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  1. Article ; Online: Changing life styles for children with Tourette syndrome.

    Wang, Huei-Shyong

    Biomedical journal

    2022  Volume 45, Issue 2, Page(s) 227–228

    MeSH term(s) Attention Deficit Disorder with Hyperactivity ; Child ; Humans ; Life Style ; Tourette Syndrome
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2022.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Changing life styles for children with Tourette syndrome

    Huei-Shyong Wang

    Biomedical Journal, Vol 45, Iss 2, Pp 227-

    2022  Volume 228

    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Recent update in pediatric neurocritical care: Preface.

    Wang, Huei-Shyong

    Biomedical journal

    2020  Volume 43, Issue 3, Page(s) 203–204

    MeSH term(s) Child ; Critical Care ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric ; Nervous System Diseases
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent update in pediatric neurocritical care

    Huei-Shyong Wang

    Biomedical Journal, Vol 43, Iss 3, Pp 203-

    Preface

    2020  Volume 204

    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Psychosocial experiences in youth with Tourette syndrome: a systematic review and meta-synthesis.

    Lee, Mei-Yin / Wang, Huei-Shyong / Chen, Chen-Jung

    European child & adolescent psychiatry

    2023  

    Abstract: Suffering from Tourette syndrome (TS) disrupts the daily lives and interpersonal relationships of patients. The psychosocial experiences of young people with TS are not yet clear. The aim of the systematic review is to identify and synthesize the ... ...

    Abstract Suffering from Tourette syndrome (TS) disrupts the daily lives and interpersonal relationships of patients. The psychosocial experiences of young people with TS are not yet clear. The aim of the systematic review is to identify and synthesize the psychosocial experiences of young people with TS. A meta-synthesis was conducted. PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Chinese Electronic Periodical Services databases were searched for articles published from their inception to February 2023. This review followed the Joanna Briggs Institute's Guidelines for Systematic Reviews according to a previously developed protocol. We used the confidence of synthesized qualitative findings (ConQual) approach to evaluate the credibility and dependability of the synthesized findings. This review included 12 qualitative studies from Western and Asian countries published between 2005 and 2019, representing 190 young people with TS. We identified five synthesized findings: affliction by intractable TS, TS was negatively perceived in the social and cultural context, self-adjustment in response to social interaction, response to receiving various interventions, and positivity in promoting self-acceptance. The ConQual grade for each generated synthesized finding ranged from low to moderate. The psychosocial experiences of youths living with TS are unique and are influenced by their interpersonal relationships, social context, and cultural framework. The findings recommend that healthcare providers assist young people in developing personalized symptom management strategies and provide guidance and care that meets the needs of each individual.
    Language English
    Publishing date 2023-12-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-023-02339-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Role of vitamins in epilepsy.

    Yang, Ming-Tao / Chou, I-Ching / Wang, Huei-Shyong

    Epilepsy & behavior : E&B

    2022  Volume 139, Page(s) 109062

    Abstract: Epilepsy is a chronic neurological disorder that presents as recurrent, unprovoked seizures. Pharmacotherapy is the main treatment for epilepsy, but at least 30% of patients with epilepsy have pharmacoresistant epilepsy. Therefore, non-pharmacological ... ...

    Abstract Epilepsy is a chronic neurological disorder that presents as recurrent, unprovoked seizures. Pharmacotherapy is the main treatment for epilepsy, but at least 30% of patients with epilepsy have pharmacoresistant epilepsy. Therefore, non-pharmacological treatments are still required. In addition to electrophysiological aberrations contributing to epileptogenesis and pathophysiology in epilepsy, neuroinflammation, oxidative stress, and metabolic derangement have been investigated as drug targets in the treatment of epilepsy. Vitamins have antioxidant, anti-inflammatory, and immunomodulatory effects, which can be beneficial for the treatment of epilepsy. Herein, we comprehensively review the role of vitamins in epilepsy. Certain epilepsies are vitamin-dependent or vitamin-responsive. Most studies on vitamins in epilepsy are of low evidence level or limited to animal studies. Nevertheless, vitamin supplementation should be considered in epilepsy therapy. Additionally, certain anti-seizure medications may alter the serum levels of certain vitamins. Monitoring the serum levels of vitamins and supplementing vitamins when needed are suggested during the follow-up of patients with epilepsy.
    MeSH term(s) Animals ; Vitamins/therapeutic use ; Anticonvulsants/therapeutic use ; Epilepsy/drug therapy ; Epilepsy, Generalized/drug therapy ; Vitamin A/therapeutic use ; Vitamin K/therapeutic use
    Chemical Substances Vitamins ; Anticonvulsants ; Vitamin A (11103-57-4) ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2022.109062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Psychosocial stress, self-esteem, and social adjustment: A moderated mediation analysis in Taiwanese adolescents with Tourette syndrome.

