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  1. Article: Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear

    Villatoro, Tatiana M / Mardekian, Stacey K

    Case reports in pathology

    2018  Volume 2018, Page(s) 8741017

    Abstract: Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules ... ...

    Abstract Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of
    Language English
    Publishing date 2018-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2018/8741017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Utility of Tumor Capsule Thickness as a Predictor of Invasion in Encapsulated Follicular Variant of Papillary Thyroid Carcinoma and a Diagnostic Tool for Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features.

    French, Brenda / Hattier, Georgette / Mardekian, Stacey K

    International journal of surgical pathology

    2019  Volume 28, Issue 1, Page(s) 13–19

    Abstract: ... ...

    Abstract Context
    MeSH term(s) Adenocarcinoma, Follicular/diagnosis ; Adenocarcinoma, Follicular/pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Thyroid Cancer, Papillary/diagnosis ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Young Adult
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896919859085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions.

    Ghias, Adeeba F / Epps, Gregory / Cottrill, Elizabeth / Mardekian, Stacey K

    Case reports in pathology

    2019  Volume 2019, Page(s) 9890716

    Abstract: The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a ... ...

    Abstract The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. We present the case of a 67-year-old woman who presented with dysphonia and dysphagia secondary to multinodular goiter and was found to have multifocal metastatic breast carcinoma in her surgical resection specimen. The histologic appearance focally mimicked C cell hyperplasia and medullary thyroid carcinoma, so immunohistochemistry was critical for establishing the diagnosis. Metastasis to the thyroid should always be included in the differential diagnosis for a thyroid nodule in a patient with a history of previous malignancy.
    Language English
    Publishing date 2019-03-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2019/9890716
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  4. Article ; Online: Diagnostic Options and Challenges for Dengue and Chikungunya Viruses.

    Mardekian, Stacey K / Roberts, Amity L

    BioMed research international

    2015  Volume 2015, Page(s) 834371

    Abstract: Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of ... ...

    Abstract Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus possessing any specific distinguishing clinical features. Because the outcomes and management strategies for these two viruses are vastly different, early and accurate diagnosis is imperative. Diagnosis is also important for surveillance, outbreak control, and research related to vaccine and drug development. Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response. In this review, we describe the recent progress and continued challenges related to the diagnosis of DENV and CHIKV infections.
    MeSH term(s) Aedes/virology ; Animals ; Chikungunya Fever/diagnosis ; Chikungunya Fever/transmission ; Chikungunya Fever/virology ; Chikungunya virus/genetics ; Chikungunya virus/isolation & purification ; Chikungunya virus/pathogenicity ; Dengue/diagnosis ; Dengue/transmission ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Dengue Virus/pathogenicity ; Disease Outbreaks ; Humans ; Insect Vectors/virology
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2015/834371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Malignant sarcomatous transformation of fibrous dysplasia.

    Mardekian, Stacey K / Tuluc, Madalina

    Head and neck pathology

    2014  Volume 9, Issue 1, Page(s) 100–103

    Abstract: A case of osteosarcoma developing from fibrous dysplasia of the sphenoid bone in a 59-year-old female will be discussed. The characteristic radiologic and histologic features of the entity will be described. ...

    Abstract A case of osteosarcoma developing from fibrous dysplasia of the sphenoid bone in a 59-year-old female will be discussed. The characteristic radiologic and histologic features of the entity will be described.
    MeSH term(s) Bone Neoplasms/pathology ; Cell Transformation, Neoplastic/pathology ; Female ; Fibrous Dysplasia of Bone/pathology ; Humans ; Middle Aged ; Osteosarcoma/pathology
    Language English
    Publishing date 2014-08-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-014-0567-z
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  6. Article ; Online: Ductal carcinoma in situ of the breast: the importance of morphologic and molecular interactions.

    Mardekian, Stacey K / Bombonati, Alessandro / Palazzo, Juan P

    Human pathology

    2016  Volume 49, Page(s) 114–123

    Abstract: Ductal carcinoma in situ (DCIS) of the breast is a lesion characterized by significant heterogeneity, in terms of morphology, immunohistochemical staining, molecular signatures, and clinical expression. For some patients, surgical excision provides ... ...

