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Article ; Online: Indications for surgery in necrotizing otitis externa.

Kuczkowski, Jerzy / Nowicki, Tomasz K

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2020 Volume 279, Issue 6, Page(s) 3219–3220

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Humans ; Necrosis/surgery ; Otitis Externa/drug therapy ; Otitis Externa/surgery
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-06-01
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-020-06092-7
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Article ; Online: Aortic Stiffness Is Independently Associated with Intracranial Carotid Artery Calcification in Patients with Ischemic Stroke.

Gozdalski, Jacek / Nowicki, Tomasz K / Kwarciany, Mariusz / Kowalczyk, Kamil / Narkiewicz, Krzysztof / Gasecki, Dariusz

Cerebrovascular diseases (Basel, Switzerland)

2023 Volume 53, Issue 2, Page(s) 216–223

Abstract: Introduction: Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in the medial or intimal arterial layer. Traditional cardiovascular risk factors (CVRFs) are associated with ... ...

Abstract	Introduction: Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in the medial or intimal arterial layer. Traditional cardiovascular risk factors (CVRFs) are associated with ICAC; however, its association with new markers of vascular function is less understood. The paper aimed to evaluate the relationship between carotid-femoral pulse wave velocity (CF-PWV) and ICAC subtypes. Methods: We enrolled 65 patients with ischemic stroke. CF-PWV, systolic, diastolic, mean blood pressure, and pulse pressure were measured within 6 ± 2 days after stroke onset, and CT was performed within 24 h. ICAC on the stroke site was classified by two methods: volume and score based. Tertiles of ICAC volume were determined, and low-grade ICAC (T1) was regarded as a reference. According to the score-based method, (dominant) medial and (dominant) intimal ICAC subtypes were determined. Data were analyzed with multivariate logistic regression. Results: Medial and intimal ICAC subtypes were found in 34 (52%) and 24 (37%) patients, respectively. In 11% of patients, no ICAC calcifications were found. CF-PWV was higher in patients with high-grade ICAC (OR = 1.56, 95% CI = 1.03-2.35, p = 0.035). CF-PWV was higher in patients with the medial ICAC subtype (OR = 1.60, 95% CI = 1.00-2.55, p = 0.049) after adjustment for traditional CVRFs. Conclusion: Our study demonstrates that among patients with ischemic stroke, aortic stiffness is independently associated with ICAC and that medial ICAC, compared with intimal ICAC, is accompanied by more advanced aortic stiffness.
MeSH term(s)	Humans ; Vascular Stiffness ; Ischemic Stroke/complications ; Pulse Wave Analysis ; Risk Factors ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Stroke/diagnostic imaging ; Stroke/etiology ; Carotid Arteries
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000533510
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Article ; Online: Fluid in the mastoid is a common finding on MRI and CT: a radiologist and otolaryngologist perspective.

Nowicki, Tomasz K / Kuczkowski, Jerzy

2019 Volume 277, Issue 9, Page(s) 2649–2650

MeSH term(s)	Brain ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Mastoid/diagnostic imaging ; Otolaryngologists ; Radiologists ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-04-20
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-019-05430-8
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Article: Vascular Abnormalities of the Parotid Region: An Uncommon Presentation of a Common Condition-A Case Series.

Nowicki, Tomasz K / Joskowski, Michał / Garsta, Ewa / Mikaszewski, Bogusław

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: A variety of non-neoplastic diseases and benign and malignant lesions may involve parotid glands. In clinical practice, effective diagnosis is crucial to ensure proper treatment and achieve a good therapeutic effect. Unclear anamnesis and short medical ... ...

Abstract	A variety of non-neoplastic diseases and benign and malignant lesions may involve parotid glands. In clinical practice, effective diagnosis is crucial to ensure proper treatment and achieve a good therapeutic effect. Unclear anamnesis and short medical history are factors that make diagnosis difficult, especially when cancer should be excluded. We present a case series of four patients who reported to the outpatient clinic with a unilateral nodule in the parotid region. The clinical presentation prevented an unequivocal diagnosis. The suspicion of a neoplastic disease resulted in profound diagnostics, including repeated cytology, ultrasound and magnetic resonance examination. Combining all the acquired information and follow-up, or a histopathologic examination, facilitated the final diagnosis. In all cases, thrombosis was diagnosed. We then analysed the diagnostic process and the associated difficulties. When thrombosis in vascular malformation occurs in the parotid region, it may have an unclear clinical and radiological presentation. Such an image can imitate both benign and malignant tumours. Ambiguous imaging in conjunction with blood cells in cytology should result in the inclusion of thrombosis in vascular malformations in the differential diagnosis.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12092236
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Article: Assessment of the Carotid Bodies in Magnetic Resonance-A Head-to-Head Comparison with Computed Tomography.

