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Article: Comparison of different estimated glomerular filtration rates for monitoring of kidney function in oncology patients.

Vermassen, Tijl / Geboes, Karen / Lumen, Nicolaas / Van Praet, Charles / Rottey, Sylvie / Delanghe, Joris

2024 Volume 17, Issue 1, Page(s) sfae006

Abstract: Background: Tyrosine kinase inhibitors (TKIs) are associated with kidney function deterioration. A shift is ongoing towards glomerular filtration rate (GFR) equations based on other protein markers, such as cystatin C (CSTC) and β-trace protein (BTP). ... ...

Abstract	Background: Tyrosine kinase inhibitors (TKIs) are associated with kidney function deterioration. A shift is ongoing towards glomerular filtration rate (GFR) equations based on other protein markers, such as cystatin C (CSTC) and β-trace protein (BTP). We evaluated various GFR equations for monitoring of kidney function in actively treated oncology patients. Methods: We monitored 110 patients receiving a TKI. Blood and urine were collected during therapy. Serum analysis included creatinine (Cr), CSTC and BTP; for consequent GFR determination. Urine was analysed for protein, albumin, immunoglobulin G, and α-1-microglobulin. A similar analysis was done in a patient subgroup receiving immune checkpoint inhibitors (ICI) as prior or subsequent line of therapy. Results: Cr remained constant during TKI treatment ( Conclusion: GFR equations, in which CSTC is incorporated, fail to correctly estimate the GFR in oncology patients treated with TKIs. As TKI-treated patients show clear signs of glomerular injury, further assessment is needed on how to correctly monitor the kidney function in actively treated oncology patients.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfae006
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Article ; Online: The Therapeutic Landscape of Salivary Gland Malignancies-Where Are We Now?

Cleymaet, Robbert / Vermassen, Tijl / Coopman, Renaat / Vermeersch, Hubert / De Keukeleire, Stijn / Rottey, Sylvie

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Salivary gland malignancies (SGMs) account for less than 5% of new diagnoses in head and neck tumors. If feasible, surgery is the preferred treatment modality. Nevertheless, some malignancies have a tendency of recurrence, with possible distant ... ...

Abstract	Salivary gland malignancies (SGMs) account for less than 5% of new diagnoses in head and neck tumors. If feasible, surgery is the preferred treatment modality. Nevertheless, some malignancies have a tendency of recurrence, with possible distant metastasis. Alternative treatment strategies, such as primary radiation or chemotherapeutics, often present low response rates. As a result, there is an unmet need for novel therapeutic approaches. Nowadays, target-based therapies (e.g., small inhibitors and immunotherapy) are used by the medical oncologist for possible treatment of advanced SGMs. Based on recent published trials, some novel treatments may provide additional disease control for some patients. However, sample sizes are small, the general findings are unsatisfactory, and a lot of uncertainties remain to be elucidated. Nevertheless, research shows that patients do not benefit from blind administration of systemic treatments and therefore a more personalized approach is highly needed. The aim of this review paper is to summarize the most recent advances in the biological understanding and molecular pathways of salivary gland cancers, the association of these pathways with the current treatments used and their implications for more personalized targeted-based therapies.
Language	English
Publishing date	2022-11-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232314891
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Article ; Online: Choice of surgery in intestinal-type adenocarcinoma of the sinonasal tract: a long-term comparative study.

Vermassen, Tijl / De Keukeleire, Stijn / Saerens, Michael / Heerwegh, Sylvester / Debacker, Jens M / Huvenne, Wouter / Deron, Philippe / Creytens, David / Ferdinande, Liesbeth / Rottey, Sylvie / Bachert, Claus / Duprez, Fréderic / Van Zele, Thibaut

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024

Abstract: Purpose: Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy. Curative treatment requires multidisciplinary approach, with surgical options consist of the endonasal endoscopic approach (EEA) and external surgery (EXTS). Here, we provide ...

