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Article ; Online: Genetic characterization of the glycoprotein G of Chandipura viruses in India with emphasis on an outbreak of 2015.

Damle, R G / Sankararaman, V / Bhide, V S / Mahamuni, S A / Walimbe, A M / Cherian, S S

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2017 Volume 55, Page(s) 112–116

Abstract: ... Phylogenetic study of the G gene sequences of strains from Gujarat 2015 along with available sequences ... strains of 2003. Analyses of selection pressure in the G gene revealed positively selected sites ... within the signal peptide region and a putative CHPV epitope. These results indicate a probable role of G protein-based ...

Abstract	Chandipura virus (CHPV) is found to be associated with sporadic encephalitis outbreaks in humans in India since 1965. We report here, the investigation of CHPV activity during the period of June-August 2015 in the state of Gujarat, which revealed 24.44% positivity among 45 referred encephalitis cases. Phylogenetic study of the G gene sequences of strains from Gujarat 2015 along with available sequences of additional strains from different geographical locations and isolation years (1965-2015), indicated the relatedness of the 2015 strain to a group of the CHPV prototype strain of 1965 and the earliest outbreak strains of 2003. Analyses of selection pressure in the G gene revealed positively selected sites within the signal peptide region and a putative CHPV epitope. These results indicate a probable role of G protein-based immune selection and underline the need for continued surveillance to monitor genetic and antigenic variations in the CHPV.
MeSH term(s)	Amino Acid Sequence ; Disease Outbreaks ; Genetic Variation ; Humans ; India/epidemiology ; Phylogeny ; Sequence Analysis, DNA ; Vesicular Stomatitis/epidemiology ; Vesicular Stomatitis/virology ; Vesiculovirus/classification ; Vesiculovirus/genetics ; Viral Fusion Proteins/genetics
Chemical Substances	Viral Fusion Proteins
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2017.09.002
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Article: Genetic characterization of the glycoprotein G of Chandipura viruses in India with emphasis on an outbreak of 2015

Damle, R.G / A.M. Walimbe / S.A. Mahamuni / S.S. Cherian / V. Sankararaman / V.S. Bhide

Infection, genetics, and evolution. 2017 Nov., v. 55

2017

Abstract	Chandipura virus (CHPV) is found to be associated with sporadic encephalitis outbreaks in humans in India since 1965. We report here, the investigation of CHPV activity during the period of June–August 2015 in the state of Gujarat, which revealed 24.44% positivity among 45 referred encephalitis cases. Phylogenetic study of the G gene sequences of strains from Gujarat 2015 along with available sequences of additional strains from different geographical locations and isolation years (1965–2015), indicated the relatedness of the 2015 strain to a group of the CHPV prototype strain of 1965 and the earliest outbreak strains of 2003. Analyses of selection pressure in the G gene revealed positively selected sites within the signal peptide region and a putative CHPV epitope. These results indicate a probable role of G protein-based immune selection and underline the need for continued surveillance to monitor genetic and antigenic variations in the CHPV.
Keywords	Chandipura virus ; encephalitis ; epitopes ; genes ; glycoproteins ; humans ; monitoring ; nucleotide sequences ; phylogeny ; prototypes ; selection pressure ; signal peptide ; India
Language	English
Dates of publication	2017-11
Size	p. 112-116.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2017.09.002
Database	NAL-Catalogue (AGRICOLA)

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Article: Rapid cycling affective disorder associated with e.e.g. Abnormality : a report on four cases.

Cherian, A / Kuruvilla, K / Prabhakar, S

Indian journal of psychiatry

2011 Volume 32, Issue 1, Page(s) 89–92

Language	English
Publishing date	2011-07-07
Publishing country	India
Document type	Journal Article
ZDB-ID	221523-8
ISSN	0019-5545
ISSN	0019-5545
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Article ; Online: Type I retinopathy of prematurity in infants with birth weight less than 1251 g: incidence and risk factors for its development in a nursery in Kuwait.

Wani, Vivek B / Uboweja, Anil K / Gani, Muzaffar / Al-Kandari, Jamal / Kazem, Mahmood / Al-Naqeeb, Niran / Thomas, Cherian / Al-Serafi, Murad / Shukkur, Mumtaz M

Middle East African journal of ophthalmology

2013 Volume 20, Issue 1, Page(s) 66–71

Abstract: ... with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP.: Materials and ... methods: A retrospective review of ROP records of infants with BW <1251 g was performed to identify ... Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 ...

