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Article: Development of novel tools for dissection of central versus peripheral dopamine D

Bonifazi, Alessandro / Ellenberger, Michael / Farino, Zachary J / Aslanoglou, Despoina / Rais, Rana / Pereira, Sandra / Mantilla-Rivas, José O / Boateng, Comfort A / Eshleman, Amy J / Janowsky, Aaron / Hahn, Margaret K / Schwartz, Gary J / Slusher, Barbara S / Newman, Amy Hauck / Freyberg, Zachary

bioRxiv : the preprint server for biology

2024

Abstract: Dopamine (DA) D ...

Abstract	Dopamine (DA) D
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.21.581451
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Article ; Online: Precise Measurement of the D_{s}^{+} Lifetime at Belle II.

Adachi, I / Aggarwal, L / Aihara, H / Akopov, N / Aloisio, A / Anh Ky, N / Asner, D M / Atmacan, H / Aushev, T / Aushev, V / Aversano, M / Babu, V / Bae, H / Bahinipati, S / Bambade, P / Banerjee, Sw / Barrett, M / Baudot, J / Bauer, M /

Baur, A / Beaubien, A / Becker, J / Behera, P K / Bennett, J V / Bernlochner, F U / Bertacchi, V / Bertemes, M / Bertholet, E / Bessner, M / Bettarini, S / Bhuyan, B / Bianchi, F / Bilka, T / Biswas, D / Bodrov, D / Bondar, A / Bozek, A / Bračko, M / Branchini, P / Briere, R A / Browder, T E / Budano, A / Bussino, S / Campajola, M / Cao, L / Casarosa, G / Cecchi, C / Cerasoli, J / Chang, M-C / Chang, P / Cheema, P / Chekelian, V / Cheon, B G / Chilikin, K / Chirapatpimol, K / Cho, H-E / Cho, K / Choi, S-K / Choudhury, S / Cochran, J / Corona, L / Das, S / Dattola, F / De La Motte, S A / de Marino, G / De Nardo, G / De Nuccio, M / De Pietro, G / de Sangro, R / Destefanis, M / Dey, S / Dhamija, R / Di Canto, A / Di Capua, F / Dingfelder, J / Doležal, Z / Domínguez Jiménez, I / Dong, T V / Dorigo, M / Dort, K / Dreyer, S / Dubey, S / Dujany, G / Ecker, P / Epifanov, D / Feichtinger, P / Ferlewicz, D / Finck, C / Finocchiaro, G / Fodor, A / Forti, F / Frey, A / Fulsom, B G / Gabrielli, A / Ganiev, E / Garcia-Hernandez, M / Garmash, A / Gaudino, G / Gaur, V / Gaz, A / Gellrich, A / Ghevondyan, G / Ghosh, D / Ghumaryan, H / Giakoustidis, G / Giordano, R / Giri, A / Glazov, A / Gobbo, B / Godang, R / Gogota, O / Goldenzweig, P / Gradl, W / Graziani, E / Greenwald, D / Gruberová, Z / Gu, T / Guan, Y / Gudkova, K / Han, Y / Hayasaka, K / Hayashii, H / Hazra, S / Hearty, C / Heredia de la Cruz, I / Hershenhorn, A / Higuchi, T / Hill, E C / Hoek, M / Hohmann, M / Hsu, C-L / Humair, T / Iijima, T / Inami, K / Ipsita, N / Ishikawa, A / Ito, S / Itoh, R / Iwasaki, M / Jackson, P / Jacobs, W W / Jaffe, D E / Jang, E-J / Ji, Q P / Jia, S / Jin, Y / Junkerkalefeld, H / Kaliyar, A B / Kandra, J / Karyan, G / Kawasaki, T / Keil, F / Ketter, C / Kiesling, C / Kim, C-H / Kim, D Y / Kim, K-H / Kim, Y-K / Kindo, H / Kinoshita, K / Kodyš, P / Koga, T / Kohani, S / Kojima, K / Korobov, A / Korpar, S / Kowalewski, R / Kraetzschmar, T M G / Križan, P / Krokovny, P / Kuhr, T / Kumar, J / Kumar, M / Kumar, R / Kumara, K / Kuzmin, A / Kwon, Y-J / Lacaprara, S / Lai, Y-T / Lam, T / Lange, J S / Laurenza, M / Leboucher, R / Le Diberder, F R / Leitl, P / Levit, D / Lewis, P M / Li, L K / Libby, J / Liu, Q Y / Liu, Z Q / Liventsev, D / Longo, S / Lueck, T / Lyu, C / Ma, Y / Maggiora, M / Maharana, S P / Maiti, R / Maity, S / Manfredi, R / Manoni, E / Mantovano, M / Marcantonio, D / Marcello, S / Marinas, C / Martellini, C / Martini, A / Martinov, T / Massaccesi, L / Masuda, M / Matsuda, T / Matsuoka, K / Matvienko, D / Maurya, S K / McKenna, J A / Mehta, R / Meier, F / Merola, M / Metzner, F / Milesi, M / Miller, C / Mirra, M / Miyabayashi, K / Mohanty, G B / Molina-Gonzalez, N / Mondal, S / Moneta, S / Moser, H-G / Mrvar, M / Mussa, R / Nakamura, I / Nakazawa, Y / Narimani Charan, A / Naruki, M / Natkaniec, Z / Natochii, A / Nayak, L / Nazaryan, G / Nisar, N K / Nishida, S / Ono, H / Otani, F / Oxford, E R / Pakhlov, P / Pakhlova, G / Paladino, A / Panta, A / Paoloni, E / Pardi, S / Passeri, A / Patra, S / Paul, S / Pedlar, T K / Peruzzi, I / Peschke, R / Pestotnik, R / Pham, F / Piccolo, M / Piilonen, L E / Podobnik, T / Pokharel, S / Praz, C / Prell, S / Prencipe, E / Prim, M T / Purwar, H / Rados, P / Raeuber, G / Raiz, S / Reif, M / Reiter, S / Remnev, M / Ripp-Baudot, I / Rizzo, G / Roney, J M / Rostomyan, A / Rout, N / Russo, G / Sandilya, S / Sangal, A / Santelj, L / Sato, Y / Savinov, V / Scavino, B / Schmitt, C / Schwanda, C / Schwartz, A J / Seino, Y / Selce, A / Senyo, K / Serrano, J / Sevior, M E / Sfienti, C / Shan, W / Shi, X D / Shillington, T / Shiu, J-G / Shtol, D / Sibidanov, A / Simon, F / Sobie, R J / Sobotzik, M / Soffer, A / Sokolov, A / Solovieva, E / Spataro, S / Spruck, B / Starič, M / Stavroulakis, P / Stottler, Z S / Stroili, R / Sumihama, M / Svidras, H / Takahashi, M / Takizawa, M / Tamponi, U / Tanida, K / Tenchini, F / Tittel, O / Tonelli, D / Torassa, E / Trabelsi, K / Tsaklidis, I / Unger, K / Unno, Y / Uno, K / Uno, S / Urquijo, P / Ushiroda, Y / Vahsen, S E / van Tonder, R / Varvell, K E / Veronesi, M / Vismaya, V S / Vitale, L / Volpe, R / Wach, B / Wallner, S / Wang, E / Wang, M-Z / Wang, X L / Wang, Z / Warburton, A / Watanabe, M / Wessel, C / Won, E / Xu, X P / Yabsley, B D / Yamada, S / Yan, W / Yang, S B / Yoshihara, K / Yuan, C Z / Yusa, Y / Zhang, Y / Zhilich, V / Zhou, J S / Zhou, Q D / Zhukova, V I / Žlebčík, R

Physical review letters

2023 Volume 131, Issue 17, Page(s) 171803

Abstract: We measure the lifetime of the D_{s}^{+} meson using a data sample of 207 fb^{-1} collected ... determined by fitting the decay-time distribution of a sample of 116×10^{3} D_{s}^{+}→ϕπ^{+} decays ... Our result is τ_{D_{s}^{+}}=(499.5±1.7±0.9) fs, where the first uncertainty is statistical and the second is ...

