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Article ; Online: Battery Testing and Discharge Model Validation for Electric Unmanned Aerial Vehicles (UAV).

Di Nisio, Attilio / Avanzini, Giulio / Lotano, Daniel / Stigliano, Donato / Lanzolla, Anna M L

2023 Volume 23, Issue 15

Abstract: Electrical engines are becoming more common than thermal ones. Therefore, there is an increasing interest in the characterization of batteries and in measuring their state of charge, as an overestimation would cause the vehicle to run out of energy and ... ...

Abstract	Electrical engines are becoming more common than thermal ones. Therefore, there is an increasing interest in the characterization of batteries and in measuring their state of charge, as an overestimation would cause the vehicle to run out of energy and an underestimation means that the vehicle is running in suboptimal conditions. This is of paramount importance for flying vehicles, as their endurance decreases with the increase in weight. This work aims at finding a novel empirical model for the discharge curve of an arbitrary number of battery pack cells, that uses as few tunable parameters as possible and hence is easy to adapt for every single battery pack needed by the operator. A suitable measurement setup for battery tests, which includes voltage and current sensors, has been developed and described. Tests are performed on both constant and variable power loads to investigate different real-world scenarios that are easy to reproduce. The main achievement of this novel model is indeed the ability to predict discharges at variable power based on a preliminary characterization performed at constant power. This leads to the possibility of rapidly tuning the model for each battery with promising accuracy. The results will show that the predicted discharged capacities of the model have a normalized error below 0.7%.
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23156937
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Article ; Online: Potentiometric Chloride Ion Biosensor for Cystic Fibrosis Diagnosis and Management: Modeling and Design.

la Grasta, Annabella / De Carlo, Martino / Di Nisio, Attilio / Dell'Olio, Francesco / Passaro, Vittorio M N

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 5

Abstract: ... of chloride ions in sweat with a limit-of-detection of 0.004 mol/m ...

Abstract	The ion-sensitive field-effect transistor is a well-established electronic device typically used for pH sensing. The usability of the device for detecting other biomarkers in easily accessible biologic fluids, with dynamic range and resolution compliant with high-impact medical applications, is still an open research topic. Here, we report on an ion-sensitive field-effect transistor that is able to detect the presence of chloride ions in sweat with a limit-of-detection of 0.004 mol/m
MeSH term(s)	Humans ; Cystic Fibrosis ; Chlorides/chemistry ; Sweating ; Potentiometry ; Biosensing Techniques
Chemical Substances	Chlorides
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23052491
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Article ; Online: Risk Assessment Models for Thrombosis and Anticoagulant-Related Bleeding in Ambulatory Cancer Patients.

Candeloro, Matteo / Guman, Noori A M / Kraaijpoel, Noémie / Di Nisio, Marcello

Seminars in thrombosis and hemostasis

2021 Volume 47, Issue 8, Page(s) 972–981

Abstract: Cancer patients have a high risk of developing venous thromboembolism and arterial thrombosis, along with an increased risk of anticoagulant-related bleeding with primary and secondary prophylaxis of cancer-associated thrombosis. Decisions on initiation, ...

Abstract	Cancer patients have a high risk of developing venous thromboembolism and arterial thrombosis, along with an increased risk of anticoagulant-related bleeding with primary and secondary prophylaxis of cancer-associated thrombosis. Decisions on initiation, dosing, and duration of anticoagulant therapy for prevention and treatment of cancer-associated thrombosis are challenging, as clinicians have to balance patients' individual risk of (recurrent) thrombosis against the risk of bleeding complications. For this purpose, several dedicated risk assessment models for venous thromboembolism in cancer patients have been suggested. However, most of these scores perform poorly and have received limited to no validation. For bleeding and arterial thrombosis, no risk scores have been developed specifically for cancer patients, and treatment decisions remain based on clinical gestalt and rough and unstructured estimation of the risks. The aims of this review are to summarize the characteristics and performance of risk assessment scores for (recurrent) venous thromboembolism and discuss available data on risk assessment for bleeding and arterial thrombosis in the cancer population. This summary can help clinicians in daily practice to make a balanced decision when considering the use of risk assessment models for cancer-associated venous thromboembolism. Future research attempts should aim at improving risk assessment for arterial thrombosis and anticoagulant-related bleeding in cancer patients.
MeSH term(s)	Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Risk Assessment ; Risk Factors ; Thrombosis/drug therapy ; Venous Thromboembolism/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0040-1722608
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Article ; Online: Update on bioethical, medical and fertility issues in gender incongruence during transition age.

