LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 130

Search options

  1. Article ; Online: Response to the Letter of Neira-Somoza et al.

    Baysal, Ayse / Sagıroglu, Gonul / Dogukan, Mevlut / Ozkaynak, Ismail

    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

    2022  Volume 37, Issue 5, Page(s) 584–585

    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1329844-6
    ISSN 1532-8473 ; 0883-9433 ; 1089-9472
    ISSN (online) 1532-8473
    ISSN 0883-9433 ; 1089-9472
    DOI 10.1016/j.jopan.2022.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Characterizing the interaction between micro(nano)plastics and simulated body fluids and their impact on human lung epithelial cells.

    Saygin, Hasan / Soyocak, Ahu / Baysal, Asli / Saridag, Ayse Mine

    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

    2023  Volume 58, Issue 10, Page(s) 855–868

    Abstract: Micro(nano)plastics are considered an emerging threat to human health because they can interact with biological systems. In fact, these materials have already been found in the human body, such as in the lungs. However, limited data are available on the ... ...

    Abstract Micro(nano)plastics are considered an emerging threat to human health because they can interact with biological systems. In fact, these materials have already been found in the human body, such as in the lungs. However, limited data are available on the behavior of these materials under biological conditions and their impact on human cells, specifically on alveolar epithelial cells. In this study, micro(nano)plastics were exposed to various simulated biological fluids (artificial lysosomal fluids and Gamble's solution) for 2-80 h. Pristine and treated plastic particles were characterized based on their surface chemistry, zeta potentials, and elemental composition. Various toxicological endpoints (mitochondrial membrane potential, lactate dehydrogenase, protein, and antioxidant levels) were examined using A549 lung carcinoma cells. The surface characteristics of the treated micro(nano)plastics and the toxicological endpoints of A549 cells were found to be influenced by the simulated biological media, specifically with high concentrations of the treated micro(nano)plastics and increasing exposure under biological conditions. Moreover, the toxicological endpoints were strongly linked to the chemistry of plastics and included multiple processes in response to the plastics; different biological pathways were obtained in artificial lysosomal fluid and Gamble's solution.
    MeSH term(s) Humans ; Plastics ; Lung/metabolism ; Body Fluids ; Epithelial Cells ; Feces
    Chemical Substances Plastics
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 196584-0
    ISSN 1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
    ISSN (online) 1532-4117
    ISSN 0360-1226 ; 1077-1204 ; 1093-4529
    DOI 10.1080/10934529.2023.2243190
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells.

    Baysal, Asli / Soyocak, Ahu / Saygin, Hasan / Saridag, Ayse Mine

    Toxicology mechanisms and methods

    2023  Volume 34, Issue 1, Page(s) 72–97

    Abstract: The occurrence of micro(nano)plastics into various environmental and biological settings influences their physicochemical and toxic behavior. Simulated body fluids are appropriate media for understanding the degradation, stability, and interaction with ... ...

    Abstract The occurrence of micro(nano)plastics into various environmental and biological settings influences their physicochemical and toxic behavior. Simulated body fluids are appropriate media for understanding the degradation, stability, and interaction with other substances of any material in the human body. When the particles enter the human body via inhalation, which is one of the avenues for micro(nano)plastics, they first come into contact with the lung lining fluid under neutral conditions and then are phagocytosed under acidic conditions to be removed. Therefore, it is important to examine the physicochemical transformation and toxicity characteristics after interaction with phagolysosomal simulant fluid (PSF). Here, we focused on exploring how the physicochemical differences (e.g. surface chemistry, elemental distribution, and surface charge) of micro(nano)plastics under pH 4.5 phagolysosome conditions impact cytotoxicity and the oxidative characteristics of lung epithelia cells. The cytotoxicity of lung epithelia cells to those treated with PSF and non-treated micro(nano)plastics was tested by various viability indicators including cell counting kit-8 (CCK-8), MTT, and LDH. Furthermore, the cytotoxicity background was examined through the oxidative processes (e.g. reactive oxygen species, antioxidant, superoxide dismutase (SOD), catalase, and reduced glutathione). The results showed that all tested surface physicochemical characteristics were significantly influenced by the phagolysosome conditions. The staged responses were observed with the treatment duration, and significant changes were calculated in carbonyl, carbon-nitrogen, and sulfonyl groups. Moreover, the negativity of the zeta potentials declined between exposure of 2-40 h and then increased at 80 h compared to control owing to the chemical functional groups and elemental distribution of the plastic particles. The tested viability indicators showed that the micro(nano)plastics treated with PSF were cytotoxic to the lung epithelia cells compared to non-treated micro(nano)plastics, and SOD was the dominant enzyme triggering cytotoxicity due to the particle degradation and instability.
    MeSH term(s) Humans ; Lung ; Water Pollutants, Chemical ; Superoxide Dismutase ; Positron-Emission Tomography
    Chemical Substances Water Pollutants, Chemical ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2023.2256847
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Half-Dose Sugammadex After Neostigmine Versus Neostigmine as a Routine Reversal Agent: A Pilot Randomized Trial.

