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Article ; Online: Viola xadrez e liminaridade

Michel Presley Fernandes

Ideação, Vol 26, Iss

anotações epistemológicas entre a antropologia e a história oral a partir da teoria de fronteiras

2024 Volume 1

Abstract: Mediante a revisão de contribuições teóricas de autores como José de Souza Martins e João Pacheco de Oliveira, promove-se breve inventário de noções, conceitos, categorias epistemológicas que se julgam proveitosas para o desembaraço da proposta de ... ...

Abstract	Mediante a revisão de contribuições teóricas de autores como José de Souza Martins e João Pacheco de Oliveira, promove-se breve inventário de noções, conceitos, categorias epistemológicas que se julgam proveitosas para o desembaraço da proposta de pesquisa encetada em sede de História Oral, qual seja, focalizar a sucessão de três gerações de proprietários de uma “fábrica” de instrumentos musicais de cordas situada no interior do Estado de São Paulo, Brasil. As noções e conceitos buscados invariavelmente acenam para a necessidade de o pesquisador em Ciências Sociais adotar como metodológica a noção mais geral de “liminaridade”, cujas nuances são explicitadas pelos autores ao enfrentarem questões concernentes à teoria de fronteiras. De tais explicitações, parte-se para cotejo com pesquisa antropológica realizada por Rainer Miranda Brito acerca das atividades atuais da aludida fábrica, evidenciando as dificuldades de alocação terminológica face aos critérios mercadológicos atuais, o que leva o autor do presente texto a entendê-la também como possível caso de “liminaridade”.
Keywords	epistemologia ; teoria de fronteiras ; liminaridade ; History of scholarship and learning. The humanities ; AZ20-999 ; Education (General) ; L7-991
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Universidade do Oeste do Paraná - Unioeste
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Viola xadrez e liminaridade

Michel Presley Fernandes

Ideação, Vol 26, Iss

anotações epistemológicas entre a antropologia e a história oral a partir da teoria de fronteiras

2024 Volume 1

Abstract	Mediante a revisão de contribuições teóricas de autores como José de Souza Martins e João Pacheco de Oliveira, promove-se breve inventário de noções, conceitos, categorias epistemológicas que se julgam proveitosas para o desembaraço da proposta de pesquisa encetada em sede de História Oral, qual seja, focalizar a sucessão de três gerações de proprietários de uma “fábrica” de instrumentos musicais de cordas situada no interior do Estado de São Paulo, Brasil. As noções e conceitos buscados invariavelmente acenam para a necessidade de o pesquisador em Ciências Sociais adotar como metodológica a noção mais geral de “liminaridade”, cujas nuances são explicitadas pelos autores ao enfrentarem questões concernentes à teoria de fronteiras. De tais explicitações, parte-se para cotejo com pesquisa antropológica realizada por Rainer Miranda Brito acerca das atividades atuais da aludida fábrica, evidenciando as dificuldades de alocação terminológica face aos critérios mercadológicos atuais, o que leva o autor do presente texto a entendê-la também como possível caso de “liminaridade”.
Keywords	epistemologia ; teoria de fronteiras ; liminaridade ; History of scholarship and learning. The humanities ; AZ20-999 ; Education (General) ; L7-991
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Universidade do Oeste do Paraná - Unioeste
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of guttiferone E in melanoma-bearing mice.

Ribeiro, Arthur Barcelos / de Melo, Matheus Reis Santos / de Melo Junqueira, Marcela / Rodrigues, Mônica Garcia Leal / de Souza, Thiago Olimpio / Fernandes, Gabriela / Santos, Mário Ferreira Conceição / Ambrósio, Sérgio Ricardo / Bastos, Jairo Kenupp / Tavares, Denise Crispim

Naunyn-Schmiedeberg's archives of pharmacology

2024

Abstract: ... antineoplastic agents. Therefore, this study investigated the antimelanoma potential of guttiferone E (GE ...

