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  1. Article ; Online: Diagnostic accuracy of the 'Dysphagia Screening Tool for Geriatric Patients' (DSTG) compared to Flexible Endoscopic Evaluation of Swallowing (FEES) for assessing dysphagia in hospitalized geriatric patients - a diagnostic study.

    Thiem, Ulrich / Jäger, Martin / Stege, Holger / Wirth, Rainer

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 856

    Abstract: Background: Oropharyngeal dysphagia is highly prevalent among hospitalized geriatric patients. The screening instruments used to date have been evaluated primarily in stroke patients. This diagnostic study aimed to validate a new screening instrument ... ...

    Abstract Background: Oropharyngeal dysphagia is highly prevalent among hospitalized geriatric patients. The screening instruments used to date have been evaluated primarily in stroke patients. This diagnostic study aimed to validate a new screening instrument for oropharyngeal dysphagia, the 'Dysphagia Screening Tool for Geriatric Patients' (DSTG), as compared to one of the gold standards, flexible endoscopic evaluation of swallowing (FEES).
    Materials and methods: Geriatric inpatients admitted to five geriatric hospitals in Germany were consecutively evaluated using both DSTG and FEES in random order and by different evaluators blinded to the results of the other evaluation. In the FEES examination, a score of more than 3 on Rosenbek's Penetration Aspiration Scale was considered evidence of clinically relevant oropharyngeal dysphagia. Sensitivity, specificity and further measures of test performance were calculated for DSTG.
    Results: The 53 volunteers recruited were on average 85 years of age, 56.6% were women. Twenty patients (37.7%) were diagnosed with dysphagia using FEES. Of these, 12 were screened as positive on DSTG. Of the 33 FEES negative patients, 4 tested positive on DSTG. The following test parameters were calculated for DSTG: sensitivity: 0.60, 95% confidence interval [0.39

    0.78], specificity 0.88 [0.73

    0.95], positive predictive value 0.75 [0.51

    0.90], negative predictive value 0.78 [0.63

    0.89], positive likelihood ratio 4.95 [1.85

    13.27], negative likelihood ratio 0.46 [0.26

    0.79]. In a receiver-operator characteristic (ROC) curve analysis, the area under the curve (AUC) was 0.77 [0.62

    0.91]. No adverse events occurred.
    Conclusion: The DSTG appears to be a valid instrument for screening of oropharyngeal dysphagia in geriatric inpatients.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Deglutition Disorders/diagnosis ; Deglutition ; Mass Screening/methods ; Predictive Value of Tests ; Inpatients
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04516-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A chimeric antigen receptor-based cellular safeguard mechanism for selective

    Svec, Mortimer / Dötsch, Sarah / Warmuth, Linda / Trebo, Manuel / Fräßle, Simon / Riddell, Stanley R / Jäger, Ulrich / D'Ippolito, Elvira / Busch, Dirk H

    Frontiers in immunology

    2024  Volume 14, Page(s) 1268698

    Abstract: Adoptive immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells has exhibited impressive clinical efficacy in treating B-cell malignancies. However, the potency of CAR-T cells carriethe potential for significant on-target/off-tumor ... ...

    Abstract Adoptive immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells has exhibited impressive clinical efficacy in treating B-cell malignancies. However, the potency of CAR-T cells carriethe potential for significant on-target/off-tumor toxicities when target antigens are shared with healthy cells, necessitating the development of complementary safety measures. In this context, there is a need to selectively eliminate therapeutically administered CAR-T cells, especially to revert long-term CAR-T cell-related side effects. To address this, we have developed an effective cellular-based safety mechanism to specifically target and eliminate the transferred CAR-T cells. As proof-of-principle, we have designed a secondary CAR (
    MeSH term(s) Mice ; Animals ; T-Lymphocytes ; Receptors, Chimeric Antigen/genetics ; Receptors, Antigen, T-Cell/genetics ; Immunotherapy, Adoptive ; B-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1268698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Invasive blackberry outcompetes the endemic Galapagos tree daisy Scalesia pedunculata.

    Riegl, Bernhard / Walentowitz, Anna / Sevilla, Christian / Chango, Rafael / Jäger, Heinke

    Ecological applications : a publication of the Ecological Society of America

    2023  Volume 33, Issue 4, Page(s) e2846

    Abstract: ... of R. niveus from 17 plots and compared with 17 additional plots where R. niveus remained. The aim ... of this study was to evaluate the impacts of the R. niveus invasion on S. pedunculata by characterizing ... the effects of R. niveus removal. Parameters measured in S. pedunculata were diameter at breast height (DBH ...