Conflitti, A C / Spaziani, M / Pallotti, F / Tarsitano, M G / Di Nisio, A / Paoli, D / Lombardo, F

Journal of endocrinological investigation

2023 Volume 46, Issue 9, Page(s) 1725–1736

Abstract: Purpose: Many issues still remain unresolved in the management of pubertal patients with gender incongruence (GI). The aim of this review is to discuss the main aspects of the treatment of these patients to provide a practical approach for clinicians.!## ...

Abstract	Purpose: Many issues still remain unresolved in the management of pubertal patients with gender incongruence (GI). The aim of this review is to discuss the main aspects of the treatment of these patients to provide a practical approach for clinicians. Methods: A comprehensive literature search within PubMed was performed to provide updates of available evidence regarding the impact on bioethical, medical and fertility issues in gender incongruence during transition age. Results: Gender Affirming Hormone Treatment (GAHT) and Gender Affirming Surgery (GAS) can induce unsatisfaction with change, future regrets, and the risk of infertility. This raises ethical issues especially in the management of pubertal patients that remain unresolved. Therapy with GnRH analogues (GnRHa) is intended to delay puberty, so as to give the adolescent a longer period of time to decide whether to continue with the treatments. At the level of physical changes, this therapy may have an effect on bone mineralization and body composition; however, long-term longitudinal data are not yet available. An important feature related to the use of GnRHa is the risk of fertility. Gamete cryopreservation is the most established method of fertility preservation (FP) and should be counselled to transgender adolescents. However, these patients are not always interested in having biological children. Conclusion: Based on the current evidence, there is a need to conduct further research to clarify certain issues and to standardize clinical practice and improve counselling in transgender adolescent decision making and avoid regrets in the future.
MeSH term(s)	Child ; Adolescent ; Humans ; Fertility Preservation ; Counseling ; Infertility ; Cryopreservation ; Transsexualism ; Transgender Persons ; Gender Dysphoria/drug therapy ; Gender Identity
Language	English
Publishing date	2023-04-18
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-023-02077-5
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Article ; Online: Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome.

Foresta, C / Rocca, M S / Di Nisio, A

Journal of endocrinological investigation

2020 Volume 44, Issue 5, Page(s) 951–956

Abstract: Background: The recent emergence of COVID-19 poses a global health emergency. One of the most frequently reported data is sex-related severity and mortality: according to the last available analysis on 239,709 patients in Italy, lethality is 17.7% in ... ...