Abstract	Melanoma, an aggressive and potentially fatal skin cancer, is constrained by immunosuppression, resistance, and high toxicity in its treatment. Consequently, there is an urgent need for innovative antineoplastic agents. Therefore, this study investigated the antimelanoma potential of guttiferone E (GE). In an allogeneic murine B16 melanoma model, GE was administered subcutaneously and intraperitoneally. Antitumor evaluation included tumor volume/weight measurements and histopathological and immunohistochemical analysis. Furthermore, the toxicity of the treatments was evaluated through body/organ weights, biochemical parameters, and genotoxicity. Subcutaneous administration of 20 mg/kg of GE resulted in a significant reduction in both tumor volume and weight, effectively suppressing melanoma cell proliferation as evidenced by a decrease in mitotic figures. The tumor growth inhibition rate was equivalent to 54%. This treatment upregulated cleaved caspase-3, indicating apoptosis induction. On the other hand, intraperitoneal administration of GE showed no antimelanoma effect. Remarkably, GE treatments exhibited no toxicity, evidenced by non-significant differences in body weight gain, as well as organ weight, biochemical parameters of nephrotoxicity and hepatotoxicity, and genotoxic damage. This study revealed, for the first time, the efficacy of subcutaneous administration of GE in reducing melanoma, in the absence of toxicity. Furthermore, it was observed that the apoptotic signaling pathway is involved in the antimelanoma property of GE. These findings offer valuable insights for further exploring GE's therapeutic applications in melanoma treatment.
Language	English
Publishing date	2024-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-02962-7
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Article ; Online: HLA-E gene polymorphisms in chronic hepatitis C: Impact on HLA-E liver expression and disease severity.

Araújo, Roberta Chaves / Bertol, Bruna Cristina / César Dias, Fabricio / Debortoli, Guilherme / Almeida, Patrícia Holanda / Fernandes Souza, Fernanda / Villanova, Marcia Guimarães / Ramalho, Leandra Naira Zambelli / Candolo Martinelli, Ana Lourdes / Cruz Castelli, Érick da / Mendes Junior, Celso Teixeira / Antonio Donadi, Eduardo

Human immunology

2021 Volume 82, Issue 3, Page(s) 177–185

Abstract: ... that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known ... about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms ... on the magnitude of HLA-E liver expression and severity of hepatitis C. HLA-E variability was evaluated in terms ...

Abstract	Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms on the magnitude of HLA-E liver expression and severity of hepatitis C. HLA-E variability was evaluated in terms of: i) single nucleotide polymorphism (SNP) alleles and genotypes along the gene (beginning of the promoter region, coding region and 3'UTR), and ii) ensemble of SNPs that defines the coding region alleles, considered individually or as genotypes. The comparisons of the HLA-E variation sites between patients and controls revealed no significant results. The HLA-E + 424 T > C (rs1059510), +756 G > A (rs1264457) and + 3777 G > A (rs1059655) variation sites and the HLA-E01:01:01:01 and HLA-E01:03:02:01 alleles, considered at single or double doses, were associated with the magnitude of HLA-E liver expression in Kupfer cell, steatosis, inflammatory activity and liver fibrosis. Although these associations were lost after corrections for multiple comparisons, these variable sites may propitiate biological clues for the understanding of the mechanisms associated with hepatitis C severity.
MeSH term(s)	Adult ; Aged ; Disease Progression ; Female ; Gene Expression Regulation ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Hepacivirus/physiology ; Hepatitis C, Chronic/genetics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Liver/metabolism ; Liver/pathology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult ; HLA-E Antigens
Chemical Substances	Histocompatibility Antigens Class I
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2021.01.018
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Article ; Online: Impact of e-cigarettes as cancer risk: A protocol for systematic review and meta-analysis.

de Medeiros, Kleyton Santos / Pacheco, Beatriz Ferreira Pereira / de Oliveira, Paula Ermans / de Góis Nogueira, Ivna Letícia / Beserra Diógenes, Vinícius Romeu / Fernandes, Fernanda Gadelha / Fernandes, Gabriela Cunha / de Moura Santos, Edilmar / do Rêgo, Amália Cinthia Menseses / Araújo-Filho, Irami

Medicine

2023 Volume 102, Issue 1, Page(s) e32233

Abstract: ... of the sympathetic nervous system by nicotine inhaled from e-cigarettes may stimulate cancer development and growth ... showing adults (18 years old age) using e-cigarettes. There will be no language or publication period ...