Abstract	We measure the lifetime of the D_{s}^{+} meson using a data sample of 207 fb^{-1} collected by the Belle II experiment running at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. The lifetime is determined by fitting the decay-time distribution of a sample of 116×10^{3} D_{s}^{+}→ϕπ^{+} decays. Our result is τ_{D_{s}^{+}}=(499.5±1.7±0.9) fs, where the first uncertainty is statistical and the second is systematic. This result is significantly more precise than previous measurements.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.171803
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Article ; Online: 1α,25-Dihydroxyvitamin D

Asmussen, Niels C / Alam, Sheikh / Lin, Zhao / Cohen, David J / Schwartz, Zvi / Boyan, Barbara D

Calcified tissue international

2023 Volume 112, Issue 4, Page(s) 493–511

Abstract: ... and export matrix vesicles (MVs) under the regulation of 1α,25-dihydroxyvitamin D ...

Abstract	Growth plate chondrocytes are regulated by numerous factors and hormones as they mature during endochondral bone formation, including transforming growth factor beta-1 (TGFb1), bone morphogenetic protein 2 (BMP2), insulin-like growth factor-1 (IFG1), parathyroid hormone and parathyroid hormone related peptide (PTH, PTHrP), and Indian hedgehog (IHH). Chondrocytes in the growth plate's growth zone (GC) produce and export matrix vesicles (MVs) under the regulation of 1α,25-dihydroxyvitamin D
MeSH term(s)	MicroRNAs/metabolism ; Hedgehog Proteins/metabolism ; Chondrocytes/metabolism ; Extracellular Matrix/metabolism ; Cells, Cultured
Chemical Substances	1,25-dihydroxyvitamin D (66772-14-3) ; MicroRNAs ; Hedgehog Proteins
Language	English
Publishing date	2023-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	304266-2
ISSN	1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
ISSN (online)	1432-0827
ISSN	0944-0747 ; 0008-0594 ; 0171-967X
DOI	10.1007/s00223-023-01067-2
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Article ; Online: 24R,25-dihydroxyvitamin D

Verma, Anjali / Schwartz, Zvi / Boyan, Barbara D

Steroids

2019 Volume 150, Page(s) 108447

Abstract: Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially ... motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D ...

Abstract	Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D
MeSH term(s)	24,25-Dihydroxyvitamin D 3/metabolism ; 24,25-Dihydroxyvitamin D 3/pharmacology ; Animals ; Breast Neoplasms/diet therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Mammary Neoplasms, Experimental/diet therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Receptors, Estrogen/metabolism
Chemical Substances	Receptors, Estrogen ; 24,25-Dihydroxyvitamin D 3 (40013-87-4)
Language	English
Publishing date	2019-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2019.108447
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Article ; Online: 24R,25-Dihydroxyvitamin D

Verma, Anjali / Cohen, D Joshua / Schwartz, Nofrat / Muktipaty, Chandana / Koblinski, Jennifer E / Boyan, Barbara D / Schwartz, Zvi

Biochimica et biophysica acta. General subjects

2019 Volume 1863, Issue 10, Page(s) 1498–1512

Abstract: Background: Epidemiological studies indicate high serum 25(OH)D: Methods: NOD-SCID-IL2γR null ...

