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Article: Kinetics of ligation reactions of rabbit hemoglobin in quaternary R and T states.

Sharma, V S / Vedvick, T S / Magde, D / Luth, R / Friedman, D / Schmidt, M R / Ranney, H M

1980 Volume 255, Issue 12, Page(s) 5879–5884

Abstract: ... reduced CO and O2 combination rates in the R state and are primarily responsible for the overall low CO ...

Abstract	Rabbit hemoglobin shows significantly lower affinity for CO than does human hemoglobin (Hb A). The overall ligand combination and dissociation rate constants reveal, however, only small differences between Hb A rabbit Hb; this is mainly due to the fact that beta chains in rabbit hemoglobin determine the kinetics of ligand dissociation and combination. The heme environment in these chains is probably not very different in rabbit Hb and human Hb A. Rabbit hemoglobin alpha chains, on the other hand, exhibit greatly reduced CO and O2 combination rates in the R state and are primarily responsible for the overall low CO affinity of rabbit Hb. We postulate that the low ligand affinity of alpha chains in rabbit Hb is due to the substitution of larger residues at positions B10(Leu leads to Val), Cd6(Leu leads to Phe), and CD7(Ser leads to Thr). The possible implication of such substitutions for the kinetic and equilibrium properties of rabbit Hb are discussed.
MeSH term(s)	Animals ; Carbon Monoxide/blood ; Carboxyhemoglobin ; Hemoglobin A ; Hemoglobins ; Humans ; Kinetics ; Oxyhemoglobins ; Photolysis ; Protein Binding ; Species Specificity
Chemical Substances	Hemoglobins ; Oxyhemoglobins ; Carbon Monoxide (7U1EE4V452) ; Hemoglobin A (9034-51-9) ; Carboxyhemoglobin (9061-29-4)
Language	English
Publishing date	1980-06-25
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
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Article ; Online: Peer specialist-led interventions in primary care at the Veterans Health Administration: An integrative review.

Ranney, Rachel M / Goldberg, Richard / Maguen, Shira / Blonigen, Daniel

Psychological services

2024

Abstract: The Veterans Health Administration (VHA) currently employs over 1,300 peer specialists-veterans with lived experience of mental illness who are in recovery and have been trained to provide support to other veterans experiencing these issues. VHA peer ... ...

Abstract	The Veterans Health Administration (VHA) currently employs over 1,300 peer specialists-veterans with lived experience of mental illness who are in recovery and have been trained to provide support to other veterans experiencing these issues. VHA peer specialists have largely been employed in behavioral health settings. In 2014, VHA began to employ peer specialists in primary care settings via the peers in Patient Aligned Care Team (PACT) program, and congressional legislation was passed to expand this program in 2022. In light of this expansion, it is important to evaluate the effectiveness of interventions provided in the Peers in PACT program. This integrative review of studies of peer specialist-led interventions in VHA primary care includes 13 articles with 11 unique studies represented in these articles. These studies targeted mental health symptoms, substance use, health/well-being, and health/treatment engagement. Seven described single-arm studies, three described two-arm studies with a treatment as usual control group, and three described two-arm studies with an active control group. The majority of these studies demonstrated statistically significant improvements on at least one main outcome. Seven studies also included qualitative interviews with veterans; several common themes emerged, including the importance of working with a veteran peer with shared lived experiences, and finding peers helpful in providing accountability, motivation, encouragement, emotional support, resources, and assistance navigating VA health care. Recommendations for future research on the peers in PACT program are discussed, including a need for more RCTs with active controls. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2156662-8
ISSN	1939-148X ; 1541-1559
ISSN (online)	1939-148X
ISSN	1541-1559
DOI	10.1037/ser0000858
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Article ; Online: Stepwise Optimization of Real-Time RT-PCR Analysis.

Maren, Nathan A / Duduit, James R / Huang, Debao / Zhao, Fanghou / Ranney, Thomas G / Liu, Wusheng

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2653, Page(s) 317–332

Abstract: ... with an R ...

