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Article ; Online: A 7-month multi-disciplinary healthy lifestyle intervention effectively improved cardiometabolic risk profile of firefighters.

Saint-Martin, D R F / Barreto, K A / Soares, E M K Von Koenig / Machado, M S / Morais, C S S / Barbosa, A M Bonadio / Nogueira, R M / D'Isabel, S / Smith, D L / Molina, G E / Porto, L G Grossi

Journal of occupational and environmental medicine

2024

Abstract: Objective: We investigated the effect of a 7-month healthy lifestyle intervention on cardiometabolic risk factors (CMRF) among male career military firefighters (FFs).: Methods: 49 FFs participated in a 7-month workplace multi-disciplinary healthy ... ...

Abstract	Objective: We investigated the effect of a 7-month healthy lifestyle intervention on cardiometabolic risk factors (CMRF) among male career military firefighters (FFs). Methods: 49 FFs participated in a 7-month workplace multi-disciplinary healthy lifestyle intervention designed to reduce CMRF through exercise, diet, and improved sleep. Medical assessments, accelerometry, and surveys at the beginning and end determined program effectiveness. Results: At the end of the intervention period, there was a significant improvement in measures of body composition and blood glucose. The prevalence of hypertension also decreased significantly (p < 0.01). The 57% of participants who fully adhered to the program had significantly greater improvements across multiple CMRF. Participants increased their physical activity and improved their diet following the intervention. Conclusion: This healthy lifestyle intervention was effective in changing behavior and lowering cardiometabolic risk among FFs.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000003116
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Article ; Online: Volatile fingerprinting, sensory characterization, and consumer acceptance of pure and blended arabica coffee leaf teas.

DePaula, Juliana / Cunha, Sara C / Ferreira, Isabel M P L V O / Porto, Ana Carolina V / G Cruz, Adriano / Petrarca, Mateus / Tereza Trevisan, Maria / Revi, Ildi / Farah, Adriana

Food research international (Ottawa, Ont.)

2023 Volume 173, Issue Pt 2, Page(s) 113361

Abstract: Coffee leaves contain several bioactive compounds and have been traditionally consumed as a medicinal infusion in the East for centuries. Coffee production generates large amounts of leaves as by-products, which are often wasted in most producing ... ...

Abstract	Coffee leaves contain several bioactive compounds and have been traditionally consumed as a medicinal infusion in the East for centuries. Coffee production generates large amounts of leaves as by-products, which are often wasted in most producing countries because of the low acceptability in the West. Nevertheless, processing and blending coffee leaves may increase aroma and flavor complexity. This study evaluated the volatile and sensory profiles and consumer acceptance of coffee leaf teas compared to two among the most consumed teas (black and maté teas) in Rio de Janeiro. Infusions were made with one experimental and one commercial coffee leaf tea (CLT), two black teas (BT), and one toasted maté tea (TMT) for volatile (GC-MS/MS) and sensory profiles. As an attempt to improve coffee leaf tea acceptance, CLT were also blended (50%) with BT or TMT. Acceptance, Check All That Apply (CATA), and Projective Mapping sensory tests were performed with untrained assessors aged 18-49 (n = 100). Volatile data were standardized by centering and normalization. Sensory data were treated by ANOVA/Fisher test, PCA, and AHCMFA, considering differences at p < 0.05. Ninety-two volatile compounds distributed in 12 classes were identified in different samples. CLT, BT, and TMT infusions shared 19 compounds, including 9 potential impact compounds for aroma and flavor: α-ionone, β-ionone, hexanal, nonanal, decanal, benzaldehyde, trans-linalool oxide, linalool, and dihydroactinidiolide. The most cited flavor attributes for CLT infusions were herbs/green leaf, woody and refreshing. For TMT and BT, herbs/green leaf, woody, burnt, and fermented were the most cited. These attributes agreed with the volatile profiles. CLT shared 22 compounds with TMT and 28 with BT. Considering pure infusions, TMT presented the highest mean acceptance scores (6.7), followed by Com. and Exp. CLT (6.1 and 5.8, on a 9-point-hedonic scale, respectively). Blending with TMT increased mean acceptance of Exp. CLT (6.4), while blending with BT, downgraded the mean acceptance of Com. CLT (5.3). In Projective Mapping, CLT was considered to have a higher sensory resemblance with TMT than BT. If produced adequately, CLT was shown to have good market potential to support sustainable coffee production and promote health.
MeSH term(s)	Coffea ; Tandem Mass Spectrometry ; Health Promotion ; Brazil ; Tea
Chemical Substances	Tea
Language	English
Publishing date	2023-08-07
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113361
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Article ; Online: Volatile fingerprinting, sensory characterization, and consumer acceptance of pure and blended arabica coffee leaf teas

