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  1. Book ; Online ; E-Book: Diagnostic and therapeutic nuclear medicine for neuroendocrine tumors

    Pacak, Karel / Taïeb, David

    (Contemporary endocrinology)

    2017  

    Author's details Karel Pacak, David Taïeb editors
    Series title Contemporary endocrinology
    Language English
    Size 1 Online-Ressource (xiv, 484 Seiten), Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019361636
    ISBN 978-3-319-46038-3 ; 9783319460369 ; 3-319-46038-2 ; 3319460366
    DOI 10.1007/978-3-319-46038-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Pheochromocytoma (PHEO) and Paraganglioma (PGL)

    Pacak, Karel / Taïeb, David

    2019  

    Abstract: This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and ... ...

    Abstract This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment
    Keywords Medicine (General)
    Size 1 electronic resource (380 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020324106
    ISBN 9783039216543 ; 9783039216550 ; 3039216546 ; 3039216554
    DOI 10.3390/books978-3-03921-655-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: New Biology of Pheochromocytoma and Paraganglioma.

    Pacak, Karel

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2022  Volume 28, Issue 12, Page(s) 1253–1269

    Abstract: Pheochromocytomas and paragangliomas continue to be defined by significant morbidity and mortality despite their several recent advances in diagnosis, localization, and management. These adverse outcomes are largely related to mass effect as well as ... ...

    Abstract Pheochromocytomas and paragangliomas continue to be defined by significant morbidity and mortality despite their several recent advances in diagnosis, localization, and management. These adverse outcomes are largely related to mass effect as well as catecholamine-induced hypertension, tachyarrhythmias and consequent target organ damage, acute coronary syndromes, and strokes (ischemic and hemorrhagic stroke). Thus, a proper understanding of the physiology and pathophysiology of these tumors and recent advances are essential to affording optimal care. These major developments largely include a redefinition of metastatic behavior, a novel clinical categorization of these tumors into 3 genetic clusters, and an enhanced understanding of catecholamine metabolism and consequent specific biochemical phenotypes. Current advances in imaging of these tumors are shifting the paradigm from poorly specific anatomical modalities to more precise characterization of these tumors using the advent and development of functional imaging modalities. Furthermore, recent advances have revealed new molecular events in these tumors that are linked to their genetic landscape and, therefore, provide new therapeutic platforms. A few of these prospective therapies translated into new clinical trials, especially for patients with metastatic or inoperable tumors. Finally, outcomes are ever-improving as patients are cared for at centers with cumulative experience and well-established multidisciplinary tumor boards. In parallel, these centers have supported national and international collaborative efforts and worldwide clinical trials. These concerted efforts have led to improved guidelines collaboratively developed by healthcare professionals with a growing expertise in these tumors and consequently improving detection, prevention, and identification of genetic susceptibility genes in these patients.
    MeSH term(s) Humans ; Neoplasms
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2022.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5034: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 508: Show issues

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  4. Book ; Conference proceedings: Pheochromocytoma

    Pacak, Karel

    first international symposium ; [First International Symposium on Pheochromocytoma (ISP2005), October 20 - 23, 2005 in Bethesda, Maryland]

    (Annals of the New York Academy of Sciences ; 1073)

    2006  

    Event/congress International Symposium on Pheochromocytoma (1, 2005, BethesdaMd.)
    Author's details ed. by Karel Pacak
    Series title Annals of the New York Academy of Sciences ; 1073
    Collection
    Keywords Pheochromocytoma / diagnosis ; Pheochromocytoma / genetics ; Diagnosis, Differential ; Pheochromocytoma / therapy
    Language English
    Size XVI, 588 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014871946
    ISBN 1-57331-597-4 ; 978-1-57331-597-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1073- verfügbar in Königswinter Königswinter

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  5. Article ; Online: International symposium on pheochromocytoma: an event of dedicated healthcare professionals and researchers striving for better patient outcomes.

    Pacak, Karel / Clifton-Bligh, Roderick

    Endocrine-related cancer

    2023  Volume 30, Issue 5

    Abstract: Pheochromocytomas and paragangliomas (PPGLs) are defined as neuroendocrine tumors that produce catecholamines. Many recent advances in their management, localization, treatment, as well as surveillance have significantly improved outcomes for patients ... ...