Budynko, Lukasz / Nowicki, Tomasz K / Kaszubowski, Mariusz F / Swieton, Dominik / Piskunowicz, Maciej

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 5

Abstract: Objectives: To evaluate carotid body visibility in contrast-enhanced magnetic resonance (MR) studies and to compare the results to contrast-enhanced computed tomography (CT).: Methods: Two observers separately evaluated MR and CT examinations of 58 ... ...

Abstract	Objectives: To evaluate carotid body visibility in contrast-enhanced magnetic resonance (MR) studies and to compare the results to contrast-enhanced computed tomography (CT). Methods: Two observers separately evaluated MR and CT examinations of 58 patients. MR scans were acquired with contrast-enhanced isometric T1-weighted water-only Dixon sequence. CT examinations were performed 90 s after contrast agent administration. Carotid bodies' dimensions were noted and their volumes calculated. To quantify the agreement between both methods, Bland-Altman plots were computed. Receiver operating characteristic (ROC) and its localization-oriented variant (LROC) curves were plotted. Results: Of the 116 expected carotid bodies, 105 were found on CT and 103 on MR at least by a single observer. Significantly more findings were concordant in CT (92.2%) than in MR (83.6%). The mean carotid body volume was smaller in CT (19.4 mm Conclusions: Carotid bodies can be visualized on contrast-enhanced MR with good accuracy and inter-observer agreement. Carotid bodies assessed on MR had similar morphology as described in anatomical studies.
Language	English
Publishing date	2023-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13050993
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Article ; Online: Assessment of the Carotid Bodies in Magnetic Resonance—A Head-to-Head Comparison with Computed Tomography

Lukasz Budynko / Tomasz K. Nowicki / Mariusz F. Kaszubowski / Dominik Swieton / Maciej Piskunowicz

Diagnostics, Vol 13, Iss 993, p

2023 Volume 993

Abstract: ... 20.8 mm 3 ). The inter-observer agreement on volumes was moderately good (ICC (2,k) 0.42, p < 0.001 ...

Abstract	Objectives: To evaluate carotid body visibility in contrast-enhanced magnetic resonance (MR) studies and to compare the results to contrast-enhanced computed tomography (CT). Methods: Two observers separately evaluated MR and CT examinations of 58 patients. MR scans were acquired with contrast-enhanced isometric T1-weighted water-only Dixon sequence. CT examinations were performed 90 s after contrast agent administration. Carotid bodies’ dimensions were noted and their volumes calculated. To quantify the agreement between both methods, Bland–Altman plots were computed. Receiver operating characteristic (ROC) and its localization-oriented variant (LROC) curves were plotted. Results: Of the 116 expected carotid bodies, 105 were found on CT and 103 on MR at least by a single observer. Significantly more findings were concordant in CT (92.2%) than in MR (83.6%). The mean carotid body volume was smaller in CT (19.4 mm 3 ) than in MR (20.8 mm 3 ). The inter-observer agreement on volumes was moderately good (ICC (2,k) 0.42, p < 0.001), but with significant systematic error. The diagnostic performance of the MR method added up to 88.4% of the ROC’s area under the curve and 78.0% in the LROC algorithm. Conclusions: Carotid bodies can be visualized on contrast-enhanced MR with good accuracy and inter-observer agreement. Carotid bodies assessed on MR had similar morphology as described in anatomical studies.
Keywords	carotid body ; magnetic resonance imaging ; computed tomography ; Dixon sequence ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Etiopathogenesis and Emerging Methods for Treatment of Vitiligo.

Iwanowski, Tomasz / Kołkowski, Karol / Nowicki, Roman Janusz / Sokołowska-Wojdyło, Małgorzata

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Vitiligo is an acquired chronic depigmenting disorder of skin. It is mostly asymptomatic and characterized by amelanotic macules and patches that affects 0.5% to 2% of the world's population. The etiology of vitiligo has not been clearly elucidated and ... ...