DePaula, Juliana / Cunha, Sara C. / M.P.L.V.O. Ferreira, Isabel / Carolina V. Porto, Ana / Cruz, Adriano / Petrarca, Mateus / Tereza Trevisan, Maria / Revi, Ildi / Farah, Adriana

Food Research International. 2023 Aug. 07, p.113361-

2023 , Page(s) 113361–

Abstract	Coffee leaves contain several bioactive compounds and have been traditionally consumed as a medicinal infusion in the East for centuries. Coffee production generates large amounts of leaves as by-products, which are often wasted in most producing countries because of the low acceptability in the West. Nevertheless, processing and blending coffee leaves may increase aroma and flavor complexity. This study evaluated the volatile and sensory profiles and consumer acceptance of coffee leaf teas compared to the most consumed teas (black and maté teas) by Rio de Janeiro consumers. Infusions were made with one experimental and one commercial coffee leaf tea (CLT), two black teas (BT), and one toasted maté tea (TMT) for volatile (GC-MS/MS) and sensory profiles. As an attempt to improve coffee leaf tea acceptance, CLT were also blended (50%) with BT or TMT. Acceptance, Check All That Apply (CATA), and Projective Mapping sensory tests were performed with untrained assessors aged 18-49 (n = 100). Volatile data were standardized by centering and normalization. Sensory data were treated by ANOVA/Fisher test, PCA, and AHCMFA, considering differences at p < 0.05. Ninety-two volatile compounds distributed in 12 classes were identified in different samples. CLT, BT, and TMT infusions shared 19 compounds, including 9 potential impact compounds for aroma and flavor: α-ionone, β-ionone, hexanal, nonanal, decanal, benzaldehyde, trans-linalool oxide, linalool, and dihydroactinidiolide. The most cited flavor attributes for CLT infusions were herbs/green leaf, woody and refreshing. For TMT and BT, herbs/green leaf woody, burnt, and fermented were the most cited. These attributes agreed with the volatile profiles. CLT shared 22 compounds with TMT and 28 with BT. Considering pure infusions, TMT presented the highest mean acceptance scores (6.7), followed by Com. and Exp. CLT (6.1 and 5.8, on a 9-point-hedonic scale, respectively). Blending with TMT increased mean acceptance of Exp. CLT (6.4), while blending with BT, downgraded the mean acceptance of Com. CLT (5.3). In Projective Mapping, CLT was considered to have a higher sensory resemblance with TMT than BT. If produced adequately, CLT was shown to have good market potential to support sustainable coffee production and promote health.
Keywords	Coffea arabica ; benzaldehyde ; consumer acceptance ; flavor ; food research ; leaves ; linalool ; markets ; odors ; sensory evaluation ; tea ; Brazil ; leaf ; infusions ; toasted maté ; volatile compounds ; sensorial
Language	English
Dates of publication	2023-0807
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113361
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Article: Joker: An algorithm to insert patterns into sequences for designing antimicrobial peptides

Porto, William F / Isabel C.M. Fensterseifer / Octavio L. Franco / Suzana M. Ribeiro

Biochimica et biophysica acta. 2018 Sept., v. 1862, no. 9

2018

Abstract: Innovative alternatives to control bacterial infections are need due to bacterial resistance rise. Antimicrobial peptides (AMPs) have been considered as the new generation of antimicrobial agents. Based on the fact that AMPs are sequence-dependent, a ... ...