Abstract	Background: The recent emergence of COVID-19 poses a global health emergency. One of the most frequently reported data is sex-related severity and mortality: according to the last available analysis on 239,709 patients in Italy, lethality is 17.7% in men and 10.8% in women, with 59% of total deaths being men. Interestingly, the infection rate is lower in males than in females, with 45.8% and 54.2% of positive cases, respectively, suggesting that gender-related factor may worsen disease evolution. A tentative hypothesis to explain these findings is the role of angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 involved in viral infection. Purpose: In this review, we summarize the available evidence pointing to gender-related differences in ACE2 and TMPRSS2 expression, from both genetic and endocrine points of view. Results: Altogether, available evidence points toward two not-mutually exclusive mechanisms in gender susceptibility to COVID-19 by sex hormonal regulation of ACE2 and TMPRSS2. On one hand, ACE2 expression could be increased in women, either by estrogens or constitutively by X chromosome inactivation escape or by reduced methylation, providing a larger reservoir of ACE2 to maintain the fundamental equilibrium of RAS regulatory axis. On the other, low levels of androgens in women may keep at low levels TMPRSS2 expression, representing a further protective factor for the development of COVID-19 infection, despite the increased expression of ACE2, which represents the Trojan horse for SARS-CoV-2 entry. Conclusions: Both mechanisms consistently point to the role of sex hormones and sex chromosomes in the differential severity and lethality of COVID-19 in men and women.
MeSH term(s)	Angiotensin-Converting Enzyme 2/blood ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/epidemiology ; COVID-19/genetics ; Chromosomes, Human, X/genetics ; Female ; Genetic Predisposition to Disease/epidemiology ; Gonadal Steroid Hormones ; Humans ; Male ; Serine Endopeptidases/blood ; Serine Endopeptidases/genetics ; Sex Characteristics ; Sex Factors
Chemical Substances	Gonadal Steroid Hormones ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
Keywords	covid19
Language	English
Publishing date	2020-09-16
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-020-01383-6
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Article ; Online: Discovery and characterization of noncanonical E2-conjugating enzymes.

Abdul Rehman, Syed Arif / Cazzaniga, Chiara / Di Nisio, Elena / Antico, Odetta / Knebel, Axel / Johnson, Clare / Şahin, Alp T / Ibrahim, Peter E G F / Lamoliatte, Frederic / Negri, Rodolfo / Muqit, Miratul M K / De Cesare, Virginia

Science advances

2024 Volume 10, Issue 13, Page(s) eadh0123

Abstract: E2-conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the attachment of ubiquitin to a substrate. This process, termed ubiquitylation, is required to maintain cellular homeostasis and affects almost all cellular process. ...

Abstract	E2-conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the attachment of ubiquitin to a substrate. This process, termed ubiquitylation, is required to maintain cellular homeostasis and affects almost all cellular process. By interacting with multiple E3 ligases, E2s dictate the ubiquitylation landscape within the cell. Since its discovery, ubiquitylation has been regarded as a posttranslational modification that specifically targets lysine side chains (canonical ubiquitylation). We used Matrix-Assisted Laser Desorption/Ionization-Time Of Flight Mass Spectrometry to identify and characterize a family of E2s that are instead able to conjugate ubiquitin to serine and/or threonine. We used structural modeling and prediction tools to identify the key activity determinants that these E2s use to interact with ubiquitin as well as their substrates. Our results unveil the missing E2s necessary for noncanonical ubiquitylation, underscoring the adaptability and versatility of ubiquitin modifications.
MeSH term(s)	Ubiquitin-Conjugating Enzymes/chemistry ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Ubiquitin/metabolism ; Protein Processing, Post-Translational
Chemical Substances	Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ubiquitin
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adh0123
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Article ; Online: Venous thromboembolism in cancer patients: ESMO Clinical Practice Guideline.

Falanga, A / Ay, C / Di Nisio, M / Gerotziafas, G / Jara-Palomares, L / Langer, F / Lecumberri, R / Mandala, M / Maraveyas, A / Pabinger, I / Sinn, M / Syrigos, K / Young, A / Jordan, K

Annals of oncology : official journal of the European Society for Medical Oncology

2023 Volume 34, Issue 5, Page(s) 452–467

MeSH term(s)	Humans ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/therapy ; Anticoagulants/therapeutic use ; Risk Factors ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Practice Guideline ; Research Support, Non-U.S. Gov't ; Journal Article
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2022.12.014
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Zs.A 2862: Show issues

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Article ; Online: Direct oral anticoagulants: The new standard of care for cancer associated thrombosis.

Di Nisio, Marcello / Lee, Agnes Y

European journal of internal medicine

2024

Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2024.03.005
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Article ; Online: Thermal Characterization of New 3D-Printed Bendable, Coplanar Capacitive Sensors.

