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  1. Article: Tardive Dyskinesia: Spotlight on Current Approaches to Treatment.

    Debrey, Sarah M / Goldsmith, David R

    Focus (American Psychiatric Publishing)

    2021  Volume 19, Issue 1, Page(s) 14–23

    Abstract: Tardive dyskinesia (TD) is a debilitating, iatrogenic, and potentially severe movement disorder characterized by involuntary, repetitive, purposeless movements that are present throughout the body. The authors present a review of studies of past, current, ...

    Abstract Tardive dyskinesia (TD) is a debilitating, iatrogenic, and potentially severe movement disorder characterized by involuntary, repetitive, purposeless movements that are present throughout the body. The authors present a review of studies of past, current, and possible future treatment approaches to the management of TD; consider the phenomenology, assessment, and putative pathophysiological mechanisms of TD, early pharmacological trials, a focus on the newer vesicular monoamine transporter 2 inhibitors, and other evidence-based approaches, such as clozapine; and present preliminary evidence for newer approaches, such as deep brain stimulation and repetitive transcranial magnetic stimulation. On the basis of the evidence presented here, the authors highlight the importance of early recognition and assessment of TD, as well as how to best approach management of these often incapacitating symptoms.
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 1541-4094
    ISSN 1541-4094
    DOI 10.1176/appi.focus.20200038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Chart-Stimulated Recall Activity to Assess Psychiatry Residents' Treatment-Based, Clinical Reasoning Skills.

    Rakofsky, Jeffrey J / Stoddard, Hugh A / Haroon, Ebrahim / Hermida, Adriana P / Debrey, Sarah M / Crowell, Andrea L / Dunlop, Boadie W

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2023  Volume 47, Issue 6, Page(s) 663–666

    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-023-01789-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2043: Show issues Location:
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  3. Article ; Online: Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series.

    Debrey, Sarah M / Leehey, Maureen A / Klepitskaya, Olga / Filley, Christopher M / Shah, Raj C / Kluger, Benzi / Berry-Kravis, Elizabeth / Spector, Elaine / Tassone, Flora / Hall, Deborah A

    Cerebellum (London, England)

    2016  Volume 15, Issue 5, Page(s) 623–631

    Abstract: Considerable research has focused on patients with trinucleotide (CGG) repeat expansions in the fragile X mental retardation 1 (FMR1) gene that fall within either the full mutation (>200 repeats) or premutation range (55-200 repeats). Recent interest in ... ...

    Abstract Considerable research has focused on patients with trinucleotide (CGG) repeat expansions in the fragile X mental retardation 1 (FMR1) gene that fall within either the full mutation (>200 repeats) or premutation range (55-200 repeats). Recent interest in individuals with gray zone expansions (41-54 CGG repeats) has grown due to reported phenotypes that are similar to those observed in premutation carriers, including neurological, molecular, and cognitive signs. The purpose of this manuscript is to describe a series of adults with FMR1 alleles in the gray zone presenting with movement disorders or memory loss. Gray zone carriers ascertained in large FMR1 screening studies were identified and their clinical phenotypes studied. Thirty-one gray zone allele carriers were included, with mean age of symptom onset of 53 years in patients with movement disorders and 57 years in those with memory loss. Four patients were chosen for illustrative case reports and had the following diagnoses: early-onset Parkinson disease (PD), atypical parkinsonism, dementia, and atypical essential tremor. Some gray zone carriers presenting with parkinsonism had typical features, including bradykinesia, rigidity, and a positive response to dopaminergic medication. These patients had a higher prevalence of peripheral neuropathy and psychiatric complaints than would be expected. The patients seen in memory clinics had standard presentations of cognitive impairment with no apparent differences. Further studies are necessary to determine the associations between FMR1 expansions in the gray zone and various phenotypes of neurological dysfunction.
    MeSH term(s) Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Alleles ; Cohort Studies ; Female ; Fragile X Mental Retardation Protein/genetics ; Heterozygote ; Humans ; Male ; Memory Disorders/diagnosis ; Memory Disorders/genetics ; Memory Disorders/therapy ; Middle Aged ; Movement Disorders/diagnosis ; Movement Disorders/genetics ; Movement Disorders/therapy ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/genetics ; Parkinsonian Disorders/therapy ; Phenotype ; Trinucleotide Repeat Expansion
    Chemical Substances FMR1 protein, human ; Fragile X Mental Retardation Protein (139135-51-6)
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Multicenter Study
    ZDB-ID 2112586-7
    ISSN 1473-4230 ; 1473-4222
    ISSN (online) 1473-4230
    ISSN 1473-4222
    DOI 10.1007/s12311-016-0809-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5795: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis.

    Mustapha, Indra Z / Debrey, Sarah / Oladubu, Michael / Ugarte, Richard

    Journal of periodontology

    2007  Volume 78, Issue 12, Page(s) 2289–2302

    Abstract: Background: Recent meta-analyses reported a weak association between periodontal disease (PD) on clinical examination and cardiovascular disease (CVD). Systemic bacterial exposure from periodontitis, which correlates poorly with the clinical examination, ...