Abstract	Innovative alternatives to control bacterial infections are need due to bacterial resistance rise. Antimicrobial peptides (AMPs) have been considered as the new generation of antimicrobial agents. Based on the fact that AMPs are sequence-dependent, a linguistic model for designing AMPs was previously developed, considering AMPs as a formal language with a grammar (patterns or motifs) and a vocabulary (amino acids). Albeit promising, that model has been poorly exploited mainly because thousands of sequences need to be generated, and the outcome has high similarity to already known AMPs. Here we present Joker, an innovative algorithm that improves the application of the linguistic model for rational design of antimicrobial peptides. We modelled the AMPs as a card game, where Joker combines the cards in the hand (patterns) with the cards in the table (sequence templates), generating a few variants. Our algorithm is capable of improving existing AMPs or even creating new AMPs from inactive peptides. A standalone version of Joker is available for download at <http://github.com/williamfp7/Joker> and requires a Linux 32-bit machine.
Keywords	algorithms ; amino acids ; anti-infective agents ; antimicrobial peptides ; bacterial infections ; computer software ; models
Language	English
Dates of publication	2018-09
Size	p. 2043-2052.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	840755-1
ISSN	0304-4165
ISSN	0304-4165
DOI	10.1016/j.bbagen.2018.06.011
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Article: Joker: An algorithm to insert patterns into sequences for designing antimicrobial peptides.

Porto, William F / Fensterseifer, Isabel C M / Ribeiro, Suzana M / Franco, Octavio L

Biochimica et biophysica acta. General subjects

2018 Volume 1862, Issue 9, Page(s) 2043–2052

Abstract	Innovative alternatives to control bacterial infections are need due to bacterial resistance rise. Antimicrobial peptides (AMPs) have been considered as the new generation of antimicrobial agents. Based on the fact that AMPs are sequence-dependent, a linguistic model for designing AMPs was previously developed, considering AMPs as a formal language with a grammar (patterns or motifs) and a vocabulary (amino acids). Albeit promising, that model has been poorly exploited mainly because thousands of sequences need to be generated, and the outcome has high similarity to already known AMPs. Here we present Joker, an innovative algorithm that improves the application of the linguistic model for rational design of antimicrobial peptides. We modelled the AMPs as a card game, where Joker combines the cards in the hand (patterns) with the cards in the table (sequence templates), generating a few variants. Our algorithm is capable of improving existing AMPs or even creating new AMPs from inactive peptides. A standalone version of Joker is available for download at <http://github.com/williamfp7/Joker> and requires a Linux 32-bit machine.
MeSH term(s)	Algorithms ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Drug Design ; Escherichia coli/drug effects ; Humans ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Antimicrobial Cationic Peptides
Language	English
Publishing date	2018-06-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0304-4165 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0304-4165 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2018.06.011
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Article ; Online: Use of polyphenols as a strategy to prevent bond degradation in the dentin-resin interface.

Porto, Isabel C C M / Nascimento, Ticiano G / Oliveira, José M S / Freitas, Pedro H / Haimeur, Asmaa / França, Rodrigo

European journal of oral sciences

2018 Volume 126, Issue 2, Page(s) 146–158

Abstract: This study evaluated the effect of dentin pretreatment with the polyphenols quercetin and resveratrol on the resin-dentin microtensile bonding strength (μTBS) and collagen fibrils stability of the adhesive interface. Different concentrations (100, 250, ... ...