Abstract	Quantitative real-time reverse transcription PCR (qRT-PCR) analysis has been used routinely to quantify gene expression levels. Primer design and the optimization of qRT-PCR parameters are critical for the accuracy and reproducibility of qRT-PCR analysis. Computational tool-assisted primer design often overlooks the presence of homologous sequences of the gene of interest and the sequence similarities between homologous genes in a plant genome. This sometimes results in skipping the optimization of qRT-PCR parameters due to the false confidence in the quality of the designed primers. Here we present a stepwise optimization protocol for single nucleotide polymorphisms (SNPs)-based sequence-specific primer design and sequential optimization of primer sequences, annealing temperatures, primer concentrations, and cDNA concentration range for each reference and target gene. The goal of this optimization protocol is to achieve a standard cDNA concentration curve with an R
MeSH term(s)	Reverse Transcriptase Polymerase Chain Reaction ; DNA, Complementary/genetics ; DNA Primers/genetics ; Reproducibility of Results ; Real-Time Polymerase Chain Reaction
Chemical Substances	DNA, Complementary ; DNA Primers
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3131-7_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Social Media Use on Connectivity and Emotions During Pandemic-Induced School Closures: Qualitative Interview Study Among Adolescents.

Liang, Elisa / Kutok, Emily R / Rosen, Rochelle K / Burke, Taylor A / Ranney, Megan L

JMIR mental health

2023 Volume 10, Page(s) e37711

Abstract: Background: The COVID-19 pandemic provided a unique opportunity to examine social media and technology use during a time in which technology served as adolescents' primary form of socialization. The literature is mixed regarding how increased screen ... ...

Abstract	Background: The COVID-19 pandemic provided a unique opportunity to examine social media and technology use during a time in which technology served as adolescents' primary form of socialization. The literature is mixed regarding how increased screen time during this period affected adolescent mental health and well-being. The mechanisms by which screen time use affected adolescent psychosocial outcomes are also unknown. Objective: We aimed to deepen our understanding of how social media and technology use, social connectivity, and emotional well-being intersected during pandemic-related school closures. Methods: English-speaking adolescents aged 13 to 17 years were recruited on Instagram for a brief screening survey; 39 participants were purposefully selected to complete a semistructured interview regarding their social media and technology use during the pandemic. Interview summaries were abstracted from recordings, and deductive codes were created for the primary question stems. These codes were subsequently reviewed for the main themes. Results: The main themes were as follows: adolescent social media and technology use during school closures usually allowed for more and easier social connectivity, but the amount and relative ease of connectivity differed according to purpose and type of use. Emotions, particularly those of stress and happiness, were connected to whether adolescents actively or passively engaged with social media and technology. Conclusions: Our results suggest a nuanced relationship among social media and technology use, adolescent social support, and emotional well-being, including during the pandemic. Specifically, how adolescents use or engage with web-based platforms greatly influences their ability to connect with others and their feelings of stress and happiness. In the context of the COVID-19 pandemic and as technology in general remains at the core of the adolescent experience, future research should continue to examine how adolescents navigate and use web-based spaces in beneficial and harmful ways. This will inform education and interventions that foster healthy social media and technological habits.
Language	English
Publishing date	2023-02-23
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2798262-2
ISSN	2368-7959
ISSN	2368-7959
DOI	10.2196/37711
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The exceptional form and function of the giant bacterium

Sannino, David R / Arroyo, Francine A / Pepe-Ranney, Charles / Chen, Wenbo / Volland, Jean-Marie / Elisabeth, Nathalie H / Angert, Esther R

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 52, Page(s) e2306160120

Abstract: ... ...

Abstract	Epulopiscium
MeSH term(s)	Animals ; Sodium/metabolism ; Bacteria/metabolism ; Clostridiales/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism ; Adenosine Triphosphate/metabolism
Chemical Substances	Sodium (9NEZ333N27) ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2306160120
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Zs.A 1148: Show issues

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Article ; Online: How Americans encounter guns: Mixed methods content analysis of YouTube and internet search data.