Abstract	Vitiligo is an acquired chronic depigmenting disorder of skin. It is mostly asymptomatic and characterized by amelanotic macules and patches that affects 0.5% to 2% of the world's population. The etiology of vitiligo has not been clearly elucidated and multiple theories have been proposed regarding the causes of the disorder. Among the most prevalent theories, the genetic predisposition, oxidative stress theory, promotion of cellular stress and pathologic influence of lymphocytes T have been highlighted. As a result of increases in in-depth knowledge concerning the pathogenetic processes in vitiligo, we review the most recent information concerning its etiopathogenesis and treatment methods including topical and oral Janus kinase inhibitors, prostaglandins and their analogues, namely afamelanotide, Wnt/β-catenin-signaling agonists and cell-based therapies. Topical ruxolitinib has been registered for vitiligo treatment, whereas other agents as oral ritlecitinib, afamelanotide and latanoprost have been studied in ongoing clinical trials. New highly effective therapeutic strategies may be developed thanks to molecular and genetic studies.
MeSH term(s)	Humans ; Vitiligo/drug therapy ; Vitiligo/etiology ; Janus Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Skin ; Prostaglandins/therapeutic use
Chemical Substances	Janus Kinase Inhibitors ; Protein Kinase Inhibitors ; Prostaglandins
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119749
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Article ; Online: Neural Network Training With Asymmetric Crosspoint Elements.

Onen, Murat / Gokmen, Tayfun / Todorov, Teodor K / Nowicki, Tomasz / Del Alamo, Jesús A / Rozen, John / Haensch, Wilfried / Kim, Seyoung

Frontiers in artificial intelligence

2022 Volume 5, Page(s) 891624

Abstract: Analog crossbar arrays comprising programmable non-volatile resistors are under intense investigation for acceleration of deep neural network training. However, the ubiquitous asymmetric conductance modulation of practical resistive devices critically ... ...

Abstract	Analog crossbar arrays comprising programmable non-volatile resistors are under intense investigation for acceleration of deep neural network training. However, the ubiquitous asymmetric conductance modulation of practical resistive devices critically degrades the classification performance of networks trained with conventional algorithms. Here we first describe the fundamental reasons behind this incompatibility. Then, we explain the theoretical underpinnings of a novel fully-parallel training algorithm that is compatible with asymmetric crosspoint elements. By establishing a powerful analogy with classical mechanics, we explain how device asymmetry can be exploited as a useful feature for analog deep learning processors. Instead of conventionally tuning weights in the direction of the error function gradient, network parameters can be programmed to successfully minimize the total energy (Hamiltonian) of the system that incorporates the effects of device asymmetry. Our technique enables immediate realization of analog deep learning accelerators based on readily available device technologies.
Language	English
Publishing date	2022-05-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-8212
ISSN (online)	2624-8212
DOI	10.3389/frai.2022.891624
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Article ; Online: Why does the acquired cholesteatoma trigger resorption of the temporal bone?

Kuczkowski, Jerzy / Nowicki, Tomasz K / Starzyńska, Anna

2017 Volume 274, Issue 12, Page(s) 4251–4252

Language	English
Publishing date	2017
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-017-4633-5
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Article ; Online: Neural Network Training With Asymmetric Crosspoint Elements

Murat Onen / Tayfun Gokmen / Teodor K. Todorov / Tomasz Nowicki / Jesús A. del Alamo / John Rozen / Wilfried Haensch / Seyoung Kim

Frontiers in Artificial Intelligence, Vol

2022 Volume 5

Abstract	Analog crossbar arrays comprising programmable non-volatile resistors are under intense investigation for acceleration of deep neural network training. However, the ubiquitous asymmetric conductance modulation of practical resistive devices critically degrades the classification performance of networks trained with conventional algorithms. Here we first describe the fundamental reasons behind this incompatibility. Then, we explain the theoretical underpinnings of a novel fully-parallel training algorithm that is compatible with asymmetric crosspoint elements. By establishing a powerful analogy with classical mechanics, we explain how device asymmetry can be exploited as a useful feature for analog deep learning processors. Instead of conventionally tuning weights in the direction of the error function gradient, network parameters can be programmed to successfully minimize the total energy (Hamiltonian) of the system that incorporates the effects of device asymmetry. Our technique enables immediate realization of analog deep learning accelerators based on readily available device technologies.
Keywords	analog computing ; DNN training ; hardware accelerator architecture ; neuromorphic accelerator ; learning algorithm ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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