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  1. Article ; Online: Letter to the Editor: "Dynamic Pituitary-Adrenal Interactions in the Critically ill After Cardiac Surgery".

    Dorin, Richard I / Urban, Frank K / Qualls, Clifford R

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 9

    MeSH term(s) Cardiac Surgical Procedures/adverse effects ; Critical Illness ; Humans ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa418
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    Uh III Zs.134: Show issues Location:
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  2. Article ; Online: Letter to the Editor: "Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery".

    Dorin, Richard I / Urban, Frank K / Qualls, Clifford R

    The Journal of clinical endocrinology and metabolism

    2020  Volume 106, Issue 1, Page(s) e393–e394

    MeSH term(s) Acute Disease ; Adrenal Insufficiency/drug therapy ; Adrenal Insufficiency/prevention & control ; Cosyntropin ; Humans ; Hydrocortisone
    Chemical Substances Cosyntropin (16960-16-0) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  3. Article: Hypernatremia in Hyperglycemia: Clinical Features and Relationship to Fractional Changes in Body Water and Monovalent Cations during Its Development.

    Wagner, Brent / Ing, Todd S / Roumelioti, Maria-Eleni / Sam, Ramin / Argyropoulos, Christos P / Lew, Susie Q / Unruh, Mark L / Dorin, Richard I / Degnan, James H / Tzamaloukas, Antonios H

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: In hyperglycemia, the serum sodium concentration ( ...

    Abstract In hyperglycemia, the serum sodium concentration (
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071957
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  4. Book ; Online: Improved iron-tolerance in recycled aluminum alloys via direct strip casting process

    Jiang, Lu / Marceau, Ross. K. W. / Dorin, Thomas

    2023  

    Abstract: ... undermining their properties and recyclability. Conventional manufacturing processes result in coarse Fe-rich ... produced by DSC exhibit significantly refined microstructures and are free from coarse Fe-rich ...

    Abstract Recycled aluminum alloys are pivotal for sustainable manufacturing, offering strength, durability, and environmental advantages. However, the presence of iron (Fe) impurities poses a major challenge, undermining their properties and recyclability. Conventional manufacturing processes result in coarse Fe-rich intermetallic compounds that limit the tolerance of Fe content and negatively influence performance of advanced aluminum alloys. To address this, rapid solidification techniques like direct strip casting have been explored. In this work, a detailed study of the strip cast microstructure was conducted by scanning electron microscopy, electron backscattered diffraction and atom probe tomography. Our results reveal that alloys produced by DSC exhibit significantly refined microstructures and are free from coarse Fe-rich intermetallics, thereby retaining the majority of Fe in solid solution. These findings indicate that strip casting significantly enhances Fe-tolerance in aluminum alloys, making it an attractive process for future aluminum recycling, with implications for sustainable high-performance applications.
    Keywords Condensed Matter - Materials Science
    Subject code 669
    Publishing date 2023-10-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Decreased maximal cortisol secretion rate in patients with cirrhosis: Relation to disease severity.

    Lovato, Christina M / Thévenot, Thierry / Borot, Sophie / Di Martino, Vincent / Qualls, Clifford R / Urban, Frank K / Dorin, Richard I

    JHEP reports : innovation in hepatology

    2021  Volume 3, Issue 3, Page(s) 100277

    Abstract: Background & aims: Hepatic enzymes play a major role in the metabolic elimination of cortisol, and reduced rates of cortisol clearance have been consistently observed in patients with chronic liver disease. It is less clear whether there are concomitant ...

    Abstract Background & aims: Hepatic enzymes play a major role in the metabolic elimination of cortisol, and reduced rates of cortisol clearance have been consistently observed in patients with chronic liver disease. It is less clear whether there are concomitant abnormalities of adrenocortical function in patients with cirrhosis. In the present study, we sought to assess adrenocortical function in patients with cirrhosis using measures of free cortisol appearance and elimination rates that are independent of serum concentrations of cortisol binding proteins.
    Methods: Post hoc
    Results: Maximal cortisol secretion rate (CSR
    Conclusions: CSR
    Lay summary: We applied numerical analytic methods to characterise adrenocortical function in patients with varying stages of chronic liver disease. We found that patients with more severe cirrhosis have decreased rate of free cortisol elimination and decreased maximal cortisol secretion rate, which is a measure of adrenocortical function. In contrast to conventional measures of adrenocortical function, those obtained using numerical methods were not affected by variation in corticosteroid binding globulin and albumin concentrations. We conclude that patients with cirrhosis demonstrate measurable abnormalities of adrenocortical function, evidence of which supports aspects of the hepatoadrenal syndrome hypothesis.
    Language English
    Publishing date 2021-03-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2021.100277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro.