    Baysal, Ayse / Sagıroglu, Gonul / Dogukan, Mevlut / Ozkaynak, Ismail

    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

    2022  Volume 37, Issue 3, Page(s) 326–332

    Abstract: Purpose: The use of sugammadex at a lower dose after a routine reversal dose of neostigmine may prevent residual neuromuscular blockade (rNMB). Our goal was to investigate the effects of the use of half-dose sugammadex for reversing rNMB after ... ...

    Abstract Purpose: The use of sugammadex at a lower dose after a routine reversal dose of neostigmine may prevent residual neuromuscular blockade (rNMB). Our goal was to investigate the effects of the use of half-dose sugammadex for reversing rNMB after administration of neostigmine, and compare these effects to a routine full-dose of neostigmine.
    Design: Prospective, single-blinded, randomized trial.
    Methods: Ninety-eight patients having lower abdominal tumor resection surgery under general anesthesia were randomized into two groups. Group N (Neostigmine) (n = 48) patients received standard reversal dose of intravenous neostigmine 0.05 mg/kg and atropine 0.02 mg/kg before extubationl Group N + S (Neostigmine + Sugammadex) (n = 50) patients received 1 mg/kg of intravenous sugammadex three minutes after a standard neostigmine reversal dose. The primary end-point was the incidence of a train-of-four (TOF) ratio less than 0.9 at tracheal extubation. Secondary end-points were periods between the start of administration of reversal agents and extubation or operating room discharge in minutes to achieve recovery of TOF ratio < 0.9 to 0.7 and TOF ratio ≥ 0.9.
    Findings: The demographic data were not different between the two groups (P > .005). The incidence of rNMB presented as TOF ratio < 0.9 to 0.7 was present in 52% of Group N patients compared to 8% in Group N + S patients (P < .0001). The time to recovery between administering reversal and extubation as well as operating room discharge in Group N were; 18.52 ± 6.34 minutes and 23.27 ± 6.95 minutes, respectively, whereas; in Group N + S, they were; 12.86 ± 5.05 and 17.82 ± 4.99 minutes, respectively. (P < .0001, P < .0001, respectively). Adverse events were similar between groups (P > .05).
    Conclusions: A half-dose sugammadex (1 mg/kg) after full-dose reversal of neostigmine provides a lower incidence of rNMB and shorter recovery times as compared to full-dose neostigmine reversal agent. This practice is safe and effective in case of rNMB.
    MeSH term(s) Cholinesterase Inhibitors/adverse effects ; Delayed Emergence from Anesthesia/drug therapy ; Delayed Emergence from Anesthesia/etiology ; Delayed Emergence from Anesthesia/prevention & control ; Humans ; Neostigmine/pharmacology ; Neostigmine/therapeutic use ; Neuromuscular Blockade/adverse effects ; Neuromuscular Nondepolarizing Agents/adverse effects ; Pilot Projects ; Prospective Studies ; Sugammadex ; gamma-Cyclodextrins
    Chemical Substances Cholinesterase Inhibitors ; Neuromuscular Nondepolarizing Agents ; gamma-Cyclodextrins ; Sugammadex (361LPM2T56) ; Neostigmine (3982TWQ96G)
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1329844-6
    ISSN 1532-8473 ; 0883-9433 ; 1089-9472
    ISSN (online) 1532-8473
    ISSN 0883-9433 ; 1089-9472
    DOI 10.1016/j.jopan.2021.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients: a randomized controlled trial.