Ranney, Megan L / Conrey, Frederica R / Perkinson, Leah / Friedhoff, Stefanie / Smith, Rory / Wardle, Claire

Preventive medicine

2022 Volume 165, Issue Pt A, Page(s) 107258

Abstract: Firearm-related injury and death is a serious public health issue in the U.S. As more Americans consume news and media online, there is growing interest in using these channels to prevent firearm-related harms. Understanding the firearm-related ... ...

Abstract	Firearm-related injury and death is a serious public health issue in the U.S. As more Americans consume news and media online, there is growing interest in using these channels to prevent firearm-related harms. Understanding the firearm-related narratives to which consumers are exposed is foundational to this work. This research used the browsing behavior of a representative sample of American adults to identify seven firearm-related content "ecosystems" (defined as naturally occurring networks of channels watched by the same users) on YouTube; we then described the demographics and internet search patterns of users affiliated with each ecosystem. Over the 9-month study period, 72,205 panelists had 16,803,075 person-video encounters with 7,274,093 videos. Among these, 282,419 were related to firearms. Using fast greedy clustering, we partitioned users and channel interactions into seven distinct channel-based content ecosystems that reached more than 1/1000 YouTube users per day. These ecosystems were diverse in reach, users, and content (e.g., guns for self-protection, guns for fun). On average, 0.5% of panelists performed a firearm-related internet search on a given day. The vast majority of searches were related to mass shootings or police-involved shootings (e.g., "active shooter"), and virtually none were about more common firearm harm such as suicide. Searches for firearm safety information were most common among panelists affiliated with the "Hunting & Fishing" and "Guns & Gear" ecosystems, which were watched primarily by older, white men. These findings identify an opportunity for analyzing firearm-related narratives and tailoring firearm safety messaging for users affiliated with specific online content ecosystems.
MeSH term(s)	Adult ; Male ; United States ; Humans ; Firearms ; Social Media ; Ecosystem ; Police ; Wounds, Gunshot/prevention & control ; Suicide Prevention
Language	English
Publishing date	2022-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2022.107258
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Zs.A 878: Show issues

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Article ; Online: Comparison of Diagnostic and Triage Accuracy of Ada Health and WebMD Symptom Checkers, ChatGPT, and Physicians for Patients in an Emergency Department: Clinical Data Analysis Study.

Fraser, Hamish / Crossland, Daven / Bacher, Ian / Ranney, Megan / Madsen, Tracy / Hilliard, Ross

JMIR mHealth and uHealth

2023 Volume 11, Page(s) e49995

Abstract: Background: Diagnosis is a core component of effective health care, but misdiagnosis is common and can put patients at risk. Diagnostic decision support systems can play a role in improving diagnosis by physicians and other health care workers. Symptom ... ...