    Lee, Mei-Yin / Wang, Huei-Shyong / Lee, Tzu-Ying

    Journal of pediatric nursing

    2021  Volume 62, Page(s) e84–e90

    Abstract: Purpose: Recent studies have shown that tics and related comorbidities can cause poorer social adjustment, lower self-esteem, and higher psychosocial stress among adolescents with Tourette syndrome. This study explored the role of self-esteem in ... ...

    Abstract Purpose: Recent studies have shown that tics and related comorbidities can cause poorer social adjustment, lower self-esteem, and higher psychosocial stress among adolescents with Tourette syndrome. This study explored the role of self-esteem in mediating the relationship between psychosocial stress and social adjustment among adolescents with Tourette syndrome, and the role of comorbidities in moderating the relationship between self-esteem and social adjustment.
    Design and methods: In this descriptive cross-sectional study, 118 Taiwanese adolescents with Tourette syndrome aged between 12 and 20 years old were recruited via convenience sampling. Their demographic information, Yale Global Tic Severity Scale, stress index for children and adolescents with Tourette syndrome, social adjustment scale for adolescents with Tourette syndrome, and Self-Esteem Scale results were collected. Moderated mediation analysis of the study data was performed with the Hayes's PROCESS macro.
    Results: Our results revealed that the self-esteem of adolescents with Tourette syndrome fully mediates the relationship between their psychosocial stress and social adjustment (B = -0.0703, 95% CI, [-0.0176, -0.001]), while comorbidities moderates the relationship between their self-esteem and social adjustment (B = -0.8416, 95% CI, [-1.4529, -0.2302]). The relationship between self-esteem and social adjustment was more pronounced in adolescents without comorbidities than those with comorbidities.
    Conclusions: Psychosocial stress correlates negatively with social adjustment and self-esteem, and indirectly influences social adjustment through self-esteem, while comorbidities (particularly their absence) moderates the relationship between self-esteem and social adjustment.
    Practice implications: Different self-esteem strengthening programs to enhance social adjustment for adolescents with Tourette syndrome may be developed in future studies.
    MeSH term(s) Adolescent ; Adult ; Child ; Cross-Sectional Studies ; Humans ; Mediation Analysis ; Social Adjustment ; Stress, Psychological/epidemiology ; Tourette Syndrome/diagnosis ; Young Adult
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2021.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2871: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 375: Show issues

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  8. Article ; Online: Application of ketogenic diets for pediatric neurocritical care.

    Lin, Kuang-Lin / Lin, Jann-Jim / Wang, Huei-Shyong

    Biomedical journal

    2020  Volume 43, Issue 3, Page(s) 218–225

    Abstract: In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants. A ketogenic diet is a high-fat, low- ... ...