Abstract	Background: The use of electronic cigarettes is one of the current public health problems on increasing alert, has been growing at an accelerating rate, and has become a public health emergency. Its importance is explained by the continuous growth and acceleration of oncological rates among all ages versus the absence of high-quality evidence, correlated to the use of nicotine derived products, being at their regular versions or the new ones. Available preclinical data indicate that activation of the sympathetic nervous system by nicotine inhaled from e-cigarettes may stimulate cancer development and growth by several mechanisms, which results can significantly reduce life's quality. This systematic review and meta-analysis protocol aims to clarify the connection between the use of electronic cigarettes by adults over the age of 18 and the development of malignant neoplastic diseases. Method: The proposed systematic review and meta-analysis will be reported conforming to the preferred reporting items for systematic reviews and meta-analyses guidelines. Will include the following studies: case-control or cohort studies showing adults (18 years old age) using e-cigarettes. There will be no language or publication period restrictions. Articles published, but not peer-reviewed, will not be included in the review. Data will be entered in the Review Manager software (RevMan5.2.3). For dichotomous outcomes, we extracted or calculated the OR and 95% CI for each study. In case of heterogeneity (I²>50%), the random-effects model will be used to combine the studies to calculate the OR and 95% CI.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Adolescent ; Nicotine/adverse effects ; Electronic Nicotine Delivery Systems ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Public Health ; Neoplasms/epidemiology ; Neoplasms/etiology
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032233
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Article ; Online: Evaluation of Antifungal Activity and Potential Application as Fluorescent Probes of Indolenine and Benzo[e]Indole-Based Squarylium Dyes.

Gomes, Vanessa S D / Ferreira, João C C / Boto, Renato E / Almeida, Paulo / Fernandes, José R / Sousa, Maria João / Reis, Lucinda V / Gonçalves, M Sameiro T

Photochemistry and photobiology

2023 Volume 99, Issue 5, Page(s) 1282–1292

Abstract: ... dyes derived from indolenine and benzo[e]indole previously synthesized was evaluated ...

Abstract	The antifungal performance and the possible use as fluorescent probes of a series of squarylium dyes derived from indolenine and benzo[e]indole previously synthesized was evaluated. Some photophysical properties were performed in ethanol and phosphate buffer, and the type of aggregates form in phosphate buffer was analyzed. Using the 1,3-diphenylisobenzofuran assay, a qualitative assessment of the capacity of dyes to produce singlet oxygen after irradiation was performed. Regarding the antifungal activity, this was studied through a broth microdilution assay using Saccharomyces cerevisiae PYCC 4072 as a biological model. The effect of irradiation of the dyes, with an appropriate light emitting diode system, on the antifungal activity was also evaluated, and it was verified that some of the dyes improve their activity after irradiation. Using fluorescence microscopy techniques, the colocalization of dyes in S. cerevisae cells was investigated and it was possible to verify that some of the squarylium dyes with a barbituric moiety in the four-membered central ring stained and accumulated preferentially in the mitochondrial web and perinuclear membrane of the cells. The possible use as a fluorescent probe for the detection of HSA was also evaluated for one of the dyes of the series, demonstrating a linear variation in the fluorescence intensity accompanied by the increase in the protein concentration.
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	123540-0
ISSN	1751-1097 ; 0031-8655
ISSN (online)	1751-1097
ISSN	0031-8655
DOI	10.1111/php.13762
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Article ; Online: Branquitude, antirracismo e democracia:

Richard Santos / Alexandre de de Oliveira Fernandes / Ana Helena Ithamar Passos

Revista Espaço Acadêmico, Vol

2022 Volume 21

Abstract: Apresentação de Dossiê Especial "Branquitude, Antirracismo e Democracia" ...

Abstract	Apresentação de Dossiê Especial "Branquitude, Antirracismo e Democracia"
Keywords	Branquitude ; Antirracismo ; Democracia ; Social sciences (General) ; H1-99
Language	Portuguese
Publishing date	2022-02-01T00:00:00Z
Publisher	Universidade Estadual de Maringá
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Acute Effects of 2C-E in Humans: An Observational Study.