Ragolia, Mattia Alessandro / Lanzolla, Anna M L / Percoco, Gianluca / Stano, Gianni / Di Nisio, Attilio

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 19

Abstract: In this paper a new low-cost stretchable coplanar capacitive sensor for liquid level sensing is presented. It has been 3D-printed by employing commercial thermoplastic polyurethane (TPU) and conductive materials and using a fused filament fabrication ( ... ...

Abstract	In this paper a new low-cost stretchable coplanar capacitive sensor for liquid level sensing is presented. It has been 3D-printed by employing commercial thermoplastic polyurethane (TPU) and conductive materials and using a fused filament fabrication (FFF) process for monolithic fabrication. The sensor presents high linearity and good repeatability when measuring sunflower oil level. Experiments were performed to analyse the behaviour of the developed sensor when applying bending stimuli, in order to verify its flexibility, and a thermal characterization was performed in the temperature range from 10 °C to 40 °C to evaluate its effect on sunflower oil level measurement. The experimental results showed negligible sensitivity of the sensor to bending stimuli, whereas the thermal characterization produced a model describing the relationship between capacitance, temperature, and oil level, allowing temperature compensation in oil level measurement. The different temperature cycles allowed to quantify the main sources of uncertainty, and their effect on level measurement was evaluated.
MeSH term(s)	Electric Capacitance ; Electric Conductivity ; Polyurethanes ; Printing, Three-Dimensional ; Temperature
Chemical Substances	Polyurethanes
Language	English
Publishing date	2021-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21196324
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Article ; Online: Risk factors on testicular function in adolescents.

Cargnelutti, F / Di Nisio, A / Pallotti, F / Spaziani, M / Tarsitano, M G / Paoli, D / Foresta, C

Journal of endocrinological investigation

2022 Volume 45, Issue 9, Page(s) 1625–1639

Abstract: Purpose: Adolescence represents an important window for gonadal development. The aim of this review is to carry out a critical excursus of the most recent literature on endogenous and exogenous risk factors related to testicular function, focusing the ... ...

Abstract	Purpose: Adolescence represents an important window for gonadal development. The aim of this review is to carry out a critical excursus of the most recent literature on endogenous and exogenous risk factors related to testicular function, focusing the research on adolescence period. Methods: A comprehensive literature search within PubMed was performed to provide a summary of currently available evidence regarding the impact on adolescence of varicocele, cryptorchidism, cancer, diabetes, lifestyle factors, endocrine disruptors, obesity and sexually transmitted diseases. We focused on human studies that evaluated a possible impact of these factors on puberty timing and their effects on andrological health. Results: Evidence collected seems to suggest that andrological health in adolescence may be impaired by several factors, as varicocele, cryptorchidism, and childhood cancer. Despite an early diagnosis and treatment, many adolescents might still have symptoms and sign of a testicular dysfunction in their adult life and at the current time it is not possible to predict which of them will experience andrological problems. Lifestyle factors might have a role in these discrepancies. Most studies point out towards a correlation between obesity, insulin resistance, alcohol, smoking, use of illegal drugs and testicular function in pubertal boys. Also, endocrine disruptors and sexually transmitted diseases might contribute to impair reproductive health, but more studies in adolescents are needed. Conclusion: According to currently available evidence, there is an emerging global adverse trend of high-risk and unhealthy behaviors in male adolescents. A significant proportion of young men with unsuspected and undiagnosed andrological disorders engage in behaviors that could impair testicular development and function, with an increased risk for later male infertility and/or hypogonadism during the adult life. Therefore, adolescence should be considered a key time for intervention and prevention of later andrological diseases.
MeSH term(s)	Adolescent ; Adult ; Child ; Cryptorchidism ; Endocrine Disruptors/adverse effects ; Humans ; Male ; Obesity/complications ; Risk Factors ; Testis ; Varicocele
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2022-03-14
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-022-01769-8
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