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Article ; Online: m

Pereira, Marisa / Ribeiro, Diana R / Pinheiro, Miguel M / Ferreira, Margarida / Kellner, Stefanie / Soares, Ana R

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: ... deregulation on tsRNAs generation is only now beginning to be uncovered. The 5-methyluridine (m ...

Abstract	Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. Recent evidence indicates that tsRNAs are also modified, however, the impact of tRNA epitranscriptome deregulation on tsRNAs generation is only now beginning to be uncovered. The 5-methyluridine (m
MeSH term(s)	Humans ; Oxidative Stress/genetics ; RNA Cleavage/genetics ; RNA Processing, Post-Transcriptional/genetics ; RNA Stability/genetics ; RNA, Small Untranslated/genetics ; RNA, Transfer/chemistry ; RNA, Transfer/genetics ; Ribonuclease, Pancreatic/genetics ; Stress, Physiological/genetics ; Uridine/analogs & derivatives ; Uridine/genetics ; tRNA Methyltransferases/genetics
Chemical Substances	RNA, Small Untranslated ; ribothymidine (1463-10-1) ; RNA, Transfer (9014-25-9) ; tRNA Methyltransferases (EC 2.1.1.-) ; angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2021-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22062941
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanobiology of the nucleus during the G2-M transition.

Lima, Joana T / Ferreira, Jorge G

Nucleus (Austin, Tex.)

2024 Volume 15, Issue 1, Page(s) 2330947

Abstract: ... cell cycle regulation. In particular, the transition from G2 to mitosis (G2-M) shows significant changes ... with the nucleus to determine the timing and efficiency of the G2-M transition. Finally, we discuss how ...

Abstract	Cellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events. Therefore, the nucleus has emerged as a regulator of cellular response to mechanical stimuli. Cell cycle progression is regulated by cyclin-CDK complexes. Recent studies demonstrated these biochemical pathways are influenced by mechanical signals, highlighting the interdependence of cellular mechanics and cell cycle regulation. In particular, the transition from G2 to mitosis (G2-M) shows significant changes in nuclear structure and organization, ranging from nuclear pore complex (NPC) and nuclear lamina disassembly to chromosome condensation. The remodeling of these mechanically active nuclear components indicates that mitotic entry is particularly sensitive to forces. Here, we address how mechanical forces crosstalk with the nucleus to determine the timing and efficiency of the G2-M transition. Finally, we discuss how the deregulation of nuclear mechanics has consequences for mitosis.
MeSH term(s)	Mechanotransduction, Cellular ; Cell Nucleus/metabolism ; Mitosis ; Cytoskeleton/metabolism ; Biophysics
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2619626-8
ISSN	1949-1042 ; 1949-1042
ISSN (online)	1949-1042
ISSN	1949-1042
DOI	10.1080/19491034.2024.2330947
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Article ; Online: Setting of import tolerances for metalaxyl-M in oil palms fruits and peppercorn.

EFSA journal. European Food Safety Authority

2023 Volume 21, Issue 5, Page(s) e08008

Abstract: ... for the active substance metalaxyl-M in oil palms fruits and peppercorn (black, green and white). The data submitted ... peppercorn. Adequate analytical methods for enforcement are available to control the residues of metalaxyl-M ... from the use of metalaxyl-M according to the authorised agricultural practices is unlikely to present a risk ...

Abstract	In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Belgium to set an import tolerance for the active substance metalaxyl-M in oil palms fruits and peppercorn (black, green and white). The data submitted in support of the request were found to be sufficient to derive MRL proposals for oil palms fruits and peppercorn. Adequate analytical methods for enforcement are available to control the residues of metalaxyl-M in the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short-term and long-term intake of residues resulting from the use of metalaxyl-M according to the authorised agricultural practices is unlikely to present a risk to consumer health.
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2023.8008
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Article ; Online: Gold-Based Coronands as Hosts for M

Sucena, Suelen Ferreira / Demirer, Türkan Ilgin / Baitullina, Anna / Hagenbach, Adelheid / Grewe, Jacqueline / Spreckelmeyer, Sarah / März, Juliane / Barkleit, Astrid / Maia, Pedro Ivo da Silva / Nguyen, Hung Huy / Abram, Ulrich

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 14

Abstract: The controlled, self-assembled synthesis of multinuclear coordination compounds can be performed via different approaches. Frequently, steric, geometric and/or electronic factors located at the ligand systems predefine the way in which metal ions can ... ...