    Sagiroglu, Gonul / Baysal, Ayse

    Annals of Saudi medicine

    2020  Volume 40, Issue 3, Page(s) 175–182

    Abstract: Background: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure. Unexpected adverse events can occur in ... ...

    Abstract Background: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure. Unexpected adverse events can occur in chronic renal failure patients undergoing short procedures.
    Objective: Investigate and compare the sedoanalgesic and adverse effects of intravenous continuous infusion (CI) use of midazolam with intravenous intermittent bolus (IB) doses of midazolam while using intravenous remifentanil as a rescue medication, and assess patient and surgeon satisfaction.
    Design: Prospective, randomized, single-blind controlled study.
    Settings: Two tertiary care hospitals.
    Patients and methods: Study included patients aged 43-81 years with a diagnosis of chronic renal failure who were referred for an arteriovenous fistula procedure with modified anesthesia care between August 2012 and April 2016. The patients were randomized to intravenous CI or IB doses of midazolam. IB doses of remifentanil were used as a rescue medication.
    Main outcome measures: Primary outcomes were amounts of midazolam and remifentanil medications during the operation, the amount of remifentanil as a rescue medication, and the satisfaction of patient and surgeon.
    Sample size: 116 assessed for eligibility; 99 randomized to CI (n=50) or IB doses (n=49 of midazolam).
    Results: The total dose of midazolam by CI was greater than with midazolam by IB (
    Conclusion: Intravenous CI midazolam during MAC provides better surgeon satisfaction then IB midazolam and can be used safely for arteriovenous fistula procedures.
    Limitations: Two different surgeon groups.
    Conflict of interest: None.
    MeSH term(s) Administration, Intravenous/methods ; Adult ; Aged ; Aged, 80 and over ; Anesthetics, Intravenous/administration & dosage ; Arteriovenous Fistula/etiology ; Arteriovenous Fistula/surgery ; Conscious Sedation/methods ; Female ; Humans ; Kidney Failure, Chronic/complications ; Male ; Midazolam/administration & dosage ; Middle Aged ; Patient Satisfaction ; Prospective Studies ; Remifentanil/administration & dosage ; Single-Blind Method ; Treatment Outcome
    Chemical Substances Anesthetics, Intravenous ; Remifentanil (P10582JYYK) ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2020-06-04
    Publishing country Saudi Arabia
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 639014-6
    ISSN 0975-4466 ; 0256-4947
    ISSN (online) 0975-4466
    ISSN 0256-4947
    DOI 10.5144/0256-4947.2020.175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: An Investigation of Pregnant Women's Attitudes Towards Childhood Vaccination and Trust in Health Services.

    Savci Bakan, Ayse Berivan / Aktas, Betül / Yalcinoz Baysal, Hasret / Aykut, Nese

    Maternal and child health journal

    2023  Volume 27, Issue 6, Page(s) 1051–1059

    Abstract: Background: Vaccination of children is of great importance for their healthy growth and development. Several concerns that have been mentioned by families due to various reasons could affect vaccination acceptance.: Objectives: This study aims to ... ...

    Abstract Background: Vaccination of children is of great importance for their healthy growth and development. Several concerns that have been mentioned by families due to various reasons could affect vaccination acceptance.
    Objectives: This study aims to investigate pregnant women's attitudes toward childhood vaccinations and trust in health services.
    Methods: This study was designed as a descriptive study. It was conducted in a city located in the eastern part of Turkey between March and May 2019. The sample was 193 volunteer pregnant women. Data were collected using the Socio-demographic Form, the Multidimensional Trust in Health-care System Scale, and the Public Attitude toward Vaccination Scale - Health Belief Model.
    Results: A positive, statistically significant relationship was found between the Multidimensional Trust in Healthcare System Scale total mean score and Perceived Susceptibility, Perceived Severity, Perceived Benefits, and Health Responsibility (p < .01). In addition, education and income level, having social security, having had a vaccination or not, and knowing vaccines affected trusts in health services; having social security, having had vaccinations or not, and knowing vaccines affected health beliefs about vaccinations (p < 0.05).
    Conclusions for practice: This study found that knowing vaccines affects both trust in health services and health beliefs about vaccination. Therefore, community health nurses working in primary care should provide parents with accurate and effective information about vaccinations.
    MeSH term(s) Child ; Female ; Humans ; Pregnancy ; Pregnant Women ; Health Knowledge, Attitudes, Practice ; Vaccination ; Vaccines ; Parents/education ; Patient Acceptance of Health Care
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-023-03630-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients

    Gonul Sagiroglu / Ayse Baysal

    Annals of Saudi Medicine, Vol 40, Iss 3, Pp 175-

    a randomized controlled trial

    2020  Volume 182

    Abstract: BACKGROUND: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure. Unexpected adverse events can occur in ... ...

    Abstract BACKGROUND: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure. Unexpected adverse events can occur in chronic renal failure patients undergoing short procedures. OBJECTIVE: Investigate and compare the sedoanalgesic and adverse effects of intravenous continuous infusion (CI) use of midazolam with intravenous intermittent bolus (IB) doses of midazolam while using intravenous remifentanil as a rescue medication, and assess patient and surgeon satisfaction. DESIGN: Prospective, randomized, single-blind controlled study. SETTINGS: Two tertiary care hospitals. PATIENTS AND METHODS: Study included patients aged 43-81 years with a diagnosis of chronic renal failure who were referred for an arteriovenous fistula procedure with modified anesthesia care between August 2012 and April 2016. The patients were randomized to intravenous CI or IB doses of midazolam. IB doses of remifentanil were used as a rescue medication. MAIN OUTCOME MEASURES: Primary outcomes were amounts of midazolam and remifentanil medications during the operation, the amount of remifentanil as a rescue medication, and the satisfaction of patient and surgeon. SAMPLE SIZE: 116 assessed for eligibility; 99 randomized to CI (n=50) or IB doses (n=49 of midazolam). RESULTS: The total dose of midazolam by CI was greater than with midazolam by IB (P=.002). The total dose of remifentanil was higher with IB doses of midazolam in comparison to CI of midazolam (P=.001). The groups were similar in sedation and pain control, duration of procedure, recovery time, patient satisfaction and adverse events; surgeon satisfaction was greater with CI versus IB (P=.035). CONCLUSION: Intravenous CI midazolam during MAC provides better surgeon satisfaction then IB midazolam and can be used safely for arteriovenous fistula procedures. LIMITATIONS: Two different surgeon groups. CONFLICT OF INTEREST: None.
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher King Faisal Specialist Hospital and Research Centre
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  8. Article ; Online: Modeling growth of

    Molva, Celenk / Baysal, Ayse Handan

    AIMS microbiology

    2017  Volume 3, Issue 2, Page(s) 315–322

    Abstract: In the present study, the effect of storage temperature ... ...

    Abstract In the present study, the effect of storage temperature on
    Language English
    Publishing date 2017-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1888
    ISSN (online) 2471-1888
    DOI 10.3934/microbiol.2017.2.315
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Investigation of Risk Factors Related to the Development of Hepatic Dysfunction in Patients with a Low and Moderate Cardiac Risk During Open-Heart Surgeries.

    Baysal, Ayse / Sagiroglu, Gonul / Dogukan, Mevlut / Ozkaynak, Ismail

    Brazilian journal of cardiovascular surgery

    2021  Volume 36, Issue 2, Page(s) 219–228

    Abstract: Objective: To determine the possible risk factors associated with hepatic dysfunction during open-heart surgeries.: Methods: After excluding 71 patients, 307 patients with possible low and moderate cardiac risk who underwent either coronary artery ... ...