Abstract	Background: Diagnosis is a core component of effective health care, but misdiagnosis is common and can put patients at risk. Diagnostic decision support systems can play a role in improving diagnosis by physicians and other health care workers. Symptom checkers (SCs) have been designed to improve diagnosis and triage (ie, which level of care to seek) by patients. Objective: The aim of this study was to evaluate the performance of the new large language model ChatGPT (versions 3.5 and 4.0), the widely used WebMD SC, and an SC developed by Ada Health in the diagnosis and triage of patients with urgent or emergent clinical problems compared with the final emergency department (ED) diagnoses and physician reviews. Methods: We used previously collected, deidentified, self-report data from 40 patients presenting to an ED for care who used the Ada SC to record their symptoms prior to seeing the ED physician. Deidentified data were entered into ChatGPT versions 3.5 and 4.0 and WebMD by a research assistant blinded to diagnoses and triage. Diagnoses from all 4 systems were compared with the previously abstracted final diagnoses in the ED as well as with diagnoses and triage recommendations from three independent board-certified ED physicians who had blindly reviewed the self-report clinical data from Ada. Diagnostic accuracy was calculated as the proportion of the diagnoses from ChatGPT, Ada SC, WebMD SC, and the independent physicians that matched at least one ED diagnosis (stratified as top 1 or top 3). Triage accuracy was calculated as the number of recommendations from ChatGPT, WebMD, or Ada that agreed with at least 2 of the independent physicians or were rated "unsafe" or "too cautious." Results: Overall, 30 and 37 cases had sufficient data for diagnostic and triage analysis, respectively. The rate of top-1 diagnosis matches for Ada, ChatGPT 3.5, ChatGPT 4.0, and WebMD was 9 (30%), 12 (40%), 10 (33%), and 12 (40%), respectively, with a mean rate of 47% for the physicians. The rate of top-3 diagnostic matches for Ada, ChatGPT 3.5, ChatGPT 4.0, and WebMD was 19 (63%), 19 (63%), 15 (50%), and 17 (57%), respectively, with a mean rate of 69% for physicians. The distribution of triage results for Ada was 62% (n=23) agree, 14% unsafe (n=5), and 24% (n=9) too cautious; that for ChatGPT 3.5 was 59% (n=22) agree, 41% (n=15) unsafe, and 0% (n=0) too cautious; that for ChatGPT 4.0 was 76% (n=28) agree, 22% (n=8) unsafe, and 3% (n=1) too cautious; and that for WebMD was 70% (n=26) agree, 19% (n=7) unsafe, and 11% (n=4) too cautious. The unsafe triage rate for ChatGPT 3.5 (41%) was significantly higher (P=.009) than that of Ada (14%). Conclusions: ChatGPT 3.5 had high diagnostic accuracy but a high unsafe triage rate. ChatGPT 4.0 had the poorest diagnostic accuracy, but a lower unsafe triage rate and the highest triage agreement with the physicians. The Ada and WebMD SCs performed better overall than ChatGPT. Unsupervised patient use of ChatGPT for diagnosis and triage is not recommended without improvements to triage accuracy and extensive clinical evaluation.
MeSH term(s)	Humans ; Triage/methods ; Emergency Service, Hospital ; Physicians ; Health Personnel ; Self Report
Language	English
Publishing date	2023-10-03
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2719220-9
ISSN	2291-5222 ; 2291-5222
ISSN (online)	2291-5222
ISSN	2291-5222
DOI	10.2196/49995
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Article ; Online: A 4-Year Longitudinal Firearm Screening and Safety Program for Medical Students.

Blackwood, Kristy L / Knopov, Anita / Merritt, Rory / Ranney, Megan L

Academic medicine : journal of the Association of American Medical Colleges

2022 Volume 96, Issue 12, Page(s) 1626

MeSH term(s)	Curriculum ; Education, Medical/methods ; Firearms ; Humans ; Mass Screening ; Safety Management ; United States ; Wounds, Gunshot
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Letter
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000004392
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Zs.A 112: Show issues

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Article ; Online: The contributions of Dr. Gies: Promoting standards of dental education, research. 1924.

Ranney, Richard R

Journal of the American Dental Association (1939)

2013 Volume 144 Spec No, Page(s) 20S–23S

MeSH term(s)	Dental Research/history ; Education, Dental/history ; History, 20th Century ; Humans ; Schools, Dental/history ; United States
Language	English
Publishing date	2013-09-06
Publishing country	England
Document type	Biography ; Classical Article ; Historical Article ; Journal Article
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.14219/jada.archive.2013.0243
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Ul III Zs.72: Show issues

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Book ; Conference proceedings: Nitric oxide in brain development, plasticity, and disease

Mize, R. Ranney

with a digital atlas accessible on the World Wide Web ; [outgrowth of a satellite symposium that was held in conjunction with the twenty-seventh annual meeting of the Society for Neurosciences, held in New Orleans, LA on October 24 - 25, 1997]

(Progress in brain research ; 118)

1998

Author's details	ed. by R. Ranney Mize
Series title	Progress in brain research ; 118
Collection
Keywords	Brain / growth & development ; Neuronal Plasticity / physiology ; Nitric Oxide / physiology ; Receptors, N-Methyl-D-Aspartate / physiology ; Hirnstoffwechsel ; Stickstoffmonoxid
Subject	Cerebraler Stoffwechsel ; Gehirn ; Gehirnstoffwechsel
Language	English
Size	XIII, 302 S. : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book ; Conference proceedings
HBZ-ID	HT009510822
ISBN	0-444-82885-0 ; 978-0-444-82885-9
Database	Catalogue ZB MED Medicine, Health

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