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  1. Article ; Online: Disruption of the Surgical Paradigm for Chronic Subdural Hematoma.

    Ecker, Robert D

    World neurosurgery

    2018  Volume 117, Page(s) 120–121

    MeSH term(s) Hematoma, Subdural, Chronic ; Humans
    Language English
    Publishing date 2018-06-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.06.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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  2. Article ; Online: No Need for Repeat Imaging in Patients with Mild Traumatic Subarachnoid Hemorrhage without Clinical Progression.

    Ecker, Robert D

    World neurosurgery

    2018  Volume 113, Page(s) 404–405

    MeSH term(s) Disease Progression ; Glasgow Coma Scale ; Humans ; Subarachnoid Hemorrhage ; Subarachnoid Hemorrhage, Traumatic ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.03.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Rheology of Subarachnoid Hemorrhage.

    Ecker, Robert D

    World neurosurgery

    2016  Volume 87, Page(s) 494–497

    MeSH term(s) Aneurysm, Ruptured/complications ; Erythrocyte Transfusion ; Female ; Humans ; Intracranial Aneurysm/complications ; Male ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/physiopathology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2015.09.023
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  4. Article ; Online: Epistemology of Brain Arteriovenous Malformations.

    Ecker, Robert D

    World neurosurgery

    2016  Volume 89, Page(s) 697–698

    MeSH term(s) Brain/pathology ; Brain/surgery ; Humans ; Intracranial Arteriovenous Malformations/epidemiology ; Intracranial Arteriovenous Malformations/pathology ; Intracranial Arteriovenous Malformations/surgery ; Knowledge
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2015.11.035
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  5. Article ; Conference proceedings: Wie gesundheitskompetent sind 9- bis 13-jährige Kinder in Tirol?

    Leuprecht, Eva / Griebler, Robert / Zoller, Claudia / Schütze, Denise / Sahling, Friederike / Ecker, Sandra / Heiss, Raffael

    Das Gesundheitswesen

    2023  Volume 85, Issue S 04

    Event/congress Vom Wir zum Ich - Vom Ich zum Wir. Braucht es [noch] eine Solidargemeinschaft?, St. Pölten, Österreich, 2023-05-25
    Language German
    Publishing date 2023-10-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0043-1773703
    Database Thieme publisher's database

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  6. Article: Decompressive craniectomy for severe traumatic brain injury: clinical study, literature review and meta-analysis.

    Grindlinger, Gene A / Skavdahl, David H / Ecker, Robert D / Sanborn, Matthew R

    SpringerPlus

    2016  Volume 5, Issue 1, Page(s) 1605

    Abstract: Objective: To examine the clinical and neurological outcome of patients who sustained a severe non-penetrating traumatic brain injury (TBI) and underwent unilateral decompressive craniectomy (DC) for refractory intracranial hypertension.: Design: ... ...

    Abstract Objective: To examine the clinical and neurological outcome of patients who sustained a severe non-penetrating traumatic brain injury (TBI) and underwent unilateral decompressive craniectomy (DC) for refractory intracranial hypertension.
    Design: Single center, retrospective, observational.
    Setting: Level I Trauma Center in Portland, Maine.
    Patients: 31 patients aged 16-72 of either sex who sustained a severe, non-penetrating TBI and underwent a unilateral DC for evacuation of parenchymal or extra-axial hematoma or for failure of medical therapy to control intracranial pressure (ICP).
    Interventions: Review of the electronic medical record of patients undergoing DC for severe TBI and assessment of extended Glasgow Outcome Score (e-GOS) at 6-months following DC.
    Measurements and main results: The mean age was 39.3y ± 14.5. The initial GCS was 5.8 ± 3.2, and the ISS was 29.7 ± 6.3. Twenty-two patients underwent DC within the first 24 h, two within the next 24 h and seven between the 3rd and 7th day post injury. The pre-DC ICP was 30.7 ± 10.3 and the ICP was 12.1 ± 6.2 post-DC. Cranioplasty was performed in all surviving patients 1-4 months post-DC. Of the 29 survivors following DC, the e-GOS was 8 in seven patients, and 7 in ten patients. The e-GOS was 5-6 in 6 others. Of the 6 survivors with poor outcomes (e-GOS = 2-4), five were the initial patients in the series.
    Conclusions: In patients with intractable cerebral hypertension following TBI, unilateral DC in concert with practice guideline directed brain resuscitation is associated with good functional outcome and acceptable-mortality.
    Language English
    Publishing date 2016-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/s40064-016-3251-9
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  7. Article ; Online: CEREBRAL ENDOVASCULAR NEUROSURGERY.