Abstract	Background: Epidemiological studies indicate high serum 25(OH)D Methods: NOD-SCID-IL2γR null female mice with MCF7 breast cancer xenografts in the mammary fat pad were treated with 24R,25(OH) Results: 24R,25(OH) Conclusion: These results indicate that 24R,25(OH) General significance: 24R,25(OH)
MeSH term(s)	24,25-Dihydroxyvitamin D 3/metabolism ; Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Estradiol/administration & dosage ; Estradiol/pharmacology ; Female ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred NOD ; Phospholipase D/metabolism ; Receptors, Estrogen/metabolism ; Signal Transduction
Chemical Substances	Receptors, Estrogen ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Estradiol (4TI98Z838E) ; Phospholipase D (EC 3.1.4.4)
Language	English
Publishing date	2019-05-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2019.05.013
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Article ; Online: Local production of active vitamin D

Dennis, Cydney / Dillon, Jonathan / Cohen, David J / Halquist, Matthew S / Pearcy, Adam C / Schwartz, Zvi / Boyan, Barbara D

The Journal of steroid biochemistry and molecular biology

2023 Volume 232, Page(s) 106331

Abstract: The role of vitamin D ...

Abstract	The role of vitamin D
MeSH term(s)	Humans ; Female ; Cholecalciferol/pharmacology ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism ; Breast Neoplasms/drug therapy ; Estrogen Receptor alpha ; Vitamin D/pharmacology ; Vitamin D/metabolism ; Receptors, Calcitriol/metabolism
Chemical Substances	Cholecalciferol (1C6V77QF41) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Estrogen Receptor alpha ; Vitamin D (1406-16-2) ; Receptors, Calcitriol ; CYP27B1 protein, human (EC 1.14.15.18) ; CYP24A1 protein, human (EC 1.14.15.16)
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106331
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Article ; Online: New roles for dopamine D

Molecular psychiatry

2019 Volume 25, Issue 9, Page(s) 2070–2085

Abstract: ... mediated by DA D ...

Abstract	Although long-studied in the central nervous system, there is increasing evidence that dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin-secreting pancreatic β-cells express the machinery for DA synthesis and catabolism, as well as all five DA receptors. In these cells, DA functions as a negative regulator of glucose-stimulated insulin secretion (GSIS), which is mediated by DA D
MeSH term(s)	Animals ; Dopamine/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Mice ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/genetics ; Receptors, Dopamine D3/metabolism
Chemical Substances	Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2019-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-018-0344-6
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Article ; Online: Effect of high dose vitamin D supplementation on subsequent immune responses to administration of the live herpes zoster vaccine to long-term care residents.

Levin, Myron J / Ginde, Adit A / Schmid, D Scott / Lang, Nancy / Canniff, Jennifer / Schwartz, Robert S / Weinberg, Adriana

Vaccine

2024 Volume 42, Issue 9, Page(s) 2278–2281

Abstract: ... in which they were randomized to receive either oral daily standard dose (400-1000 IU/day) 25-hydroxy vitamin D ...

Abstract	Thirty-three long-term care residents (mean age 76.5 years), who were participating in a study in which they were randomized to receive either oral daily standard dose (400-1000 IU/day) 25-hydroxy vitamin D (vitamin D3) (SD) or high dose (3000-4000 IU/day) (HD) vitamin D3, were vaccinated with the live, attenuated herpes zoster vaccine. Blood was drawn at vaccination and three weeks later to determine varicella-zoster virus (VZV) antibody and T-cell mediated immune responses. ELISA and neutralizing antibodies increased significantly, but to the same extent, in both groups. The antibody avidity significantly increased from pre- to post-vaccination only in the HD group. VZV-CMI, as measured by FLUOROSPOT significantly increased post-vaccination in both groups, but the difference in interferon-γ spot-forming cells (SFC) and interleukin-2 SFC was lower in the HD than SD group. The increase in VZV-CMI correlated inversely with circulating regulatory T cells in the HD group. We conclude that pre-treatment with HD vitamin D3 does not appreciably enhance the antibody response to a live vaccine and that VZV-CMI responses were diminished in HD vitamin D3 recipients.
MeSH term(s)	Humans ; Aged ; Herpes Zoster Vaccine ; Long-Term Care ; Immunity, Cellular ; Herpesvirus 3, Human ; Herpes Zoster/prevention & control ; Antibodies, Viral ; Vitamin D ; Cholecalciferol ; Vaccines, Attenuated ; Dietary Supplements
Chemical Substances	Herpes Zoster Vaccine ; Antibodies, Viral ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Vaccines, Attenuated
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.055
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Article: [Full and D-Box-Deficient PTTG1 Isoforms: Effects on Cell Proliferation].