    Abstract Ductal carcinoma in situ (DCIS) of the breast is a lesion characterized by significant heterogeneity, in terms of morphology, immunohistochemical staining, molecular signatures, and clinical expression. For some patients, surgical excision provides adequate treatment, but a subset of patients will experience recurrence of DCIS or progression to invasive ductal carcinoma (IDC). Recent years have seen extensive research aimed at identifying the molecular events that characterize the transition from normal epithelium to DCIS and IDC. Tumor epithelial cells, myoepithelial cells, and stromal cells undergo alterations in gene expression, which are most important in the early stages of breast carcinogenesis. Epigenetic modifications, such as DNA methylation, together with microRNA alterations, play a major role in these genetic events. In addition, tumor proliferation and invasion is facilitated by the lesional microenvironment, which includes stromal fibroblasts and macrophages that secrete growth factors and angiogenesis-promoting substances. Characterization of DCIS on a molecular level may better account for the heterogeneity of these lesions and how this manifests as differences in patient outcome and response to therapy. Molecular assays originally developed for assessing likelihood of recurrence in IDC are recently being applied to DCIS, with promising results. In the future, the classification of DCIS will likely incorporate molecular findings along with histologic and immunohistochemical features, allowing for personalized prognostic information and therapeutic options for patients with DCIS. This review summarizes current data regarding the molecular characterization of DCIS and discusses the potential clinical relevance.
    MeSH term(s) Animals ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biopsy ; Breast Neoplasms/chemistry ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma/chemistry ; Carcinoma/genetics ; Carcinoma/pathology ; Carcinoma, Intraductal, Noninfiltrating/chemistry ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/therapy ; Disease Progression ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; Mastectomy ; Molecular Diagnostic Techniques ; Neoplasm Recurrence, Local ; Phenotype ; Predictive Value of Tests ; Reproducibility of Results ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2015.11.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 722: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Diagnostic Options and Challenges for Dengue and Chikungunya Viruses

    Stacey K. Mardekian / Amity L. Roberts

    BioMed Research International, Vol

    2015  Volume 2015

    Abstract: Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of ... ...

    Abstract Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus possessing any specific distinguishing clinical features. Because the outcomes and management strategies for these two viruses are vastly different, early and accurate diagnosis is imperative. Diagnosis is also important for surveillance, outbreak control, and research related to vaccine and drug development. Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response. In this review, we describe the recent progress and continued challenges related to the diagnosis of DENV and CHIKV infections.
    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Assessment of quality and consistency of monoclonal antibodies for CB1 and CB2 in head and neck squamous cell carcinoma.

    Daniels, Kelly E / Luginbuhl, Adam J / Mardekian, Stacey K / Cognetti, David M / Curry, Joseph M / South, Andrew P

    Head & neck

    2019  Volume 41, Issue 9, Page(s) 3105–3113

    Abstract: Background: Marijuana has numerous roles as an agonist in the endocannabinoid signaling system (ESS). This study evaluated monoclonal antibodies across experimental techniques to establish a framework for studying ESS receptors, CB1 and CB2.: Methods!# ...

    Abstract Background: Marijuana has numerous roles as an agonist in the endocannabinoid signaling system (ESS). This study evaluated monoclonal antibodies across experimental techniques to establish a framework for studying ESS receptors, CB1 and CB2.
    Methods: Tissue from five patients with head and neck cancer were used to generate cell lines and formalin-fixed paraffin-embedded (FFPE) sections, which were analyzed by western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Subgroup analysis was performed on FFPE sections from 8 marijuana users and 10 controls by IHC. Results were compared across methods for consistency.
    Results: In all patients, WB and IF were CB1 positive, whereas IHC was negative. Select samples were CB2 positive by WB, but failed IF and IHC applications. In subgroup analysis, 1 of 8 users and 3 of 10 nonusers were CB1 positive.
    Conclusions: Interpretation of CB1/CB2 antibody data should be performed cautiously and confirmation of findings across multiple experimental methods is recommended.
    MeSH term(s) Aged ; Antibodies, Monoclonal/metabolism ; Biopsy ; Blotting, Western ; Cannabis/immunology ; Case-Control Studies ; Cell Line, Tumor ; Female ; Fluorescent Antibody Technique ; Head and Neck Neoplasms/immunology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Squamous Cell Carcinoma of Head and Neck/immunology
    Chemical Substances Antibodies, Monoclonal ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.25794
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Two interesting cases of intracranial IgG4-related disease and discussion of therapy options.