Abstract	Purpose: To report the rate of acute retinopathy of prematurity (ROP) and Type I ROP among infants with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP. Materials and methods: A retrospective review of ROP records of infants with BW <1251 g was performed to identify infants with acute ROP and Type I ROP. Infants with Type I ROP were compared with those without Type I ROP to assess the risk factors for the development of Type I ROP. P < 0.05 was statistically significant. Multivariate analysis was performed and odds ratio (OR) and 95% confidence intervals (CI) were calculated. Results: Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 infants (24.4%). The numbers of infants with BW <750 g and BW <1000 g were 19.3% and 58.4%, respectively, and the incidences of Type I ROP were 50% and 36.4%, respectively, among them. Forty-four (46.3%) eyes were treated at stage 2+ ROP in zone I or II. All the eyes treated for Type I ROP showed complete regression. Gestational age at birth (OR 0.657, 95% CI: 0.521-0.827; P < 0.0001) and number of ventilated days (OR 1.017, 95% CI: 1.005-1.029; P = 0.006) were identified as independent risk factors for the development of Type I ROP. Conclusions: The rate of Type I ROP in this study is higher than that in previous studies due to the higher number of infants with BW <1000 g in our cohort and the treatment of more eyes with stage 2+ ROP. However, all the treated eyes had a favorable outcome. Gestational age at birth and number of ventilated days were independent risk factors for the development of Type I ROP.
MeSH term(s)	Birth Weight ; Female ; Gestational Age ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Very Low Birth Weight ; Kuwait/epidemiology ; Male ; Nurseries, Hospital/statistics & numerical data ; Retinopathy of Prematurity/classification ; Retinopathy of Prematurity/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2013-05-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2545467-5
ISSN	0975-1599 ; 0975-1599
ISSN (online)	0975-1599
ISSN	0975-1599
DOI	10.4103/0974-9233.106393
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Article ; Online: Type I retinopathy of prematurity in infants with birth weight less than 1251 g

Vivek B Wani / Anil K Uboweja / Muzaffar Gani / Jamal Al-Kandari / Mahmood Kazem / Niran Al-Naqeeb / Cherian Thomas / Murad Al-Serafi / Mumtaz M Shukkur

Middle East African Journal of Ophthalmology, Vol 20, Iss 1, Pp 66-

Incidence and risk factors for its development in a nursery in Kuwait

2013 Volume 71

Abstract: ... with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP. Materials and ... Methods: A retrospective review of ROP records of infants with BW <1251 g was performed to identify ... Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 ...

Abstract	Purpose: To report the rate of acute retinopathy of prematurity (ROP) and Type I ROP among infants with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP. Materials and Methods: A retrospective review of ROP records of infants with BW <1251 g was performed to identify infants with acute ROP and Type I ROP. Infants with Type I ROP were compared with those without Type I ROP to assess the risk factors for the development of Type I ROP. P < 0.05 was statistically significant. Multivariate analysis was performed and odds ratio (OR) and 95% confidence intervals (CI) were calculated. Results: Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 infants (24.4%). The numbers of infants with BW <750 g and BW <1000 g were 19.3% and 58.4%, respectively, and the incidences of Type I ROP were 50% and 36.4%, respectively, among them. Forty-four (46.3%) eyes were treated at stage 2+ ROP in zone I or II. All the eyes treated for Type I ROP showed complete regression. Gestational age at birth (OR 0.657, 95% CI: 0.521-0.827; P < 0.0001) and number of ventilated days (OR 1.017, 95% CI: 1.005-1.029; P = 0.006) were identified as independent risk factors for the development of Type I ROP. Conclusions: The rate of Type I ROP in this study is higher than that in previous studies due to the higher number of infants with BW <1000 g in our cohort and the treatment of more eyes with stage 2+ ROP. However, all the treated eyes had a favorable outcome. Gestational age at birth and number of ventilated days were independent risk factors for the development of Type I ROP.
Keywords	Incidence ; Retinopathy of Prematurity ; Risk Factors ; Type I Retinopathy of Prematurity ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
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Article: Hatching egg polyunsaturated fatty acids and the broiler chick.