    Shelley, Jennifer R / McHugh, Brian J / Wills, Jimi / Dorin, Julia R / Weller, Richard / Clarke, David J / Davidson, Donald J

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2271

    Abstract: The human skin barrier, a biological imperative, is impaired in inflammatory skin diseases such as atopic dermatitis (AD). Staphylococcus aureus is associated with AD lesions and contributes to pathological inflammation and further barrier impairment. S. ...

    Abstract The human skin barrier, a biological imperative, is impaired in inflammatory skin diseases such as atopic dermatitis (AD). Staphylococcus aureus is associated with AD lesions and contributes to pathological inflammation and further barrier impairment. S. aureus secretes extracellular proteases, such as V8 (or 'SspA'), which cleave extracellular proteins to reduce skin barrier. Previous studies demonstrated that the host defence peptide human beta-defensin 2 (HBD2) prevented V8-mediated damage. Here, the mechanism of HBD2-mediated barrier protection in vitro is examined. Application of exogenous HBD2 provided protection against V8, irrespective of timeline of application or native peptide folding, raising the prospect of simple peptide analogues as therapeutics. HBD2 treatment, in context of V8-mediated damage, modulated the proteomic/secretomic profiles of HaCaT cells, altering levels of specific extracellular matrix proteins, potentially recovering V8 damage. However, HBD2 alone did not substantially modulate cellular proteomic/secretomics profiles in the absence of damage, suggesting possible therapeutic targeting of lesion damage sites only. HBD2 did not show any direct protease inhibition or induce expression of known antiproteases, did not alter keratinocyte migration or proliferation, or form protective nanonet structures. These data validate the barrier-protective properties of HBD2 in vitro and establish key protein datasets for further targeted mechanistic analyses.
    MeSH term(s) Humans ; beta-Defensins/pharmacology ; beta-Defensins/metabolism ; Staphylococcus aureus/metabolism ; Proteomics ; Skin/metabolism ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Proteins
    Chemical Substances beta-Defensins ; Proteins
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29558-0
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  7. Article ; Online: Portable biosensors for rapid on-site determination of cannabinoids in cannabis, a review.

    Harpaz, Dorin / Bernstein, Nirit / Namdar, Dvora / Eltzov, Evgeni

    Biotechnology advances

    2022  Volume 61, Page(s) 108031

    Abstract: ... consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects ...

    Abstract Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, there is flourishing demand for Cannabis sativa varieties containing high levels of CBD. Additionally, legal regulations around the world restrict the cultivation and consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects. Therefore, the use of cannabis varieties that are high in CBD is permitted as long as their THC content does not exceed a low threshold of 0.3%-0.5%, depending on the jurisdiction. These chemovars are legally termed 'hemp'. This controlled cannabinoid requirement highlights the need to detect low levels of THC, already in the field. In this review, cannabis profiling and the existing methods used for the detection of cannabinoids are firstly evaluated. Then, selected valuable biosensor technologies are discussed, which suggest portable, rapid, sensitive, reproducible, and reliable methods for on-site identification of cannabinoids levels, mainly THC. Recent cutting-edge techniques of promising potential usage for both cannabis and hemp analysis are identified, as part of the future cultivation and agricultural improvement of this crop.
    MeSH term(s) Cannabis ; Cannabinoids ; Dronabinol ; Cannabidiol ; Biosensing Techniques
    Chemical Substances Cannabinoids ; Dronabinol (7J8897W37S) ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2022.108031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Portable biosensors for rapid on-site determination of cannabinoids in cannabis, a review

    Harpaz, Dorin / Bernstein, Nirit / Namdar, Dvora / Eltzov, Evgeni

    Biotechnology advances. 2022 Dec., v. 61

    2022  

    Abstract: ... consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects ...