Papaseit, Esther / Olesti, Eulalia / Pérez-Mañá, Clara / Torrens, Marta / Grifell, Marc / Ventura, Mireia / Pozo, Oscar J / de Sousa Fernandes Perna, Elizabeth B / Ramaekers, Johannes G / de la Torre, Rafael / Farré, Magí

Frontiers in pharmacology

2020 Volume 11, Page(s) 233

Abstract: 2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine ...

Abstract	2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT
Language	English
Publishing date	2020-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00233
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Learning Outcomes and Educational Effectiveness of E-Learning as a Continuing Professional Development Intervention for Practicing Surgeons and Proceduralists: A Systematic Review.

Williams, Erin / Fernandes, Rosephine Del / Choi, Ken / Fasola, Laurie / Zevin, Boris

Journal of surgical education

2023 Volume 80, Issue 8, Page(s) 1139–1149

Abstract: Background: Electronic learning (e-Learning) has become a prevalent mode of delivering medical ... education. We aimed to determine the learning outcomes and educational effectiveness of e-Learning ... We searched MEDLINE databases and included studies reporting learning outcomes of e-learning CPD interventions ...

Abstract	Background: Electronic learning (e-Learning) has become a prevalent mode of delivering medical education. We aimed to determine the learning outcomes and educational effectiveness of e-Learning as a continuing professional development (CPD) intervention for practicing surgeons and proceduralists. Methods: We searched MEDLINE databases and included studies reporting learning outcomes of e-learning CPD interventions for practicing surgeons and physicians performing technical procedures. We excluded articles only studying surgical trainees and those not reporting learning outcomes. Two reviewers independently screened, extracted data, and assessed study quality using the Critical Appraisal Skills Programme (CASP) tools. Learning outcomes and educational effectiveness were categorized using Moore's Outcomes Framework (PROSPERO: CRD42022333523). Results: Of 1307 identified articles, 12 were included- 9 cohort studies, one randomized controlled trial and 2 qualitative studies, with a total of 2158 participants. Eight studies were rated as moderate, five as strong, and 2 as weak in study quality. E-Learning CPD interventions included web-based modules, image recognition, videos, a repository of videos and schematics, and an online journal club. Seven studies reported participants' satisfaction with the e-Learning interventions (Moore's Level 2), 4 reported improvements in participants' declarative knowledge (Level 3a), 1 reported improvements in procedural knowledge (Level 3b) and five reported improvements in participants' procedural competence in an educational setting (Level 4). No studies demonstrated improvements in participants' workplace-based performance, the health of patients, or community health (Levels 5-7). Conclusions: E-Learning as a CPD educational intervention is associated with high satisfaction and improvements in knowledge and procedural competencies of practicing surgeons and proceduralists in an educational setting. Future research is required to investigate whether e-Learning is associated with higher-level learning outcomes.
MeSH term(s)	Humans ; Computer-Assisted Instruction ; Learning ; Education, Medical ; Educational Status ; Surgeons ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2023.05.017
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Article ; Online: The influence of light intensities and micropollutants on the removal of total coliforms and E. coli from wastewater in a flat-panel photobioreactor.

Pompei, Caroline Moço Erba / Ruas, Graziele / Bolzani, Hugo Renan / Fernandes, Luiza Maria / Silva, Gustavo Henrique Ribeiro da

Environmental pollution (Barking, Essex : 1987)

2024 Volume 349, Page(s) 123935

Abstract: ... on the removal of E. coli and total coliforms from real anaerobically treated wastewater, a pilot flat-panel ... an experiment in a tropical climate region. E. coli had better removal (from 10 ...

Abstract	The presence of micropollutants and pathogens in sanitary wastewater and surface water is a growing concern that impacts public health, environmental balance and the maintenance of water supply services. To improve sanitary wastewater treatment, it is necessary to develop and improve sustainable technologies. Among the available options, microalgae-based systems stand out for their efficiency and generation of value-added byproducts. To study the impact of luminosity and the presence of micropollutants (13 selected) on the removal of E. coli and total coliforms from real anaerobically treated wastewater, a pilot flat-panel photobioreactor (50 L) was operated in batch mode in a tropical climate region. This is the first study to evaluate whether micropollutants interfere with coliform groups, considering a microalgae-based system and an experiment in a tropical climate region. E. coli had better removal (from 10
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123935
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