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  1. Article: A Review of Thromboembolic Events in Hospitalized COVID-19 Patients.

    Fontelo, Paul / Bastola, Mrigendra M / Zheng, Zhaonian / Baik, Seo Hyon

    Research square

    2021  

    Abstract: Context: ...

    Abstract Context:
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-393440/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A review of thromboembolic events in hospitalized COVID-19 patients.

    Fontelo, Paul / Bastola, Mrigendra M / Zheng, Zhaonian / Baik, Seo Hyon

    Thrombosis journal

    2021  Volume 19, Issue 1, Page(s) 47

    Abstract: Context: A higher incidence of thromboembolic disorders in COVID-19 has been reported by many clinicians worldwide.: Objective, design and data sources: Selected studies found in PubMed that reported thromboembolic events were included for meta- ... ...

    Abstract Context: A higher incidence of thromboembolic disorders in COVID-19 has been reported by many clinicians worldwide.
    Objective, design and data sources: Selected studies found in PubMed that reported thromboembolic events were included for meta-analysis using weighted fixed and random effects. Data from 19 articles on cohort studies in patients diagnosed with COVID-19 and thromboembolic events, including thrombosis and embolism were included in this review.
    Results: The likelihood for developing thromboembolic disorders in hospitalized COVID-19 patients was 0.28 (95% CI 0.21-0.36).
    Conclusion: This study further validates the increased risk of VTE in COVID-19 patients when compared to healthy, non-hospitalized people, and hospitalized patients. These findings will be useful to researchers and medical practitioners caring for COVID-19 patients.
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-021-00298-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diagnostic Laboratory Tests for COVID-19 in US: Methodology and Performance.

    Bastola, Mrigendra M / Locatis, Craig / Fontelo, Paul

    Research square

    2020  

    Abstract: Background: COVID-19 is a global pandemic caused by a new coronavirus strain. Innovative tests have been developed to diagnose and characterize the spread of COVID-19. Only a few studies have reported the diagnostic value of currently available tests. ... ...

    Abstract Background: COVID-19 is a global pandemic caused by a new coronavirus strain. Innovative tests have been developed to diagnose and characterize the spread of COVID-19. Only a few studies have reported the diagnostic value of currently available tests. The diagnostic performance of the tests is a major concern after the recent resurgence in COVID-19.
    Methods: Published papers and FDA data on the currently available tests were used for analysis. Likelihood ratios, and predictive values of tests were computed. Only FDA approved tests were included. RT-PCR performance among different specimen types were also explored.
    Main results: All the published reports on the COVID-19 tests reported RT-PCR as the validation tool for their results. Not all available COVID-19 tests reported their sensitivity and specificity. Among the publications which reported, the positive likelihood ratio ranged between 0.15 to 0.88 and tests had high negative likelihood ratio (0.99).
    Conclusion: Although most recent publications showed high positive and negative likelihood ratios and high predictive values, the publications on test accuracy and validity have limited scope primarily due to their small sample size and insufficiencies in methodology and published data. Although most lab tests reported high sensitivity and specificity, false omission and false discovery rates were found notable in several COVID-19 lab tests. These results suggest need for caution on test results' interpretation. Practitioners also need to integrate evidence that is evolving rapidly.
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-43374/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effectiveness of Mobile Phone-Based Text Messaging to Intervene with Problem Drinking in Youth and Younger Adult Population: A Meta-Analysis.

    Bastola, Mrigendra M / Locatis, Craig / Maisiak, Richard / Fontelo, Paul

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2019  Volume 26, Issue 3, Page(s) 270–277

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Alcoholism/epidemiology ; Blood Alcohol Content ; Cell Phone ; Humans ; Randomized Controlled Trials as Topic ; Text Messaging ; Young Adult
    Chemical Substances Blood Alcohol Content
    Language English
    Publishing date 2019-04-13
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2018.0307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011-2016).

    Bastola, Mrigendra M / Locatis, Craig / Maisiak, Richard / Fontelo, Paul

    BMC cardiovascular disorders

    2020  Volume 20, Issue 1, Page(s) 45

    Abstract: Background: Hypertension is a major cardiovascular illness worldwide with many underlying causes. The role of trace elements selenium, copper, and zinc in hypertension is uncertain. The objective of this study was to evaluate the role of these trace ... ...