    Abstract Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, there is flourishing demand for Cannabis sativa varieties containing high levels of CBD. Additionally, legal regulations around the world restrict the cultivation and consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects. Therefore, the use of cannabis varieties that are high in CBD is permitted as long as their THC content does not exceed a low threshold of 0.3%–0.5%, depending on the jurisdiction. These chemovars are legally termed ‘hemp’. This controlled cannabinoid requirement highlights the need to detect low levels of THC, already in the field. In this review, cannabis profiling and the existing methods used for the detection of cannabinoids are firstly evaluated. Then, selected valuable biosensor technologies are discussed, which suggest portable, rapid, sensitive, reproducible, and reliable methods for on-site identification of cannabinoids levels, mainly THC. Recent cutting-edge techniques of promising potential usage for both cannabis and hemp analysis are identified, as part of the future cultivation and agricultural improvement of this crop.
    Keywords Cannabis sativa ; biosensors ; biotechnology ; cannabidiol ; chemotypes ; hemp ; tetrahydrocannabinol ; therapeutics
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 47165-3
    ISSN 0734-9750
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2022.108031
    Database NAL-Catalogue (AGRICOLA)

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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Dialysis-associated hyperglycemia: manifestations and treatment.

    Sun, Yijuan / Roumelioti, Maria-Eleni / Ganta, Kavitha / Glew, Robert H / Gibb, James / Vigil, Darlene / Do, Catherine / Servilla, Karen S / Wagner, Brent / Owen, Jonathan / Rohrscheib, Mark / Dorin, Richard I / Murata, Glen H / Tzamaloukas, Antonios H

    International urology and nephrology

    2020  Volume 52, Issue 3, Page(s) 505–517

    Abstract: Purpose: Dialysis-associated hyperglycemia (DAH), is associated with a distinct fluid and electrolyte pathophysiology. The purpose of this report was to review the pathophysiology and provide treatment guidelines for DAH.: Methods: Review of ... ...

    Abstract Purpose: Dialysis-associated hyperglycemia (DAH), is associated with a distinct fluid and electrolyte pathophysiology. The purpose of this report was to review the pathophysiology and provide treatment guidelines for DAH.
    Methods: Review of published reports on DAH. Synthesis of guidelines based on these reports.
    Results: The following fluid and solute abnormalities have been identified in DAH: (a) hypoglycemia: this is a frequent complication of insulin treatment and its prevention requires special attention. (b) Elevated serum tonicity. The degree of hypertonicity in DAH is lower than in similar levels of hyperglycemia in patients with preserved renal function. Typically, correction of hyperglycemia with insulin corrects the hypertonicity of DAH. (c) Extracellular volume abnormalities ranging from pulmonary edema associated with osmotic fluid shift from the intracellular into the extracellular compartment as a consequence of gain in extracellular solute (glucose) to hypovolemia from osmotic diuresis in patients with residual renal function or from fluid losses through extrarenal routes. Correction of DAH by insulin infusion reverses the osmotic fluid transfer between the intracellular and extracellular compartments and corrects the pulmonary edema, but can worsen the manifestations of hypovolemia, which require saline infusion. (d) A variety of acid-base disorders including ketoacidosis correctable with insulin infusion and no other interventions. (e) Hyperkalemia, which is frequent in DAH and is more severe when ketoacidosis is also present. Insulin infusion corrects the hyperkalemia. Extreme hyperkalemia at presentation or hypokalemia developing during insulin infusion require additional measures.
    Conclusions: In DAH, insulin infusion is the primary management strategy and corrects the fluid and electrolyte abnormalities. Patients treated for DAH should be monitored for the development of hypoglycemia or fluid and electrolyte abnormalities that may require additional treatments.
    MeSH term(s) Humans ; Hyperglycemia/diagnosis ; Hyperglycemia/etiology ; Hyperglycemia/therapy ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/therapy ; Patient Care Management/methods ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Water-Electrolyte Imbalance/therapy
    Language English
    Publishing date 2020-01-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-019-02373-1
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    Zs.A 733: Show issues Location:
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  10. Article: Respiratory Failure in the Course of Treatment of Diabetic Ketoacidosis.

    Regmi, Anil / Konstantinov, Nikifor K / Agaba, Emmanuel I / Rohrscheib, Mark / Dorin, Richard I / Tzamaloukas, Antonios H

    Clinical diabetes : a publication of the American Diabetes Association

    2014  Volume 32, Issue 1, Page(s) 28–31

    Language English
    Publishing date 2014-05-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1025953-3
    ISSN 0891-8929
    ISSN 0891-8929
    DOI 10.2337/diaclin.32.1.28
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    Zs.A 2591: Show issues Location:
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