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  1. Article: Chemopreventive effects of Xiang Sha Liu Jun Zi Tang on paclitaxel-induced leucopenia and neuropathy in animals.

    Shiah, Her-Shyong / Lee, Chia-Jung / Lee, Fang-Yu / Tseng, Sung-Hui / Chen, Shih-Han / Wang, Ching-Chiung

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1106030

    Abstract: ... widely use Xiang Sha Liu Jun Zi Tang (XSLJZT) to treat breast cancer patients who have received ...

    Abstract Paclitaxel frequently induces peripheral neuropathy and myelosuppression during cancer treatment. According to the National Health Insurance Research Database of Taiwan, traditional Chinese medicine doctors widely use Xiang Sha Liu Jun Zi Tang (XSLJZT) to treat breast cancer patients who have received paclitaxel. We explored the combined therapeutic effects of XSLZJT with paclitaxel. XSLJZT did not exhibit significant cytotoxic effects on P388-D1 cells; however, the combination of XSLJZT (100 and 500 mg/kg) with paclitaxel prolonged the survival rate in P388-D1 tumor-bearing mice compared to paclitaxel-only. In addition, XSLJZT was found to enhance white blood cells (WBC) counts and promote leukocyte rebound in paclitaxel-induced leukopenia in mice. XSLJZT also reduced paclitaxel-induced mechanical pain and inhibited c-Fos protein expression in the L4-6 spinal cords of Wistar rats. Moreover, paclitaxel-induced shortening of the nerve fibers of dorsal root ganglion cells was ameliorated by pre-treatment with XSLJZT. Therefore, we suggest that XSLJZT could be used as an adjunct for cancer patients, as the formula could decrease paclitaxel-induced neuropathy and myelosuppression.
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1106030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Xiang Qin Kang Gan Granules Treated the Human Coronavirus 229E Induced Pneumonia with Damp-Heat Syndrome in Mice.

    Cao, Fang / Liu, Zhaoheng / Hao, Qingxun / Zhao, Ronghua / Bao, Lei / Cui, Xiaolan / Jiao, Yang

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2022  Volume 2022, Page(s) 7609550

    Abstract: Coronavirus disease 2019 (COVID-19), which causes severe respiratory illness, was first reported in Wuhan, China. The etiology of the disease is a new novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was ... ...

    Abstract Coronavirus disease 2019 (COVID-19), which causes severe respiratory illness, was first reported in Wuhan, China. The etiology of the disease is a new novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was reported to share the same origin as SARS-CoV, causing severe public health events in 2002. Unlike the SARS-CoV, which was conquered in the early summer of 2003, this virus was still contagious widely and reached a pandemic level. It can still spread fast even if the season's temperature is raised. Here, we made a model of pneumonia of human coronavirus 229E (HCoV-229E) with damp-heat syndrome treated by Xiangqin Kanggan granules to find a new medicine for treating these kinds of infectious diseases coronaviruses induced.
    Language English
    Publishing date 2022-09-23
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2022/7609550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes

    Alinafe Magret Kapelemera / Yow-Shieng Uang / Li-Hsuan Wang / Tien-Yuan Wu / Fang-Yu Lee / Li Tai / Ching-Chiung Wang / Chia-Jung Lee

    Frontiers in Pharmacology, Vol

    2022  Volume 13

    Abstract: ... before, during, and after chemotherapy. Xiang-Sha-Liu-Jun-Zi Tang (XSLJZT) is a herbal formula commonly used ...