    Abstract Island florae are under threat from habitat loss and competition with introduced species worldwide. In the Galapagos Islands, the endemic tree daisy Scalesia pedunculata (Asteraceae) is the dominant tree in the cloud forest of Santa Cruz Island but suffers from competition with the invasive blackberry Rubus niveus. At the site Los Gemelos, a S. pedunculata population was monitored from 2014 to 2021 following mechanical and chemical removal of R. niveus from 17 plots and compared with 17 additional plots where R. niveus remained. The aim of this study was to evaluate the impacts of the R. niveus invasion on S. pedunculata by characterizing the effects of R. niveus removal. Parameters measured in S. pedunculata were diameter at breast height (DBH, from which annual growth rates were determined), total height, survival of individual plants, and recruitment. In the presence of R. niveus, S. pedunculata trees had smaller DBH stems and shorter asymptotic maximum heights, growth rates declined for thin trees, the mortality of larger trees was elevated, and S. pedunculata recruitment was absent. R. niveus removal resulted in DBH-ratios of S. pedunculata more frequently meeting our threshold for fast growth (1.2), trees growing significantly thicker and taller, annual mortality being lower (12.5% vs. 16.2% per year), and recruitment being successful. In the presence of R. niveus, lower survival, growth, and absent recruitment suggested that S. pedunculata could reach quasi-extinction in ~20 years. Swift and decisive management action is needed to prevent the Scalesia forest on Santa Cruz Island from disappearing in less than two decades.
    MeSH term(s) Animals ; Trees ; Rubus ; Thoracica ; Forests ; Asteraceae
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074505-1
    ISSN 1939-5582 ; 1051-0761
    ISSN (online) 1939-5582
    ISSN 1051-0761
    DOI 10.1002/eap.2846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Insights into the Supramolecular Structure and Degradation Mechanisms of Starch from Different Botanical Sources as Affected by Extrusion-based 3D Printing.

    Shahbazi, Mahdiyar / Jäger, Henry / Ettelaie, Rammile / Ulbrich, Marco

    Biomacromolecules

    2022  Volume 24, Issue 1, Page(s) 69–85

    Abstract: Extrusion-based 3D printing has emerged as the most versatile additive manufacturing technique for the printing of practically any material. However, 3D printing of functional materials often activates thermo-mechanical degradation, which affects the 3D ... ...

    Abstract Extrusion-based 3D printing has emerged as the most versatile additive manufacturing technique for the printing of practically any material. However, 3D printing of functional materials often activates thermo-mechanical degradation, which affects the 3D shape quality. Herein, we describe the structural changes of eight different starch sources (normal or waxy) as a consequence of the temperature of an extrusion-based 3D printing system through in-depth characterization of their molecular and structural changes. The combination of size-exclusion chromatography, small-angle X-ray scattering, X-ray diffraction, dynamic viscoelasticity measurements, and
    MeSH term(s) Starch/chemistry ; Amylose/chemistry ; Amylopectin/analysis ; Amylopectin/chemistry ; Amylopectin/metabolism ; X-Ray Diffraction ; Temperature
    Chemical Substances Starch (9005-25-8) ; Amylose (9005-82-7) ; Amylopectin (9037-22-3)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.2c00881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Promising Therapeutic Soy-Based Pickering Emulsion Gel Stabilized by a Multifunctional Microcrystalline Cellulose: Application in 3D Food Printing.

    Shahbazi, Mahdiyar / Jäger, Henry / Ettelaie, Rammile

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 7, Page(s) 2374–2388

    Abstract: The feasible application of additive manufacturing in the food and pharmaceutical industries strongly depends on the development of highly stable inks with bioactive properties. Surface-modified microcrystalline cellulose (MCC) shows the potential of ... ...

    Abstract The feasible application of additive manufacturing in the food and pharmaceutical industries strongly depends on the development of highly stable inks with bioactive properties. Surface-modified microcrystalline cellulose (MCC) shows the potential of being a useful particulate (
    MeSH term(s) Anti-Infective Agents ; Cellulose ; Emulsions/chemistry ; Meat Products ; Printing, Three-Dimensional
    Chemical Substances Anti-Infective Agents ; Emulsions ; Cellulose (9004-34-6) ; microcrystalline cellulose (OP1R32D61U)
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c05644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dual-Grafting of Microcrystalline Cellulose by Tea Polyphenols and Cationic ε-Polylysine to Tailor a Structured Antimicrobial Soy-Based Emulsion for 3D Printing.

    Shahbazi, Mahdiyar / Jäger, Henry / Ettelaie, Rammile

    ACS applied materials & interfaces

    2022  Volume 14, Issue 18, Page(s) 21392–21405

    Abstract: An imperative processing way to produce 3D printed structures with enhanced multifunctional properties is printing inks in the form of a gel-like colloidal emulsion. The surface-modified microcrystalline cellulose (MCC) is an excipient of outstanding ... ...

    Abstract An imperative processing way to produce 3D printed structures with enhanced multifunctional properties is printing inks in the form of a gel-like colloidal emulsion. The surface-modified microcrystalline cellulose (MCC) is an excipient of outstanding merit as a particulate emulsifier to manufacture a stable Pickering emulsion gel. The tuning of the MCC structure by cationic antimicrobial compounds, such as ε-polylysine (ε-PL), can offer a surface activity with an antimicrobial effect. However, the MCC/ε-PL lacks the appropriate emulsifying ability due to the development of electrostatic complexes. To overcome this challenge, (i) a surface-active MCC conjugate was synthesized by a sustainable dual-grafting technique (ii) to produce a highly stable therapeutic soy-based Pickering emulsion gel (iii) for potential application in 3D printing. In this regard, the tea polyphenols were initially introduced into MCC by the free-radical grafting method to decrease the charge density of anionic MCC. Then, the antioxidative MCC-
    MeSH term(s) Anti-Bacterial Agents ; Anti-Infective Agents/chemistry ; Cations ; Cellulose ; Emulsions/chemistry ; Polylysine/chemistry ; Polyphenols/chemistry ; Printing, Three-Dimensional ; Tea
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Cations ; Emulsions ; Polyphenols ; Tea ; Polylysine (25104-18-1) ; Cellulose (9004-34-6) ; microcrystalline cellulose (OP1R32D61U)
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c19430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HER2-low breast cancer and response to neoadjuvant chemotherapy: a population-based cohort study.

    Baez-Navarro, Ximena / van Bockstal, Mieke R / Jager, Agnes / van Deurzen, Carolien H M

    Pathology

    2024  Volume 56, Issue 3, Page(s) 334–342

    Abstract: About half of breast cancers (BC) without amplification of the human epidermal growth factor receptor 2 (HER2) have a low HER2 protein expression level (HER2-low). The clinical impact of HER2-low and the response to neoadjuvant chemotherapy (NAC) is ... ...

    Abstract About half of breast cancers (BC) without amplification of the human epidermal growth factor receptor 2 (HER2) have a low HER2 protein expression level (HER2-low). The clinical impact of HER2-low and the response to neoadjuvant chemotherapy (NAC) is unclear. This study aimed to assess the association between HER2-low BC and pathological response to NAC. Data from the Dutch Pathology Registry were collected for 11,988 BC patients treated with NAC between 2014 and 2022. HER2-low BC was defined as an immunohistochemical score of 1+ or 2+ and a negative molecular reflex test. We compared clinicopathological features of HER2-0 versus HER2-low BC and assessed the correlation between HER2 status and the pathological complete response (pCR) rate after NAC, including overall survival. Among hormone receptor (HR)-positive tumours, 67% (n=4,619) were HER2-low, compared to 47% (n=1,167) in the HR-negative group. Around 32% (n=207) of patients had a discordant HER2 status between the pre-NAC biopsy and the corresponding post-NAC resection, within which 87% (n=165) changed from HER2-0 to HER2-low or vice versa. The pCR rate was significantly lower in HER2-low BC compared to HER2-0 BC within the HR-positive group (4% versus 5%; p=0.022). However, the absolute difference was limited, so the clinical relevance is questionable. In HR-negative cases, the difference in pCR was not significant (32% versus 34%; p=0.266). No significant difference in overall survival was observed between HER2-low and HER2-0 tumours, regardless of hormone receptor status. The antibody-drug conjugate trastuzumab deruxtecan (T-DXd) has improved survival outcomes of patients with HER2-low metastatic BC. The finding that one-third of the patients in this study had a discordant HER2 status between the pre-NAC biopsy and the post-NAC resection specimen could impact clinical decision-making should T-DXd be used in early BC treatment.
    MeSH term(s) Female ; Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/pathology ; Cohort Studies ; Hormones/metabolism ; Neoadjuvant Therapy ; Receptor, ErbB-2/metabolism
    Chemical Substances Hormones ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.10.022
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  8. Article ; Online: Surgical correction of partial anomalous left superior pulmonary venous connection to the innominate vein.

    Di Pasquale, Luigi / Jäger, Olivia / Cesnjevar, Robert / Dave, Hitendu

    Multimedia manual of cardiothoracic surgery : MMCTS

    2022  Volume 2022

    Abstract: Partial anomalous pulmonary venous connection is reported to occur in 0.4 to 0.7% of children. Only 3% of these cases involve an anomalous left-sided pulmonary venous connection to the innominate vein [1]. In this video tutorial, we present the technique ...

    Abstract Partial anomalous pulmonary venous connection is reported to occur in 0.4 to 0.7% of children. Only 3% of these cases involve an anomalous left-sided pulmonary venous connection to the innominate vein [1]. In this video tutorial, we present the technique of reimplantation of the partial anomalous left superior pulmonary venous connection to the left atrial appendage through a median sternotomy and with a cardioplegic heart. We debate the merits of our strategy with respect to our ultimate goal of achieving long-term patency.
    MeSH term(s) Child ; Humans ; Brachiocephalic Veins/surgery ; Pulmonary Veins/surgery ; Pulmonary Veins/abnormalities ; Scimitar Syndrome/surgery ; Sternotomy/methods
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Video-Audio Media
    ZDB-ID 2280156-X
    ISSN 1813-9175 ; 1813-9175
    ISSN (online) 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2022.065
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  9. Article ; Online: A smart thermoresponsive macroporous 4D structure by 4D printing of Pickering-high internal phase emulsions stabilized by plasma-functionalized starch nanomaterials for a possible delivery system.

    Shahbazi, Mahdiyar / Jäger, Henry / Ettelaie, Rammile / Chen, Jianshe / Mohammadi, Adeleh / Kashi, Peyman Asghartabar / Ulbrich, Marco

    Current research in food science

    2024  Volume 8, Page(s) 100686

    Abstract: Hierarchically porous structures combine microporosity, mesoporosity, and microporosity to enhance pore accessibility and transport, which are crucial to develop high performance materials for biofabrication, food, and pharmaceutical applications. This ... ...

    Abstract Hierarchically porous structures combine microporosity, mesoporosity, and microporosity to enhance pore accessibility and transport, which are crucial to develop high performance materials for biofabrication, food, and pharmaceutical applications. This work aimed to develop a 4D-printed smart hierarchical macroporous structure through 3D printing of Pickering-type high internal phase emulsions (Pickering-HIPEs). The key was the utilization of surface-active (hydroxybutylated) starch nanomaterials, including starch nanocrystals (SNCs) (from waxy maize starch through acid hydrolysis) or starch nanoparticles (SNPs) (obtained through an ultrasound treatment). An innovative procedure to fabricate the functionalized starch nanomaterials was accomplished by grafting 1,2-butene oxide using a cold plasma technique to enhance their surface hydrophobicity, improving their aggregation, and thus attaining a colloidally stabilized Pickering-HIPEs with a low concentration of each surface-active starch nanomaterial. A flocculation of droplets in Pickering-HIPEs was developed after the addition of modified SNCs or SNPs, leading to the formation of a gel-like structure. The 3D printing of these Pickering-HIPEs developed a highly interconnected large pore structure, possessing a self-assembly property with thermoresponsive behavior. As a potential drug delivery system, this thermoresponsive macroporous 3D structure offered a lower critical solution temperature (LCST)-type phase transition at body temperature, which can be used in the field of smart releasing of bioactive compounds.
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2024.100686
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  10. Article ; Online: Development of an Antioxidative Pickering Emulsion Gel through Polyphenol-Inspired Free-Radical Grafting of Microcrystalline Cellulose for 3D Food Printing.

    Shahbazi, Mahdiyar / Jäger, Henry / Ettelaie, Rammile

    Biomacromolecules

    2021  Volume 22, Issue 11, Page(s) 4592–4605

    Abstract: The manufacture of next-generation 3D-printed foods with personalized requirements can be accelerated by in-depth knowledge of the development of a multifunctional biopolymeric-based ink. As a fat replacer in the food industry, microcrystalline cellulose ...

    Abstract The manufacture of next-generation 3D-printed foods with personalized requirements can be accelerated by in-depth knowledge of the development of a multifunctional biopolymeric-based ink. As a fat replacer in the food industry, microcrystalline cellulose (MCC) has the potential to address the growing need for sustainable healthy reduced-fat 3D printed foods. The modification of MCC structure by polyphenols gives the way to produce a multifunctional antioxidative Pickering emulsion with improved emulsifying properties. In this study, different types of polyphenols, including gallic acid (GA), tannic acid (TA), and cyanidin-3-
    MeSH term(s) Antioxidants ; Cellulose ; Emulsions ; Gels ; Polyphenols ; Printing, Three-Dimensional
    Chemical Substances Antioxidants ; Emulsions ; Gels ; Polyphenols ; Cellulose (9004-34-6) ; microcrystalline cellulose (OP1R32D61U)
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.1c00896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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