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  1. Article ; Online: Where are we with the benefit-risk ratio of JAK inhibitors in rheumatoid arthritis?

    Avouac, Jérôme

    Joint bone spine

    2022  Volume 89, Issue 6, Page(s) 105454

    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Odds Ratio ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Antirheumatic Agents/pharmacology
    Chemical Substances Janus Kinase Inhibitors ; Antirheumatic Agents
    Language English
    Publishing date 2022-08-12
    Publishing country France
    Document type Editorial
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2022.105454
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  2. Article: Importance of SARS-CoV-2 Spike Antibodies and B Cell Reconstitution to Optimize the Prevention Strategy of COVID-19.

    Thomas, Marion / Avouac, Jérôme

    The Journal of rheumatology

    2023  Volume 50, Issue 3, Page(s) 304–306

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Antibodies, Viral ; Vaccination
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-02-01
    Publishing country Canada
    Document type Editorial ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.221282
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  3. Article ; Online: Persistent remission of severe rheumatoid arthritis associated with myelodysplastic syndrome upon treatment with lenalidomide.

    Carvès, Sandrine / Birsen, Rudy / Avouac, Jérôme

    Joint bone spine

    2024  Volume 91, Issue 3, Page(s) 105693

    Language English
    Publishing date 2024-01-19
    Publishing country France
    Document type Letter
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2024.105693
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  4. Article ; Online: Severe immune thrombocytopenia in two patients with systemic sclerosis.

    Boleto, Gonçalo / Avouac, Jérôme / Godeau, Bertrand / Allanore, Yannick

    Joint bone spine

    2023  Volume 90, Issue 4, Page(s) 105560

    Abstract: Thrombocytopenia in the context of systemic sclerosis (SSc) is rare. It should primarily raise the possibility of scleroderma renal crisis. Immune thrombocytopenia (ITP) is another cause of low platelets that is common in systemic lupus erythematosus, ... ...

    Abstract Thrombocytopenia in the context of systemic sclerosis (SSc) is rare. It should primarily raise the possibility of scleroderma renal crisis. Immune thrombocytopenia (ITP) is another cause of low platelets that is common in systemic lupus erythematosus, but tremendously rare in patients with SSc. We herein report two cases of severe ITP in patients with SSc. The first case is a 29-year-old woman with very low platelet counts (2×10
    MeSH term(s) Female ; Humans ; Adult ; Aged ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Immunoglobulins, Intravenous/therapeutic use ; Rituximab/therapeutic use ; Thrombocytopenia ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis
    Chemical Substances Immunoglobulins, Intravenous ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-03-17
    Publishing country France
    Document type Case Reports
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2023.105560
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Response to comments on "The phenotype of mixed connective tissue disease patients having associated interstitial lung disease" by Chevalier K et al. and Shih PC.

    Boleto, Gonçalo / Avouac, Jérôme / Allanore, Yannick

    Seminars in arthritis and rheumatism

    2023  Volume 64, Page(s) 152333

    MeSH term(s) Humans ; Mixed Connective Tissue Disease/complications ; Lung Diseases, Interstitial/complications ; Phenotype
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Letter
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152333
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  6. Article ; Online: Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts.

    Avouac, Jérôme / Hecquet, Sophie / Thomas, Marion / Combier, Alice / Carvès, Sandrine / Allanore, Yannick

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 5, Page(s) 679–680

    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Severity of Illness Index ; Remission Induction
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-225272
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    Zs.MO 167: Show issues

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  7. Article ; Online: DAS28-γGT for the prediction of major cardiovascular events in rheumatoid arthritis: results from the ESPOIR cohort.

    Dupont, Anne / Constantin, Arnaud / Soubrier, Martin / Rincheval, Nathalie / Avouac, Jérôme

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 3, Page(s) 665–671

    Abstract: Objective: To validate the predictive value of the DAS28 γ-glutamyl transferase (DAS28-γGT) for the occurrence of major cardiovascular (CV) events (MACE) in the 'Etude et Suivi des Polyarthrites Indifférenciées Récentes' ESPOIR cohort.: Methods: ... ...