    Abstract Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects. Herbal medicines are commonly used to treat the side effects of chemotherapy. They can be administered before, during, and after chemotherapy. Xiang-Sha-Liu-Jun-Zi Tang (XSLJZT) is a herbal formula commonly used in breast cancer patients. The main purpose of this study was to assess the pharmacokinetic (PK) influence of XSLJZT on paclitaxel PK parameters, determine its effect on CYP-450 enzyme expression, and evaluate its effect on enzyme activity. Sprague Dawley rats were classified into pretreatment and co-treatment groups, where XSLJZT was pre-administered for 3, 5, and 7 days and co-administered 2 h before paclitaxel administration. The rat liver tissues and Hep-G2 cells were used to determine the effects of XSLJZT on CYP3A1/2 and CYP3A4 enzymes respectively. Western blot analysis was used to detect changes in the CYP3A1/2 and CYP3A4 enzymes expression. The influence of XSLJZT on enzyme activity was evaluated using human liver microsomes, and a liquid chromatography-tandem mass spectrometric system was developed to monitor paclitaxel levels in rat plasma. Results demonstrated that XSLJZT increased the area under the concentration versus time curve (AUC) for paclitaxel in pretreatment groups by 2-, 3-, and 4-fold after 3, 5, and 7 days, respectively. In contrast, no significant change in the AUC was observed in the co-treatment group. However, the half-life was prolonged in all groups from 17.11 min to a maximum of 37.56 min. XSLJZT inhibited CYP3A1/2 expression in the rat liver tissues and CYP3A4 enzymes in Hep-G2 cells in a time-dependent manner, with the highest inhibition observed after 7 days of pretreatment in rat liver tissues. In the enzyme kinetics study, XSLJZT inhibited enzyme activity in a competitive dose-dependent manner. In conclusion, there is a potential interaction between XSLJZT and paclitaxel at ...
    Keywords traditional Chinese medicine formula ; Xiang-Sha-Liu-Jun-Zi tang ; paclitaxel ; pharmacokinetics ; enzyme kinetics ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: [Scale effect of Li-Xiang Railway construction impact on landscape pattern and its ecological risk].

    Wang, De-zhi / Qiu, Peng-hua / Fang, Yuan-min

    Ying yong sheng tai xue bao = The journal of applied ecology

    2015  Volume 26, Issue 8, Page(s) 2493–2503

    Abstract: ... of Li-Xiang Railway as study object, and using present land use map (1:10000) in 2012 and DEM ...

    Abstract As a large corridor project, plateau railway has multiple points and passes various sensitive environments along the railway. The determination of the scope of impact on ecological environment from railway construction is often controversial in ecological impact assessment work. Taking the Tangbu-Jiantang section of Li-Xiang Railway as study object, and using present land use map (1:10000) in 2012 and DEM as data sources, corridor cutting degree index ( CCI) and cumulative effect index of corridor (CCEI) were established by topology, buffer zone and landscape metrics methods. Besides, the ecological risk index used for railway construction was improved. By quantitative analysis of characteristics of the spatio-temporal change of landscape pattern and its evolution style at different spatial scales before and after railway construction, the most appropriate evaluation scale of the railway was obtained. Then the characteristics of the spatio-temporal variation of ecological risk within this scale before and after railway construction were analyzed. The results indicated that the cutting model and degree of railway corridor to various landscape types could be effectively reflected by CCI, and the exposure and harm relations between risk sources and risk receptors of railway can be measured by CCEI. After the railway construction, the railway corridor would cause a great deal of middle cutting effect on the landscape along the railroad, which would influence wood land and grassland landscape most greatly, while would cause less effect of edge cutting and internal cutting. Landscape indices within the 600 m buffer zone demonstrated the most obvious scale effect, therefore, the 600 m zone of the railway was set as the most suitable range of ecological impact assessment. Before railway construction, the low ecological risk level covered the biggest part of the 600 m assessment zone. However, after the railway construction, the ecological risk increased significantly, and the most part of the study area was at the moderate ecological risk level. The ecological risk presented ring-shaped and multi-kernel patterns, and was lower in the southern part than in the northern part of the study area.
    MeSH term(s) China ; Conservation of Natural Resources ; Ecology ; Environment ; Models, Theoretical ; Railroads ; Risk Assessment ; Spatio-Temporal Analysis
    Language Chinese
    Publishing date 2015-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Tu shuo xiang qi yin dao zhan shu