Abstract	Purpose: Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy. Curative treatment requires multidisciplinary approach, with surgical options consist of the endonasal endoscopic approach (EEA) and external surgery (EXTS). Here, we provide the post-operative and survival results from a single-center long-term follow-up. Methods: We report long-term follow-up of 92 ITAC cases treated between 1998 and 2018, treated with EEA (n = 40) or EXTS (n = 52). Survival estimates, post-operative complications and duration of hospitalization were compared between surgical modalities. Results: Baseline characteristics were similar. A higher number of T4b tumors (16%), and subsequently more tumoral invasion (39%), was present in patients undergoing EXTS compared to EEA (3% and 18%, respectively). No difference in Barnes histology subtypes was noticed. Patients undergoing EEA had a shorter post-operative hospitalization stay versus EXTS (4 versus 7 days). Use of EEA was associated to improved disease-specific survival (DSS; 11.4 versus 4.4 years; HR Conclusions: Long-term follow-up in locally advanced ITAC demonstrates that resection by EEA is correlated with improved DSS compared to EXTS, especially for T3-4 tumors. No significant differences between both treatment modalities was observed regarding per- and post-operative complications, although hospitalization in patients undergoing EEA was shorter than for patients treated with EXTS. These results confirm that EEA should remain the preferred surgical procedure in operable cases of sinonasal ITAC.
Language	English
Publishing date	2024-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08447-w
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Article ; Online: Tissue

Vermassen, Tijl / Van Den Broeck, Arne / Lumen, Nicolaas / Callewaert, Nico / Rottey, Sylvie / Delanghe, Joris

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2021 Volume 26, Issue 3, Page(s) 275–285

Abstract: Purpose: Only few biomarkers have been evaluated for their prognostic value following radical prostatectomy. We explored if tissue : Materials and methods: Tissue : Results: Majority presented with Gleason score 3 + 4 (41%), extensive local ... ...

Abstract	Purpose: Only few biomarkers have been evaluated for their prognostic value following radical prostatectomy. We explored if tissue Materials and methods: Tissue Results: Majority presented with Gleason score 3 + 4 (41%), extensive local disease (62%) and without pelvic lymph nodes invasion (83%). Several parameters (low T stage, low Gleason score, low EAU risk groups for BCR, absence of positive surgical margins, high ratio of fucosylated triantennary structures on total of multiantennary structures [3AFc/MA], low ratio of fucosylated biantennary with core-branched Conclusions: Tissue
MeSH term(s)	Aged ; Biomarkers, Tumor/metabolism ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Glycomics ; Glycosylation ; Humans ; Lymph Node Excision ; Male ; Margins of Excision ; Middle Aged ; Polysaccharides/metabolism ; Predictive Value of Tests ; Prostatectomy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Radiotherapy, Adjuvant ; Risk Assessment ; Risk Factors ; Time Factors
Chemical Substances	Biomarkers, Tumor ; Polysaccharides
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1324372-x
ISSN	1366-5804 ; 1354-750X
ISSN (online)	1366-5804
ISSN	1354-750X
DOI	10.1080/1354750X.2021.1891290
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Article: Tumor-Infiltrating Lymphocytes in Head and Neck Cancer: Ready for Prime Time?

Almangush, Alhadi / De Keukeleire, Stijn / Rottey, Sylvie / Ferdinande, Liesbeth / Vermassen, Tijl / Leivo, Ilmo / Mäkitie, Antti A

Cancers

2022 Volume 14, Issue 6

Abstract: The evaluation of tumor-infiltrating lymphocytes (TILs) has received global attention as a promising prognostic cancer biomarker that can aid in clinical decision making. Proof of their significance was first shown in breast cancer, where TILs are now ... ...

Abstract	The evaluation of tumor-infiltrating lymphocytes (TILs) has received global attention as a promising prognostic cancer biomarker that can aid in clinical decision making. Proof of their significance was first shown in breast cancer, where TILs are now recommended in the classification of breast tumors. Emerging evidence indicates that the significance of TILs extends to other cancer types, including head and neck cancer. In the era of immunotherapy as a treatment choice for head and neck cancer, assessment of TILs and immune checkpoints is of high clinical relevance. The availability of the standardized method from the International Immuno-oncology Biomarker Working Group (IIBWG) is an important cornerstone toward standardized assessment. The aim of the current article is to summarize the accumulated evidence and to establish a clear premise for future research toward the implementation of TILs in the personalized management of head and neck squamous cell carcinoma patients.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14061558
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Article: Immuno-Oncological Biomarkers for Squamous Cell Cancer of the Head and Neck: Current State of the Art and Future Perspectives.

De Keukeleire, Stijn J / Vermassen, Tijl / Hilgert, Elien / Creytens, David / Ferdinande, Liesbeth / Rottey, Sylvie

Cancers

2021 Volume 13, Issue 7

Abstract: The era of immune checkpoint inhibitors has altered the therapeutic landscape in squamous cell cancer of the head and neck (SCCHN). Our knowledge about the tumor microenvironment has fueled the research in SCCHN, leading to several well-known and less- ... ...

