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  1. Article ; Online: Dysautonomia and response to guanfacine in individuals with an SCN9A variant.

    Palma, Jose-Alberto

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Letter
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-024-01029-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3270: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Muscarinic control of cardiovascular function in humans: a review of current clinical evidence.

    Palma, Jose-Alberto

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2024  Volume 34, Issue 1, Page(s) 31–44

    Abstract: Purpose: To review the available evidence on the impact of muscarinic receptor modulation on cardiovascular control in humans.: Methods: In this narrative Review we summarize data on cardiovascular endpoints from clinical trials of novel subtype- ... ...

    Abstract Purpose: To review the available evidence on the impact of muscarinic receptor modulation on cardiovascular control in humans.
    Methods: In this narrative Review we summarize data on cardiovascular endpoints from clinical trials of novel subtype-selective or quasi-selective muscarinic modulators, mostly PAMs, performed in the last decade. We also review the cardiovascular phenotype in recently described human genetic and autoimmune disorders affecting muscarinic receptors.
    Results: Recent advancements in the development of compounds that selectively target muscarinic acetylcholine receptors are expanding our knowledge about the physiological function of each muscarinic receptor subtype (M1, M2, M3, M4, M5). Among these novel compounds, positive allosteric modulators (PAMs) have emerged as the preferred therapeutic to regulate muscarinic receptor subtype function. Many muscarinic allosteric and orthosteric modulators (including but not limited to xanomeline-trospium and emraclidine) are now in clinical development and approaching regulatory approval for multiple indications, including the treatment of cognitive and psychiatric symptoms in patients with schizophrenia as well as Alzheimer's disease and other dementias. The results of these clinical trials provide an opportunity to understand the influence of muscarinic modulation on cardiovascular autonomic control in humans. While the results and the impact of each of these therapies on heart rate and blood pressure control have been variable, in part because the clinical trials were not specifically designed to measure cardiovascular endpoints, the emerging data is valuable to elucidate the relative cardiovascular contributions of each muscarinic receptor subtype.
    Conclusion: Understanding the muscarinic control of cardiovascular function is of paramount importance and may contribute to the development of novel therapeutic strategies for treating cardiovascular disease.
    MeSH term(s) Humans ; Receptors, Muscarinic/therapeutic use ; Alzheimer Disease/drug therapy ; Schizophrenia/drug therapy ; Blood Pressure ; Cholinergic Agents/therapeutic use
    Chemical Substances Receptors, Muscarinic ; Cholinergic Agents
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-024-01016-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pharmacologic Treatment for High BP and Risk of CVD.

    Palma, Jose-Alberto / Kaufmann, Horacio

    JAMA

    2024  Volume 331, Issue 6, Page(s) 530–531

    MeSH term(s) Humans ; Cardiovascular Diseases/prevention & control ; Hypertension/complications ; Hypertension/drug therapy ; Risk Factors ; Risk
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.26082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reader Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.

    Palma, Jose-Alberto

    Neurology

    2022  Volume 99, Issue 6, Page(s) 260

    MeSH term(s) Genetic Therapy/adverse effects ; Humans ; Levodopa ; Parkinson Disease/genetics ; Parkinson Disease/therapy
    Chemical Substances Levodopa (46627O600J)
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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  5. Article ; Online: Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.

    Palma, Jose-Alberto / Thijs, Roland D

    Journal of Parkinson's disease

    2023  

    Abstract: Symptoms of autonomic dysfunction are prevalent and can be very debilitating, reducing the quality of life in patients with Parkinson's disease (PD) and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Non- ... ...

    Abstract Symptoms of autonomic dysfunction are prevalent and can be very debilitating, reducing the quality of life in patients with Parkinson's disease (PD) and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Non-pharmacological therapies are key to effective management and are frequently used alone in patients with mild autonomic symptoms, or in combination with pharmacological therapies in patients with moderate and severe symptoms. This article focuses on non-pharmacological approaches. Our objective was to review the non-drug and non-surgical approaches to treating autonomic symptoms in patients with PD and other synucleinopathies, focusing on cardiovascular, gastrointestinal, and genitourinary autonomic dysfunction. Evidence supporting the effectiveness of non-pharmacological treatment for the management of neurogenic orthostatic hypotension, supine hypertension, constipation, and bladder and sexual dysfunction is available. High-quality prospective trials are scarce, yet some non-pharmacological interventions (e.g., physical counter maneuvers) can be evaluated relatively quickly on an individual basis and often seem effective. The emerging variety of clinical presentations advocates for a stepwise, individualized, and non-pharmacological approach for the management of autonomic symptoms. Often, the first step is to reduce or discontinue drugs that cause or aggravate autonomic symptoms followed by lifestyle measures. While non-pharmacological and non-surgical treatments are available and, in many cases, effective to improve symptoms of autonomic dysfunction in PD and other synucleinopathies, they are often overlooked. Large randomized trials testing and comparing non-pharmacological approaches are warranted.
    Language English
    Publishing date 2023-09-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6964: Show issues Location:
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  6. Article ; Online: Renal dysfunction might be a marker of cardiovascular dysautonomia in prodromal α-synucleinopathies.

    Palma, Jose-Alberto

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 2, Page(s) 374

    MeSH term(s) Aged ; Humans ; Kidney Diseases ; Parkinson Disease ; Primary Dysautonomias ; Proteinuria ; Synucleinopathies
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27840
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    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  7. Article ; Online: Views on Memory and Treatment of Cognitive Impairment in 17th-Century Spain: Juan Gutiérrez de Godoy's Work.

    Palma, Jose-Alberto / Palma, Fermin

    Neurology

    2022  Volume 99, Issue 10, Page(s) 424–427

    Abstract: Memory and its care were significant sociocultural and scientific topics in early modern Spain. Although a major interest in memory was related to its legal and rhetorical implications, medical treatises discussing memory, cognitive impairment, and its ... ...

    Abstract Memory and its care were significant sociocultural and scientific topics in early modern Spain. Although a major interest in memory was related to its legal and rhetorical implications, medical treatises discussing memory, cognitive impairment, and its treatment began to appear in the 16th and 17th century. Among these treatises,
    MeSH term(s) Humans ; Amnesia ; Cognitive Dysfunction/therapy ; Europe ; Memory Disorders/therapy ; Spain
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201025
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    Ui II Zs.153: Show issues Location:
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  8. Article ; Online: Blood Pressure and Risk of Dementia in Parkinson Disease and Multiple System Atrophy: Should You Buy the Dip in Such a Volatile Market?

    Palma, Jose-Alberto / Cortelli, Pietro

    Neurology

    2022  Volume 100, Issue 10, Page(s) 451–453

    MeSH term(s) Humans ; Parkinson Disease/complications ; Multiple System Atrophy/complications ; Blood Pressure ; Lewy Body Disease ; Dementia/epidemiology ; Dementia/etiology ; Atrophy
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000206803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dysautonomia in the synucleinopathies: not just orthostatic hypotension.

    Palma, Jose-Alberto

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2019  Volume 29, Issue 6, Page(s) 547–548

    MeSH term(s) Humans ; Primary Dysautonomias/etiology ; Synucleinopathies/complications
    Language English
    Publishing date 2019-10-24
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-019-00645-5
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  10. Article ; Online: Neurogenic hypertension: introduction to the series.

    Palma, Jose-Alberto

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2018  Volume 28, Issue 4, Page(s) 353–354

    MeSH term(s) Humans ; Hypertension/physiopathology ; Supine Position/physiology
    Language English
    Publishing date 2018-07-17
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-018-0549-4
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