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  1. Book: Clinical applications of PCR

    Luthra, Rajyalakshmi / Singh, Rajesh R. / Patel, Keyur P.

    (Methods in molecular biology ; 1392 ; Springer protocols)

    2016  

    Author's details ed. by Rajyalakshmi Luthra, Rajesh R. Singh, and Keyur P. Patel
    Series title Methods in molecular biology ; 1392
    Springer protocols
    Collection
    Keywords Polymerase-Kettenreaktion ; Labormedizin
    Subject Labordiagnostik ; Medizinische Labortechnik ; Laboratoriumsdiagnostik ; Laboratoriumsmedizin ; PCR ; Polymerase chain reaction
    Language English
    Size X, 191 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018895009
    ISBN 978-1-4939-3358-7 ; 978-1-4939-3360-0 ; 1-4939-3358-2 ; 1-4939-3360-4
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Invited Commentary: A Pragmatic Approach to Calculating Risk of Hollow Viscus Injury in Trauma Patients with a Seat-Belt Sign.

    Park, Caroline / Patel, Keyur

    Journal of the American College of Surgeons

    2023  Volume 237, Issue 6, Page(s) 833–834

    MeSH term(s) Humans ; Accidents, Traffic ; Abdominal Injuries/diagnosis ; Abdominal Injuries/etiology ; Abdominal Injuries/surgery ; Viscera ; Wounds, Nonpenetrating
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000000876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients.

    Bera, Chinmay / Hamdan-Perez, Nashla / Patel, Keyur

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: The aim of this review is to provide updated information on the clinical use of non-invasive serum and imaging-based tests for fibrosis assessment in chronic hepatitis B (CHB) virus infection. In recent years, non-invasive tests (NIT) have been ... ...

    Abstract The aim of this review is to provide updated information on the clinical use of non-invasive serum and imaging-based tests for fibrosis assessment in chronic hepatitis B (CHB) virus infection. In recent years, non-invasive tests (NIT) have been increasingly used to determine eligibility for treatment. Liver biopsy is still considered the gold standard for assessing inflammatory activity and fibrosis staging, but it is an invasive procedure with inherent limitations. Simple serum markers such as APRI and FIB-4 are limited by indeterminate results but remain useful initial tests for fibrosis severity if imaging elastography is not available. Point-of-care US-based elastography techniques, such as vibration-controlled transient elastography or 2D shear wave elastography, are increasingly available and have better accuracy than simple serum tests for advanced fibrosis or cirrhosis, although stiffness cut-offs are variable based on E-antigen status and inflammatory activity. Current NITs have poor diagnostic performance for following changes in fibrosis with antiviral therapy. However, NITs may have greater clinical utility for determining prognosis in patients with CHB that have advanced disease, especially for the development of hepatocellular carcinoma and/or liver decompensation. Algorithms combining serum and imaging NITs appear promising for advanced fibrosis and prognostic risk stratification.
    Language English
    Publishing date 2024-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Noninvasive assessment of liver fibrosis and portal hypertension.

    Duarte-Rojo, Andres / Patel, Keyur / Rockey, Don C

    Current opinion in gastroenterology

    2024  Volume 40, Issue 3, Page(s) 148–155

    Abstract: Purpose of review: The result of ongoing liver injury - and disease, regardless of cause - is fibrosis, and fibrosis appears to be a critically important result of ongoing injury. Further, in a number of different liver diseases, the presence of ... ...

    Abstract Purpose of review: The result of ongoing liver injury - and disease, regardless of cause - is fibrosis, and fibrosis appears to be a critically important result of ongoing injury. Further, in a number of different liver diseases, the presence of fibrosis has prognostic value. Therefore, the assessment of fibrosis is of critical clinical importance. Given the importance of fibrosis, there has been a rapid evolution in the use of noninvasive liver tests. This review highlights a number of the core principles surrounding.
    Recent findings: The use of noninvasive test has progressed rapidly over the last decade and data are rapidly accumulating. New terminology has been adapted by the American Association for the Study of Liver Disease (AASLD) for noninvasive assessment of liver disease and termed 'NILDA' (Non-Invasive Liver Disease Assessment). Blood based such as APRI and or FIB-4 and imaging tests such as liver stiffness measurement (LSM) have moderate to high degrees of accuracy for detection of advanced liver fibrosis (≥ F2) and even higher accuracy for detection of severe fibrosis (F4 or cirrhosis). NILDA are particularly effective at the ends of the liver disease spectrum. For example, a very low LSM (less than 7 kPa) essentially excludes significant fibrosis or portal hypertension, and a very high LSM (> 25 kPa) makes significant fibrosis with portal hypertension (cirrhosis) highly likely.
    Summary: NILDA are currently front and center in terms of assessment of the severity of liver disease. In all patients with known or suspected liver disease, noninvasive blood tests, including APRI and or FIB-4, should be the initial choice to assess the severity of liver fibrosis and/or portal hypertension. In most patients, these tests should be followed with imaging evaluation. The most commonly available imaging is LSM, which appears to be more accurate in predicting fibrosis severity, and is superior to blood tests in the assessment of portal hypertension. In situations in which there is diagnostic uncertainly, liver biopsy with or without HVPG remains an important consideration.
    MeSH term(s) Humans ; Elasticity Imaging Techniques/methods ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver/diagnostic imaging ; Liver/pathology ; Hypertension, Portal/diagnosis ; Hypertension, Portal/etiology ; Prognosis ; Fibrosis
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000001019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: pCold-assisted expression of a thermostable xylanase from