    Abstract Pheochromocytomas and paragangliomas (PPGLs) are defined as neuroendocrine tumors that produce catecholamines. Many recent advances in their management, localization, treatment, as well as surveillance have significantly improved outcomes for patients with PPGLs or carriers of pathogenic genetic variants linked to the development of these tumors. At present, those advances mainly include the molecular stratification of PPGLs into seven clusters, the 2017 WHO revised definition of these tumors, the presence of specific clinical features pointing toward PPGL, the use of plasma metanephrines and 3-methoxytyramine with specific reference limits to assess the likelihood of having a PPGL (e.g. patients at high and low risk) including age-specific reference limits, nuclear medicine guidelines outlining cluster- and metastatic disease-specific functional (here mainly positron emission tomography and metaiodobenzylguanidine scintigraphy) imaging in the precise diagnostic localization of PPGLs, the guidelines for using radio- vs chemotherapy for patients with metastatic disease, and the international consensus on initial screening and follow-up of asymptomatic germline SDHx pathogenic variant carriers. Furthermore, new collaborative efforts particularly based on multi-institutional and worldwide initiatives are now considered key forces in improving our understanding and knowledge about these tumors and future successful treatments or even preventative interventions.
    MeSH term(s) Humans ; Pheochromocytoma/diagnosis ; Pheochromocytoma/genetics ; Pheochromocytoma/therapy ; Paraganglioma/genetics ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/genetics ; Adrenal Gland Neoplasms/therapy ; Positron-Emission Tomography ; Metanephrine ; Delivery of Health Care
    Chemical Substances Metanephrine (5001-33-2)
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-23-0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4192: Show issues Location:
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  6. Article: Editorial: Pediatric adrenal neoplasms.

    Pamporaki, Christina / Redlich, Antje / Taïeb, David / Pacak, Karel

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1227835

    MeSH term(s) Humans ; Child ; Adrenal Gland Neoplasms/therapy ; Pheochromocytoma
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1227835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Stress

    Pacak, Karel

    current neuroendocrine and genetic approaches ; [result of the Eighth Symposium on Catecholamines and Other Neurotransmitters in Stress held on June 28 - July 3, 2003 in Smolenice Castle, Slovakia]

    (Annals of the New York Academy of Science ; 1018)

    2004  

    Event/congress Symposium on Catecholamines and Other Neurotransmitters in Stress (8, 2003, Smolenice)
    Author's details ed. by Karel Pacak
    Series title Annals of the New York Academy of Science ; 1018
    Annals of the New York Academy of Sciences
    Collection Annals of the New York Academy of Sciences
    Keywords Stress ; Endokrinologie ; Genetik
    Subject Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre ; Nervöse Belastung ; Physischer Stress ; Psychischer Stress ; Stresssituation
    Language English
    Size XIV, 590 S. : Ill., graph. Darst.
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014153991
    ISBN 1-57331-494-3 ; 1-57331-495-1 ; 978-1-57331-494-7 ; 978-1-57331-495-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1018- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Immune Landscape of Pheochromocytoma and Paraganglioma: A Potentially Novel Avenue for Prognostic Reclassification?

    Pacak, Karel / Nazari, Matthew A / Taieb, David

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1456–e1457

    MeSH term(s) Humans ; Pheochromocytoma/diagnosis ; Prognosis ; Neutrophils ; Paraganglioma/diagnosis ; Adrenal Gland Neoplasms/diagnosis
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  9. Book ; Conference proceedings: Endocrine hypertension

    Pacak, Karel

    [result of the First International Workshop on Endocrine Hypertension ... held on November 16, 2001 in Bethesda, Maryland]

    (Annals of the New York Academy of Sciences ; 970)

    2002  

    Institution National Institute of Child Health and Human Development / Pediatric and Reproductive Endocrinology Branch
    Event/congress International Workshop on Endocrine Hypertension (1, 2001, BethesdaMd.)
    Author's details [presented by the Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development ...]. Ed. by Karel Pacak
    Series title Annals of the New York Academy of Sciences ; 970
    Collection
    Keywords Adrenal Gland Neoplasms ; Pheochromocytoma ; Cushing Syndrome ; Hypertension / etiology ; Endokrine Hypertonie
    Subject Hormonbedingte Hypertonie
    Language English
    Size VIII, 193 S. : Ill., graph. Darst.
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013603315
    ISBN 1-57331-418-8 ; 1-57331-419-6 ; 978-1-57331-418-3 ; 978-1-57331-419-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -970- verfügbar in Königswinter Königswinter

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  10. Article ; Online: Approach to the patient: Concept and application of targeted radiotherapy in the paraganglioma patient.

    Pacak, Karel / Taieb, David / Lin, Frank I / Jha, Abhishek

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Paragangliomas can metastasize, posing potential challenges in both symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This ... ...

    Abstract Paragangliomas can metastasize, posing potential challenges in both symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This clinical scenario and discussion aim to enhance physicians' knowledge of the stepwise approach to treat these patients with paraganglioma targeted radiotherapies. It comprehensively discusses current approaches to selecting paraganglioma patients for targeted radiotherapies and how to choose between the two radiotherapies based on specific patient and tumor characteristics, when either therapy is feasible, or one is superior to another one. The safety, efficacy, toxicity profiles, and optimization of these radiotherapies are also discussed, along with other therapeutic options including radiotherapies, available for patients besides these two therapies. As conclusion, perspectives in radiotherapies of paraganglioma patients are outlined since they hold near future promising approaches that can improve patient outcomes.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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