma2 1Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan; 2Postgraduate Diploma Research Methodology & Biostatistics, Graduate College, University of Medical Sciences and Technology, Khartoum, Sudan; 3Soba University Hospital & Research Methodology and Biostatistics, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan; 4Faculty of Disaster and Humanitarian Security, International University of Africa, Khartoum, Sudan; 5Public Health, Graduate College, University of Medical Sciences and Technology, Khartoum, Sudan; 6University of Medical Sciences and Technology, Khartoum, SudanCorrespondence: Hiba Waleed Makki, Tel +249906566001, Email hibawaleed70@gmail.com
Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Uncovering the antimicrobial activity of G-type lysozyme 2 derived from Cyprinus carpio mucus against bacterial and fungal pathogens.

Shabir, Uzma / Dar, Jehangir Shafi / Bhat, Aashaq Hussain / Ganai, Bashir Ahmad / Mahmoud, Mohamed H / Batiha, Gaber El-Saber

Developmental and comparative immunology

2024 Volume 153, Page(s) 105135

Abstract: This study aimed to explore the antimicrobic potential of mucus samples collected from Cyprinus carpio and identify the specific antimicrobial peptides responsible for its activity. The crude extract was tested against various bacterial and fungal ... ...

Abstract	This study aimed to explore the antimicrobic potential of mucus samples collected from Cyprinus carpio and identify the specific antimicrobial peptides responsible for its activity. The crude extract was tested against various bacterial and fungal pathogens, and its protein content and profile were analyzed. Purification steps, including gel filtration chromatography, were employed to isolate the most active fraction (peak IV), which was further identified via liquid chromatography and mass spectroscopy. The results revealed varying degrees of antimicrobial activity of the crude extract against different bacterial and fungal strains, with Leclercia adecarboxylata, Candida glabrata, and Candida parapsilosis showing the highest susceptibility. SDS-PAGE analysis demonstrated the existence of multiple low molecular weight protein bands in the crude extract, while fraction IV obtained from gel filtration chromatography exhibited the strongest antimicrobial activity. Peak IV displayed a range of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values against the tested pathogens, spanning from 0.038 to 4.960 mg/mL. Further investigation identified the purified peptide derived from peak IV as G-type lysozyme 2, characterized by a molecular weight of 21 kDa. These findings shed light on the existence of a highly effective antimicrobial peptide, G-type lysozyme 2, within the mucus of Cyprinus carpio. This peptide demonstrates notable activity against diverse bacterial and fungal pathogens. The insights from this study enhance our understanding of the fish's antimicrobial defense mechanisms and hold promise for developing novel antimicrobial agents.
MeSH term(s)	Animals ; Muramidase ; Carps ; Anti-Infective Agents/pharmacology ; Bacteria ; Peptides/pharmacology ; Complex Mixtures/analysis ; Complex Mixtures/pharmacology ; Mucus ; Microbial Sensitivity Tests
Chemical Substances	Muramidase (EC 3.2.1.17) ; Anti-Infective Agents ; Peptides ; Complex Mixtures
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2024.105135
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1327: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito