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  1. Article ; Online: Diagnosis of the Coronavirus disease (COVID-19)

    Long, Chunqin / Xu, Huaxiang / Shen, Qinglin / Zhang, Xianghai / Fan, Bing / Wang, Chuanhong / Zeng, Bingliang / Li, Zicong / Li, Xiaofen / Li, Honglu

    European Journal of Radiology

    rRT-PCR or CT?

    2020  Volume 126, Page(s) 108961

    Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2020.108961
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1630: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?

    Long, Chunqin / Xu, Huaxiang / Shen, Qinglin / Zhang, Xianghai / Fan, Bing / Wang, Chuanhong / Zeng, Bingliang / Li, Zicong / Li, Xiaofen / Li, Honglu

    European journal of radiology

    2020  Volume 126, Page(s) 108961

    Abstract: Purpose: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia.: Methods: This retrospective study included all patients with COVID-19 pneumonia ... ...

    Abstract Purpose: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia.
    Methods: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated.
    Results: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%.
    Conclusion: rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis.
    MeSH term(s) Adult ; Aged ; Betacoronavirus/genetics ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances COVID-19 Vaccines ; Covid-19 aAPC vaccine
    Keywords covid19
    Language English
    Publishing date 2020-03-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2020.108961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1630: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.

    Liu, Zhiheng / Gao, Xu / Zhou, Zhou / Kang, Sung Wook / Yang, Yong / Liu, Hao / Zhang, Chunqin / Wen, Zheng / Rao, Xiaoquan / Wang, Daowen / White, Donnell / Yang, Qinglin / Long, Qinqiang

    Biochimica et biophysica acta. Molecular basis of disease

    2021  Volume 1867, Issue 11, Page(s) 166237

    Abstract: R-loops are naturally occurring transcriptional intermediates containing RNA/DNA hybrids. Excessive R-loops cause genomic instability, DNA damage, and replication stress. Senataxin-associated exonuclease (San1) is a protein that interacts with Senataxin ( ...

    Abstract R-loops are naturally occurring transcriptional intermediates containing RNA/DNA hybrids. Excessive R-loops cause genomic instability, DNA damage, and replication stress. Senataxin-associated exonuclease (San1) is a protein that interacts with Senataxin (SETX), a helicase resolving R-loops. It remains unknown if R-loops-induced DNA damage plays a role in the heart, especially in the proliferative neonatal cardiomyocytes (CMs). San1-/- mice were generated using the CRISPR/Cas9 technique. The newborn San1-/- mice show no overt phenotype, but their hearts were smaller with larger, yet fewer CMs. CM proliferation was impaired with reduced cell cycle-related transcripts and proteins. S9.6 staining revealed that excessive R-loops accumulated in the nucleus of neonatal San1-/- CMs. Increased γH2AX staining on newborn and adult heart sections exhibited increased DNA damage. Similarly, San1-/- AC16-cardiomyocytes showed cumulative R-loops and DNA damage, leading to the activation of cell cycle checkpoint kinase ATR and PARP1 hyperactivity, arresting G2/M cell-cycle and CM proliferation. Together, the present study uncovers an essential role of San1 in resolving excessive R-loops that lead to DNA damage and repressing CM proliferation, providing new insights into a novel biological function of San1 in the neonatal heart. San1 may serve as a novel therapeutic target for the treatment of hypoplastic cardiac disorders.
    MeSH term(s) Animals ; Cardiomyopathies/complications ; Cardiomyopathies/genetics ; Cardiomyopathies/pathology ; Cell Line ; DNA Damage ; Disease Models, Animal ; Exodeoxyribonucleases/deficiency ; Exodeoxyribonucleases/genetics ; Gene Knockout Techniques ; Heart Failure/genetics ; Heart Failure/pathology ; Heart Ventricles/cytology ; Heart Ventricles/pathology ; Humans ; Mice ; Mice, Knockout ; Myocytes, Cardiac/pathology ; Primary Cell Culture ; R-Loop Structures ; Trans-Activators/deficiency ; Trans-Activators/genetics
    Chemical Substances Trans-Activators ; Exodeoxyribonucleases (EC 3.1.-) ; FAM120B protein, human (EC 3.1.-) ; Fam120b protein, mouse (EC 3.1.-)
    Language English
    Publishing date 2021-07-31
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2021.166237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?

    Long, Chunqin / Xu, Huaxiang / Shen, Qinglin / Zhang, Xianghai / Fan, Bing / Wang, Chuanhong / Zeng, Bingliang / Li, Zicong / Li, Xiaofen / Li, Honglu

    Eur J Radiol

    Abstract: PURPOSE: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. METHODS: This retrospective study included all patients with COVID-19 pneumonia ... ...

    Abstract PURPOSE: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. METHODS: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. RESULTS: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%. CONCLUSION: rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #15135
    Database COVID19

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  5. Article: [Investigation on human

    Guo-Hua, Peng / Zhu-Hua, Hu / Jun, Ge / Chun-Qin, Hang / Ren-Long, Fu / Xiao-Wu, Feng

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

    2016  Volume 28, Issue 5, Page(s) 545–549

    Abstract: Objective: To investigate the endemic situation of human : Methods: The high-risk population of : Results: The total positive rate of human : Conclusions: The high risk population ... ...

    Abstract Objective: To investigate the endemic situation of human
    Methods: The high-risk population of
    Results: The total positive rate of human
    Conclusions: The high risk population of
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; China/epidemiology ; Cities/epidemiology ; Diet ; Humans ; Infant ; Infant, Newborn ; Male ; Meat/parasitology ; Middle Aged ; Multivariate Analysis ; Occupations/statistics & numerical data ; Risk ; Toxoplasmosis/epidemiology ; Young Adult
    Language Chinese
    Publishing date 2016-05-26
    Publishing country China
    Document type Journal Article
    ISSN 1005-6661
    ISSN 1005-6661
    DOI 10.16250/j.32.1374.2016032
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  6. Article ; Online: Multiple sclerosis with brain demyelinating pseudotumor as first manifestation

    Shou-hua LI / Ju-feng DENG / Xiang-hai ZHANG / Chun-qin LONG

    Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 14, Iss 1, Pp 60-

    a case report and review of literatures

    2014  Volume 63

    Keywords Demyelinating diseases ; Central nervous system diseases ; Multiple sclerosis ; Case reports ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Chinese
    Publishing date 2014-01-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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