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  1. Article ; Online: J-MISFET Hybrid Dual-Gate Switching Device for Multifunctional Optoelectronic Logic Gate Applications.

    Yu, Si Eun / Lee, Han Joo / Kim, Min-Gu / Im, Seongil / Lee, Young Tack

    ACS nano

    2024  Volume 18, Issue 17, Page(s) 11404–11415

    Abstract: ... of the vertically stacked junction and metal-insulator-semiconductor (MIS) gate structure, named J-MISFET. It shows ...

    Abstract High-performance and low operating voltage are becoming increasingly significant device parameters to meet the needs of future integrated circuit (IC) processors and ensure their energy-efficient use in upcoming mobile devices. In this study, we suggest a hybrid dual-gate switching device consisting of the vertically stacked junction and metal-insulator-semiconductor (MIS) gate structure, named J-MISFET. It shows excellent device performances of low operating voltage (<0.5 V), drain current ON/OFF ratio (∼4.7 × 10
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.4c01450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?

    Camilleri, Michael / Tack, Jan

    Gastroenterology

    2023  Volume 165, Issue 1, Page(s) 1–4

    MeSH term(s) Humans ; Gastroparesis/diagnosis ; Gastroparesis/pathology ; Interstitial Cells of Cajal/pathology ; Gastric Emptying ; Biopsy
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.03.204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 572: Show issues

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  3. Book: A guide to gastrointestinal motility disorders

    Bredenoord, Albert J. / Smout, André / Tack, Jan

    2016  

    Author's details Albert J. Bredenoord ; André Smout ; Jan Tack
    Keywords manometry ; gastroesophageal reflux ; dyspepsia ; abdominal pain ; constipation
    Language English
    Size VIII, 112 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018877573
    ISBN 978-3-319-26936-8 ; 978-3-319-26938-2 ; 3-319-26936-4 ; 3-319-26938-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 352 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: A tale of two fish tails: does a forked tail really perform better than a truncate tail when cruising?

    Tack, Nils B / Gemmell, Brad J

    The Journal of experimental biology

    2022  Volume 225, Issue 22

    Abstract: Many fishes use their tail as the main thrust producer during swimming. This fin's diversity in shape and size influences its physical interactions with water as well as its ecological functions. Two distinct tail morphologies are common in bony fishes: ... ...

    Abstract Many fishes use their tail as the main thrust producer during swimming. This fin's diversity in shape and size influences its physical interactions with water as well as its ecological functions. Two distinct tail morphologies are common in bony fishes: flat, truncate tails which are best suited for fast accelerations via drag forces, and forked tails that promote economical, fast cruising by generating lift-based thrust. This assumption is based primarily on studies of the lunate caudal fin of Scombrids (i.e. tuna, mackerel), which is comparatively stiff and exhibits an airfoil-type cross-section. However, this is not representative of the more commonly observed and taxonomically widespread flexible forked tail, yet similar assumptions about economical cruising are widely accepted. Here, we present the first comparative experimental study of forked versus truncate tail shape and compare the fluid mechanical properties and energetics of two common nearshore fish species. We examined the hypothesis that forked tails provide a hydrodynamic advantage over truncate tails at typical cruising speeds. Using experimentally derived pressure fields, we show that the forked tail produces thrust via acceleration reaction forces like the truncate tail during cruising but at increased energetic costs. This reduced efficiency corresponds to differences in the performance of the two tail geometries and body kinematics to maintain similar overall thrust outputs. Our results offer insights into the benefits and tradeoffs of two common fish tail morphologies and shed light on the functional morphology of fish swimming to guide the development of bio-inspired underwater technologies.
    MeSH term(s) Animals ; Swimming ; Fishes/anatomy & histology ; Hydrodynamics ; Biomechanical Phenomena ; Perciformes/anatomy & histology
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.244967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2629: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Fish can use coordinated fin motions to recapture their own vortex wake energy.

    Tack, Nils B / Du Clos, Kevin T / Gemmell, Brad J

    Royal Society open science

    2024  Volume 11, Issue 1, Page(s) 231265

    Abstract: During swimming, many fishes use pectoral fins for propulsion and, in the process, move substantial amounts of water rearward. However, the effect that this upstream wake has on the caudal fin remains largely unexplored. By coordinating motions of the ... ...

    Abstract During swimming, many fishes use pectoral fins for propulsion and, in the process, move substantial amounts of water rearward. However, the effect that this upstream wake has on the caudal fin remains largely unexplored. By coordinating motions of the caudal fin with the pectoral fins, fishes have the potential to create constructive flow interactions which may act to partially recapture the upstream energy lost in the pectoral fin wake. Using experimentally derived velocity and pressure fields for the silver mojarra (
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.231265
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  6. Article: Editorial.

    Tack, Jan

    United European gastroenterology journal

    2018  Volume 6, Issue 10, Page(s) 1447

    Language English
    Publishing date 2018-11-29
    Publishing country England
    Document type Editorial
    ISSN 2050-6406
    ISSN 2050-6406
    DOI 10.1177/2045125318814098
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  7. Article ; Online: The Role of Food in Disorders of Gut-Brain Interaction: Introduction to a Rome Foundation Working Group Series.