    Abstract Background: Recent meta-analyses reported a weak association between periodontal disease (PD) on clinical examination and cardiovascular disease (CVD). Systemic bacterial exposure from periodontitis, which correlates poorly with the clinical examination, has been proposed as the more biologically pertinent risk factor. The purpose of this study was to review and analyze the association between PD with elevated systemic bacterial exposure and CVD.
    Methods: We searched in the PubMed, Cochrane Controlled Trials Register, EMBASE, and SCOPUS databases for all literature examining PD and CVD. From 10 selected publications, we extracted 12 cohort (N = 5) and cross-sectional (N = 7) studies and included 11 of these in a meta-analysis. With stratified analyses, this resulted in 14 analyses of coronary heart disease (CHD; N = 7), stroke (N = 4), and carotid intima-medial thickening (CIMT; N = 3) as a measure of early atherosclerosis. Systemic bacterial exposure was measured by periodontal bacterial burden (N = 1), periodontitis-specific serology (N = 12), or C-reactive protein (N = 1).
    Results: Periodontal disease with elevated markers of systemic bacterial exposure was associated strongly with CHD compared to subjects without PD, with a summary odds ratio of 1.75 (95% confidence interval (CI): 1.32 to 2.34; P <0.001). This group was not associated with CVD events or with stroke but was associated with a significant increase in mean CIMT (0.03 mm; 95% CI: 0.02 to 0.04).
    Conclusion: Periodontal disease with elevated bacterial exposure is associated with CHD events and early atherogenesis (CIMT), suggesting that the level of systemic bacterial exposure from periodontitis is the biologically pertinent exposure with regard to atherosclerotic risk.
    MeSH term(s) Aggregatibacter actinomycetemcomitans/immunology ; Antibodies, Bacterial/blood ; Atherosclerosis/etiology ; Biomarkers ; C-Reactive Protein/analysis ; Cardiovascular Diseases/etiology ; Carotid Stenosis/etiology ; Coronary Disease/etiology ; Humans ; Odds Ratio ; Periodontitis/blood ; Periodontitis/complications ; Periodontitis/microbiology ; Porphyromonas gingivalis/immunology ; Risk Factors
    Chemical Substances Antibodies, Bacterial ; Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2007-12
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 390921-9
    ISSN 1943-3670 ; 0022-3492 ; 1049-8885 ; 0095-960X
    ISSN (online) 1943-3670
    ISSN 0022-3492 ; 1049-8885 ; 0095-960X
    DOI 10.1902/jop.2007.070140
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    Ul III Zs.146: Show issues Location:
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  5. Article ; Online: Diagnostic accuracy of magnetic resonance angiography for internal carotid artery disease: a systematic review and meta-analysis.

    Debrey, Sarah M / Yu, Hua / Lynch, John K / Lövblad, Karl-Olof / Wright, Violet L / Janket, Sok-Ja D / Baird, Alison E

    Stroke

    2008  Volume 39, Issue 8, Page(s) 2237–2248

    Abstract: Background and purpose: Accurate diagnosis of the degree of internal carotid artery (ICA) stenosis is needed for decisions regarding optimal stroke prevention. Noninvasive magnetic resonance angiography (MRA) is being proposed and used as a replacement ... ...

    Abstract Background and purpose: Accurate diagnosis of the degree of internal carotid artery (ICA) stenosis is needed for decisions regarding optimal stroke prevention. Noninvasive magnetic resonance angiography (MRA) is being proposed and used as a replacement for the gold standard, intra-arterial angiography. Our purpose was to perform a systematic review and diagnostic meta-analysis to determine the sensitivity and specificity of time-of-flight (TOF) MRA and contrast-enhanced (CE) MRA for the detection of (1) high-grade (> or = 70% to 99%) ICA stenoses; (2) ICA occlusions; (3) moderately severe (50% to 69%) ICA stenoses; and (4) compare the overall accuracy of the 2 MRA techniques.
    Methods: The medical literature on MRA and the diagnosis of ICA steno-occlusive disease was reviewed through the PubMed, EMBASE, and SCOPUS databases. All publication years were included through to November 2006. Studies were eligible for inclusion if they compared the accuracy of TOF or CE MRA for the detection of ICA disease against intra-arterial angiography and reported sufficient data.
    Results: The overall sensitivity of TOF MRA for the detection of > or = 70% to 99% ICA stenoses was 91.2% (95% CI: 88.9% to 93.1%) with a specificity of 88.3% (86.7% to 89.7%), whereas the sensitivity of CE MRA was 94.6% (92.4% to 96.4%) with a specificity of 91.9% (90.3% to 93.4%). For the detection of ICA occlusions, the sensitivity of TOF MRA was 94.5% (91.2% to 96.8%) and the specificity was 99.3% (98.9% to 99.6%), whereas the sensitivity and specificity values for CE MRA were 99.4% (96.8% to 100%) and 99.6% (99.2% to 99.9%), respectively. For moderately severe (50% to 69%) stenoses, TOF MRA had a sensitivity of only 37.9% (29.3% to 47.1%) and a specificity of 92.1% (89.6% to 94.1%); for CE MRA, the pooled sensitivity value was somewhat better at 65.9% (57.0% to 74.0%), whereas the specificity was 93.5% (91.3% to 95.3%).
    Conclusions: TOF MRA and CE MRA showed high accuracy for the detection of high-grade ICA stenoses and occlusions with CE MRA having the edge over TOF MRA, but had only poor (TOF MRA) to fair (CE MRA) sensitivity for the detection of moderately severe stenoses.
    MeSH term(s) Carotid Artery Diseases/pathology ; Carotid Artery, Internal/pathology ; Humans ; Magnetic Resonance Angiography/methods ; Magnetic Resonance Angiography/standards ; Reproducibility of Results ; Sensitivity and Specificity
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.107.509877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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