Abstract	The controlled, self-assembled synthesis of multinuclear coordination compounds can be performed via different approaches. Frequently, steric, geometric and/or electronic factors located at the ligand systems predefine the way in which metal ions can assemble them to large aggregates. For the compounds in the present paper, also the Pearson's acidities and preferred coordination geometries of the metal ions were used as organization principles. The ligand under study, 2,6-dipicolinoylbis(
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28145421
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Zs.MO 81: Show issues

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Article ; Online: The SARS-CoV-2 main protease M

Wenzel, Jan / Lampe, Josephine / Müller-Fielitz, Helge / Schuster, Raphael / Zille, Marietta / Müller, Kristin / Krohn, Markus / Körbelin, Jakob / Zhang, Linlin / Özorhan, Ümit / Neve, Vanessa / Wagner, Julian U G / Bojkova, Denisa / Shumliakivska, Mariana / Jiang, Yun / Fähnrich, Anke / Ott, Fabian / Sencio, Valentin / Robil, Cyril /

Pfefferle, Susanne / Sauve, Florent / Coêlho, Caio Fernando Ferreira / Franz, Jonas / Spiecker, Frauke / Lembrich, Beate / Binder, Sonja / Feller, Nina / König, Peter / Busch, Hauke / Collin, Ludovic / Villaseñor, Roberto / Jöhren, Olaf / Altmeppen, Hermann C / Pasparakis, Manolis / Dimmeler, Stefanie / Cinatl, Jindrich / Püschel, Klaus / Zelic, Matija / Ofengeim, Dimitry / Stadelmann, Christine / Trottein, François / Nogueiras, Ruben / Hilgenfeld, Rolf / Glatzel, Markus / Prevot, Vincent / Schwaninger, Markus

Nature neuroscience

2021 Volume 24, Issue 11, Page(s) 1522–1533

Abstract: ... We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M ...

Abstract	Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries. We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M
MeSH term(s)	Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/metabolism ; Brain/pathology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/genetics ; Coronavirus 3C Proteases/metabolism ; Cricetinae ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mesocricetus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microvessels/metabolism ; Microvessels/pathology ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Vero Cells
Chemical Substances	Intracellular Signaling Peptides and Proteins ; NEMO protein, mouse ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-021-00926-1
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Zs.A 4891: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 67: Show issues

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Article ; Online: Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (M

Mahgoub, Radwa E / Mohamed, Feda E / Ali, Bassam R / Ferreira, Juliana / Rabeh, Wael M / Atatreh, Noor / Ghattas, Mohammad A

Journal of molecular graphics & modelling

2023 Volume 127, Page(s) 108672

Abstract: The main protease (M ...

Abstract	The main protease (M
MeSH term(s)	Humans ; Pharmacophore ; COVID-19 ; SARS-CoV-2 ; Coronavirus 3C Proteases ; Antiviral Agents/pharmacology ; Molecular Docking Simulation ; Protease Inhibitors/pharmacology
Chemical Substances	3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Antiviral Agents ; Protease Inhibitors
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1396450-1
ISSN	1873-4243 ; 1093-3263
ISSN (online)	1873-4243
ISSN	1093-3263
DOI	10.1016/j.jmgm.2023.108672
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Zs.A 3491: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The Discovery of Novel Small Oxindole-Based Inhibitors Targeting the SARS-CoV-2 Main Protease (M

Alzyoud, Lara / Mahgoub, Radwa E / Mohamed, Feda E / Ali, Bassam R / Ferreira, Juliana / Rabeh, Wael M / Atatreh, Noor / Ghattas, Mohammad A

Chemistry & biodiversity

2023 Volume 20, Issue 11, Page(s) e202301176

Abstract: ... development of antiviral inhibitors against SARS-CoV-2 is essential. The M ...

Abstract	With the potential for coronaviruses to re-emerge and trigger future pandemics, the urgent development of antiviral inhibitors against SARS-CoV-2 is essential. The M
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Antiviral Agents/chemistry ; Oxindoles/pharmacology ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation
Chemical Substances	Antiviral Agents ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Oxindoles ; Protease Inhibitors
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301176
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Article: Bridging the ICD11 and the DSM-5 personality disorders classification systems: The role of the PID5BF + M.

Pires, Rute / Henriques-Calado, Joana / Sousa Ferreira, Ana / Gama Marques, João / Ribeiro Moreira, Ana / Barata, Bernardo C / Paulino, Marco / Gonçalves, Bruno

Frontiers in psychiatry

2023 Volume 14, Page(s) 1004895

Abstract: ... beneficial for the clinical profession. With this goal in mind, the PID5BF + M, an algorithm that assesses ... M has potential to assess the severity of personality disfunction and to characterize the stylistic ... regarding the convergent validity of the PID5BF + M, this new test contributes to the harmonization ...