    Wang, Guodong / Fang, Shiqing / Li, Yangui

    2008  

    Title variant Tushuo xiangqi yindao zhanshu ; T'u-shuo-hsiang-ch'i-yin-tao-chan-shu / Wang K'uo-tung, Fang Shih-ch'ing, Li Yan-kui p'ien-chu
    Author's details Wang Guodong, Fang Shiqing, Li Yangui bianzhu
    Keywords Chinesisches Schach
    Language Chinese
    Size 415 S, graph. Darst.
    Publisher Jin dun chu ban she
    Publishing place Beijing
    Document type Book
    Note In chines. Schr.
    ISBN 9787508250564 ; 7508250567
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book: Shen jing nei ke ji bing ying xiang zhen duan si wei

    Fang, Yannan

    2014  

    Author's details zhu bian Fang Yannan , Luo Boning, Chen Shaoqiong, Zhang Aiwu
    MeSH term(s) Nervous System Diseases/diagnosis ; Diagnostic Imaging/methods
    Language Chinese
    Size 2, 2, 293 pages :, illustrations
    Edition Di 2 ban.
    Document type Book
    ISBN 9787535958891 ; 7535958893
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Zhongguo xian dai xue shu si xiang shi lun ji

    Zhang, Maoze / Zhang, Qizhi / Hou, Qie'an / Fang, Guanghua

    (Xi bu ren wen xue shu cong shu ; 西部人文学术丛书)

    2003  

    Author's details Zhang Maoze, Hou Qie'an, Fang Guanghua zhu; Zhang Qizhi zhu bian
    Series title Xi bu ren wen xue shu cong shu
    西部人文学术丛书
    Language Chinese
    Size 5, 2, 573 S
    Edition Di 1 ban
    Publisher Shanxi ren min chu ban she
    Publishing place Xi'an
    Document type Book
    ISBN 7224068152 ; 9787224068153
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  8. Book: Wei mei zhi shang. Biao xiang zhu yi you hua ming jia xi lie

    Li, Fang

    Xia Xiaowan, Ren Rong, Liu Ye, Ji Dachun, Xu He = Aestheticism supremacy : image oil painting masters series

    (Zhongguo yi shu jia zhi zui cong shu = Chinese top artists series ; 中国艺术家之最丛书 = Chinese top artists series)

    2007  

    Author's details Li Fang zhu
    Series title Zhongguo yi shu jia zhi zui cong shu = Chinese top artists series
    中国艺术家之最丛书 = Chinese top artists series
    Language Chinese
    Size 135 p, Ill
    Edition Di 1 ban
    Publisher Tianjin Yang liu qing hua she
    Publishing place Tianjin
    Document type Book
    ISBN 9787807382287 ; 7807382287
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Guang dong, guang xi, fu jian, hai nan, xiang gang, ao men, tai wan

    Gu, Fang

    (Zhong guo chu tu yu qi quan ji : 中国出土玉器全集 ; / Gu fang zhu bian ; 11)

    2005  

    Title variant Guangdong, Guangxi, Fujian, Hainan, Xianggang, Aomen, Taiwan
    Series title Zhong guo chu tu yu qi quan ji : 中国出土玉器全集
    / Gu fang zhu bian ; 11
    Language Chinese ; English
    Size x, 240 p, col. ill, 30 cm
    Edition Di 1 ban
    Publisher Ke xue chu ban she
    Publishing place Bei jing
    Document type Book
    Note Hier auch später erschienene, unveränderte Nachdrucke
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: She hui zhu yi si xiang shi

    Gao, Fang / Huang, Daqiang

    1987  

    Author's details Gao fang, huang da qiang zhu bian
    Language Chinese
    Edition Di 1 ban
    Publisher Zhong guo ren min chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 7300001513 ; 9787300001517
    Database Former special subject collection: coastal and deep sea fishing

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