    Abstract In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants. A ketogenic diet is a high-fat, low-carbohydrate, adequate-protein diet. It can alter the primary cerebral energy metabolism from glucose to ketone bodies, which involves multiple mechanisms of antiepileptic action, antiepileptogenic properties, neuro-protection, antioxidant and anti-inflammatory effects, and it is potentially a disease-modifying intervention. Although a ketogenic diet is typically used for the chronic stage of pharmacoresistant of epilepsy, recent studies have shown its efficacy in patients with the acute stage of refractory/super-refractory status epilepticus. The application of a ketogenic diet in pediatric intensive care units is a challenge because of the critical status of the patients, who are often in a coma or have a nothing by mouth order. Moreover, a ketogenic diet needs to be started early and sometimes through parenteral administration in patients with critical conditions such as refractory status epilepticus or febrile infection-related epilepsy syndrome. Animal models and some case reports have shown that the neuro-protective effects of a ketogenic diet can be extended to other emergent neurological diseases, such as traumatic brain injury and ischemic stroke.
    MeSH term(s) Adolescent ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Diet, Ketogenic ; Drug Resistant Epilepsy/diet therapy ; Drug Resistant Epilepsy/drug therapy ; Epilepsy/drug therapy ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Status Epilepticus/drug therapy ; Young Adult
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2020-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Primary biliary cholangitis with features of autoimmune hepatitis in a 19-year-old adolescent with 14q24.1q24.2 deletion: a case report.

    Wang, Yi-Wei / Chao, Hsun-Chin / Wang, Huei-Shyong / Lin, Ju-Li / Chang, Chih-Chen / Huang, Shiu-Feng

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1280409

    Abstract: Introduction: Primary biliary cholangitis (PBC) is a rare and chronic autoimmune liver disease characterized by the progressive destruction of small intrahepatic bile ducts that may eventually lead to cirrhosis. PBC with features of autoimmune hepatitis ...

    Abstract Introduction: Primary biliary cholangitis (PBC) is a rare and chronic autoimmune liver disease characterized by the progressive destruction of small intrahepatic bile ducts that may eventually lead to cirrhosis. PBC with features of autoimmune hepatitis (AIH) has rarely been reported in pediatric patients with genetic defects. We present the case of an adolescent with chromosome 14q24.1q24.2 deletion who was given the diagnosis of stage IV PBC with features of AIH.
    Case presentation: A 19-year-old male adolescent with multiple congenital abnormalities and an intellectual disability presented with abnormal liver enzymes levels and pruritus for more than 5 years. Laboratory examinations revealed elevated levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase. After the exclusion of viral hepatitis, alpha-1 antitrypsin deficiency, Wilson's disease, and other genetic cholestatic liver diseases by laboratory tests and whole exome sequencing, a liver biopsy was performed and stage IV PBC was diagnosed. Notably, features of AIH were also noted in the histopathological report, indicating the presence of PBC with AIH features. The patient responded well to a combination therapy of ursodeoxycholic acid and steroids. Array comparative genomic hybridization analysis performed to study the congenital abnormalities revealed a 3.89 Mb 14q24.1q24.2 deletion.
    Conclusion: PBC with AIH features has rarely been reported in an adolescent with a chromosomal abnormality. The present case can increase awareness for early-onset PBC and its possible correlation with chromosomal defects.
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1280409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Application of ketogenic diets for pediatric neurocritical care

    Kuang-Lin Lin / Jann-Jim Lin / Huei-Shyong Wang

    Biomedical Journal, Vol 43, Iss 3, Pp 218-

    2020  Volume 225

    Abstract: In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants. A ketogenic diet is a high-fat, low- ... ...

    Abstract In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants. A ketogenic diet is a high-fat, low-carbohydrate, adequate-protein diet. It can alter the primary cerebral energy metabolism from glucose to ketone bodies, which involves multiple mechanisms of antiepileptic action, antiepileptogenic properties, neuro-protection, antioxidant and anti-inflammatory effects, and it is potentially a disease-modifying intervention. Although a ketogenic diet is typically used for the chronic stage of pharmacoresistant of epilepsy, recent studies have shown its efficacy in patients with the acute stage of refractory/super-refractory status epilepticus. The application of a ketogenic diet in pediatric intensive care units is a challenge because of the critical status of the patients, who are often in a coma or have a nothing by mouth order. Moreover, a ketogenic diet needs to be started early and sometimes through parenteral administration in patients with critical conditions such as refractory status epilepticus or febrile infection-related epilepsy syndrome. Animal models and some case reports have shown that the neuro-protective effects of a ketogenic diet can be extended to other emergent neurological diseases, such as traumatic brain injury and ischemic stroke.
    Keywords Ketogenic diet ; Pediatric intensive care unit ; Epilepsy ; Status epilepticus ; Traumatic brain injury ; Stroke ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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