Abstract	This study evaluated the effect of dentin pretreatment with the polyphenols quercetin and resveratrol on the resin-dentin microtensile bonding strength (μTBS) and collagen fibrils stability of the adhesive interface. Different concentrations (100, 250, 500, or 1,000 μg ml
MeSH term(s)	Acid Etching, Dental ; Analysis of Variance ; Chlorhexidine/analogs & derivatives ; Dental Stress Analysis ; Dentin ; Dentin-Bonding Agents ; Materials Testing ; Quercetin ; Resins, Synthetic ; Resveratrol ; Surface Properties ; Tensile Strength
Chemical Substances	Dentin-Bonding Agents ; Resins, Synthetic ; Quercetin (9IKM0I5T1E) ; chlorhexidine gluconate (MOR84MUD8E) ; Resveratrol (Q369O8926L) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2018-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1224820-4
ISSN	1600-0722 ; 0909-8836
ISSN (online)	1600-0722
ISSN	0909-8836
DOI	10.1111/eos.12403
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Article ; Online: Reduced HIV/AIDS diagnosis rates and increased AIDS mortality due to late diagnosis in Brazil during the COVID-19 pandemic.

Andrade, Lucas Almeida / de França Amorim, Thiago / da Paz, Wandklebson Silva / do Rosário Souza, Mariana / S Camargo, Emerson Lucas / Dos Santos Tavares, Débora / M A Lima, Shirley Verônica / Vieira de Melo, Enaldo / de O Góes, Marco Aurélio / Feliciano do Carmo, Rodrigo / Dornels F de Souza, Carlos / Dantas Dos Santos, Allan / L de Sousa, Álvaro Francisco / C Mendes, Isabel Amélia / Silva-Júnior, Abelardo / N Porto, Wagnner José / Bezerra-Santos, Márcio

Scientific reports

2023 Volume 13, Issue 1, Page(s) 23003

Abstract: The COVID-19 pandemic has severely affected global health, leading to the suspension of numerous routine healthcare services and posing challenges in efforts to control other diseases, such as HIV/AIDS. This study aimed to assess the impact of the COVID- ... ...

Abstract	The COVID-19 pandemic has severely affected global health, leading to the suspension of numerous routine healthcare services and posing challenges in efforts to control other diseases, such as HIV/AIDS. This study aimed to assess the impact of the COVID-19 pandemic on HIV/AIDS diagnoses and mortality rates in Brazil during 2020 and 2021. The percentage change was calculated to determine whether there was an increase or decrease in HIV/AIDS diagnoses and mortality, considering the average numbers from the last 5 years. Additionally, a Joinpoint regression model and an interrupted time series analysis were applied to assess time trends before and after the onset of the pandemic. Lastly, choropleth maps were prepared. We observed a reduction of 22.4% (2020) and 9.8% (2021) in the diagnosis of HIV/AIDS in Brazil. Conversely, there was a significant increase in the percentage change of late diagnosis of AIDS deaths in 2020 (6.9%) and 2021 (13.9%), with some states showing an increase of over 87%. Decreasing time trends in the diagnosis of HIV/AIDS were identified before the pandemic in Brazil, especially in the Southeast and South regions, and then time trends stabilized after including the pandemic years. Along with the dissemination of COVID-19, there was a reduction in the diagnosis of HIV/AIDS and an increase in late diagnosis AIDS deaths, signaling a serious impact of the pandemic on HIV/AIDS control strategies in Brazil. Therefore, we highlight the need for continuous efforts to control both diseases, that is, maintaining regular health services even in crisis situations.
MeSH term(s)	Humans ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/epidemiology ; Pandemics ; Delayed Diagnosis ; Brazil/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; COVID-19 Testing
Language	English
Publishing date	2023-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50359-y
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Article ; Online: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Freitas, Florencio Porto / Alborzinia, Hamed / Dos Santos, Ancély Ferreira / Nepachalovich, Palina / Pedrera, Lohans / Zilka, Omkar / Inague, Alex / Klein, Corinna / Aroua, Nesrine / Kaushal, Kamini / Kast, Bettina / Lorenz, Svenja M / Kunz, Viktoria / Nehring, Helene / Xavier da Silva, Thamara N / Chen, Zhiyi / Atici, Sena / Doll, Sebastian G / Schaefer, Emily L /