    Chey, William D / Tack, Jan

    The American journal of gastroenterology

    2022  Volume 117, Issue 6, Page(s) 935–936

    MeSH term(s) Brain/diagnostic imaging ; Food ; Gastrointestinal Diseases ; Humans ; Rome
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: Tegaserod: What's Old Is New Again.

    Sayuk, Gregory S / Tack, Jan

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 20, Issue 10, Page(s) 2175–2184.e19

    Abstract: Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) are common gastrointestinal disorders imposing considerable impact on the quality of life and well-being of affected individuals. A paucity of evidence-based ... ...

    Abstract Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) are common gastrointestinal disorders imposing considerable impact on the quality of life and well-being of affected individuals. A paucity of evidence-based treatment options exist for CIC and IBS-C sufferers. Tegaserod, a 5-HT<sub>4</sub> agonist, has a substantial body of preclinical and clinical study evidence to support its beneficial role in modulating sensorimotor function of the luminal gastrointestinal tract. Tegaserod was first approved for use by the U.S. Food and Drug Administration for the management of IBS-C and CIC in 2002 and 2004, respectively. Tegaserod enjoyed a successful uptake in the management of these disorders during its first several years of availability in the United States, but was later withdrawn from the market in 2007 over concerns related to adverse cardiovascular events. Since then, additional safety data has been generated, and following a resubmission and review by the Food and Drug Administration, in April 2019, tegaserod was once again approved for use in IBS-C under a more restricted labeling, confining use to women under 65 years of age without heart disease or additional cardiovascular risk factors. This review summarizes the regulatory journey of tegaserod and details the existing pharmacokinetic, physiologic, clinical, and safety data of tegaserod generated over the last 2 decades. The discussion also examines the future of tegaserod in the treatment of these constipation disorders, as well as its potential role in other related disorders of brain-gut interaction.
    MeSH term(s) Constipation/drug therapy ; Female ; Gastrointestinal Agents/adverse effects ; Humans ; Indoles ; Irritable Bowel Syndrome/drug therapy ; Quality of Life ; Serotonin/therapeutic use ; Serotonin Receptor Agonists/therapeutic use
    Chemical Substances Gastrointestinal Agents ; Indoles ; Serotonin Receptor Agonists ; Serotonin (333DO1RDJY) ; tegaserod (458VC51857)
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.01.024
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    Zs.A 5836: Show issues Location:
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  9. Article ; Online: Post-COVID-19 Gastro-Intestinal Disturbances.

    Scarpellini, Emidio / Tack, Jan

    Reviews on recent clinical trials

    2022  Volume 18, Issue 1, Page(s) 34–40

    Abstract: Background: Since the end of 2019, SARS-CoV-2 has been responsible for the multisystemic hyper-inflammatory disease, namely, COVID-19, as a majorly impactful pandemic. Gastrointestinal (GI) symptoms occurring during and after disease are gaining ... ...

    Abstract Background: Since the end of 2019, SARS-CoV-2 has been responsible for the multisystemic hyper-inflammatory disease, namely, COVID-19, as a majorly impactful pandemic. Gastrointestinal (GI) symptoms occurring during and after disease are gaining increasing attention among experts.
    Methods: We briefly review and comment on preliminary and recent evidences on prevalence, pathophysiology, and perspective treatment options for GI disturbances during and after COVID-19.
    Results: Several reports from the literature show a significant portion of COVID-19 patients suffering from GI symptoms both at the early stages of the disease and after the end of it, sometimes for several months, namely "long-COVID-19" patients, irrespective of vaccination. An unsolved issue regarding COVID-19 is the association between GI symptoms and the outcome of COVID-19 patients. Several studies and metanalyses suggest a worse evolution of COVID-19 in patients presenting with GI symptoms. However, these data have not been agreed. Indeed, only one uniform observation can be found in the literature: patients with chronic liver disease have a worse outcome from COVID-19 infection. Upper and lower GI symptoms have similarities with postinfectious functional dyspepsia (FD) and irritable bowel syndrome (IBS). FD and IBS following infection are recognize as pathophysiological factor the gut microbial, which is a gut microbial quali- and quantitative unbalance, namely dysbiosis. Furthermore, several preliminary reports and ongoing clinical trials have shown gut microbiota modulation by pre-, pro- and postbiotics to be effective in changing and preventing COVID-19 natural course.
    Conclusion: GI symptoms characterize both long- and non-long-COVID-19 with a potentially significant impact on its natural course. Gut microbiota modulation seems to be a sensible target for disease treatment and/or prevention.
    MeSH term(s) Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; COVID-19/complications ; SARS-CoV-2 ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/diagnosis ; Dyspepsia
    Language English
    Publishing date 2022-12-04
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887118666221201104833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: refractory reflux sensitivity-A place for baclofen? Authors' reply.

    Raymenants, Karlien / Tack, Jan

    Alimentary pharmacology & therapeutics

    2022  Volume 56, Issue 4, Page(s) 725–726

    MeSH term(s) Baclofen/therapeutic use ; Esophagitis, Peptic ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/drug therapy ; Humans
    Chemical Substances Baclofen (H789N3FKE8)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17129
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