Cherian, Gita

Journal of animal science and biotechnology

2022 Volume 13, Issue 1, Page(s) 98

Abstract: Transgenerational effects of certain nutrients such as essential fatty acids are gaining increased attention in the field of human medicine and animal sciences as a new tool to improve health and animal performance during perinatal life. Omega-3 (n-3) ... ...

Abstract	Transgenerational effects of certain nutrients such as essential fatty acids are gaining increased attention in the field of human medicine and animal sciences as a new tool to improve health and animal performance during perinatal life. Omega-3 (n-3) and omega-6 (n-6) fatty acids are denoted by the position of the first double bond from methyl end of the hydrocarbon chain. Alpha-linolenic acid (18:3 n-3) and linoleic acid (18:2 n-6) are essential n-3 and n-6 fatty acids and cannot be synthesized by the vertebrates including chickens. Alpha-linolenic acid and linoleic acid are the parent fatty acids of long chain (> 20-22C) n-3 and n-6 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (20:5 n-3, EPA), docosapentaenoic acid (22:5 n-3/or 22:5 n-6, DPA), docosahexaenoic acid (22:6 n-3, DHA) and arachidonic acid (20:4 n-6). As components of cell membrane phospholipids, PUFA serves as precursors of eicosanoids, act as ligands for membrane receptors and transcription factors that regulate gene expression and are pivotal for normal chick growth and development. Considering the role of egg lipids as the sole source of essential fatty acids to the hatchling, dietary deficiencies or inadequate in ovo supply may have repercussions in tissue PUFA incorporation, lipid metabolism, chick growth and development during pre and early post-hatch period. This review focus on studies showing how maternal dietary n-3 or n-6 fatty acids can lead to remodeling of long chain n-3 and n-6 PUFA in the hatching egg and progeny chick tissue phospholipid molecular species and its impact on chick growth and PUFA metabolism during early life.
Language	English
Publishing date	2022-09-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-022-00757-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A modified Murashige and Skoog media for efficient multipleshoot induction in G. arborea Roxb

Madke, Shilpa S / Cherian, Konglanth J / Badere, Rupesh S

Journal of forestry research. 2014 Sept., v. 25, no. 3

2014

Abstract: This paper reports on the effect of various micropropagation factors of Gmelina arborea Roxb. through multiple shoot induction. Factors like the source and age of explants, plant growth regulators (PGRs), media composition, and carbon source affected ... ...

Abstract	This paper reports on the effect of various micropropagation factors of Gmelina arborea Roxb. through multiple shoot induction. Factors like the source and age of explants, plant growth regulators (PGRs), media composition, and carbon source affected multiple shooting in the present study. Among all the explants used, only shoot tips derived from one, two, and three week old seedlings could form multiple shoots. Besides, the formation of multiple shoots depended on the concentration and combination of PGRs. Among all the PGRs, BAP (6-benzylaminopurine) alone gave the highest regeneration efficiency. Similarly, IBA (Indole-3-butyric acid) was the most efficient PGR in inducing root formation in the microshoots. Media composition and carbon source also affected the regeneration efficiency. MS (Murashige and Skoog medium) proved to be the best media for regeneration followed by B5, SH (Schenk and Hilderbrandt medium) and WPM (Woody plant medium) in that order. Similarly, among sugars, only sucrose and glucose supported induction of microshoots. Based on this study we recommend the use of glucose in place of sucrose in MS medium for maximum regeneration efficiency.
Keywords	Gmelina arborea ; benzyladenine ; carbon ; explants ; glucose ; indole butyric acid ; micropropagation ; seedlings ; shoots ; sucrose ; woody plants
Language	English
Dates of publication	2014-09
Size	p. 557-564.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2299615-1
ISSN	1993-0607 ; 1007-662X
ISSN (online)	1993-0607
ISSN	1007-662X
DOI	10.1007/s11676-014-0449-y
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Article: Hatching egg polyunsaturated fatty acids and the broiler chick