Abstract	The era of immune checkpoint inhibitors has altered the therapeutic landscape in squamous cell cancer of the head and neck (SCCHN). Our knowledge about the tumor microenvironment has fueled the research in SCCHN, leading to several well-known and less-known prognostic and predictive biomarkers. The clinical staging, p16/HPV status, and PD-L1 expression are currently the main tools for assessing the patients' diagnosis and prognosis. However, several novel biomarkers have been thoroughly investigated, some reaching actual significant clinical contributions. The untangling of the immune infiltrate with the subtyping of tissue-associated tumor infiltrating lymphocytes, tumor-associated macrophages, and circulating blood-based biomarkers are an interesting avenue to be further explored and prospectively assessed. Although PD-L1 expression remains the most important response predictor for immune checkpoint inhibitors, several flaws impede proper assessment such as technical issues, different scoring protocol, and intra-, inter-, and temporal heterogeneity. In addition, the construction of an immune-related gene panel has been proposed as a prognostic and predictive stratification but lacks consensus. Recently, the role of microbioma have also been explored regarding its systemic and antitumor immunity. This review gives a comprehensive overview of the aforementioned topics in SCCHN. To this end, the integration of these clinically advantageous biomarkers via construction of an immunogram or nomogram could be an invaluable tool for SCCHN in future prospects.
Language	English
Publishing date	2021-04-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13071714
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Article: Exercise Induced Myoglobinuria is Determined by Haptoglobin Polymorphism.

Maenhout, Thomas M / Vermassen, Tijl / Dalewyn, Lode / Buyzere, Marc L De / Delanghe, Joris R

Clinical laboratory

2021 Volume 67, Issue 5

Abstract: Background: In professional soccer players (n = 27), confounders of quantitative myoglobinuria following physical training were assessed in order to improve interpretation of post-exercise myoglobinuria.: Methods: Urine samples were collected in the ... ...

Abstract	Background: In professional soccer players (n = 27), confounders of quantitative myoglobinuria following physical training were assessed in order to improve interpretation of post-exercise myoglobinuria. Methods: Urine samples were collected in the morning before training sessions, 48 to 72 hours following a game. Urine myoglobin was assayed using immunoturbidimetry. Blood was drawn 48 hours following training session. Creatinine was assayed using a Jaffe method. Creatine kinase (CK) activity was assayed according to the IFCC reference method. Serum myoglobin was assayed using the same assay as the one used for urine. Hp polymorphism was assessed on hemoglobin supplemented serum. Serum Hp concentration was assayed nephelometrically. Training intensity was assessed using a wearable GPS tracking system. Physical load monitoring included the covered total distance, the distance at different speed zones, and the number of sprints/accelerations/decelerations/jumps. Multiple regression analysis was used to detect the determinants of post-exercise myoglobinuria. Results: Myoglobinuria negatively correlated with serum haptoglobin (Hp) concentration. Athletes presented with Hp values, which were lower than the Hp phenotype reference ranges, which can be explained by depletion of circulating Hp stores. Myoglobinuria was most pronounced in players carrying a Hp 2-2 phenotype, which is associated with the lowest Hp reference range. Myoglobin clearance was inversely correlated with Hp 2-2 concentration. Correlation between myoglobinuria and biomarkers of muscle damage was weak. Neither age nor glomerular filtration rate were found to be confounders of myoglobinuria. When comparing myoglobinuria with training intensity, the number of sprints, average acceleration speed, and maximal speed were determining factors for predicting exercise-induced myoglobinuria. Conclusions: In athletes, plasma myoglobin binding capacity is depleted. Moderate myoglobinuria not only should be regarded as a muscle damage marker, but also should be interpreted as an indicator for Hp depletion. Apart from its significance as a biomarker for muscle damage and rhabdomyolysis, myoglobinuria in athletes should be a warning that the heme binding capacity of plasma Hp is depleted, indicating an exhausted defense against Fenton chemistry induced free radicals. Fenton chemistry is associated with free radical formation, which is to be avoided because of the causative relationship with inflammatory processes and tissue damage.
MeSH term(s)	Creatinine ; Exercise ; Haptoglobins/genetics ; Humans ; Myoglobin/genetics ; Myoglobinuria/diagnosis ; Myoglobinuria/genetics ; Rhabdomyolysis
Chemical Substances	Haptoglobins ; Myoglobin ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-05-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2020.200855
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Article ; Online: Prostate Protein N-Glycosylation Profiling by Means of DNA Sequencer-Assisted Fluorophore-Assisted Carbohydrate Electrophoresis.

Vermassen, Tijl / Callewaert, Nico / Rottey, Sylvie / Delanghe, Joris R

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1972, Page(s) 235–250

Abstract: DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis allows for accurate profiling of the asparagine-linked (N-) glycosylation patterns, a posttranslational modification present on many soluble and membrane proteins. This technique ... ...

Abstract	DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis allows for accurate profiling of the asparagine-linked (N-) glycosylation patterns, a posttranslational modification present on many soluble and membrane proteins. This technique has been extensively tested to identify N-glycosylation patterns associated with serum proteins. Here we describe the use of DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis to identify the N-glycosylation patterns of prostate proteins in urine.
MeSH term(s)	Carbohydrates/analysis ; Carbohydrates/chemistry ; Electrophoresis/methods ; Fluorescent Dyes/chemistry ; Glycomics/methods ; Glycoproteins/chemistry ; Glycosylation ; Humans ; Male ; Polysaccharides/analysis ; Prostate/metabolism ; Proteins/analysis ; Proteins/genetics ; Sequence Analysis, DNA/instrumentation
Chemical Substances	Carbohydrates ; Fluorescent Dyes ; Glycoproteins ; Polysaccharides ; Proteins
Language	English
Publishing date	2019-03-04
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9213-3_17
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Article ; Online: To treat or not to treat? Managing comorbidities in cancer patients under immune checkpoint inhibition.

De Keukeleire, Stijn / Vermassen, Tijl / De Schoenmakere, Gert / Kruse, Vibeke / Vermaelen, Karim / Rottey, Sylvie

Acta clinica Belgica

2019 Volume 75, Issue 6, Page(s) 434–441

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Age Factors ; Autoimmune Diseases/epidemiology ; Brain Neoplasms/secondary ; Comorbidity ; Functional Status ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunocompromised Host ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Liver Diseases/epidemiology ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Organ Transplantation ; Renal Dialysis ; Renal Insufficiency/epidemiology ; Ventricular Dysfunction, Left/epidemiology
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2019-07-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	390201-8
ISSN	2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online)	2295-3337
ISSN	0001-5512 ; 1784-3286
DOI	10.1080/17843286.2019.1646516
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Article ; Online: Managing viral hepatitis in cancer patients under immune checkpoint inhibitors: should we take the risk?

De Keukeleire, Stijn J / Vermassen, Tijl / Nezhad, Zahra M / Kerre, Tessa / Kruse, Vibeke / Vlierberghe, Hans Van / Vermaelen, Karim / Rottey, Sylvie

Immunotherapy

2021 Volume 13, Issue 5, Page(s) 409–418

Abstract: More patients with chronic hepatitis B and C infection are being exposed to immune checkpoint inhibitors (ICIs), but the safety and efficacy of ICIs in patients with chronic viral hepatitis are still poorly described. To explore this interaction, we ... ...

Abstract	More patients with chronic hepatitis B and C infection are being exposed to immune checkpoint inhibitors (ICIs), but the safety and efficacy of ICIs in patients with chronic viral hepatitis are still poorly described. To explore this interaction, we identified eight studies of cancer patients with viral hepatitis treated with one or more ICIs, formally assessed tumor responses and safety by grading liver dysfunction. ICIs appear to be relatively safe in HBV/HCV-infected patients, and hepatitis related to viral reactivation is rare. In some patients, viral load regressed during ICI treatment, so immune checkpoints may play a role in viral clearance. HBV/HCV do not appear to be a contraindication to ICIs, although careful clinical and biochemical follow-up is recommended and, whenever necessary, antiviral therapy commenced.
MeSH term(s)	Chronic Disease ; Hepacivirus/drug effects ; Hepacivirus/physiology ; Hepatitis B virus/drug effects ; Hepatitis B virus/physiology ; Hepatitis, Viral, Human/complications ; Hepatitis, Viral, Human/drug therapy ; Hepatitis, Viral, Human/immunology ; Hepatitis, Viral, Human/virology ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Liver/drug effects ; Liver/immunology ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/virology ; Review Literature as Topic ; Viral Load/drug effects ; Virus Activation/drug effects
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2020-0273
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