    Fortuna, Danielle / Mardekian, Stacey K / Garchow, Barry / Evans, James / Kiriakidou, Marianthi / Curtis, Mark T

    Clinical and experimental rheumatology

    2016  Volume 34, Issue 6, Page(s) 1126–1127

    MeSH term(s) Autoimmune Diseases/diagnostic imaging ; Autoimmune Diseases/drug therapy ; Brain Diseases/diagnostic imaging ; Brain Diseases/drug therapy ; Female ; Humans ; Immunoglobulin G ; Immunologic Factors/therapeutic use ; Magnetic Resonance Imaging ; Middle Aged ; Prednisone/therapeutic use ; Rituximab/therapeutic use ; Treatment Outcome
    Chemical Substances Immunoglobulin G ; Immunologic Factors ; Rituximab (4F4X42SYQ6) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2016-11
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Cytological interpretation of p16 immunohistochemistry in head and neck carcinomas: does the choice of fixative matter?

    Gargano, Stacey M / Sebastiano, Christopher / Mardekian, Jack / Solomides, Charalambos C / HooKim, Kim

    Journal of the American Society of Cytopathology

    2020  Volume 10, Issue 2, Page(s) 216–224

    Abstract: Introduction: Fine-needle aspiration (FNA) of nodal metastases plays a key role in the diagnosis of oropharyngeal squamous cell carcinoma (OPSCC). Because of significant clinical implications of human papillomavirus (HPV)-related OPSCC, ... ...

    Abstract Introduction: Fine-needle aspiration (FNA) of nodal metastases plays a key role in the diagnosis of oropharyngeal squamous cell carcinoma (OPSCC). Because of significant clinical implications of human papillomavirus (HPV)-related OPSCC, immunohistochemistry for p16 as a surrogate marker for high-risk HPV is an important ancillary test. After our laboratory switched from CytoLyt to formalin fixative for FNA needle rinses generating cell block (CB) material, we investigated the impact of this protocol change on the accuracy of p16 results.
    Materials and methods: FNA specimens of head and neck lesions with p16 staining performed on CB, from 1 year before and after the implementation of formalin-fixed CB (FCB) were identified. Nuclear and cytoplasmic p16 expression was scored and compared to p16 status on corresponding surgical specimens.
    Results: There were no false-positive results with either fixative. CytoLyt-fixed CB (CCB) had 47% (7 of 15) false-negative cases, whereas FCB had none, with 100% diagnostic accuracy for p16-negative (n = 6) and p16-positive (n = 15) results. False-negative CCB showed 0% to 10% nuclear and 0% to 65% weak cytoplasmic staining, whereas true-positive CCB showed 10% to 85% nuclear and 35% to 90% cytoplasmic staining. p16-negative FCB showed 0% nuclear and cytoplasmic staining, and p16-positive FCB showed 30% to 100% moderate-strong nuclear and cytoplasmic staining. Interobserver variability was greater with CCB.
    Conclusions: In our laboratory, formalin fixation of CB material improved the accuracy of p16 interpretation. Staining in FCB was also more robust than CCB, which showed weaker cytoplasmic and more focal nuclear staining. Therefore, we advocate formalin fixation for head and neck cytology specimens that may require p16 testing.
    MeSH term(s) Biopsy, Fine-Needle ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cytological Techniques/methods ; Fixatives ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/pathology ; Humans ; Immunohistochemistry/methods ; Retrospective Studies ; Tissue Fixation/methods
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16 ; Fixatives
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 2213-2945
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2020.09.012
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