    Abstract Objective: To determine the possible risk factors associated with hepatic dysfunction during open-heart surgeries.
    Methods: After excluding 71 patients, 307 patients with possible low and moderate cardiac risk who underwent either coronary artery bypass graft surgery (CABG) (n=176) or valve repair surgery (mitral valve, mitral and aortic valves and/or tricuspid valve) (n=131) were investigated prospectively during a 6-month period. Hyperbilirubinemia is defined as an occurrence of a plasma total bilirubin concentration >34 µmol/L (2 mg/dL) in any measurement during the postoperative period; the patients were divided into groups with or without postoperative hyperbilirubinemia. The collected parameters were: alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TBil), gamma-glutamyl transpeptidase (GGT) and albumin. The parameters were collected preoperatively and postoperatively on days 1, 3 and 7. Preoperative, intraoperative, and postoperative risk factors were investigated. Logistic regression analysis was performed to identify the risk factors for postoperative hyperbilirubinemia.
    Results: Postoperative hyperbilirubinemia was observed in 7 of 176 patients (4%) who underwent CABG, and in 11 of 131 patients (8.4%) who underwent valve replacement surgeries. Independent risk factors for early postoperative hyperbilirubinemia were found as: ejection fraction (EF), aortic cross-clamp (ACC) time, intensive care unit stay and extubation time (P<0.001). In comparison to CABG procedures, postoperative hyperbilirubinemia was observed more frequently in patients undergoing valve surgeries (P=0.027).
    Conclusion: Low EF and prolonged ACC time are significant independent risk factors for early postoperative hyperbilirubinemia during open-heart surgeries with cardiopulmonary bypass. Valve surgeries show a higher incidence of hyperbilirubinemia in comparison to CABG.
    MeSH term(s) Aortic Valve/surgery ; Cardiac Surgical Procedures/adverse effects ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Hyperbilirubinemia/etiology ; Mitral Valve/surgery ; Retrospective Studies ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2021-04-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2183753-3
    ISSN 1678-9741 ; 0102-7638
    ISSN (online) 1678-9741
    ISSN 0102-7638
    DOI 10.21470/1678-9741-2019-0427
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: The Comparison of Two Different Techniques of Remifentanil Administration During Implantable Vascular Access Device Procedures.

    Sagiroglu, Gonul / Baysal, Ayse / Yanik, Fazli

    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

    2021  Volume 36, Issue 6, Page(s) 664–671

    Abstract: Purpose: The aim was to compare analgesic efficacy and adverse effects of two different techniques of intravenous remifentanil administration in patients undergoing vascular; access device procedures with monitored anesthesia care.: Design: A ... ...

    Abstract Purpose: The aim was to compare analgesic efficacy and adverse effects of two different techniques of intravenous remifentanil administration in patients undergoing vascular; access device procedures with monitored anesthesia care.
    Design: A randomized, single-blinded controlled study.
    Methods: The patients (N = 92) were 30-80 years old and of American Society of Anesthesiologists Physical Status I-III. The first group was the continuous infusion group (group CI). Intravenous continuous remifentanil was infused after starting at a dosage of 0.1 mcg/kg/min, and the dose was raised incrementally up to 1 mcg/kg/min if required. The second group was intravenous bolus patient-controlled sedation analgesia (PCSA) with remifentanil infusion at a dose of 0.05 mcg/kg per minute and bolus of 0.1 mcg/kg with lock-out time of 3 minutes. In both groups, a bolus dose of 0.1 mcg/kg remifentanil was administered. The data evaluated include level of pain and sedation, total amount of remifentanil consumption, bolus doses of remifentanil, patient and surgeon satisfaction, hemodynamic data, and adverse events.
    Findings: In comparison between techniques, pain and sedation scores during procedure, duration of procedure, patient and surgeon satisfaction, additional rescue medication, and bolus doses were not statistically different (P > .05). The total amount of remifentanil administered was significantly lower in the infusion group than that in the bolus group (P = .031).
    Conclusions: For central venous access device procedures under monitored anesthesia care, remifentanil use in both infusion and bolus techniques could provide sufficient sedation and analgesia without serious adverse effects. Total remifentanil consumption amount in infusion group is lower than that in the bolus group.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Analgesia, Patient-Controlled ; Analgesics, Opioid/therapeutic use ; Humans ; Infusions, Intravenous ; Middle Aged ; Piperidines ; Remifentanil ; Vascular Access Devices
    Chemical Substances Analgesics, Opioid ; Piperidines ; Remifentanil (P10582JYYK)
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1329844-6
    ISSN 1532-8473 ; 0883-9433 ; 1089-9472
    ISSN (online) 1532-8473
    ISSN 0883-9433 ; 1089-9472
    DOI 10.1016/j.jopan.2021.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top