    Hopkins, L Nelson / Ecker, Robert D

    Neurosurgery

    2008  Volume 62, Issue suppl_3, Page(s) SHC1483–SHC1502

    Language English
    Publishing date 2008-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.NEU.0000315304.66122.F0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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    Zs.MO 539: Show issues

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  8. Article: Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.

    Díaz, Roberto Efraín / Ecker, Andrew K / Correy, Galen J / Asthana, Pooja / Young, Iris D / Faust, Bryan / Thompson, Michael C / Seiple, Ian B / Van Dyken, Steven J / Locksley, Richard M / Fraser, James S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mammalian ...

    Abstract Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mammalian Chitinase (AMCase), is an enzyme known for its ability to function under acidic conditions in the stomach but is also active in tissues with more neutral pHs, such as the lung. Here, we used a combination of biochemical, structural, and computational modeling approaches to examine how the mouse homolog (mAMCase) can act in both acidic and neutral environments. We measured kinetic properties of mAMCase activity across a broad pH range, quantifying its unusual dual activity optima at pH 2 and 7. We also solved high resolution crystal structures of mAMCase in complex with oligomeric GlcNAcn, the building block of chitin, where we identified extensive conformational ligand heterogeneity. Leveraging these data, we conducted molecular dynamics simulations that suggest how a key catalytic residue could be protonated via distinct mechanisms in each of the two environmental pH ranges. These results integrate structural, biochemical, and computational approaches to deliver a more complete understanding of the catalytic mechanism governing mAMCase activity at different pH. Engineering proteins with tunable pH optima may provide new opportunities to develop improved enzyme variants, including AMCase, for therapeutic purposes in chitin degradation.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.03.542675
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  9. Article: 'Leveling' the playing field for analyses of single-base resolution DNA methylomes.

    Schultz, Matthew D / Schmitz, Robert J / Ecker, Joseph R

    Trends in genetics : TIG

    2012  Volume 28, Issue 12, Page(s) 583–585

    MeSH term(s) Cytosine/metabolism ; DNA Methylation ; Genome ; Sequence Analysis, DNA/methods ; Sequence Analysis, DNA/statistics & numerical data ; Sulfites
    Chemical Substances Sulfites ; Cytosine (8J337D1HZY) ; hydrogen sulfite (OJ9787WBLU)
    Language English
    Publishing date 2012-11-03
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2012.10.012
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    Zs.A 2272: Show issues Location:
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  10. Article ; Online: Hyperperfusion syndrome after stent/coiling of a ruptured carotid bifurcation aneurysm.

    Ecker, Robert D / Murray, Richard D / Seder, David B

    Neurocritical care

    2012  Volume 18, Issue 1, Page(s) 54–58

    Abstract: The authors report a syndrome of regional, symptomatic cerebral hyperperfusion, and edema mimicking infarction in a 54-year-old woman following coiling of a ruptured right carotid bifurcation aneurysm and stenting of the right middle cerebral artery. The ...

    Abstract The authors report a syndrome of regional, symptomatic cerebral hyperperfusion, and edema mimicking infarction in a 54-year-old woman following coiling of a ruptured right carotid bifurcation aneurysm and stenting of the right middle cerebral artery. The patient presented with a Hunt and Hess grade III subarachnoid hemorrhage 7 days after developing thunderclap headache. She underwent successful coiling under general anesthesia of the 1.6 × 1.5 × 1.6 cm aneurysm, but immediately after the coil was placed occlusion of the proximal M1 segment was developed. This occlusion was stented after ~5-min delay, and flow restored without angiographic evidence of distal emboli. Following the procedure, she was extubated and noted to have left hemiparesis, neglect, and mutism without a CT correlate. Cerebral infarction was suspected, but urgent repeat angiography demonstrated patent cerebral vasculature. On the following day, symptoms persisted, and non-contrast head CT now showed cerebral edema localized to the right middle cerebral artery territory mimicking subacute infarction. CT perfusion imaging and angiography showed a widely patent MCA circulation, and suggested a regional hyperperfusion syndrome. The blood pressure was incrementally lowered, with rapid and sustained neurological improvement. Hyperperfusion events following aneurysm repair and related circumstances are reviewed.
    MeSH term(s) Aneurysm, Ruptured/surgery ; Brain Edema/diagnostic imaging ; Brain Edema/etiology ; Carotid Artery Diseases/surgery ; Cerebral Angiography ; Cerebrum/blood supply ; Endovascular Procedures/adverse effects ; Female ; Humans ; Middle Aged ; Middle Cerebral Artery/surgery ; Reperfusion Injury/diagnostic imaging ; Reperfusion Injury/etiology ; Stents ; Syndrome ; Tomography, X-Ray Computed
    Language English
    Publishing date 2012-08-30
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-012-9733-x
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