Ekpo, Ifedapo / Schmitz, Werner / Horling, Aline / Imming, Peter / Miyamoto, Sayuri / Wehman, Ann M / Genaro-Mattos, Thiago C / Mirnics, Karoly / Kumar, Lokender / Klein-Seetharaman, Judith / Meierjohann, Svenja / Weigand, Isabel / Kroiss, Matthias / Bornkamm, Georg W / Gomes, Fernando / Netto, Luis Eduardo Soares / Sathian, Manjima B / Konrad, David B / Covey, Douglas F / Michalke, Bernhard / Bommert, Kurt / Bargou, Ralf C / Garcia-Saez, Ana / Pratt, Derek A / Fedorova, Maria / Trumpp, Andreas / Conrad, Marcus / Friedmann Angeli, José Pedro

Nature

2024 Volume 626, Issue 7998, Page(s) 401–410

Abstract: Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract ... ...

Abstract	Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation
MeSH term(s)	Animals ; Humans ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; Cell Survival ; Dehydrocholesterols/metabolism ; Ferroptosis ; Lipid Peroxidation ; Neoplasm Transplantation ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Oxidation-Reduction ; Phenotype ; Reproducibility of Results
Chemical Substances	7-dehydrocholesterol (BK1IU07GKF) ; 7-dehydrocholesterol reductase (EC 1.3.1.21) ; Dehydrocholesterols ; perhydroxyl radical (3170-83-0)
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06878-9
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Article ; Online: Bioactivity screening of pinhão (

de Oliveira, Anielle / Moreira, Thaysa Fernandes Moya / Pepinelli, Ana Luisa Silva / Costa, Luis Gustavo Médice Arabel / Leal, Luana Eloísa / da Silva, Tamires Barlati Vieira / Gonçalves, Odinei Hess / Porto Ineu, Rafael / Dias, Maria Inês / Barros, Lillian / Abreu, Rui M V / Ferreira, Isabel C F R / Bracht, Lívia / Leimann, Fernanda Vitória

Food & function

2021 Volume 12, Issue 20, Page(s) 9820–9828

Abstract: The objective of this work was to determine the potential bioactive properties of extracts from bio-residues ... ...

Abstract	The objective of this work was to determine the potential bioactive properties of extracts from bio-residues of
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Araucaria/chemistry ; Catechin/analysis ; Cell Line, Tumor ; Cholinesterase Inhibitors/pharmacology ; Cholinesterases/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Plant Extracts/analysis ; Plant Extracts/pharmacology ; Seeds/chemistry ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Cholinesterase Inhibitors ; Plant Extracts ; Catechin (8R1V1STN48) ; Cholinesterases (EC 3.1.1.8) ; alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2021-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo01163d
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Article ; Online: Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties.

Silva, Osmar N / Torres, Marcelo D T / Cao, Jicong / Alves, Elaine S F / Rodrigues, Leticia V / Resende, Jarbas M / Lião, Luciano M / Porto, William F / Fensterseifer, Isabel C M / Lu, Timothy K / Franco, Octavio L / de la Fuente-Nunez, Cesar

Proceedings of the National Academy of Sciences of the United States of America

2020 Volume 117, Issue 43, Page(s) 26936–26945

Abstract: Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms represent previously untapped sources of novel drugs. Here we repurposed mastoparan-L, the toxic active principle derived from the venom of the ... ...

Abstract	Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms represent previously untapped sources of novel drugs. Here we repurposed mastoparan-L, the toxic active principle derived from the venom of the wasp
MeSH term(s)	Animals ; Bacteremia/drug therapy ; Drug Design ; Drug Evaluation, Preclinical ; HEK293 Cells ; Humans ; Mice ; Microbial Sensitivity Tests ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/therapeutic use ; Pore Forming Cytotoxic Proteins/toxicity ; Wasp Venoms/chemistry ; Wasp Venoms/therapeutic use ; Wasp Venoms/toxicity
Chemical Substances	Pore Forming Cytotoxic Proteins ; Wasp Venoms
Language	English
Publishing date	2020-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2012379117
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