Demin, D E / Stasevich, E M / Murashko, M M / Tkachenko, E A / Uvarova, A N / Schwartz, A M

Molekuliarnaia biologiia

2022 Volume 56, Issue 6, Page(s) 1104

Abstract: ... exons encode the main recognition site (D-box) of the anaphase-promoting complex (APC/C). We show ... with a PTTG1-like set of APC/C recognition sites have known isoforms without the D-box. Overall, the data ...

Abstract	Human securin (PTTG1) is a protooncogene whose expression is elevated in many types of malignant cells. We previously discovered a minor short isoform of securin lacking exons 3 and 4. The missing exons encode the main recognition site (D-box) of the anaphase-promoting complex (APC/C). We show that these two PTTG1 isoforms have different effects on transcription. Here, we have studied the effects of overexpression and selective knockdown of the short and complete securin isoforms on cell proliferation using the xCELLigence system. Notably, selective knockdown of the short isoform mRNA led to a dramatic decrease in cell growth, while overexpression of both isoforms accelerated cell growth. To search for genes with alternative isoforms similar to securin, we analyzed the GENCODE database and found that 54 of 128 genes with a PTTG1-like set of APC/C recognition sites have known isoforms without the D-box. Overall, the data obtained indicate the existence of a new class of alternative isoforms and reinstates the importance of minor isoforms.
MeSH term(s)	Humans ; Protein Isoforms/genetics ; Cell Proliferation/genetics
Chemical Substances	Protein Isoforms
Language	Russian
Publishing date	2022-12-07
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	213542-5
ISSN	0026-8984
ISSN	0026-8984
DOI	10.31857/S0026898422060076
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Article ; Online: Structural rearrangements allow nucleic acid discrimination by type I-D Cascade.

Schwartz, Evan A / McBride, Tess M / Bravo, Jack P K / Wrapp, Daniel / Fineran, Peter C / Fagerlund, Robert D / Taylor, David W

Nature communications

2022 Volume 13, Issue 1, Page(s) 2829

Abstract: ... I-D interference proteins contain characteristic features of both type I and type III systems. Here ... we present the structures of type I-D Cascade bound to both a double-stranded (ds)DNA and a single-stranded ... ss)RNA target at 2.9 and 3.1 Å, respectively. We show that type I-D Cascade is capable ...

Abstract	CRISPR-Cas systems are adaptive immune systems that protect prokaryotes from foreign nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems include type I and type III. Interestingly, the type I-D interference proteins contain characteristic features of both type I and type III systems. Here, we present the structures of type I-D Cascade bound to both a double-stranded (ds)DNA and a single-stranded (ss)RNA target at 2.9 and 3.1 Å, respectively. We show that type I-D Cascade is capable of specifically binding ssRNA and reveal how PAM recognition of dsDNA targets initiates long-range structural rearrangements that likely primes Cas10d for Cas3' binding and subsequent non-target strand DNA cleavage. These structures allow us to model how binding of the anti-CRISPR protein AcrID1 likely blocks target dsDNA binding via competitive inhibition of the DNA substrate engagement with the Cas10d active site. This work elucidates the unique mechanisms used by type I-D Cascade for discrimination of single-stranded and double stranded targets. Thus, our data supports a model for the hybrid nature of this complex with features of type III and type I systems.
MeSH term(s)	CRISPR-Associated Proteins/metabolism ; CRISPR-Cas Systems ; DNA/metabolism ; DNA Cleavage ; Nucleic Acids ; RNA
Chemical Substances	CRISPR-Associated Proteins ; Nucleic Acids ; RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-30402-8
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Full text online

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In stock of ZB MED Cologne/Königswinter

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Order via subito