    Patel, Dharti Keyur / Dave, Gayatri

    3 Biotech

    2022  Volume 12, Issue 10, Page(s) 245

    Abstract: The biotechnological application of bacterial xylanases requires a high thermostability, a catalytically active state for a broad pH range. The : Supplementary information: The online version contains supplementary material available at 10.1007/s13205- ...

    Abstract The biotechnological application of bacterial xylanases requires a high thermostability, a catalytically active state for a broad pH range. The
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-022-03315-y.
    Language English
    Publishing date 2022-08-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03315-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Recent Advances in Local Anesthesia: A Review of Literature.

    Patel, Bhumika J / Surana, Pratik / Patel, Keyur J

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36291

    Abstract: Even if local anesthetic is still the mainstay of pain management in dentistry, research will keep striving for novel and effective pain management techniques. The majority of research efforts are focused on improving anesthetic medications, delivery ... ...

    Abstract Even if local anesthetic is still the mainstay of pain management in dentistry, research will keep striving for novel and effective pain management techniques. The majority of research efforts are focused on improving anesthetic medications, delivery systems, and related methods. There are more recent technologies available that can assist the dentist in providing better pain relief with fewer unpleasant injections and fewer negative adverse effects. The purpose of the current review of the literature is to compile evidence that will convince dentists to employ modern local anesthetics, as well as other methods and techniques to reduce patient discomfort while administering anesthesia.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Computational choreography: dissecting the dance of hydrogen bonding and π-π stacking in the fluorescence discrimination mechanism of ciprofloxacin with supramolecular assembly.

    Parikh, Jaymin / Bhatt, Keyur / Modi, Krunal / Desai, Ajay / Patel, Nihal / Patel, Chirag / Bhola, Ravibhai

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–12

    Abstract: The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing ... ...

    Abstract The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing out the fluorescence study with selected antibiotics, we observed remarkable enhancement of fluorescence spectra in the presence of ciprofloxacin, singling out the PCACP_Ciprofloxacin complex. The detailed binding mechanism is explored
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2329295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Study on Urinary Isolates of

    Patel, Sanjaykumar P / Nimavat, Keyur / Patel, Pragnesh / Kachhadia, Jenish

    Journal of pharmacy & bioallied sciences

    2023  Volume 15, Issue Suppl 2, Page(s) S1291–S1293

    Abstract: Aim: In order to determine which species of : Materials and methods: One hundred inpatients were part of the study group. Urine samples were collected from each subject and spun at 3000 rpm for 10-15 minutes in individual sterile centrifuge tubes. ... ...

    Abstract Aim: In order to determine which species of
    Materials and methods: One hundred inpatients were part of the study group. Urine samples were collected from each subject and spun at 3000 rpm for 10-15 minutes in individual sterile centrifuge tubes. Color, size, texture, and the presence of color diffusion into the surrounding agar were used to identify the distinct
    Results: A total of 86.7% of the
    Conclusion: To help clinicians decide on an empirical treatment in an emergency, accurate identification of
    Language English
    Publishing date 2023-07-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_114_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction: Clinical outcomes in patients with complicated appendicitis.

    Madeka, Isheeta / Patel, Keyur / Altshuler, Peter / Iyer, Amrita / Dukle, Sonali / Kohli, Anirudh

    Surgical endoscopy

    2023  Volume 38, Issue 1, Page(s) 469

    Language English
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10574-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: When blood pressure refuses to budge: exploring the complexity of resistant hypertension.

    Champaneria, Meeti Keyur / Patel, Rushi Sanjaykumar / Oroszi, Terry L

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1211199

    Abstract: Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased ... ...

    Abstract Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite the availability of a wide range of pharmacological therapies, achieving optimal blood pressure control in patients with resistant hypertension remains a significant challenge. However, recent advances in the field have identified several promising treatment options, including spironolactone, mineralocorticoid receptor antagonists, and renal denervation. In addition, personalized management approaches based on genetic and other biomarkers may offer new opportunities to tailor therapy and improve outcomes. This review aims to provide an overview of the current state of knowledge regarding managing resistant hypertension, including the epidemiology, pathophysiology, and clinical implications of the condition, as well as the latest developments in therapeutic strategies and future prospects.
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1211199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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