    Abstract Objective: To validate the predictive value of the DAS28 γ-glutamyl transferase (DAS28-γGT) for the occurrence of major cardiovascular (CV) events (MACE) in the 'Etude et Suivi des Polyarthrites Indifférenciées Récentes' ESPOIR cohort.
    Methods: Analysis of 13-year outcome from the ESPOIR cohort. RA patients with missing data for baseline γGT activity and those not followed-up to 1 year were excluded. Baseline DAS28-γGT was calculated using the following formula: 0.56*√TJ-28 + 0.28 * √SJ-28 + 2*ln(γGT) + 0.014 * GH. Our primary outcome was the merit of the DAS28-γGT in predicting the occurrence of MACE.
    Results: Among the 696 patients [536 women, mean (s.d.) age of 49 (12) years], 34 MACE were recorded, with a mean time to event of 71 (44) months. Receiver operating characteristic curve analysis indicated that a DAS28-γGT >9.4 had the best sensitivity and specificity for the diagnosis of MACE during the observation period. DAS28-γGT >9.4 was predictive of the occurrence of MACE, with a hazard ratio (HR) of 3.11 (95% CI 1.41, 5.43). Multivariate Cox analyses confirmed higher DAS28-γGT (HR 2.44, 95% CI 1.05, 5.64) together with age (HR 1.04, 95% CI 1.01, 1.07) and diabetes mellitus (HR 4.12, 95% CI 1.55, 10.95) as independent predictors of MACE. There was a dose effect of the DAS28-γGT for MACE-risk prediction, which was in line with the application of the Framingham risk score.
    Conclusion: The DAS28-γGT was identified in this large prospective cohort as an independent predictor of MACE in patients with RA. The DAS28-γGT is a simple and useful tool to evaluate CV risk in routine and warn the clinician about the CV risk burden in patients with RA.
    MeSH term(s) Humans ; Female ; Middle Aged ; Cohort Studies ; Prospective Studies ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Risk Factors ; Cardiovascular Diseases/etiology
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead251
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  8. Article: The role of antifibrotic therapies in the treatment of systemic sclerosis-associated interstitial lung disease.

    Boleto, Gonçalo / Avouac, Jérôme / Allanore, Yannick

    Therapeutic advances in musculoskeletal disease

    2022  Volume 14, Page(s) 1759720X211066686

    Abstract: Systemic sclerosis (SSc) is a rare autoimmune condition with complex pathogenesis characterized by a heterogeneous presentation and different disease courses. Fibrosis of multiple organs including the lungs favored by inflammation and vasculopathy is the ...

    Abstract Systemic sclerosis (SSc) is a rare autoimmune condition with complex pathogenesis characterized by a heterogeneous presentation and different disease courses. Fibrosis of multiple organs including the lungs favored by inflammation and vasculopathy is the hallmark of SSc. SSc-associated interstitial lung disease (SSc-ILD) is common and can be associated with poor outcomes, this complication being the leading cause of death in recent series. Because of its huge heterogeneity, SSc-ILD management can be very challenging. Immunosuppressive therapy has long been used to prevent SSc-ILD progression with modest effects in clinical trials. However, thanks to a better understating of SSc pathogenesis, innovative therapies including antifibrotics are increasingly being developed. The achievement of the Safety and Efficacy of Nintedanib in Systemic SClerosIS (SENSCIS) trial has led to the approval by drug agencies of the first antifibrotic drug for SSc-ILD. In parallel, other antifibrotics are being investigated as possible beneficial therapies in SSc-ILD. An important unmet need remains to clarify the positioning of the various strategies, such as the added value of combination of immunosuppressants and antifibrotic therapies in patients at high risk of progression. Indeed, irreversible lung injury or self-perpetuated progression highlights the concept of a window of opportunity in SSc-ILD patients. Herewith, we provide an overview of the most significant clinical trials with antifibrotic drugs developed in recent years for the management of SSc-ILD and a viewpoint about their positioning in treatment algorithms.
    Language English
    Publishing date 2022-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X211066686
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  9. Article ; Online: Mouse model of experimental dermal fibrosis: the bleomycin-induced dermal fibrosis.

    Avouac, Jérôme

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1142, Page(s) 91–98

    Abstract: Relevant animal models are essential tools to investigate in depth the pathogenesis of autoimmune disease. Systemic sclerosis (SSc) is an autoimmune connective tissue disorder that affects particularly the skin. SSc is characterized by vasculopathy, ... ...

    Abstract Relevant animal models are essential tools to investigate in depth the pathogenesis of autoimmune disease. Systemic sclerosis (SSc) is an autoimmune connective tissue disorder that affects particularly the skin. SSc is characterized by vasculopathy, immune disturbances, and fibrosis. Expression of each of the three pathologic features varies among SSc patients leading to disease heterogeneity and variable organ manifestations. Several animal models of SSc are available; however, some models display inflammation followed by fibrosis, whether some others primarily mimic autonomous fibroblast activation. Here, we describe the mouse model of bleomycin-induced dermal fibrosis, which mimics early and inflammatory stages of SSc, and is widely used in SSc research.
    MeSH term(s) Animals ; Bleomycin ; Disease Models, Animal ; Fibrosis/chemically induced ; Mice ; Skin/pathology
    Chemical Substances Bleomycin (11056-06-7)
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-0404-4_11
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  10. Article ; Online: Stress‐Based and Convolutional Forecasting of Injection‐Induced Seismicity: Application to the Otaniemi Geothermal Reservoir Stimulation

    Kim, Taeho / Avouac, Jean‐Philippe

    Journal of Geophysical Research: Solid Earth. 2023 Apr., v. 128, no. 4 p.e2022JB024960-

    2023  

    Abstract: ... 1997, https://doi.org/10.1111/j.1365-246x.1997.tb01215.x) can be biased. We suggest a heuristic method ...

    Abstract Induced seismicity observed during Enhanced Geothermal Stimulation at Otaniemi, Finland is modeled using both statistical and physical approaches. The physical model produces simulations closest to the observations when assuming rate‐and‐state friction for shear failure with diffusivity matching the pressure build‐up at the well‐head at onset of injections. Rate‐and‐state friction implies a time‐dependent earthquake nucleation process which is found to be essential in reproducing the spatial pattern of seismicity. This implies that permeability inferred from the expansion of the seismicity triggering front (Shapiro et al., 1997, https://doi.org/10.1111/j.1365-246x.1997.tb01215.x) can be biased. We suggest a heuristic method to account for this bias that is independent of the earthquake magnitude detection threshold. Our modeling suggests that the Omori law decay during injection shut‐ins results mainly from stress relaxation by pore pressure diffusion. During successive stimulations, seismicity should only be induced where the previous maximum of Coulomb stress changes is exceeded. This effect, commonly referred to as the Kaiser effect, is not clearly visible in the data from Otaniemi. The different injection locations at the various stimulation stages may have resulted in sufficiently different effective stress distributions that the effect was muted. We describe a statistical model whereby seismicity rate is estimated from convolution of the injection history with a kernel which approximates earthquake triggering by fluid diffusion. The statistical method has superior computational efficiency to the physical model and fits the observations as well as the physical model. This approach is applicable provided the Kaiser effect is not strong, as was the case in Otaniemi.
    Keywords acoustic properties ; detection limit ; diffusivity ; earthquakes ; friction ; geophysics ; permeability ; phase transition ; research ; statistical models ; stress relaxation ; Finland
    Language English
    Dates of publication 2023-04
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB024960
    Database NAL-Catalogue (AGRICOLA)

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