Abstract	Introduction: In both the ICD-11 Classification of Personality Disorders and the DSM-5 Alternative Model of Personality Disorders (AMPD) personality disorders (PD) are characterized by impairments in self- and interpersonal functioning which distinguish the various levels of dysfunction. Moreover, pathological traits are used by these classification systems to define the stylistic expression of personality dysfunction. Negative affectivity, detachment, antagonism/dissociality, and disinhibition feature as trait domains in each of these models. However, there are also differences between the two models, namely, in the psychoticism domain, which does not feature as a personality trait domain in the ICD-11, and in the anankastia domain, corresponding to compulsivity in the DSM-5, which was removed from the final AMPD model. Furthermore, facets are acknowledged by the DSM-5 within each trait domain, while this does not occur in the ICD-11. In view of the similarity between these classification systems, their harmonization would be beneficial for the clinical profession. With this goal in mind, the PID5BF + M, an algorithm that assesses the DSM-5 and ICD-11 six trait domains and 18 facets, was developed and has proven to adequately characterize the ICD-11 trait domains by means of DSM-5 trait facets. Methods: The current study compares a community sample ( Results: As expected, there were strong, significant, and positive relations between the measures. Furthermore, higher scores were observed in all the variables for the PD group against the community group. Discussion: Although this study has limitations, its findings sustain that the PID5BF + M has potential to assess the severity of personality disfunction and to characterize the stylistic features of PD as they are conceived by both the ICD-11 and the DSM-5. Although more research is needed regarding the convergent validity of the PID5BF + M, this new test contributes to the harmonization of both systems and to parsimony in the assessment of PD, which is the main objective of clinical practice.
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1004895
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Article ; Online: SARS-COV-2 M

Ferreira, Glaucio Monteiro / Kronenberger, Thales / Tonduru, Arun Kumar / Hirata, Rosario Dominguez Crespo / Hirata, Mario Hiroyuki / Poso, Antti

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 22, Page(s) 12347–12357

Abstract: SARS-CoV-2's main protease (M ...

Abstract	SARS-CoV-2's main protease (M
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Ligands ; Dimerization ; Molecular Docking Simulation ; Protease Inhibitors ; Molecular Dynamics Simulation
Chemical Substances	Ligands ; Protease Inhibitors
Language	English
Publishing date	2021-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1970626
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Zs.A 2093: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities.

Ćirić, Ana / Kruljević, Ivana / Stojković, Dejan / Fernandes, Ângela / Barros, Lillian / Calhelha, Ricardo C / Ferreira, Isabel C F R / Soković, Marina / Glamočlija, Jasmina

Food & function

2020 Volume 10, Issue 12, Page(s) 7678–7686

Abstract: ... growing and edible Macrolepiota species (M. mastoidea, M. rhacodes and Macrolepiota procera) from Serbia ...

Abstract	This study was oriented towards the investigation of the biological properties of three wild growing and edible Macrolepiota species (M. mastoidea, M. rhacodes and Macrolepiota procera) from Serbia. The results revealed that the mushrooms have a low caloric value; free sugars such as mannitol and trehalose were identified; oxalic and malic acids were predominant organic acids, while p-hydroxybenzoic and p-coumaric acids were identified as the main phenolic compounds. Also, they were a rich source of polyunsaturated fatty acids, which dominated over monounsaturated and saturated fatty acids. Three isoforms of tocopherols were identified and quantified: α-, β-, and δ-tocopherol. Regarding biological properties, all three species exhibited antioxidant potential, antimicrobial potential and cytotoxic activity within the different tumour cell lines tested. This study indicates that these species are indeed functional foods, due to the fact that they are edible, consumable and hold different pharmacological activities.
MeSH term(s)	Agaricales/chemistry ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Bacteria/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Fatty Acids, Unsaturated/analysis ; Functional Food/analysis ; Humans ; Nutritive Value ; Phenols/chemistry ; Phenols/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Tocopherols/chemistry ; Tocopherols/pharmacology
Chemical Substances	Anti-Infective Agents ; Antioxidants ; Fatty Acids, Unsaturated ; Phenols ; Plant Extracts ; Tocopherols (R0ZB2556P8)
Language	English
Publishing date	2020-11-20
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c9fo01900f
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Z 7872: Show issues

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