    Abstract Background: Hypertension is a major cardiovascular illness worldwide with many underlying causes. The role of trace elements selenium, copper, and zinc in hypertension is uncertain. The objective of this study was to evaluate the role of these trace elements in hypertension.
    Method: Data from 6683 National Health and Nutrition Examination Survey (NHANES) participants from 2011 to 2016 were analyzed using Statistical Analytical System (SAS, version 9.4) software for the role of trace elements in hypertension in age range 8 to 80 years, irrespective of the antihypertensive medication taken. Recent American Heart Association guidelines and pediatric practice guidelines for hypertension were used.
    Results: Findings showed a significant positive association between serum selenium levels and hypertension but not serum zinc and copper. At optimal levels for transport and distribution, serum selenium levels of 120 μg/L or higher (reference level 70-150 μg/L) were significantly associated with hypertension (OR = 1.46, 95% CI = 1.29-1.66) after adjusting for confounding factors. At serum selenium level greater than 150 μg/L, the association with hypertension strengthened (OR = 1.69, 95% CI = 1.32-2.17).
    Conclusion: A positive association was found between serum selenium and hypertension, irrespective of age or anti-hypertensive medications intake. These findings also suggest that the reference levels of serum levels in healthy individuals may need to be re-determined, if supported by additional studies. If validated, patients with hypertension may also need to be cautioned about selenium intake.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Biomarkers/blood ; Blood Pressure/drug effects ; Child ; Copper/blood ; Female ; Humans ; Hypertension/blood ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Male ; Middle Aged ; Nutrition Surveys ; Prognosis ; Risk Factors ; Selenium/blood ; United States/epidemiology ; Young Adult ; Zinc/blood
    Chemical Substances Antihypertensive Agents ; Biomarkers ; Copper (789U1901C5) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2020-01-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-020-01355-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diagnostic Laboratory Tests for COVID-19 in US: Methodology and Performance

    Bastola, Mrigendra M. / Locatis, Craig / Fontelo, Paul

    Research square

    Abstract: Background: COVID-19 is a global pandemic caused by a new coronavirus strain Innovative tests have been developed to diagnose and characterize the spread of COVID-19 Only a few studies have reported the diagnostic value of currently available tests The ... ...

    Abstract Background: COVID-19 is a global pandemic caused by a new coronavirus strain Innovative tests have been developed to diagnose and characterize the spread of COVID-19 Only a few studies have reported the diagnostic value of currently available tests The diagnostic performance of the tests is a major concern after the recent resurgence in COVID-19 Methods: Published papers and FDA data on the currently available tests were used for analysis Likelihood ratios, and predictive values of tests were computed Only FDA approved tests were included RT-PCR performance among different specimen types were also explored Main results: All the published reports on the COVID-19 tests reported RT-PCR as the validation tool for their results Not all available COVID-19 tests reported their sensitivity and specificity Among the publications which reported, the positive likelihood ratio ranged between 0 15 to 0 88 and tests had high negative likelihood ratio (0 99) Conclusion: Although most recent publications showed high positive and negative likelihood ratios and high predictive values, the publications on test accuracy and validity have limited scope primarily due to their small sample size and insufficiencies in methodology and published data Although most lab tests reported high sensitivity and specificity, false omission and false discovery rates were found notable in several COVID-19 lab tests These results suggest need for caution on test results’ interpretation Practitioners also need to integrate evidence that is evolving rapidly
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #693305
    Database COVID19

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  7. Article ; Online: Diagnostic Reliability of In-Person Versus Remote Dermatology: A Meta-Analysis.

    Bastola, Mrigendra / Locatis, Craig / Fontelo, Paul

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2020  Volume 27, Issue 3, Page(s) 247–250

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Dermatology ; Humans ; Referral and Consultation ; Remote Consultation ; Reproducibility of Results ; Skin Diseases/diagnosis ; Telemedicine
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2020.0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension.

    Gairhe, Salina / Joshi, Sachindra R / Bastola, Mrigendra M / McLendon, Jared M / Oka, Masahiko / Fagan, Karen A / McMurtry, Ivan F

    Pulmonary circulation

    2016  Volume 6, Issue 3, Page(s) 369–380

    Abstract: Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine-1-phosphate (S1P) is a ... ...

    Abstract Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine-1-phosphate (S1P) is a lysophospholipid synthesized by sphingosine kinase 1 (SphK1) and SphK2. Considering the regulatory roles of S1P in several tissues leading to vasoconstriction, inflammation, proliferation, and fibrosis, we investigated whether S1P plays a role in the pathogenesis of PAH. To test this hypothesis, we used plasma samples and lung tissue from patients with idiopathic PAH (IPAH) and the Sugen5416/hypoxia/normoxia rat model of occlusive PAH. Our study revealed an increase in the plasma concentration of S1P in patients with IPAH and in early and late stages of PAH in rats. We observed increased expression of both SphK1 and SphK2 in the remodeled pulmonary arteries of patients with IPAH and PAH rats. Exogenous S1P stimulated the proliferation of cultured rat pulmonary arterial endothelial and smooth-muscle cells. We also found that 3 weeks of treatment of late-stage PAH rats with an SphK1 inhibitor reduced the increased plasma levels of S1P and the occlusive pulmonary arteriopathy. Although inhibition of SphK1 improved cardiac index and the total pulmonary artery resistance index, it did not reduce right ventricular systolic pressure or right ventricular hypertrophy. Our study supports that S1P is involved in the pathogenesis of occlusive arteriopathy in PAH and provides further evidence that S1P signaling may be a novel therapeutic target.
    Language English
    Publishing date 2016-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1086/687766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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