Cherian, Gita

Journal of animal science and biotechnology. 2022 Dec., v. 13, no. 1

2022

Abstract	Transgenerational effects of certain nutrients such as essential fatty acids are gaining increased attention in the field of human medicine and animal sciences as a new tool to improve health and animal performance during perinatal life. Omega-3 (n-3) and omega-6 (n-6) fatty acids are denoted by the position of the first double bond from methyl end of the hydrocarbon chain. Alpha-linolenic acid (18:3 n-3) and linoleic acid (18:2 n-6) are essential n-3 and n-6 fatty acids and cannot be synthesized by the vertebrates including chickens. Alpha-linolenic acid and linoleic acid are the parent fatty acids of long chain (> 20–22C) n-3 and n-6 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (20:5 n-3, EPA), docosapentaenoic acid (22:5 n-3/or 22:5 n-6, DPA), docosahexaenoic acid (22:6 n-3, DHA) and arachidonic acid (20:4 n-6). As components of cell membrane phospholipids, PUFA serves as precursors of eicosanoids, act as ligands for membrane receptors and transcription factors that regulate gene expression and are pivotal for normal chick growth and development. Considering the role of egg lipids as the sole source of essential fatty acids to the hatchling, dietary deficiencies or inadequate in ovo supply may have repercussions in tissue PUFA incorporation, lipid metabolism, chick growth and development during pre and early post-hatch period. This review focus on studies showing how maternal dietary n-3 or n-6 fatty acids can lead to remodeling of long chain n-3 and n-6 PUFA in the hatching egg and progeny chick tissue phospholipid molecular species and its impact on chick growth and PUFA metabolism during early life.
Keywords	alpha-linolenic acid ; animal performance ; arachidonic acid ; biotechnology ; broiler chickens ; cell membranes ; chicks ; docosahexaenoic acid ; docosapentaenoic acid ; eggs ; eicosanoids ; eicosapentaenoic acid ; gene expression ; growth and development ; ligands ; linoleic acid ; lipid metabolism ; medicine ; omega-6 fatty acids ; phospholipids ; progeny
Language	English
Dates of publication	2022-12
Size	p. 98.
Publishing place	BioMed Central
Document type	Article
Note	Review
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-022-00757-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: AI-assisted Boolean search.

Kurian, N / Cherian, J M / Cherian, K K / Varghese, K G

British dental journal

2023 Volume 235, Issue 6, Page(s) 363

MeSH term(s)	Artificial Intelligence
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-023-6345-0
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Ul III Zs.143: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 447: Show issues

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Article: A Systematic Review of the Neurocognitive Effects of Psychedelics in Healthy Populations: Implications for Depressive Disorders and Post-Traumatic Stress Disorder.

Velit-Salazar, Mario Renato / Shiroma, Paulo R / Cherian, Eloise

Brain sciences

2024 Volume 14, Issue 3

Abstract: ... during the peak effect of psychedelics with a few exceptions (e.g., MDMA improved psychomotor function ... Performance on the type of neurocognitive dimension (e.g., attention, memory, executive function, psychomotor ...

Abstract	Objective: This study aims to provide an overview of pharmacological trials that examine the neurocognitive effects of psychedelics among healthy individuals and patients with post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). Methods: The Preferred Reporting Items for Systematic Reviews (PRISMA) was used as a guide to structure and report the findings for this review. A literature search included the MEDLINE database up until December 2022. We included randomized or open-label human studies of MDMA, psilocybin, mescaline, LSD, DMT, or cannabis reporting non-emotionally charged neurocognitive outcomes ("cold cognition") measured through validated neuropsychological tests. Results: A total of 43 full-text papers on MDMA (15), cannabis (12), LSD (6), psilocybin (9), DMT/ayahuasca (1), and mescaline (0) were included, mostly on healthy subjects. A single article on MDMA's effects on cognition in subjects with PTSD was included; there were no studies on psychedelics and neurocognition in MDD. Most of the studies on healthy subjects reported detrimental or neutral effects on cognition during the peak effect of psychedelics with a few exceptions (e.g., MDMA improved psychomotor function). Performance on the type of neurocognitive dimension (e.g., attention, memory, executive function, psychomotor) varies by type of psychedelic, dosage, and cognitive testing. Conclusions: Small samples and a lack of uniformed methods across studies preclude unequivocal conclusions on whether psychedelics enhance, decrease, or have no significant effect on cognitive performance. It is foreseen that psychedelics will soon become an available treatment for various psychiatric disorders. The acute and long-term effects on cognition caused by psychedelics should be assessed in future studies.
Language	English
Publishing date	2024-03-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14030248
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